association	dataset	threshold value	standardized value
METAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00345351
METTL7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00739714
GTEX-QCQG-1726-SM-3GIJ9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.876876
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.32758
periaqueductal gray substance, dorsolateral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05284
spinal (inferior) vestibular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.89102
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43011
ABT-199	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
Pancreatic adenocarcinoma_PAAD_TCGA-F2-6880-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HDAC2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lymphnode_5a	HPA Tissue Sample Gene Expression Profiles	1.0	2.75883
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.20239
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5462-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R55F-1726-SM-2TF4R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929034
Perturb_4826_KD_Nfya_SRP149362	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	11.4768
H3K4me3_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K20600965	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11644
WRNIP1	ENCODE Transcription Factor Targets	1.0	null
BRD-K58066822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27007
GTEX-POYW-0726-SM-2XCEO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09712
Lung adenocarcinoma_LUAD_TCGA-49-4501-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LDN-192960	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
Perturb_13222_KO_Hdac3_ERP123505	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	10.4085
874_BOP1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.555412
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.94331
DAPK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47433
MXI1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Chloroplast outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.869
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-2226-SM-3GIKP	GTEx Tissue Sample Gene Expression Profiles	1.0	0.914071
GSE216043_7_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTF2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248045,GSE248046_0_v_1_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-A7TJ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K80724972	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03581
BRD-K04143779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58341
hsa-miR-124	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
DAN-G	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03923
A549_Aurora A Inhibitor I_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143834
hsa-miR-4799-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
BRD-K91671568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13918
BRD-A20463452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22859
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4193
YY1-26981420-C2C12-MOUSE-MUSCLE	ChEA Transcription Factor Targets 2022	1.0	null
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.627251
GTEX-XQ8I-0426-SM-4BOPO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.834104
GABRG3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056031
UHMK1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15546
inner SZ in dorsolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.824105
COPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22664
BRD-K85919350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08051
ELF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF189	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.4005
hsa-miR-548z	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
TAF1	ENCODE Transcription Factor Targets	1.0	null
SPI1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.831443
GSE158834_7_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.53595
H3K4me3_HL-60_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
E2F4_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2AphosphoS5_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Hemorrhage	CTD Gene-Disease Associations	1.0	1.15156
NCIH441	CCLE Cell Line Gene CNV Profiles	-1.0	-1.90064
7505_RPS16_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.52768
primary visual cortex (striate cortex, area V1/17)_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.59485
BRD-K45964657	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0418
10032_ZCCHC10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.544877
POLR2AphosphoS5_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QV31-0226-SM-447BO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22445
FOXA1-25329375-VCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K23075656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02356
TCF3	ENCODE Transcription Factor Targets	1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XLM4-0004-SM-4AT5I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71016
GSE164508_1_v_0_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE167224,GSE168147_3_v_5_hnrnpk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JHOC5	DepMap CRISPR Gene Dependency	1.0	2.71166
BICR 22	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.928803
A-2058 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.209
K562_BMS-536924_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154773
MDAMB415	CCLE Cell Line Gene CNV Profiles	1.0	1.75428
Hydrogen Peroxide	CTD Gene-Chemical Interactions	1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4957_KO_Zbtb2_ERP125292	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.65598
DOHH2	CCLE Cell Line Gene Expression Profiles	1.0	1.80492
PTX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51638
NFATC1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.880713
Leukemialymphoblastic(MOLT-4)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.85417
posteroventral (inferior) parietal cortex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.898684
BRD-K45904718	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07866
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
C5orf34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17266
Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.966468
BRD-K91241684	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58697
GTEX-S32W-1626-SM-4AD6G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21038
organism form	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052645
ZNF530	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	74.8316
BRD-K94378105	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40964
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71352
NCOR-22424771-293T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-518d-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
alsterpaullone-7056	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K9ac_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K84199148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01759
dorsal thalamus_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.848302
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.40365
hsa-miR-3155	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-OXRN-1726-SM-3NM9B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829843
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPU-0011-R7A-SM-2XCAB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.866474
GTEX-R53T-1326-SM-48FCQ	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13697
9454_TXNIP_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.577851
GTEX-X8HC-0126-SM-4E3JW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911565
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Lomustine_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0252431
BRD-K03287885	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16147
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.59804
DAUDI	CCLE Cell Line Gene Expression Profiles	1.0	1.53277
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4193
BRD-K69879051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27751
primary motor cortex (area M1, area 4)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0201
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242290_1_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12892_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.49758
magnocellular (medial) division of MD	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.23868
MED25	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-548c-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
MED24	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-5639-01A-01R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K9ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-K1-A42W-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
facial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.961295
H3K4me1_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DDB1	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K71138333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2112
COR-L88	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.41996
EP300	ENCODE Transcription Factor Targets	1.0	null
HCFC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:E19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2348
PMC4445818-13062_2015_58_MOESM2_ESM.xlsx-NSCL_Adjacency_Lists-Gene_symmbol_for_Protein_B_NHLH1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K35472285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03401
PCNX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29578
TNFAIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12879
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40602242	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48915
GSE131660_1_v_0_piperlongumine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111247_2_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PSMB7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22343
Quinidine	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
GTEX-X4XY-0011-R8A-SM-46MVC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22345
18304324-GeneList	GeneSigDB Published Gene Signatures	1.0	null
EKVX	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.984636
BRD-K28276275	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10554
VMRCRCZ	CCLE Cell Line Gene CNV Profiles	1.0	1.41961
7437_RPL13_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.540332
lateral hypothalamic area, anterior part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.988906
K562_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230054
IPO4	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K84077642	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00357
BRD-K75076471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80068
ZNF263	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	56.6124
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U4-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG8-2226-SM-3GIL9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853422
GSE165122_2_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-203	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE210093_3_v_2_taf15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EU-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PPARG-20887899-3T3-L1-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
HEK293	BioGPS Cell Line Gene Expression Profiles	1.0	1.11871
hsa-miR-633	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
H3K36me3_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
BRD-K03308716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2283
1148_CACTIN_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.541467
hsa-miR-509-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
hsa-miR-4438	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Sultiame	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
VPS9D1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00625424
MCF7_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126812
RCOR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EZH2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-3746	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29919
GSE135686_2_v_3_etomoxir_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27ac_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AG-2926-SM-2HMJ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.900781
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.837506
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CRCGN017_MCF10A.WT.HP_24H:L20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08835
GTEX-NFK9-0926-SM-2HMJU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12479
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A3IV-01A-22R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_1_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5909_NVL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.688983
YY1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K73290515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01399
hsa-miR-548h	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918794
SART1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K98301999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82285
Lung adenocarcinoma_LUAD_TCGA-05-5420-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.62228
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
PD-70-VS77_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325655
CRCGN008_HEPG2_24H:O01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7648
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MYBL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0306
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.34185
TLR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536082
BRD-K61795707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53832
BRD-K21620541	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07048
UBTF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7125-11A-01R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-down_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
DLAT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05022
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:P11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.7869
NR2F1	JASPAR Predicted Transcription Factor Targets	1.0	null
GTEX-TKQ1-0003-SM-3NMAE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82075
GSE207433_2_v_3_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3772-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.51586
hsa-miR-600	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
ventrolateral prefrontal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1286
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.33718
CAPAN1	CCLE Cell Line Gene Expression Profiles	-1.0	-2.6988
H3K4me3_Jurkat_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K20196153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80084
BRD-K15099225	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07689
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0106242
H3K4me3_H1 Derived Neuronal Progenitor Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-NPJ8-1926-SM-3MJGB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33531
GTEX-V955-2426-SM-3GAEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1773
BRD-K13229082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00537
amygdaloid complex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.13337
U2SURP	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
JUND	ENCODE Transcription Factor Targets	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4c-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
PTS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10727
A549_MK-0752_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0157206
POLR2A_brain_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K65969715	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65504
trichostatin A-5065	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3406-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A_48H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.85626
ELF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Spliceosomal tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.048
HUVEC	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.05204
A549_FLLL32_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143421
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838962
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.860913
GTEX-XXEK-0726-SM-4BRWF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21476
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.02227
YY1_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K51490423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.20653
MCF7_AG-14361_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0163385
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89999
POLR2A_Raji_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.538478
Gli1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.1656
PREP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.98091
LU-65	GDSC Cell Line Gene Expression Profiles	-1.0	-1.97016
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JK-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-XUZC-0926-SM-4BOQF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865778
Plastid outer membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.862
9210_TPP2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677633
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06832
SP in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.12921
H3K4me1_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
K562_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145107
MXI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Valproic acid sodium salt_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0179435
BRD-K47783463	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1016
BRD-K50942788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84355
NOP58	Pathway Commons Protein-Protein Interactions	1.0	null
GSE131649_6_v_7_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOS_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MYADM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.15871
RNPS1	Pathway Commons Protein-Protein Interactions	1.0	null
MCF7_Linifanib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137597
hsa-miR-3168	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GTEX-XBED-0226-SM-47JY8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911495
BRD-K02881560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26769
TRIM28_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-A4CL-01A-41R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Acute Myeloid Leukemia_LAML_TCGA-AB-2952-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me1_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ2-1326-SM-4DXT9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892451
nuclear part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Hand1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	24.9689
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
apomorphine-2005	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SP1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Perturb_4955_KO_Zbtb2_ERP125291	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.96054
GPC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45414
POLR2A	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K38084509	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18534
H3K4me3_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.83251
5748_NOP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.620524
BRCA1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-IB-8127-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.36003
17660535-TableS4a	GeneSigDB Published Gene Signatures	1.0	null
SP1	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3J3-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.08746
inferolateral temporal cortex (area TEv, area 20)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.38234
Lung adenocarcinoma_LUAD_TCGA-35-3615-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIN1	Pathway Commons Protein-Protein Interactions	1.0	null
connecting stalk	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.133937
seminal vesicle	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
BRD-K44797534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.08658
BRD-K31778735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85507
TRIFLUPERIDOL-2HCL	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12046
BRD-K76309489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.23175
BRD-K45172622	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47453
K562_INO-1001_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182467
UNC5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552465
SW954	DepMap CRISPR Gene Dependency	1.0	3.62573
caudal portion of VFC (area 44)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.13723
A549_Baricitinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132167
acetohexamide-1829	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7994-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
1175_CAP1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.601595
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tolfenamic acid-1437	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_14657_KD_LINC00673_SRP102315	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
H3K27ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_CH12.LX_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
TMEM88B_KD_GPL10558_471_human_cardiovascular progenitors cells differentiated from hES cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-K45874102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67799
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.511348
IRF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7604
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16631
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.931742
liver	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
paracentral lobule, posterior part, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2531
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-G8-6907-01A-11R-2213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1-19122651-HELAS3-HUMAN-CERVICALCANCER	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K52436508	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.60241
GTEX-WFJO-0002-SM-3P61X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0587
CRCGN017_MCF10A.WT.HP_24H:N03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.91172
FOS	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
germ layer	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071974
BRD-K82460510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31948
AD-58-PW17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.304198
PMC12513837-41588_2025_2336_MOESM4_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_List_of_AR-only_and_p300_AR-shared_enhancer_regulated_genes_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PRDM1	JASPAR Predicted Transcription Factor Targets	1.0	null
H3K4me3_Colon Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NANOG-16518401-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K27121064	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.95682
CIAPIN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03545
H3K27ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2A_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X3Y1-0726-SM-3P5YU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0253
hsa-miR-519c-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K74537058	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90616
POLR2AphosphoS2_myocyte_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.9047
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TEN	CCLE Cell Line Gene CNV Profiles	1.0	1.39139
POLR2A	ENCODE Transcription Factor Targets	1.0	null
IC-28-HS37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.98657
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16283
BRD-K18637162	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05124
anterior (rostral) cingulate (medial prefrontal) cortex_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.88085
tonsil	HPA Tissue Gene Expression Profiles	1.0	1.31562
BRD-K11004561	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14286
IRF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.8046
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
HCC1897	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3616
7525_RPS3_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.56769
AN3 CA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1154
PDE3B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581214
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25039
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05466
GTEX-WI4N-1026-SM-3LK7N	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952407
BRD-K44304623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44065
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.50405
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18473
PRPF4B	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K81568980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43329
2932_RIPOR1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.891902
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.9228
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.66072
ZNF143_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-W5X1-2326-SM-3GIL6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.5463
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE216273,GSE216292_0_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Panobinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0104179
GTEX-X261-0011-R7A-SM-4E3JJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998208
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.76332
BRD-K60653414	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39635
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24265
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K92849826	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62705
OVCAR4	CCLE Cell Line Gene CNV Profiles	1.0	1.34412
POLR2A_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11145
DDX50	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K47415214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01212
A549_Crizotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014742
REL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25335
EMC7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.77019
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58696904	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96991
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.21425
H3K27ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hippocampus (hippocampal formation)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.42405
BRD-K79152256	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05634
A549_Epothilone A_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144442
BRD-K19411393	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01978
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31413
CRCGN016_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.2952
TEAD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44556
trichostatin A-1234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFK_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE48812_9_v_5_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-35-4122-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CF-50-MN16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.359154
BLZ-945	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.825844
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.49525
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.22397
GW-8510-7062	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WHPG-0004-SM-3NMDO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.78884
K562_Selisistat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169809
CRCGN017_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.24573
BRD-K53127431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33124
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26116
BHLHE40_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SK-MEL-31	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.30639
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873562
POLR2AphosphoS5_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.108141
Perturb_6170_KD_PROX1_SRP073100	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	3.18651
BRD-K14942405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43758
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MED4	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Triamcinolone Acetonide_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127463
BRD-K92570288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00301
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.951685
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K75100119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41562
KMS-12-PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.64095
NC-52-HX69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.314459
H3K27ac_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.875568
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154234
CRCGN011_HEPG2_24H:G23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07075
BRD-K23232542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19394
MXI1	ENCODE Transcription Factor Targets	1.0	null
ETS1	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_megakaryocyte_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
RELA_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ARID3A	ENCODE Transcription Factor Targets	1.0	null
POU2F2_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7606-01A-11R-2090-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAJB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4656
K562_Rucaparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149924
preoptic region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.96326
BRD-K26091803	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25287
Lung squamous cell carcinoma_LUSC_TCGA-NC-A5HO-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
496100335_PCx_no dementia_TBI_81_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26958
A549_GSK-LSD1 2HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016238
ONS76	DepMap CRISPR Gene Dependency	1.0	2.48779
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902602
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MCF7_AZD1480_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130443
GTEX-POYW-1226-SM-2XCEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07758
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49045
NC-27-AD53_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305517
HCC1187	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.63456
Nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
A549_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167833
REST_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-0126-SM-2I3EN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15792
LF-27-NX16_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200038
GTEX-P4QT-2026-SM-3NMCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03514
hsa-miR-4448	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
superior frontal gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.976499
colonrectum_d	HPA Tissue Sample Gene Expression Profiles	1.0	1.35305
NCI-H2073	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.840775
19050837-Table2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K04992384	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03312
CAMK1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575698
GTEX-U3ZN-2126-SM-4DXU1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08694
SK-MEL-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7125
TCF21-26020271-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K49664555	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35574
BRD-K58300049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56378
ACE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0068285
K562_Prednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.021593
BRD-K67535324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.94329
MBD4	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-67-3770-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCIH441	CCLE Cell Line Gene Expression Profiles	-1.0	-3.412
CA2 field, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44417
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K38633800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01726
POLR2G	Pathway Commons Protein-Protein Interactions	1.0	null
NCI-H835	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-3783-01A-01R-1201-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-UPK5-2026-SM-4JBIM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826664
IK	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CHD1	ENCODE Transcription Factor Targets	1.0	null
sulfinpyrazone-1574	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67591072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78604
MCTS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06736
H3K9ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.13339
MDAMB436	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.796554
TC-O 9311	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
CB-83-LF14_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.246561
H3K9ac_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Genetic disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
GSE48812_0_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
KDM5B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K21384875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13768
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K04275703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36414
hsa-miR-548d-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K88156935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58944
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.898903
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.998526
BRD-K18136154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86101
SB-674042	DeepCoverMOA Drug Mechanisms of Action	1.0	0.4
POLR2A_GM18505_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
trichostatin A-6439	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7679
BRD-K09960817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31564
GTEX-U3ZH-1526-SM-4DXV1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29517
BRD-K40838215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03684
PNISR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.34381
7576_RSL1D1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.605566
SP1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE248045,GSE248046_6_v_2_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-25-VR48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.370337
Penis_Foreskin_Fibroblast_Primary_Cells_skin02	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.10334
Adrenocortical carcinoma_ACC_TCGA-OR-A5LL-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A619-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5702_NLE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.523747
pou5f1_16518401_mesc_lof_mouse_gpl1261_gds1824	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.38266
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10486
DDX52	Pathway Commons Protein-Protein Interactions	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902602
dexamethasone_homo sapiens_gpl4133_gse42619	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
JAM3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31411
primary motor cortex (area M1, area 4)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.84074
POU2F2_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K69423881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58251
H3K4me3_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
4651_LRP8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.69914
MITF	ChEA Transcription Factor Targets	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.885066
Lung adenocarcinoma_LUAD_TCGA-38-4627-11A-01R-1758-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-S4P3-0008-SM-3NM8R	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20916
K562_SB431542_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014926
GTEX-P4PP-0426-SM-3NM9H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01896
guanabenz-1961	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20794
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3466-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11109217-41420_2024_2017_MOESM3_ESM.xlsx-Fig_4H_TAF2-bound_genes-Tag_dentsity_of_TBP_ChIP-seq_signal_for_TAF2-bound_genes_in_Fig_4H_TBP	Rummagene Transcription Factor Associations 2026	1.0	null
GSE155836,GSE155839_3_v_2_alvocidib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.27194
CAMA1	CCLE Cell Line Gene CNV Profiles	1.0	2.03118
tonsil_8b1	HPA Tissue Sample Gene Expression Profiles	1.0	1.36223
BRD-K39979888	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07837
dorsolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19509
MC116	CCLE Cell Line Gene Expression Profiles	1.0	1.51674
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-TSE9-0326-SM-3DB82	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03509
PIN1	Hub Proteins Protein-Protein Interactions	1.0	null
H3K4me3_Neurosphere Cultured Cells Cortex Derived	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RPL4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36856
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RN-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SRSF3	Pathway Commons Protein-Protein Interactions	1.0	null
heart_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.884772
USF2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1395	GDSC Cell Line Gene Expression Profiles	-1.0	-1.75202
BRL 54443	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
K562_Filgotinib_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0234044
A-CA-04-2009(H1N1)_0Hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.43814
GTEX-XXEK-0126-SM-4BRVU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01511
fulvestrant-6918	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2E	Pathway Commons Protein-Protein Interactions	1.0	null
P3HR1	CCLE Cell Line Gene Expression Profiles	1.0	1.41323
BRD-K14442101	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58833
BRD-K80575072	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20496
skbr3	HPA Cell Line Gene Expression Profiles	-1.0	-1.78572
Telomerase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.266
hsa-miR-499a-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16961
BRD-K35943892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08584
Alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
YAPC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873562
Brain Lower Grade Glioma_LGG_TCGA-DB-5276-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
YY1_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135743
Drug-Induced Liver Injury	CTD Gene-Disease Associations	1.0	1.2744
CRCGN013_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.84162
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.8989
GTEX-PVOW-0008-SM-48TE8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19214
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A10T-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_ZM 447439_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171009
preoptic	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.87167
BRD-K85232515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33916
BRD-K05329107	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06195
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
molecular layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.10135
BRD-K46334103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06463
CRCGN017_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.3532
PMC6488577-41598_2019_43010_MOESM2_ESM.xlsx-Proteingroups_MBD3_pos-Gene_names_MBD3	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_K562_hg19_9	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-1.68277
BRD-K98018160	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9173
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.604858
CRCGN016_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.53747
POLR2A_testis_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
309_ANAPC5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540688
A549_ZM 447439_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164564
BRD-K15499806	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20693
BRD-K57907671	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94809
YY1-23942234-MYOBLASTS-AND-MYOTUBES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
6709_PPY_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.53987
AE-39-DG66_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.327862
9443_TWISTNB_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.536331
NANOG-16518401-CHIP-PET-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
8622_SYNCRIP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52901
H3K4me1_CH12.LX_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WCDI-0002-SM-3P61U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18865
K562_Selisistat_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171883
EBF1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SG in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0765
Sensory ganglion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.649
PBX3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1937	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.10783
GSE198165,GSE198166_7_v_11_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-39-5040-11A-01R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_UNC0379_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141916
WSU-NHL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.67635
NOLC1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-U8T8-0008-SM-4DXSP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09837
intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.659084
OKAJIMA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983748
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.22184
HOP62	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.35114
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
WC-16-IR43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257153
GSE213650_3_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96877
female reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053662
H3K4me3_Brain Hippocampus Middle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K27ac_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38935
LUDLU1	DepMap CRISPR Gene Dependency	1.0	2.7433
ATF2	ENCODE Transcription Factor Targets	1.0	null
BCL11A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRKAR1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557541
hippocampus (hippocampal formation)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902837
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71055
7455_RPL27_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.13789
ChIP_ASH2L_23239880	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
MDAMB415	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.04257
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.01502
MCF7_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135779
POLR2AphosphoS5_HL-60_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17536501	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.17148
VIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.916521
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
outer CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.81301
HS766T	CCLE Cell Line Gene CNV Profiles	1.0	2.54404
Gastrointestinal system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
KG1C	CCLE Cell Line Gene CNV Profiles	1.0	1.76431
GSE225218_2_v_3_abcb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K32537206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47736
GSE198165,GSE198166_5_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
STAC3	Pathway Commons Protein-Protein Interactions	1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.538784
Ebolavirus(EBOV)_5day_PBMCs_17725815_GSE8317	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.54022
lateral nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.957761
FOXM1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUM44PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.913753
CRCGN017_MCF10A.WT.HP_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0549
GTEX-POYW-0426-SM-2XCEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895455
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931854
PML_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.32877
NOP56	Pathway Commons Protein-Protein Interactions	1.0	null
MALME3M	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4111
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050004
salivary gland	HPA Tissue Gene Expression Profiles	-1.0	-0.993129
inner SZ in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.5374
18537972-TableS4	GeneSigDB Published Gene Signatures	1.0	null
LRRN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0755
BRD-K28814368	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0037
MAFF	ENCODE Transcription Factor Targets	1.0	null
TAF1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K41135617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20242
GTEX-S7SE-0326-SM-4AT5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06471
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7UC-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-HOXD10_HOXD10	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K31748787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48767
Racecadotril	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
BRD-K48912618	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.24597
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.41709
HS294T	CCLE Cell Line Gene Expression Profiles	-1.0	-1.93338
POLR2AphosphoS5_Panc1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dexamethasone_homo sapiens_gpl570_gse33135	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K90756713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51498
GSE213650_0_v_1_everolimus_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15204
BRD-K07348252	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37106
Carcinoma Of Lung	DisGeNET Gene-Disease Associations	1.0	null
YY1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.64034
BRD-K35119180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32722
NAMPT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00354668
Perturb_6453_KD_YAP1_SRP056665	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0194466
GTEX-S7SF-0008-SM-3NM8T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64619
CE-02-FZ80_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.205355
USF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80798
BRD-K38724926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34994
oocyte	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.72364
TMPO	Pathway Commons Protein-Protein Interactions	1.0	null
HD-29-LW24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.207285
BRD-K88812688	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22626
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HCC78	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.90242
UF-85-NE30_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212269
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.02525
Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78N-01A-12R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Veliparib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0230896
A549_Azacitidine_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.017848
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65755
AA-86-YY62_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.206612
PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_UdRPC_HSC_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
DD-36-YH76_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.453115
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14152
POLR2A_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58753007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16225
H3K4me3_G1E_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
NPY5R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509753
496100604_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.33362
POU2F2_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.75552
TAF1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WYVS-0526-SM-3NM9W	GTEx Tissue Sample Gene Expression Profiles	1.0	0.934824
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.68974
BL-41	GDSC Cell Line Gene Expression Profiles	1.0	1.4879
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K72135113	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14733
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	1.0	null
LUC7L2	Pathway Commons Protein-Protein Interactions	1.0	null
ZNF558	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05045
1840_CPSF2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510987
CDC42EP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17556
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_5936_KD_MYEF2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-5.62458
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15095
ARRDC4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7842
POLR2A_GM12891_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.609685
BRD-K60517939	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47953
paracentral lobule, posterior part, right, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.92506
CRCGN017_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.47065
Mesothelioma_MESO_TCGA-LK-A4O4-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18614
HCFC1_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ventrolateral prefrontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.952051
BRD-K68257399	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45798
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC6	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K01360791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.38176
H3K4me1_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60918542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10306
GTEX-SNMC-1526-SM-2XCFN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41228
KMS34	CCLE Cell Line Gene CNV Profiles	-1.0	-1.32562
anterior cortical nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.860785
MDA MB435	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00254
KNS60	DepMap CRISPR Gene Dependency	1.0	2.94547
BRD-K45620289	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87535
FE-64-KC49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.239623
HIPK2_defectivemutant_29_GDS4233	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.38369
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26735
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE112760,GSE112767_2_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
PML_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
SIX5	ENCODE Transcription Factor Targets	1.0	null
BRD-K64698855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45162
7526_RPS4X_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510726
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
GTEX-S33H-0626-SM-2XCBJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30368
FOXH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27416
H3K4me1_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3427-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WB-48-EF24_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.446876
MBD4_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K03512847	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51993
ZNF384_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7462_RPL35A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.599903
H3K9ac_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
IRF1	ENCODE Transcription Factor Targets	1.0	null
GSE239578_0_v_3_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
IZ in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.15228
H4K91ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE220520_6_v_9_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_NVP-BSK805 2HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128025
TBP_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K37336973	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04048
BRD-K27982554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6495
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MXI1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inner CP in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.07864
A549_Regorafenib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0185949
AFF4	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K71919612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72609
AD-51-SS86_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.643346
Lung squamous cell carcinoma_LUSC_TCGA-37-4129-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
embryonic structure	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053229
RYR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00651315
GAK	GDSC Cell Line Gene Expression Profiles	-1.0	-2.82292
hippocampus (hippocampal formation)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.19074
H3K79me2_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
layer V of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-3.05971
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-5678-01A-11R-1541-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
6534_POLR1B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.734013
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75406
GTEX-PWOO-0008-SM-48TDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31161
PEO4	DepMap CRISPR Gene Dependency	1.0	3.9615
CTCF_BE2C_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Linifanib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0149706
retroparafascicular area of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04483
H3K4me1_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
decitabine_homo sapiens_gpl570_gse30985	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KDM5A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SF3B2	Pathway Commons Protein-Protein Interactions	1.0	null
7444_RPL19_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.00254
parolfactory gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.19468
BRD-K73831546	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11529
HCC1319	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.29066
CRCGN015_MCF10A.TP53.M_24H:I10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.36235
COLO680N	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69248
hsa-miR-455-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
KLF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	95.3631
TP53	Hub Proteins Protein-Protein Interactions	1.0	null
hsa-miR-3157-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K52075209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.74005
Stat2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	107.465
RUNX1-22412390-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PDE4A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551783
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7837-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.86975
pineal_day	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.860159
POU2F2	ENCODE Transcription Factor Targets	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4a-YY1_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
A549_WP1066_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0178883
TTA-1 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.583
BRD-K75990394	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31111
ZKSCAN1	ENCODE Transcription Factor Targets	1.0	null
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03616
BRD-K05605336	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0708
mRNA_ESX1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Gene_ID_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
2561_EIF4A3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.640192
vitamin c_homo sapiens_gpl570_gds3635	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
2580_EIF6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.522977
A549_Hesperadin_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118903
BRD-K73769678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72162
BRD-K48171978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22439
SAP30	ENCODE Transcription Factor Targets	1.0	null
H3K9ac_K562_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70V-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GTEX-QVJO-0008-SM-447AU	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847999
colorectum	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DNALI1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC4944136-srep28995-s2.xls-NOBOX-gene_NOBOX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.TP53.M_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18529
SLC25A12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618554
BRD-K40228963	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00886
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6473-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NCIH28	CCLE Cell Line Gene CNV Profiles	1.0	1.45897
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FA-63-WI26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.221178
7449_RPL23A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.821569
GTEX-P4PP-1426-SM-3NM9L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03546
VIIIB, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21303
BRD-K70717477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56042
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE121246_1_v_0_stat5b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.985239
7482_RPLP0_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.513725
15735024-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
CCNH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00376576
CRCGN017_MCF10A.TP53.M_24H:P21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07312
CRCGN015_MCF10A.TP53.M_24H:D03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07213
KDM1A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K70426100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78377
BRD-K01358985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02719
BORC complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.523
GTEX-S95S-0726-SM-4B64H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.849828
K562_Tranylcypromine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151974
ADPRS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2328
RFX5	ENCODE Transcription Factor Targets	1.0	null
CDH1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00568289
MRPS18A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00512966
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37542
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.14885
FRA10AC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K90313630	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47512
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4114-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE112763,GSE112767_0_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1581	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.23594
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516886
MCF7_Danusertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154388
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47347
U6 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.685
hsa-miR-580	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
MAP1LC3A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00597397
RAD21	ENCODE Transcription Factor Targets	1.0	null
GTEX-SUCS-1926-SM-32PM3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86548
H3K4me3_HepG2_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.44615
COLO741	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3479
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HMGN3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06194
daudi	HPA Cell Line Gene Expression Profiles	1.0	1.28308
Intracellular non-membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
ITK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553939
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RELA_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-LG-A9QC-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9804_WDR12_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.770768
H3K4me3_MCF-7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K21996189	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12006
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224678
GTEX-O5YT-2126-SM-3MJGD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16512
GSE129244_3_v_1_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842895
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-WT-gene_symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE229973_3_v_7_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.896106
SLFN14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00724389
GTEX-WH7G-1926-SM-4LVMM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889603
BRD-K61733751	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0832
ventrolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.18072
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC11825621-210_2024_3353_MOESM2_ESM.xlsx-AR-IL13_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81I-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K35132745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.97965
HCC630	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.1482
Brain Lower Grade Glioma_LGG_TCGA-DB-A64Q-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IC-05-AW29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-1.24597
BRD-K24076516	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07808
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21105
SOX15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.46864
GABPA_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.4447
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K78262424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06126
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
H3K4me3_erythroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7183-11A-01R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RPE1SS51	DepMap CRISPR Gene Dependency	1.0	2.00902
GTEX-XBED-0726-SM-4GIAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25291
XB-35-TO54_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345507
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8638-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.837719
GTEX-S4UY-0008-SM-3NM8H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.26131
BRD-K06431647	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96841
GSE94849_1_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-MZ-A7D7-01A-21R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE73381,GSE73382_0_v_1_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ATP13A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520666
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6472-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PW2O-0426-SM-48TCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20491
H3K4me3_Brain Anterior Caudate	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.33884
ctnnb1_21914722_ls174t_lof_human_gpl570_gds4386	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	1.22679
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.34179
GTEX-XYKS-0002-SM-4BRWN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3188
BRD-K80290360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16134
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YD-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K88662980	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12923
CRCGN014_HEPG2_3H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14208
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K98891210	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09625
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0841
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.896689
CI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.64021
Spironolactone	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.36
CRCGN015_MCF10A.WT.HP_24H:I07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06847
H3K9ac_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ES-I3 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.30506
agranular insular cortex (area Iag)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.008
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.592042
PNMT	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49564
ZMIZ1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CCDC50	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554319
ELF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2D	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RU72-0011-R9A-SM-2TF67	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956163
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.85731
SPI1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE128333_3_v_0_tcf4_human	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Resminostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162519
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
4149_INTS4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.540398
GTEX-W5WG-0002-SM-3NMDN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.98242
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A6DW-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BTBD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612803
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.8779
BRD-K86070914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41814
CEP76	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19706
GSE112765,GSE112767_1_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Runx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	29.1055
REST_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153722
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_iPS DF 19.11	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PLA2G1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00854332
KDM5A	ENCODE Transcription Factor Targets	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2771-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CBX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00393508
colon_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.919445
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.95053
JUND_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.TP53.M_24H:C02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03208
salivarygland_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.2284
Pancreatic adenocarcinoma_PAAD_TCGA-US-A779-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Adrenocortical carcinoma_ACC_TCGA-PK-A5H8-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PRDM9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	322.2
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.1039
GTEX-Q2AH-1526-SM-48TZG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26155
MRPL34	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.20397
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
COLO800	DepMap CRISPR Gene Dependency	1.0	2.01477
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB7A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.86965
K562_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0218813
GSE114013,GSE114014_0_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO 201	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.26998
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37189
H3K9ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K72255288	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22287
H3K27ac_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE218098,GSE218099_1_v_0_tcf19_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65845
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-1826-SM-32QOR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20826
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0147
H3K79me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
USF2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CARD6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00732743
BRD-K85697068	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53336
GTEX-TKQ2-1526-SM-4DXUN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06662
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
REC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12309
BHLHE40_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133683_1_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A5W6-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4135-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
TCF3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-18-3421-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21955645	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11776
H3K4me3_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.8914
SW1990	GDSC Cell Line Gene Expression Profiles	-1.0	-2.18055
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4343-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary visual cortex (striate cortex, area V1/17)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.12845
Neurosphere_Cultured_Cells_Cortex_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.983922
BRD-K52872067	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18979
BRD-K10528627	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09367
POU2F2_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00553517
ventrolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.928667
HT55	DepMap CRISPR Gene Dependency	1.0	2.33135
BRD-K26351062	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61644
mast cells	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.04359
ELK1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Hg_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE145249_1_v_2_ppm1g_human	RummaGEO Gene Perturbation Signatures	1.0	null
CRCGN010_HEPG2_24H:O19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06011
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050039
BRD-K74382273	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20059
FOSL2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57854
ZBTB7A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-GN-A4U9-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_Ivosidenib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013076
GTEX-S7PM-0126-SM-4AD6S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.827877
RAD21_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.958192
BRD-K74656131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2238
Perturb_18563_KO_Tal1_SRP117185	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.96433
A549_Bisindolylmaleimide IX_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0197991
KCNS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32448
LAMTOR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00711437
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7647-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
icSARS CoV_72Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.20684
EB2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.980672
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3458-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SKBR3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.74948
HUG1N	CCLE Cell Line Gene Expression Profiles	-1.0	-2.5796
NCI-H596	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MCF7_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141414
TCOF1	Pathway Commons Protein-Protein Interactions	1.0	null
MYB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7944
ELF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CETN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47951
POLR2AphosphoS5_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Jurkat_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7782-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN008_HEPG2_24H:L14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0289
JHUEM7	DepMap CRISPR Gene Dependency	1.0	2.17524
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE211151_1_v_0_progesterone_human	RummaGEO Drug Perturbation Signatures	1.0	null
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
fusiform gyrus, left, lateral bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.08654
STAT5A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KRBA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00562
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K77392050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33121
1966_CUL7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.506122
CTU1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16424
PPP6C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00685636
Transforming growth factor beta ligand-receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.892706
FOXM1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
hsa-miR-499-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
ASH2L	ChEA Transcription Factor Targets	1.0	null
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.898068
GB-46-CK08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.391821
S117	DepMap CRISPR Gene Dependency	1.0	2.62617
Lung squamous cell carcinoma_LUSC_TCGA-37-4133-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RUNX3	ENCODE Transcription Factor Targets	1.0	null
CRCGN017_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.17631
MAZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE199189_1_v_0_creld2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K59957369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25037
YH13	DepMap CRISPR Gene Dependency	1.0	2.48858
A549_Aurora A Inhibitor I_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0205703
Stat5b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	38.5587
HCC1263	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37669
17555561-Table1	GeneSigDB Published Gene Signatures	1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_AC480_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204747
LOVO	DepMap CRISPR Gene Dependency	1.0	2.70289
GPR75	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.59536
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
KCNK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00643497
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NOC4L	Pathway Commons Protein-Protein Interactions	1.0	null
cerebellar cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.980498
8685_TAOK3_P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.709105
colon	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
U2-type spliceosomal complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.176
8126_SLU7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.566473
H3K4me3_CD3 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-4130-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-204	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.47803
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
496100585_PCx_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.63811
H3K4me3_Penis Foreskin Keratinocyte Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2999-03B-01T-0748-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN013_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37983
BRD-K69109808	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51182
KPNA2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.03725
POLR2A_GM19193_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED22	Pathway Commons Protein-Protein Interactions	1.0	null
K562_AICAR_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0228027
central part of CEl	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21578
Perturb_1227_KD_HNRNPH1_SRP033393	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.39831
CRCGN008_HEPG2_24H:D11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.5587
E2F6_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hsa-miR-548f	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K00446585	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37115
CD80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005651
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39355
mRNA_SOX9_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K40241022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34087
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873562
IL33	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00678858
CTCF_fibroblast of gingiva_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7527_RPS5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.842432
GSE184892_0_v_5_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-P78B-0008-SM-48TE1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50373
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15073
GTEX-P4QS-2126-SM-3NMCF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11327
SW1088	CCLE Cell Line Gene CNV Profiles	1.0	1.62679
Perturb_57_KD_Suv39h2_SRP185804	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.56746
PMC9108619-EMBJ-41-e109191-s016.xlsx-UPF3A_KO_14_3B_KD-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
superior colliculus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.886799
A549_Roxadustat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182358
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
2291_DNAJC17_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.88982
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65053
skin_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04053
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00127
CAL 54	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.29557
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4876-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9738_VPS13A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52661
GSE115542_5_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A_48H:J03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.30223
PMC7616986-EMS181817-supplement-Supplemenatry_tables.pdf-239-SALL4_SALL4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00974
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164748
WC-67-DI84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.341029
PPFIA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26413
FGFR1_mutant_26_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.88238
eGFP-JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.63838
midbrain reticular formation, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23804
ELF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-484	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
RUNX3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BACH1	ENCODE Transcription Factor Targets	1.0	null
PIK3R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528068
primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.921319
GSE241701_1_v_0_daxx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K08141534	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43504
dorsolateral prefrontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.895253
ZNF384_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K67261586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85503
GTEX-XK95-0008-SM-4AT5G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16104
APOBEC3G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00672718
NCI-H520	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.834309
Acute Myeloid Leukemia_LAML_TCGA-AB-2903-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K20906316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55426
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE104604_1_v_0_eif5a_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8017594-LSA-2019-00332_Table_S1_Table_12.xls-DCX-KD_LIS1-KD_DEGs-LIS1-KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34292
MCF7_G007-LK_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145182
SW 948	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03923
cerebralcortex	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.846612
NOTCH_INHIBITION_GDS2794_61_human_MOLT4 (T-cell acute lymphoblast leukemia) cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90478
BRD-K79517375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43383
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6854
BRD-K01705159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83283
ZKSCAN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.6698
ELK1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-G3-AAV1-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U4/U6 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.86
BRD-K02548315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00682
NPM1	Pathway Commons Protein-Protein Interactions	1.0	null
OCI-AML5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.970272
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.949592
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.238566
hippocampus (hippocampal formation)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.882807
Protein N-acetylglucosaminyltransferase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.022
TLCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03597
clomipramine-1566	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SU-DHL-5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-QV44-0926-SM-2S1RH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.851439
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20P-01A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216043_7_v_6_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UCHL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551989
H3K4me1_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SYK_druginhibition_155_GSE34176	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.83697
BRD-K01899298	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1603
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02136
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0926-SM-4LVM2	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0141
MED13L	Pathway Commons Protein-Protein Interactions	1.0	null
hsa-miR-1305	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
HCC364	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.81831
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.2696
hsa-miR-30a	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
Basimglurant	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
CCNT2	ENCODE Transcription Factor Targets	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-3.03819
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-2.06064
H3K4me1_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE139966_1_v_0_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TM-A7C3-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UACC893	DepMap CRISPR Gene Dependency	1.0	3.78205
H3K4me3_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2726-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:N02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	6.4634
CENPE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35008
hesperetin-1947	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Thiothixene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.42
POLR2A_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2766-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sitaxsentan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.28
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Zinc finger, CCHC-type	InterPro Predicted Protein Domain Annotations	1.0	null
FOXA1	ENCODE Transcription Factor Targets	1.0	null
A549_RG108_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215276
hsa-miR-520c-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K64840743	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11517
PMC6377303-NIHMS1504983-supplement-2.xlsx-AR_signature-To_AR	Rummagene Transcription Factor Associations 2026	1.0	null
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.36102
Lung squamous cell carcinoma_LUSC_TCGA-37-3789-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN010_HEPG2_24H:O06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.06218
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bronchus	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
KDM5B-21448134-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K9ac_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-GeneName_AR	Rummagene Transcription Factor Associations 2026	1.0	null
K562_Temsirolimus_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154731
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-0.718235
KYSE-30	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08853
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K4me3_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.86093
H3K4me1_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BCL7C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0094385
BRD-K79885457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37176
BRD-K64559139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13873
central medullary reticular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.4835
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CEBPD_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SR	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53431
Lower respiratory tract disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H847	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.858128
496100628_FWM_dementia_TBI_77_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58639
H3K79me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	5.4267
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.072
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04548
TAF1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3155b	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-IR-A3LL-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110440_1_v_0_rad21_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K73579545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52338
CREB1	ENCODE Transcription Factor Targets	1.0	null
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JUND_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.39513
ETS1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GX-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1949
SNU-216	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09837
u698	HPA Cell Line Gene Expression Profiles	1.0	1.88871
H3K4me3_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K50432649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1331
eGFP-JUNB_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ELF1	ENCODE Transcription Factor Targets	1.0	null
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23976
BRD-K77775127	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76533
FOXA1_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24571
2551_EIF3G_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.533057
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-1026-SM-3LK74	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.880379
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053496
ELK1	ENCODE Transcription Factor Targets	1.0	null
EOMES_OE_GDS5077_65_human_RUES2	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
estradiol_homo sapiens_gpl570_gse23610	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE216043_3_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDK8	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_5163_OE_miR294_SRP051519	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.26081
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76614
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.08456
BRD-K52124788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28558
TRIM28_U2OS_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CAL72	DepMap CRISPR Gene Dependency	1.0	2.25339
H3K4me1_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BD-49-MD69_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231881
CAMA1	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.40471
H3K27ac_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.37763
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21525
PML_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Astrocytoma_CNS - Brain (MMHCC)_GSE4290	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	1.46488
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2F1-18555785-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
MTHFD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.27835
hsa-miR-577	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
GSE57875_1_v_0_hnrnpl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.24147
RMUGS	DepMap CRISPR Gene Dependency	1.0	2.75516
Lung squamous cell carcinoma_LUSC_TCGA-34-5234-01A-01R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.42745
H3K4me3_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Large intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me1_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cation binding	GO Molecular Function Annotations 2015	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW1417	GDSC Cell Line Gene Expression Profiles	-1.0	-1.93242
tonsil_8e1	HPA Tissue Sample Gene Expression Profiles	1.0	0.826013
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82577
Brain Lower Grade Glioma_LGG_TCGA-DU-A76L-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Alisertib_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0127474
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20625
BRD-K19310540	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10409
Perturb_16437_KD_NUDT21_SRP221381	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
K562_Carmofur_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171902
BRD-K82477786	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18427
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.896371
EB-3	GDSC Cell Line Gene Expression Profiles	1.0	2.04156
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13186
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YF-01A-12R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
orbital frontal cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.964136
hypoglossal nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.2499
GTEX-T8EM-0126-SM-4DM5R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.921052
IC-05-AW29_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.251944
GTEX-SN8G-0001-SM-3NM8L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58184
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A39Y-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRRC8A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671242
KMBC2	CCLE Cell Line Gene CNV Profiles	-1.0	-3.04724
HOMER2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00444492
CCNC	Pathway Commons Protein-Protein Interactions	1.0	null
Eyebrow thickness	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.552288
NB10	DepMap CRISPR Gene Dependency	1.0	3.99032
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K51927648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12832
GSE242290_3_v_0_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in orbital frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.95748
GSE148066,GSE157787_2_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-0.89587
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
EGR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05802
subcallosal cingulate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.93384
H3K4me2_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31053
H3K27ac_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RBM39	Pathway Commons Protein-Protein Interactions	1.0	null
TBC1D2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.50245
GSE109530,GSE109531_1_v_3_hdac3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_JNJ-26854165_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016165
H3K4me1_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
5470_NAT10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.718787
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K55877261	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.59463
HMY-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.901764
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.581321
GTEX-QLQW-1026-SM-447A9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41648
TP63	ChEA Transcription Factor Targets	1.0	null
GTEX-U3ZN-0726-SM-4DXT5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829751
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A5VV-06A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPD	ENCODE Transcription Factor Targets	1.0	null
mesoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.091061
MAPK6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00336594
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.931854
MED30	Pathway Commons Protein-Protein Interactions	1.0	null
ESC_J1_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
AMZ2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27295
CRCGN014_HEPG2_24H:K06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.57458
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226584,GSE226589_2_v_0_ezh2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.68215
BRD-K69408624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68514
TAF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
oxymetazoline-1431	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.62778
NB6	DepMap CRISPR Gene Dependency	1.0	2.93545
mRNA_POU5F1_16518401	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878685
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.33781
H3K27ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
rostral (anterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27866
BRD-K57687960	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3735
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.211955
BRD-K03606830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.83128
PMC8390401-12094_2021_2621_MOESM2_ESM.xls-S5-Supplemental_Table_S5_Differentially_expressed_genes_between_cases_with_CM-induced_pY-STAT3_DMFI_1_76_STAT3_Low_v_DMFI_1_76_STAT3_High_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
CA46	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-91-A4BD-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
KHM1B	CCLE Cell Line Gene CNV Profiles	1.0	1.81297
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.752049
A549_XAV-939_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141465
BRD-K51185182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07646
REST	ENCODE Transcription Factor Targets	1.0	null
GTEX-S7SE-0826-SM-4AT4D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996541
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849738
Lung adenocarcinoma_LUAD_TCGA-64-1680-01A-02R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
motor nucleus of trigeminal nerve, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.73118
POLR2AphosphoS5_SK-N-MC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56158
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923715
BRD-K34369474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02018
molecular_function	GO Molecular Function Annotations 2015	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.39188
CDK19	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SPI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10232513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.873
GTEX-WEY5-2326-SM-3GIKK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97557
TAF1_PFSK-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3ac_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ISO-1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.28
GSE210476_2_v_0_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K43484052	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49117
H3K4me2_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VI	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.871201
H3K4me2_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
APOLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00696468
ELF5	ChEA Transcription Factor Targets	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6363-01A-21R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ANAPC2	Pathway Commons Protein-Protein Interactions	1.0	null
H3K9ac_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-RWS6-0001-SM-3NMAL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.16174
RBPJ	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.6815
SIN3A	ENCODE Transcription Factor Targets	1.0	null
BRD-K03659510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22149
GSE234043_0_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
rara_21299862_mcf7_lof_human__gds4065	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.001673
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13082
A549_Baricitinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013411
PMC10881763-DataSheet_1.pdf-22-YY1_YY1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K27610371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1051
FOXA2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_PHA-680632_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0106758
496100316_TCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	3.23568
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05166
GTEX-SN8G-0008-SM-4DM4X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19249
H3K4me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NUMA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE135350_3_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
sirolimus_mus musculus_gpl1261_gse5332	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.73704
Liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
GTEX-U4B1-0726-SM-4DXUA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.906969
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45174
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.847799
CRCGN016_MCF10A.TP53.M_24H:O11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.43016
BBS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00720836
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-Q2AI-0008-SM-48U2H	GTEx Tissue Sample Gene Expression Profiles	1.0	2.38821
PMC12356310-mmc1.xlsx-Rep_3_Control_and_MTR4_KD-Gene_Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZNF80	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520926
BRD-K83673542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00259
Crx	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.5278
MZ7-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
7910_SIGMAR1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.54744
Melanoma	DisGeNET Gene-Disease Associations	1.0	null
cerebellum	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.9112
MED8	Pathway Commons Protein-Protein Interactions	1.0	null
STAT3_MCF 10A_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZMIZ1	ENCODE Transcription Factor Targets	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3918-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34372
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
H3K4ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC11531655-MCO2-5-e754-s001.docx-0-IRF7_Regulon_5_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.966101
BRD-K13390322_HY-50940_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K76661445	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22043
amiloride-1890	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.901544
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.543066
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49359
SUPT1	CCLE Cell Line Gene Expression Profiles	1.0	1.49699
GTEX-RUSQ-2126-SM-47JXK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833362
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.13141
GTEX-RNOR-1226-SM-48FDQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831926
BRCA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZH-0926-SM-4DXU4	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95782
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32873
imatinib_homo sapiens_gpl96_gds3045	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
POLR2B	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
rostral ventral respiratory cell group	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.16469
H3K27ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.51844
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.72945
BRD-K74968522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47209
ZFYVE9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.6671
IRF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A3GN-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LS513	CCLE Cell Line Gene Expression Profiles	1.0	1.4376
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SYM-2206	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10889
Aorta	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	2.44022
FOXA1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CP in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.88773
Lung squamous cell carcinoma_LUSC_TCGA-77-7335-11A-01R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.28386
PMC11445528-44318_2024_208_MOESM5_ESM.xlsx-AA-geneSymbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.08802
GSE216273,GSE216292_0_v_6_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06586
H3K4me1_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
ZNF384_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-1726-SM-4B64Z	GTEx Tissue Sample Gene Expression Profiles	1.0	0.860874
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7125
Lung adenocarcinoma_LUAD_TCGA-05-5429-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-AR_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K41116634	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.21855
0175029-0000-3691	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.7811
H3K4me3_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MTA3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DNAJC5G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00471778
GSE112763,GSE112767_2_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OHPL-2526-SM-3MJGT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862532
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23568
CRCGN008_HEPG2_24H:C21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.6019
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
urogenital system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051884
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-A7Q1-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SK-BR-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.88257
K562_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155092
striatum_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.16589
REC1	CCLE Cell Line Gene Expression Profiles	1.0	1.61457
LMNA	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K73952959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.06798
GTEX-SSA3-0426-SM-32QPI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898272
H3K4me3_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7866-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE173201_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-U3ZM-0426-SM-3DB73	GTEx Tissue Sample Gene Expression Profiles	1.0	0.89001
hsa-miR-3658	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
H2AFZ_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126463_4_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_2-Methoxyestradiol_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135631
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504761
HOXB4	ChEA Transcription Factor Targets	1.0	null
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.43735
H2BK5ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K05671817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19754
K562_Iniparib_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0181041
PFEIFFER	CCLE Cell Line Gene Expression Profiles	1.0	1.70627
BRD-K76193544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09704
BRD-K72651085	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16798
vomeralnasalorgan.VMO.	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.0191
0175029-0000-6875	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K15997423	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47862
BRD-K19734887	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07882
7467_RPL37A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.607783
C1QB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00611397
DB-54-GQ68_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.515061
GTEX-QMR6-0011-R8A-SM-32PKJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.975438
18310505-TableS7	GeneSigDB Published Gene Signatures	1.0	null
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.41787
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EP300_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EBF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFJO-1026-SM-3GIKL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00125
striatum_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00517
Perturb_3945_KD_BRD4_SRP063978	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-XGQ4-0008-SM-4AT3Z	GTEx Tissue Sample Gene Expression Profiles	1.0	3.76143
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33883
FOXO1::FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.2004
MDAMB231	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.717915
ENG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5927
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.843231
A549_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182268
SUDHL1	CCLE Cell Line Gene Expression Profiles	1.0	1.93398
BRD-K17155259	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04303
H3K4me2_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
NCI-H460 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.733
SIN3A_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
8305C	CCLE Cell Line Gene Expression Profiles	-1.0	-1.54091
Lung adenocarcinoma_LUAD_TCGA-38-4631-01A-01R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_7_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K58070604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64685
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73Q-01A-21R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_MC1568_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015119
BRD-K02362691	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27218
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8444
BRD-K65423474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42729
BRD-K86545229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76386
OLIG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04008
H3K9ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_ZM 447439_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0172415
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SCC9	DepMap CRISPR Gene Dependency	1.0	2.00519
SUM 52PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.5402
POLR2A_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQW-0426-SM-447A7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856471
PCBP1	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06942
SIX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.394
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.12001
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.050039
Papillary thyroid cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.763
COLO741	CCLE Cell Line Gene Expression Profiles	-1.0	-1.5853
Lung squamous cell carcinoma_LUSC_TCGA-39-5037-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06418332	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02269
BRD-K38097136	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50374
MAFK_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PGRMC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0034278
LY-294002-5587	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEC-1326-SM-4AT69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961935
CYP4F2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00508986
GSE158834_11_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XXEK-0004-SM-4BRWO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.55387
MAZ_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Fetal Brain	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me1_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_5892_KD_CBX1_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-11.6037
9910_XRN1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543577
A549_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132723
LOVO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.32621
GSE211286_1_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TRMT2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.04857
SNU489	CCLE Cell Line Gene CNV Profiles	1.0	1.4235
BRD-K27719710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47388
BRD-K43159427	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.78499
ventral tegmental area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.866669
IRF4	ENCODE Transcription Factor Targets	1.0	null
K562_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160519
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TMEM42	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0893
TAF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K49461735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.14691
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H650	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11727
GSE131649_4_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_SNS-314 Mesylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135011
BRD-K22405104	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6312
ECC10	CCLE Cell Line Gene CNV Profiles	-1.0	-1.49247
POLR2AphosphoS5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K96708215	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00612
SPI1_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCS214	DepMap CRISPR Gene Dependency	1.0	2.19599
SF268	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.02446
CBX3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SE5C-0326-SM-4BRWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.839098
BRD-A73559168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62301
Oviduct	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
GSE180800,GSE180801_0_v_5_tex10_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K57616143	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80728
red nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.990946
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.14727
STAT5A	ENCODE Transcription Factor Targets	1.0	null
GTEX-R3RS-1326-SM-48FE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61741
MXRA7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47384
BRD-K61223323	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46998
REST_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78668110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36236
colon	HPA Tissue Gene Expression Profiles	1.0	1.0051
Gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
6555_POLR3A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.26341
Inherited metabolic disorder	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
GTF2B	ENCODE Transcription Factor Targets	1.0	null
PBX3	ENCODE Transcription Factor Targets	1.0	null
ARH-77	GDSC Cell Line Gene Expression Profiles	1.0	1.70463
BRD-K30298864	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97977
BRD-K02809100	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15195
TAF1_PFSK-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWN1-0126-SM-2I3FK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19073
BRD-K11258719	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10065
TMEM88_KD_GSE43805_682_human_hES cells differentiated along the cardiac lineage	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A615-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW900	CCLE Cell Line Gene Expression Profiles	-1.0	-1.79188
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44921612	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55165
MYC-19030024-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE148066,GSE157787_9_v_4_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K84761515	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39257
BRD-K11433244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29856
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FGFR1_mutant_25_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.73864
MZ7-mel	GDSC Cell Line Gene Expression Profiles	-1.0	-1.65166
colonrectum_f	HPA Tissue Sample Gene Expression Profiles	1.0	0.991029
GSE119498_0_v_7_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
clofazimine-1624	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.9812
GTEX-RTLS-0008-SM-48FET	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56543
Lung squamous cell carcinoma_LUSC_TCGA-51-4080-01A-01R-1100-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_Nilotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160632
ESR1-22446102-UTERUS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
GSE139966_4_v_3_figla_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A2M	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532605
K562_Roxadustat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154274
PMC13127299-mmc2.xlsx-FOXM1_kdRNAseq-hgnc_symbol_FOXM1	Rummagene Transcription Factor Associations 2026	1.0	null
HES5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29186
BRD-K76115264	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16499
A549_Resveratrol_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0147445
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD8 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A194-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GATA6-25053715-YYC3-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC1954	DepMap CRISPR Gene Dependency	1.0	2.25642
CEBPB	ENCODE Transcription Factor Targets	1.0	null
septal organ	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-1.02474
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HOXC5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47685
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.903269
PLK1_druginhibition_181_GSE46856	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-1.95648
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
496100574_HIP_possible Alzheimer's disease_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.58751
BCL11A	ENCODE Transcription Factor Targets	1.0	null
cerebellar cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.874522
PMC7181646-41523_2020_157_MOESM4_ESM.xlsx-RNAseq_KD_vs_Control_DEG-Gene_ID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
skeletalmuscle_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.3885
GTEX-XBEC-0126-SM-4GIDT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31796
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4977-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_MLN8054_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210409
K562_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175352
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-11A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
inner portion of lateral ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.90049
K562_Gandotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145382
OPRK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00759657
GSE119978,GSE180930_2_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
19286929-SuppTable2i	GeneSigDB Published Gene Signatures	1.0	null
CALU-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.05439
BRD-K30581008	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12273
H3K79me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
OLIG2-26023283-AINV15-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
USF1	ENCODE Transcription Factor Targets	1.0	null
SCC-15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09395
GTEX-UJMC-2026-SM-3GADR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907638
HARA	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25777
GTEX-SNOS-0003-SM-3NMAO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7637
496100397_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.06624
TTF2	ChEA Transcription Factor Targets	1.0	null
K562_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171739
Acute Myeloid Leukemia_LAML_TCGA-AB-2965-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE120415,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-Q734-1126-SM-48TZY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29406
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04548
Bcl11b	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	36.9629
EOLA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04661
H3K4me3_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MDST8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31628
H3K4me1_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169425
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.29992
BRD-K77718491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.77764
HDAC2_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K02707544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04808
CA2 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.98969
hsa-miR-211	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GSE239436,GSE239441_0_v_1_keap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.847458
BRD-K73092207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07931
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE229973_3_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPJH-0001-SM-3NMDE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65387
BRD-K05220907	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68571
AE-42-HT01_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234082
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958108
BRD-K25583354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0374
TAF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K12325488	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40504
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25425
NXF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.70945
BRD-K31275250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57053
MAST2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00363409
small intestine	GTEx Tissue Gene Expression Profiles	1.0	1.02994
CRCGN016_MCF10A.WT.HP_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.41267
MYC_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE228430_2_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
4780_MAK16_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.618994
IRF4_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
mRNA_TCF3_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.23609
POLR2A_erythroblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUW1-1726-SM-4BOOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10476
GTEX-WRHK-1626-SM-3MJFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864012
GTEX-OXRK-0526-SM-3NB2F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.842441
Perturb_4958_KO_Zbtb2_ERP125292	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.46658
H3K4me3_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE149124,GSE149128_2_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
496100577_FWM_probable Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.1144
GSE216043_11_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
embryonic stem feeder layer	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.23011
ATXN7L2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00748769
NE-94-VE83_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.391699
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BCL11A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE214212_2_v_1_chd6_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ATF1	ENCODE Transcription Factor Targets	1.0	null
FOXO3	ChEA Transcription Factor Targets	1.0	null
CRCGN008_HEPG2_24H:O04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8179
U4 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.749
MYC-19915707-AK7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
BRD-K93561942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.65795
2105_DDX18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543727
GTEX-VJYA-0001-SM-3NMDJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.63916
anterior hypothalamic area, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14923
BRD-K83436911	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15856
Brain Lower Grade Glioma_LGG_TCGA-FG-A713-01A-11R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
hsa-miR-548p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
H3K4me3_small intestine_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
short insular gyri, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.84045
BRD-K39710695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.84915
IM9	DepMap CRISPR Gene Dependency	1.0	3.45725
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45222
BRD-K11389666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.05352
hippocampus (hippocampal formation)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.05446
MALME3M	DepMap CRISPR Gene Dependency	1.0	4.29414
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SL-01B-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F6	ENCODE Transcription Factor Targets	1.0	null
PMC3435504-msb201237-s2.xls-Supp_Table_4b-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11633308-NIHMS2025386-supplement-MMC2.xlsx-shRNA_KD-Name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-607	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
CRCGN017_MCF10A.TP53.M_24H:M07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.20749
MTNR1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523993
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.999517
KA-81-AG66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.617937
BRD-K98320707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40549
HSG	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.1292
Lung adenocarcinoma_LUAD_TCGA-35-4123-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_SL-327_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164872
XCL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00626513
PGGHG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24743
LPAR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00536973
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	0.878242
H3K4me1_Penis Foreskin Fibroblast Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCFC1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
MED28	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-PLZ6-0726-SM-3P619	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0456
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.0362
BRD-K05479183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87503
GSE151119_2_v_0_hsf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29968
CCK81	DepMap CRISPR Gene Dependency	1.0	3.35813
BRD-K03542527	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.45076
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GABPA	ENCODE Transcription Factor Targets	1.0	null
LUC7L3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.09626
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.941634
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
ERP44	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30652
RERFLCSQ1	DepMap CRISPR Gene Dependency	1.0	4.69343
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7872-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KLF14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	122.96
PMC4728380-ncomms10153-s8.xlsx-MYC_binding_intensity_ALL-Unnamed_15_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_C2C12_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC10350897-j_biol-2022-0528-S1.pdf-187-ZBTB43_ZBTB43	Rummagene Transcription Factor Associations 2026	1.0	null
H3K9ac_Rectal Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K79303560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.03696
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42R-01A-11R-A23N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
caudal ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.889965
GSE60837_6_v_4_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14528
PSME3	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-RVPU-0011-R9A-SM-3NM8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.932946
H3K27ac_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
u2197	HPA Cell Line Gene Expression Profiles	-1.0	-1.57157
primary motor cortex (area M1, area 4)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0897
GTEX-XLM4-0011-R9A-SM-4AT45	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01635
IRF4_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.85135
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4583-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MCF7_BMS-754807_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151207
ERF::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.9664
III, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.26948
COLO-680N	GDSC Cell Line Gene Expression Profiles	-1.0	-2.37869
ANAPC1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K08966355	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03691
BT-474	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27194
outer SZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.1797
SP4_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC11502753-41467_2024_53330_MOESM11_ESM.xlsx-Sheet1-SMAD3_target_genes_hES_SMAD3	Rummagene Transcription Factor Associations 2026	1.0	null
7459_RPL31_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.830012
YY1-23942234-MYOBLASTS AND MYOTUBES-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
K562_PD98059_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0166247
CTNNBL1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K88802328	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01563
GTEX-PLZ6-0008-SM-48TD5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.833156
POLR2A_GM10847_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K39326623	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1474
HC-01-FD24_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.256141
BRD-K02920459	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.0504
POLR2A_GM18951_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
testis_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.05558
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.70606
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_SB431542_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0125322
organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PHF8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7513_RPS24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.534235
496100584_HIP_probable Alzheimer's disease_no TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.11747
H3K4me1_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
16207381-Table1Sb	GeneSigDB Published Gene Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
bone marrow	HPA Tissue Protein Expression Profiles	1.0	1.37932
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
SULT1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.90072
MYC	ChEA Transcription Factor Targets	1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38203
BRD-K99978187	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10065
ATF2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0126-SM-4AD62	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17806
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.14409
KMS-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13187
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.82781
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K31013025	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18938
Sarcoma_SARC_TCGA-DX-AB2X-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K51791049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24505
7443_RPL18_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.738558
HDAC6	ENCODE Transcription Factor Targets	1.0	null
G96	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.66464
GCN1L1	Pathway Commons Protein-Protein Interactions	1.0	null
MED20	Pathway Commons Protein-Protein Interactions	1.0	null
EC-62-OE64_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.215128
RFX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.1981
zinc ion binding	GO Molecular Function Annotations 2015	1.0	null
dorsal lateral geniculate nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.43215
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16236
GSE189683_3_v_0_rif1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_Panc1_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7426_RPF1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.518966
A549_Cyclocytidine HCl_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148677
vascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.05848
DRD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0049331
MAFF_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
striatum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.82439
FOSL2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tonsil_8a1	HPA Tissue Sample Gene Expression Profiles	1.0	1.41616
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4833
HIC2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.14292
amygdaloid complex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.2539
H3K4me3_iPS DF 6.9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
LB771HNC	DepMap CRISPR Gene Dependency	1.0	6.49369
H3K36me3_ES-Bruce4_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.07942
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5832-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57183
ALPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3599
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.50961
A361	BioGPS Cell Line Gene Expression Profiles	-1.0	-2.01835
alimentary canal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
KCNN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00355987
LOMEGUATRIB	DeepCoverMOA Drug Mechanisms of Action	1.0	0.26
inferolateral temporal cortex (area TEv, area 20)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.948411
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Nasopharyngeal carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.861
BRD-K51335814	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3072
adrenal gland	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
H3K9ac_Brain Mid Frontal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-8470-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.WT.HP_24H:A14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.4387
H3K9ac_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SCAF4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.24783
HD-51-KD29_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.994618
OVCAR433	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38346
LS123	DepMap CRISPR Gene Dependency	1.0	4.17572
K562_Alendronate sodium trihydrate_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0204882
FB-86-IO73_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.278334
COLO680N	CCLE Cell Line Gene CNV Profiles	-1.0	-2.25055
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.06994
MAX_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE217115_3_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CENPV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11942
Perturb_15851_KO_RbpJ_SRP165224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.04697
HNRNPM	Pathway Commons Protein-Protein Interactions	1.0	null
POLR2A_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
umbilical cord blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.877397
Perturb_5972_KD_TARDBP_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-6.31441
H3K4me3_lung_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-30c	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
K562_Quercetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0216124
Perturb_14970_KD_Phf23_SRP248452	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-17.0862
Lung adenocarcinoma_LUAD_TCGA-67-3773-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4537_OE_TET3_SRP099074	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.55275
Prostate adenocarcinoma_PRAD_TCGA-CH-5743-01A-21R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36393312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04216
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.13408
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845911
GTEX-S4UY-0126-SM-3K2BB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955527
COLO 741	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.984636
BRD-K74103290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18574
H3K27ac_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE211177,GSE211178_9_v_3_ets1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K96623405	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07593
hsa-miR-1179	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.91009
ZSCAN21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8828
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64221
G28T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.842797
BRD-K24930745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05691
YY1_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED13	Pathway Commons Protein-Protein Interactions	1.0	null
primary auditory cortex (core)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.09027
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
H3K4me3_Duodenum Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SB-269970	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
MED6	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8414-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-30b	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
17177833-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12146
BRD-K01296372	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00588
gigantocellular group, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.923068
GSE240258_0_v_1_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NB-80-IM48_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28726
PMC5140759-NIHMS819001-supplement-supp_dataset3.xlsx-d_GFPoe_vs_CPEB1oe-Table_S3d_APA_events_in_CPEB1_overpressing_HFFs_CPEB1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K07802542	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16712
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_heart_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4333
inferolateral temporal cortex (area TEv, area 20)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.37506
H3K4me2_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_EED226_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0134097
EP300_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-30e	TargetScan Predicted Conserved microRNA Targets	1.0	0.257113
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KDM5A	ChEA Transcription Factor Targets	1.0	null
K562_Prednisone_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144804
DOHH-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.66242
amygdaloid complex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.04122
H3K79me2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETV5::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4396
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y0-01A-12R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.369065
CRCGN014_HEPG2_24H:K23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11003
H3K4me3_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4490-11A-01R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE131649_2_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68450812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42479
M059K	CCLE Cell Line Gene CNV Profiles	1.0	1.38152
polysensory temporal cortex (area 22p)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.19997
H3K4me1_ES-E14_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04
A549_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148424
CRCGN008_HEPG2_24H:O03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28635
GC-69-JF03_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.257923
Viscus	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
K562_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0227779
H3K27ac_CD4+ CD25int CD127+ Tmem Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K36me3_cardiac mesoderm_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4528	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_brown adipose tissue_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_BRD4770_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0195832
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
umbilical cord	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.137629
BCL7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08927
TCC-PAN2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965042
GSE147662_3_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
hsa-miR-4755-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
E2F7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.987
Adrenocortical carcinoma_ACC_TCGA-OR-A5KU-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K27ac_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.845011
Kidney Chromophobe_KICH_TCGA-KN-8432-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW900	GDSC Cell Line Gene Expression Profiles	-1.0	-1.78894
hif1a_16565084_mcf7_lof_human_gpl2507_gds2761	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.216463
viscus	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-OIZH-2126-SM-3NB1P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65949
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20367
GSE171724_4_v_6_ezh2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4646-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
CRCGN015_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.2032
YY1_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE127790_10_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HCFC1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
4693_LSM4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.530385
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03923
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.39334
GTEX-QEL4-2126-SM-447AE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.4803
GSE139966_1_v_2_figla_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE81193_3_v_4_irf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28149
hsa-miR-548d-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
REST_HL-60_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CBX3_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MG63	CCLE Cell Line Gene CNV Profiles	1.0	1.38644
inferolateral temporal cortex (area TEv, area 20)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.35488
BRD-K19183365	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.111
BRD-K62555617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31027
BRD-K41532285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05479
BRD-K42455150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49923
SW579	CCLE Cell Line Gene Expression Profiles	-1.0	-2.0603
subparafascicular nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.26173
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.929571
BRD-K40612106	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61242
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
PA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84444
Lung squamous cell carcinoma_LUSC_TCGA-34-5240-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
5737_NOL8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.583116
BRD-K73849129	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01165
SW 982	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09074
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-XUZC-1726-SM-4BRWS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16051
CRCGN015_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.23481
PRPF3	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Bosutinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141316
CRCGN017_MCF10A.WT.HP_24H:F16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08635
STAT3	ENCODE Transcription Factor Targets	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
PNKP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00685995
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.864843
GTEX-S32W-2326-SM-2XCAW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20169
ZNF785	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45952
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.505604
BRD-K21982562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15329
GFI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.9523
BRD-K94353570	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48053
BRD-K05350978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80826
K562_A-366_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0161651
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.61893
GP5D	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U8T8-0126-SM-3DB94	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851776
TMF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11569
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BHLHE40_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K46085646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.94469
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16201
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9396374-Table_4.XLSX-AR_related_genes_from_GeneCards-gene_symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-7136	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
soft tissue	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4871-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
DUSP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04238
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.854464
BRD-K94521090	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.028
MXI1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Tozasertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151433
MYOM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575169
BRD-K45663146	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1232
POLR2J	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43282617	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81664
H3K4me3_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SLC2A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00566991
Perturb_14132_OE_Lmnb1_SRP299168	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.45057
BRD-K29135120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44944
H3K27ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K39223744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28891
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.73296
E2F6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	90.5925
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4146-01B-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2839
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-4115-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_limb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
K562_UNC0379_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0164984
GTEX-WHSE-0126-SM-3NMBT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.956155
PML	ENCODE Transcription Factor Targets	1.0	null
L3MBTL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00533603
A549_Curcumin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.021397
ANAPC5	Pathway Commons Protein-Protein Interactions	1.0	null
HSPA1L	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K62288678	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10439
anterior (rostral) cingulate (medial prefrontal) cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.928017
GTEX-X88G-0004-SM-47JZ6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937875
GSE87862_0_v_1_mov10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.61397
MAZ	ENCODE Transcription Factor Targets	1.0	null
GTEX-UPK5-1826-SM-3GAEB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.880315
Thymus	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.960508
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58335
H3K4me1_heart_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220520_6_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XBED-2026-SM-4AT5D	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82494
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN008_HEPG2_24H:I17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.05475
A549_Barasertib_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155901
ETS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0082
GTEX-XYKS-1326-SM-4BRUN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.836558
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.63242
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960212
DNAJA1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.734757
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.842148
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.20686
496100402_FWM_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19206
PMC4904359-12915_2016_267_MOESM12_ESM.xlsx-LEUTX_DOWN-All_significantly_up_regulated_genes_determined_by_DESeq2_fold_change_greater_than_1_25_going_down_from_an_FPKM_of_at_least_2_LEUTX	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN012_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18294
fat_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.8665
H3K27ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NOL8	Pathway Commons Protein-Protein Interactions	1.0	null
STAT1	ENCODE Transcription Factor Targets	1.0	null
CTCF_GM12871_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IGR39	CCLE Cell Line Gene CNV Profiles	1.0	1.65509
BRD-K29392777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.30116
PFEIFFER	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45165
C7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00561444
H3K4me1_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06792661_Narciclasine_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
KMS-12-BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.53199
LYRM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00618296
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.13093
BRD-K58844095	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67458
NCI-H1693	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.27264
MALME3M	CCLE Cell Line Gene Expression Profiles	-1.0	-2.21872
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19253
BRD-K09779858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00924
GTEX-OXRL-2126-SM-3NM98	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38809
MTMR3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690339
H3K27ac_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K04741797	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02645
CRCGN010_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08305
HCC1806	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01845
Lung adenocarcinoma_LUAD_TCGA-05-5428-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE134375_4_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5X1-0526-SM-3GILH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.865864
BA-84-WN26_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200755
GSE158100,GSE158101_1_v_0_runx1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDT8-0006-SM-32PL3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28376
MCF7_Belinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135486
E2F1-18555785-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
temporal pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.838617
Metolazone	DeepCoverMOA Drug Mechanisms of Action	1.0	0.36
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.11516
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.24899
pyramidal layer of caudal subiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.06897
PRPS1L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00575404
ChIP_JARID1A_20064375	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
GTEX-XPT6-0001-SM-4B64G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57639
8517_STK24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.600796
H3K4me3_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5068-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_15850_KO_Etv5_SRP165224	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.45931
17880687-TableS2	GeneSigDB Published Gene Signatures	1.0	null
HT1376	DepMap CRISPR Gene Dependency	1.0	2.30416
BRD-K38557431	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.31038
GSE222758_0_v_1_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPK5-0003-SM-3NMDI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51949
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0156
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.87335
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior frontal gyrus, triangular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.832834
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
DC-98-HC94_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.418626
VZ in thalamic region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.846888
SJSA1	CCLE Cell Line Gene CNV Profiles	1.0	1.49074
ZC3H11A	ENCODE Transcription Factor Targets	1.0	null
BRD-K31001397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.22384
sirolimus_mus musculus_gpl1261_gse21755	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K80739863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39832
PMC4486168-pone.0131961.s006.xlsx-Sheet1-ARID3B_Upregulated_Genes_ARID3B	Rummagene Transcription Factor Associations 2026	1.0	null
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
COLO 829	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09309
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.07373
ZGLP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83979
GSE236454,GSE236456_0_v_1_angiotensin ii_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505767
9682_UTP15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.508262
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
gemfibrozil-1430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Divalproex Sodium_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174848
SMN2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-T5JW-1626-SM-3GADZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.93299
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXA1_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7862-01A-21R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
skin	HPA Tissue Gene Expression Profiles	-1.0	-0.856309
KLF10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	137.256
GSE183251_4_v_0_cyp2c70_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
primary motor cortex (area M1, area 4)_3 yrs_M_12980	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.89452
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.012348
NANOG-18692474-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_Brain Substantia Nigra	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K69480055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36518
GB-06-BA49_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21213
10751_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.737765
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.24075
K562_TMP195_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0204926
GTEX-T5JC-0001-SM-3NMAK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.6306
Brain Lower Grade Glioma_LGG_TCGA-HT-7469-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.967038
MZ in dorsomedial parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.872353
A549_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177129
BRD-K12750296	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97961
colonrectum_c	HPA Tissue Sample Gene Expression Profiles	1.0	0.872556
HDAC2	ENCODE Transcription Factor Targets	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.869048
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JW-0008-SM-4DM5X	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18619
H3K27ac_Duodenum Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG4-0008-SM-48TYZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.50638
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70O-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN016_MCF10A.WT.HP_24H:C08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.06482
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62872
GSE114013,GSE114014_1_v_4_itraconazole_human	RummaGEO Drug Perturbation Signatures	1.0	null
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.739997
EWSR1-FLI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	132.648
TAF1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MDA-MB-415	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13186
Mccoy	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.572
TRIM28_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-CS-6669-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
K562_Ki16425_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0245634
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76558091	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54188
A549_Ellagic acid_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182699
ARF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.83908
NHLH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680314
Bronchoalveolar system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.091
spleen	GTEx Tissue Gene Expression Profiles	1.0	1.08423
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-CH-5752-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114883_1_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
POLR2C	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K66432757	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4357
A549_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158103
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32985
H4K8ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Adenocarcinoma	DisGeNET Gene-Disease Associations	1.0	null
BRD-K37719063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34172
A2780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.940026
striatum_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29342
GTEX-QVUS-0011-R8A-SM-3GAD7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09358
Isl1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.6319
ELF1_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K06091213	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49774
BRD-K27294633	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.60006
ESS-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_AICAR_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0171513
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A7-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CEBPB_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S95S-0002-SM-3NM8K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96036
embryo	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.054693
Cco	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.904
H3K27ac_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SKOV3	BioGPS Cell Line Gene Expression Profiles	1.0	0.859982
CHD2	ENCODE Transcription Factor Targets	1.0	null
DEL	CCLE Cell Line Gene CNV Profiles	1.0	1.37739
A704	CCLE Cell Line Gene Expression Profiles	1.0	2.77172
BRD-K89967940	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76065
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.6539
BRD-K55606442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00555
BRD-K71893034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.54889
H3K4me1_G1E_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2920-03B-01T-0760-13	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
ED-05-LQ40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.325941
BATF_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ramelteon_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182456
Skeletal Muscle Male	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-2.0876
H2BC12L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00047
PLD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00501691
Penis_Foreskin_Melanocyte_Primary_Cells_skin03	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.06616
7479_RPL7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.674107
Ibutamoren	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
H3K4me3_erythroblast_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58977196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.0912
CRCGN016_MCF10A.WT.HP_24H:P24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5356
CAKI-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.0468
BRD-K99749624_linifanib_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FARAGE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.78017
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55441
KDM5B	ChEA Transcription Factor Targets	1.0	null
CTDP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10498
BRD-K64418159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.23955
UCSD-242L	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.866024
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.853512
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0217
GTEX-XPT6-1626-SM-4B655	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23022
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.4193
BRD-K39419290	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13566
CCNT2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02
H3K4me3_H1 BMP4 Derived Mesendoderm Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
7469_RPL38_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.598259
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_MCF-7_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K63383299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36986
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE162739_7_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE127916_1_v_0_nras_human	RummaGEO Gene Perturbation Signatures	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me3_Skeletal Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SPI1	ENCODE Transcription Factor Targets	1.0	null
Respiratory system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
BRD-K99446825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0003
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
UMUC11	DepMap CRISPR Gene Dependency	1.0	2.12403
PTPN18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11997
SAP30_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
dorsal thalamus_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.962809
FOSL2	ENCODE Transcription Factor Targets	1.0	null
POLR2AphosphoS2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548j	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MCAS	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	1.0	3.21801
BRD-K56373119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19947
MCF7_GSK J1_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141441
5252917-828	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCIH1963	CCLE Cell Line Gene CNV Profiles	-1.0	-1.65245
CRCGN011_HEPG2_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0666
PMC8709578-elife-69843-supp4.xlsx-HSF1_ChIP-seq_peaks-Gene_Name_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
CAPAN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.20874
BRD-K77108448	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3408
PMC4944136-srep28995-s2.xls-OTX2-gene_OTX2	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_4767_KO_Kap1_SRP065215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.8307
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7239
GSE165122_2_v_3_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.134
RFX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	36.8637
ZNF418	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.3997
Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KT-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SPI1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-U3ZN-0626-SM-3DB7U	GTEx Tissue Sample Gene Expression Profiles	1.0	0.938667
1614_CINP_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.601481
EBF1	ENCODE Transcription Factor Targets	1.0	null
POLR2H	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Triamcinolone Acetonide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0137478
ZNF513	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.66481
BRD-K56943789	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14691
POLR2AphosphoS5_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K79me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SU-DHL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.13823
Waist-Hip Ratio	DisGeNET Gene-Phenotype Associations	1.0	null
BRD-K90675978	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07778
Brain Lower Grade Glioma_LGG_TCGA-FG-5963-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06955
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	1.0	2.77553
MG-63	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963786
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IGROV1	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.00157
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968917
GSE131377_1_v_0_spocd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skin_5f	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0213
GTEX-XUJ4-2426-SM-4BOO3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.918198
NFATC1	ENCODE Transcription Factor Targets	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-FB-A5VM-01A-11R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
MED12	Pathway Commons Protein-Protein Interactions	1.0	null
SNU620	CCLE Cell Line Gene CNV Profiles	-1.0	-2.60517
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04548
GSE116810_5_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74309
PLEKHJ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16075
BRD-K43922968	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01907
BRD-K54079231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50887
U2 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.106
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TBP_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_GSK1070916_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0117986
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.993239
CAMA-1	GDSC Cell Line Gene Expression Profiles	1.0	2.2291
GTEX-S7PM-0008-SM-3NM9Q	GTEx Tissue Sample Gene Expression Profiles	1.0	2.13924
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.61912
POLR2A_HepG2_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EEF1A1	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K33272704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.71775
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
2132_DDX56_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.790731
K562_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0145388
BRD-K47212522	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.95604
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.950884
PD-70-VS77_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.433867
MYC-19079543-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
GTEX-XK95-1026-SM-4GIDV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.873853
TBL1XR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_K562_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SGK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00419625
GTEX-WH7G-1626-SM-4LVMY	GTEx Tissue Sample Gene Expression Profiles	1.0	2.03271
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.937021
COLO205	BioGPS Cell Line Gene Expression Profiles	1.0	1.7874
BRD-K05777604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35555
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.10402
ELF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Inferior Temporal Lobe	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE247775_1_v_0_tmprss2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
3445_GNL2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.51912
Lung adenocarcinoma_LUAD_TCGA-38-4628-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.06565
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79605
BRD-K45343543	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13494
hsa-miR-519b-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-A76899420	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29844
A549_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0207706
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
MZ in dorsomedial frontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.898151
SIX5_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RF-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MPPE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48128
CD-47-YL43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.362375
HMEL	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52485
HCC364	CCLE Cell Line Gene Expression Profiles	-1.0	-1.69936
GSE158834_0_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6605_PPAN_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.663515
CRCGN016_MCF10A.TP53.M_24H:O09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.54221
paraventricular nuclei, left of thalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.4103
MXI1_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POU2F2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.3667
dorsolateral prefrontal cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19321
GTEX-S3XE-1726-SM-3K2AM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00489
BRD-K43603649	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4635
7439_RPL15_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.823435
TARDBP	Pathway Commons Protein-Protein Interactions	1.0	null
SUPM2	DepMap CRISPR Gene Dependency	1.0	4.54842
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KG1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.80755
BRD-K64376499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26094
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36145
ventrolateral prefrontal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.06948
YD-49-HM53_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.423834
POLR2A_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF7L2_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.894368
SNU1272	CCLE Cell Line Gene CNV Profiles	1.0	1.64211
salivarygland_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.870539
TAL1	ENCODE Transcription Factor Targets	1.0	null
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.07257
BRD-K87670244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08228
GSE216043_10_v_9_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10244377-41467_2023_38797_MOESM7_ESM.xlsx-4d_BioGRID_RBP-BIOGRID_CDC5L_CDC5L	Rummagene Transcription Factor Associations 2026	1.0	null
ATF1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38401
A549_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185452
GTEX-UPK5-1526-SM-4JBJA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.24968
ELF1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DD-74-PJ26_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.484813
BRD-K94962942	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.09712
H3K4me3_MEL cell line_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877781
K562_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150425
WRNIP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112762,GSE112767_2_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86773205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7218
CTCF	ENCODE Transcription Factor Targets	1.0	null
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53788
MAP3K15	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00430132
ZNF574	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	64.91
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.507433
BRD-K18686200	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29002
H3K4me3_K562_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0002-SM-3NMAH	GTEx Tissue Sample Gene Expression Profiles	1.0	2.50205
NICN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00594264
hsa-miR-3671	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
MBNL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00559565
BRD-K44944875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.55238
CKAP2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20509
BRD-K44133102	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0633
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.29804
MTA3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19232
Tizanidine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
NFPS	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
GSE127790_4_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.59619
EAF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04664
BRD-K62624148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.9185
Nuclear lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
NELFE	ENCODE Transcription Factor Targets	1.0	null
BRD-K30628727	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.62632
MLPH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00483143
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ovary	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
MED7	Pathway Commons Protein-Protein Interactions	1.0	null
SP4	ENCODE Transcription Factor Targets	1.0	null
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29226
MED19	Pathway Commons Protein-Protein Interactions	1.0	null
NRBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00654223
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NELFA-20434984-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.81125
NCI-H2170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849738
CRCGN008_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.37195
amygdaloid complex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.13559
moracizine-7297	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Anacardic Acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141985
BRD-K46126513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2142
posterior (caudal) superior temporal cortex (area 22c)_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.876803
GB-46-CK08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.268582
RBBP5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
1578_CHML_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.535911
XEN445	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
CHD1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Lysosomal storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SG in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34099
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_olfactory bulb_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
10663_ZNF830_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.35137
GTEX-P4QT-1426-SM-3NMCX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11442
6581_POT1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.995631
3395_GLIS1_ENST00000312233.2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506113
BRD-K81001899	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31467
BRD-K11143221	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24288
SCRT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2544
Anaplasmosis_Leukemic Cell_GSE2600	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.54545
K562_Ellagic acid_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0183212
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SU-DHL-1	GDSC Cell Line Gene Expression Profiles	1.0	1.51605
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.985008
hsa-miR-548y	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CREB1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW 1417	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.93413
perphenazine-1956	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE198165,GSE198166_7_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58944125	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08434
BRD-K58077750	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30804
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-2.04219
MED26	Pathway Commons Protein-Protein Interactions	1.0	null
LGR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00507668
GSE130956_0_v_3_icaritin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
U4/U6 x U5 tri-snRNP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.156
Lung squamous cell carcinoma_LUSC_TCGA-66-2758-01A-02R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7477_RPL7A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.963507
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.44951
HS 895.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-2.13457
MYBBP1A	Pathway Commons Protein-Protein Interactions	1.0	null
6071_PARK7_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	-1.0	-0.555895
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.904891
GTEX-WFON-0001-SM-3P61W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21062
BRD-K07855097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20282
TRPV1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00621728
BRD-K33505770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52855
A549_Divalproex Sodium_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176926
hsa-miR-548e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K45986774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.11314
SCC-9	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.99157
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.34201
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.23847
17699775-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A6MD-01A-41R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
indometacin-262	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SNU620	CCLE Cell Line Gene Expression Profiles	-1.0	-1.98434
GSE114883_0_v_4_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4662a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K49528360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.07477
TAF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CDK8_knockdown_128_GSE30815	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	-1.0	-2.10141
GSE196835_0_v_1_ddx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Amisulpride_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164611
MDAMB134VI	CCLE Cell Line Gene Expression Profiles	1.0	1.87657
Sarcoma_SARC_TCGA-QQ-A8VB-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4989-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MOLP2	CCLE Cell Line Gene Expression Profiles	-1.0	-2.5691
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
imatinib_homo sapiens_gpl96_gds3043	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.901366
H3K9ac_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SET2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48101
BRD-K92191804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.75061
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.955433
BRD-K06439119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85535
YY1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CHD1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRCA1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_AICAR_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193299
CD276	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0069273
MED17	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05054
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39774
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.99267
DDX21	Pathway Commons Protein-Protein Interactions	1.0	null
TUBB3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00567852
19096012-TableS5	GeneSigDB Published Gene Signatures	1.0	null
CRCGN008_HEPG2_24H:O05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.61475
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ACSBG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24231
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4771
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
Tandutinib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
BRD-K84541452	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24426
ZNF75D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.2227
hsa-miR-618	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
Liver hepatocellular carcinoma_LIHC_TCGA-RG-A7D4-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hydroxytoluic-acid	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18084
GTEX-SJXC-0726-SM-2XCFJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847068
STAT1	ChEA Transcription Factor Targets	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MYC	ENCODE Transcription Factor Targets	1.0	null
GTEX-S3XE-0326-SM-4AD6L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.895542
BRD-K52582315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12202
MCF7_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0135509
RUVBL1	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney Chromophobe_KICH_TCGA-KO-8404-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.886352
POLR2L	Pathway Commons Protein-Protein Interactions	1.0	null
PMC11373733-ABR-13-34_Suppl1.pdf-307-ZNF428_ZNF428	Rummagene Transcription Factor Associations 2026	1.0	null
BA-84-WN26_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.476241
BRD-K58888361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51989
PMC3435504-msb201237-s2.xls-Supp_Table_4a-TFDP2_TFDP2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K05802716	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32403
H3K4me3_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K77407030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16418
BRD-K81082554	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04483
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.43043
JMJD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00779221
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MQ-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HCC2157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45947
BRD-K32723442	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85571
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73S-01A-11R-A33Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Chronic obstructive pulmonary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
GTEX-WFON-2026-SM-4LVMW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81379
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.21047
7474_RPL4_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.683649
Cyanuric chloride	DeepCoverMOA Drug Mechanisms of Action	1.0	0.22
A549_Avagacestat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015618
H3K36me3_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.953906
H3K4me3_G1E-ER4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
TBL1XR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
pridinol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15025
BRD-K85627183	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14821
H3K4me3_limb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K12593465	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85794
SG in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.927733
TBP_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_NB4_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ZC3H11A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K89837874	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05617
GSE139987_1_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF281	Pathway Commons Protein-Protein Interactions	1.0	null
ELF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19263
N-acetyl-L-aspartic acid-3265	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GF-35-IT27_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.282586
Anastrozole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3295
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.984636
GTEX-RWS6-1126-SM-47JXC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04667
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.6994
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LOUCY	CCLE Cell Line Gene CNV Profiles	-1.0	-1.69673
Lung squamous cell carcinoma_LUSC_TCGA-33-4589-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ifenprodil-5044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TCF12_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SUPM2	CCLE Cell Line Gene Expression Profiles	1.0	1.72356
BRD-K54100265	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04389
ACCMESO1	CCLE Cell Line Gene Expression Profiles	1.0	1.67865
GSE224742_0_v_1_slc1a5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-3920-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
placenta	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.101687
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40782
trichostatin A-2035	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMC4	Pathway Commons Protein-Protein Interactions	1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-5526-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02634083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31161
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K42776812	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62583
7481_RPL9_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.527315
CAMA1	CCLE Cell Line Gene Expression Profiles	1.0	2.18877
A549_A-366_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153408
mRNA_JARID2_20075857	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
membrane-enclosed lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52686
MAX_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.90711
HSPA9	Pathway Commons Protein-Protein Interactions	1.0	null
B3GALT9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22986
SNU869	CCLE Cell Line Gene Expression Profiles	-1.0	-1.94581
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
HSC39	DepMap CRISPR Gene Dependency	1.0	2.60545
CHD1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SCNN1G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547451
trichostatin A-1793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXA1-27270436-CHIP-SEQ-PROSTATE-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_15235_KO_Scl/Tal1_SRP179031	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.96433
CHD2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SPI1_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ETS1-21867929-TH2-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K91387865	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06835
intracellular organelle part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K92124212	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15992
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-4099-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.36781
trichostatin A-1212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VUSG-1726-SM-4KKZL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.933345
BRD-K53192330	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39772
HMGN3	ENCODE Transcription Factor Targets	1.0	null
A549_Raltitrexed_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173584
hsa-miR-559	TargetScan Predicted Conserved microRNA Targets	1.0	0.541706
BRD-K56939159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61294
HCC1897	CCLE Cell Line Gene Expression Profiles	-1.0	-1.56534
CTCF_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Bosutinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121099
paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.919534
Metabolic dysfunction-associated steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
GSE112761,GSE112767_1_v_3_ddx6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K81884775	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.01394
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13575
SK-MES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902602
TCF12	ENCODE Transcription Factor Targets	1.0	null
RFX5_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SP in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07206
HDAC6_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Stat5a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.9949
GR-ST	GDSC Cell Line Gene Expression Profiles	1.0	1.42015
MCF7_GSK J1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141332
HCFC1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-548i	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
BACH1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PX3G-1026-SM-48TZW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911361
hsa-miR-5095	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
MCF7_Iniparib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0130647
SNU8	DepMap CRISPR Gene Dependency	1.0	2.28227
HB-06-WU12_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.345275
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
NFIC_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_Cal62_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K76544773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32071
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09856
GSE218580_1_v_0_fentanyl_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_7335_KD_TMEM119_SRP279053	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
K562_TGX-221_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168525
ventrolateral prefrontal cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.00139
H3K9ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-T2YK-2226-SM-32QPT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01142
CA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613481
EZH2_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SUCS-1326-SM-4DM5T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16187
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A119-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-TSE9-0011-R1A-SM-3DB7E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.902459
AF-99-HA02_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.349429
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
AMO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.66681
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K63864604	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7406
A549_Navitoclax_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0155411
PMC11003700-pbio.3002240.s011.xlsx-MYCN-IMR32_RawData-Unnamed_2_MYCN	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPB_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-0008-SM-3NB27	GTEx Tissue Sample Gene Expression Profiles	1.0	0.984726
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-8516-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ASH2L-23239880-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.10061
TCF7L2	ENCODE Transcription Factor Targets	1.0	null
1941_CTPS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.664026
GTEX-U3ZM-0002-SM-3NMDM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56408
GTEX-WFG7-1526-SM-4LVMG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14048
POP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12303
MAP2K3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0035928
tretinoin_homo sapiens_gpl6244_gds4180	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32132
EZH2	ENCODE Transcription Factor Targets	1.0	null
CRCGN015_MCF10A_48H:C05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34791
NDEL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05677
GTEX-RM2N-0926-SM-48FD1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37803
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.56018
striatum_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04569
hsa-miR-548a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
BRD-K07020302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04976
YY1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ESC_V6.5_UP_LATE.V1	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:L04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.59787
TCF7L2_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.083
BAG2	Pathway Commons Protein-Protein Interactions	1.0	null
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0188115
BRD-K85853281_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
7504_RPS15_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.677226
primary auditory cortex (core)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.02627
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06195
MMP3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01543
PGAP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00560054
GSE175787_11_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
U-2 OS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13334
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-02A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K21838437	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20871
BRD-K55164454	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41165
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCL11A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00569011
Necrosis	CTD Gene-Disease Associations	1.0	1.13827
SIN3A_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.884956
BRD-K62358193	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09495
GABPA_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
U937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.93579
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CHAGO-K-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.7125
lateral hypothalamic area, mammillary region, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.17505
H3K4me3_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HL60	CCLE Cell Line Gene CNV Profiles	-1.0	-1.58247
NDUFA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17963
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.999662
BRD-K40548004	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03561
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.983697
BRD-K75426080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36795
REST_HepG2_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.292335
HS 746T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.49445
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MED23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K43654313	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0398
L363	CCLE Cell Line Gene Expression Profiles	1.0	2.89093
SW1573	CCLE Cell Line Gene CNV Profiles	1.0	1.47858
IKZF1	ENCODE Transcription Factor Targets	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.067
Intracellular organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
K562_Curcumin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171858
BRD-K18313650	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.79837
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80V-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GUSB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554745
CRCGN015_MCF10A_48H:D13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.04511
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27986
YY1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Primary Malignant Neoplasm Of Lung	DisGeNET Gene-Disease Associations	1.0	null
Intestine	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
anterior (rostral) cingulate (medial prefrontal) cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920146
H3K23ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21643
A549_AICAR_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147078
HT144SKINFV2	DepMap CRISPR Gene Dependency	1.0	3.43348
YY1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ANKRD65	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06122
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.01814
GTEX-X261-0226-SM-3NMD2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883016
BRD-K19133474	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23211
721_B_lymphoblasts	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.87583
Sarcoma_SARC_TCGA-HS-A5NA-01A-11R-A26T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-VP-A87D-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
RELA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0556
Nucleoli	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
DDX3X	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
STAT5A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K10027041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10323
GSE196343_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.01856
BRD-K48188521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.28619
MYC_NB4_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3416
JARID1A-20064375-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_keratinocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
olfactory bulb	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.28647
hsa-miR-647	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
Schizophrenia_CNS - Brain - Cerebellum (MMHCC)_GSE4036	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.90224
GTEX-XXEK-1726-SM-4BRVB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04409
BRD-K90230495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41722
CRCGN016_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.58554
Uterine Carcinosarcoma_UCS_TCGA-N7-A4Y8-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
CA46	CCLE Cell Line Gene Expression Profiles	1.0	2.28532
BD-49-MD69_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.811048
H3K27ac_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MC-IXC	GDSC Cell Line Gene Expression Profiles	1.0	2.76166
BRD-K29242326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12073
H3K4me3_K562_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.49339
A549_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013721
SG in rostral entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.02828
TEAD4_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NFIC	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5989-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-548b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Large cell lung cancer cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.721
K562_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200787
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23962
SIN3A_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
USF2	JASPAR Predicted Transcription Factor Targets	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-2Y-A9H4-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
DE-34-DT75_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.331148
FLI1::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7474
cardiovascular system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.057228
GSE145311_1_v_3_glutathione_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EGR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0965
BRD-K73126584	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39423
BRD-K65987370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32856
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131649_6_v_8_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Obstructive lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
ARID3A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ABI3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00623426
ASH2L-23239880-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
PCNA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1816
TEAD4	ENCODE Transcription Factor Targets	1.0	null
PTEN_KD_GDS2958_101_human_SKBR-3 MAMMARY ADENOCARCINOMA cell line	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
GSE152441,GSE152442_6_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-V1D1-2126-SM-4JBH4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11126
BRD-K59522787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18744
GTEX-QEG4-0526-SM-48TZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.944668
BRD-K90060707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0494
GSE214823,GSE214824_5_v_7_crtc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.500496
GTEX-VJYA-1426-SM-4KL1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04035
artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.068869
CAKI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.965042
brain_3c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.05893
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.64567
GTEX-S3XE-1526-SM-4AD5A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.915727
GTEX-PVOW-1026-SM-2XCF9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04293
Nuclear exosome targeting complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.24
K562_WHI-P154_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0167839
PMC8755441-mmc3.xlsx-IRF7-Up-stat1-hela_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H1623	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849738
CRCGN008_HEPG2_24H:L13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1151
YY1-33199912-293T-HUMAN-KIDNEYEMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-SNMC-0008-SM-4DM5A	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59426
GSE157282_0_v_3_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3591-01A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mRNA_CDX2_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
15897907-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
GSE94849_1_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
PTK7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.40709
TCF12_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN016_MCF10A.WT.HP_24H:L23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.12895
7453_RPL26_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.624505
GSE129244_3_v_5_lmo2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM14-21183938-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
AN3-CA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SU-DHL-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.961004
CRCGN015_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-5.56359
POLR2A_GM18526_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NAGK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0059894
BRD-K49872883	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69997
BRD-K50389815	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.35353
HTR1D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28094
NANOG	ChEA Transcription Factor Targets	1.0	null
AHCTF1	Pathway Commons Protein-Protein Interactions	1.0	null
lymphnode_5c	HPA Tissue Sample Gene Expression Profiles	1.0	0.911007
SIN3A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-455-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4485
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
4684_LSG1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.616683
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A6R0-01A-12R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55792
GTEX-U4B1-0526-SM-4DXTK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.850018
CAPAN1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.95222
CAMA-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62334
BRD-K48235506	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.7486
BRD-K42809349	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16127
caudal (posterior) extramural migratory stream	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.26409
GTEX-Q2AI-1526-SM-3GIJ3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95587
hsa-miR-3938	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
BRD-K58863194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30667
H3K4me3_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE183335,GSE183351_1_v_2_lin28b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7450_RPL23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.738838
4951_MED28_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.516764
KDM4A	ENCODE Transcription Factor Targets	1.0	null
FCRL5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00546749
A549_Zileuton_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0184259
SNIP1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9823215-mmc4.xlsx-Sheet1-List_of_genes_commonly_upregulated_by_wild_type_and_zinc_finger_mutant_of_LIN28A_LIN28A	Rummagene Transcription Factor Associations 2026	1.0	null
H3K27ac_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K61877191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20829
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.89766
DFCI024	CCLE Cell Line Gene Expression Profiles	-1.0	-2.1861
PML_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posteroventral (inferior) parietal cortex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0631
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14548
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.03176
TAL1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BATF_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3	ENCODE Transcription Factor Targets	1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K44916315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08022
B3GNT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00653605
NCI-H1435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.12531
MERO14	DepMap CRISPR Gene Dependency	1.0	2.41863
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7XP-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MDA-MB-435	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46061
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83165
hsa-miR-654-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
POLR2A_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ChIP_MYC_19079543	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.75906
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_NT2-D1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CRCGN015_HEPG2_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.70982
BRD-K87141723	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58296
CRCGN015_MCF10A.TP53.M_24H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.29455
A549_Ellagic acid_10nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131653
hsa-miR-4484	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44393
Fetal Death	CTD Gene-Disease Associations	1.0	1.05089
Brain Lower Grade Glioma_LGG_TCGA-FG-A6J3-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
UBTF	ENCODE Transcription Factor Targets	1.0	null
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE234043_3_v_1_abcb1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29068
Glioblastoma multiforme cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.815
POLR2AphosphoS5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMK1-0126-SM-4B65F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847763
7438_RPL14_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.526418
ARL17B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00948871
NEO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00580044
K562_BMS-754807_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150972
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
RNF135	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2453
GTEX-U3ZN-0002-SM-3NMDF	GTEx Tissue Sample Gene Expression Profiles	1.0	2.21358
MCF7_BRD4770_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0165734
GTEX-UPIC-0726-SM-3GADW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.915294
GSE126621,GSE126920_1_v_3_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.901764
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.902602
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52226
H3K4me3_H1 BMP4 Derived Trophoblast Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HK2	CCLE Cell Line Gene Expression Profiles	-1.0	-1.4702
MED21	Pathway Commons Protein-Protein Interactions	1.0	null
SNU1544	DepMap CRISPR Gene Dependency	1.0	2.42612
binding	GO Molecular Function Annotations 2015	1.0	null
fetus	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.071034
dorsolateral prefrontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.69786
skeletalmuscle_e	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.04993
GSE211286_1_v_3_tcf12_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159819
PMC9859043-elife-78421-supp9.xlsx-LHX8_P-Gene_symbol_LHX8	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
YY1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TKQ1-0926-SM-4DXU2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07966
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-DX-A23Y-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posteroventral (inferior) parietal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.7992
6642_PPM1G_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.54618
Embryo Loss	CTD Gene-Disease Associations	1.0	1.10907
DDX39B	Pathway Commons Protein-Protein Interactions	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K33400588	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12792
Penis_Foreskin_Fibroblast_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.82497
AMIGO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0048181
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37954
4921_MDN1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.585118
Dermatomyositis_Muscle - Striated (Skeletal) (MMHCC)_GSE5370	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.3884
7475_RPL5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.573679
K562_Pirarubicin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0191052
GTEX-POYW-0526-SM-2XCEY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58021
GSE198165,GSE198166_7_v_1_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
REST_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZBTB9	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20962
PNPO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02735
H3K4me1_megakaryocyte_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
MKKS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16931
BRD-K84593875	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11456
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.011593
parataenial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.988165
hsa-miR-2052	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
SLC25A5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00458127
Perturb_5056_OE_MERVL_SRP161512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.24755
UBTF	Pathway Commons Protein-Protein Interactions	1.0	null
embryonic stem no feeder	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.981766
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.33187
dorsolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00656
BCAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00646807
GTEX-XXEK-0326-SM-4BRVV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.849438
paraventricular nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53935
GTEX-XXEK-0626-SM-4BRWE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03095
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15277
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YQ-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.26671
inferolateral temporal cortex (area TEv, area 20)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.21639
Arid3a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.1852
GTEX-WI4N-2726-SM-3LK7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22858
BRD-K99220724	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26813
H3K4me3_HL-60_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.55909
K562_Tubastatin A HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0174553
PMC9533694-MOL2-16-3410-s013.xlsx-FIR20vsREST_DEMs-FIR20_vs_REST_DEMs_Up_REST	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-QH-A6CV-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
rhein	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29026
BRD-K20525312	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.50533
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CD40 receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.64
H3K27ac_H1 Derived Mesenchymal Stem Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
alvimopan	DeepCoverMOA Drug Mechanisms of Action	1.0	0.25
U251MGDM	DepMap CRISPR Gene Dependency	1.0	2.38753
BRD-K19020285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76013
TCF12_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-X88G-0126-SM-47JZ3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860933
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.886284
BRD-K04886976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01513
H3K4me3_MEL cell line_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
BICR 10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00565
dorsolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	2.05443
HOP62	DepMap CRISPR Gene Dependency	1.0	3.5095
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09744
GTEX-T2IS-0426-SM-32QPE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.917575
SPDEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.3751
STAT3_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-PAX6_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_PAX6	Rummagene Transcription Factor Associations 2026	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5890-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
UBR5	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K91202220	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14899
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cerebellum_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-0008-SM-48U2E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84215
GSE198982,GSE198986_1_v_2_daunorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.49126
MAX	ENCODE Transcription Factor Targets	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-DG-A2KL-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K66214118	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.50601
motor nucleus of trigeminal nerve	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.32671
H3K4me3_Stomach Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
mediodorsal nucleus of thalamus_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.27124
YD-49-HM53_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.351711
hsa-miR-4714-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
MDST8	CCLE Cell Line Gene Expression Profiles	-1.0	-1.57536
GTEX-UPK5-2326-SM-3P5Z8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847503
GSE241701_2_v_3_daxx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
THO complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.102
GTEX-OOBJ-2126-SM-3NB1N	GTEx Tissue Sample Gene Expression Profiles	1.0	0.892038
9798_BUD23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.67186
hsa-miR-548w	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
BRD-K13016489	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.48673
GSE183271_4_v_3_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.18015
BRD-K73462370	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30616
PNN	Pathway Commons Protein-Protein Interactions	1.0	null
MED11	Pathway Commons Protein-Protein Interactions	1.0	null
MKN-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.13334
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TUBA1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00729508
GSE186005_1_v_2_klf5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE148200_0_v_2_gemcitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
sulfadiazine-1810	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
orbital frontal cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.985045
HIPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00528711
nrf1_22586274_liver_lof_mouse_gpl4134_gse35124	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.027674
Disease of metabolism	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
hippocampus	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
Brain Lower Grade Glioma_LGG_TCGA-TM-A84J-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A3A8-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
SW 837	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62334
BRD-K60807536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01597
JAM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00591874
HA-E2F1_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RUNX1	ChEA Transcription Factor Targets	1.0	null
YY1_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GCT	CCLE Cell Line Gene CNV Profiles	1.0	1.94169
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ETS1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
SP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	146.314
Prostate adenocarcinoma_PRAD_TCGA-CH-5753-01A-11R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_WHI-P154_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184999
RPAP2	Pathway Commons Protein-Protein Interactions	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4160-01A-02R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198165,GSE198166_5_v_2_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_CH12.LX_mm9_4	ENCODE Histone Modification Site Profiles	1.0	null
MYC_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
UBTF_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K32063762	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.07172
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.TP53.M_24H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03657
ELF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
7458_RPL30_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.720535
POLR2AphosphoS5_G1E_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MCF7_Aurora A Inhibitor I_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0197312
BRD-K12345912	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07074
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.395306
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GSE166536_3_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
7478_RPL7L1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.786358
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166002
posterior (caudal) superior temporal cortex (area 22c)_18 yrs_M_12984	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.30429
KIRREL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45487
pyrantel-5088	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_1 yrs_F_12830	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.828799
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
WholeBlood	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.860159
BRD-K74150320	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64438
BRD-K31801624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.68747
GSE166169_1_v_3_elp3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SG in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52237
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K99122228	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44247
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38565
TD-29-IN36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.50324
K562_Zileuton_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0297112
TAF13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00636
GSE86021_0_v_1_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7077_RAE1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.505584
MTA3	ENCODE Transcription Factor Targets	1.0	null
PPARG	ChEA Transcription Factor Targets	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.57848
BRD-K20847739	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.00011
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.0758
INT-747	DeepCoverMOA Drug Mechanisms of Action	1.0	0.34
hsa-miR-4495	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
8826_TEX10_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.504024
SB-75-TY18_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.308516
dorsolateral prefrontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.19073
ML-2 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.937
7460_RPL32_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.712347
BD-96-HO33_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.486799
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K18189580	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85354
BRD-K26836050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.44784
CRCGN008_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.14715
GSE115542_2_v_4_digoxin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-OOBK-1026-SM-48TC2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.877802
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DRAM2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55103
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12118
H3K4me3_erythroblast_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
PANC 03.27	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04548
MCF7_Ofloxacin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0162149
C2BBE1	DepMap CRISPR Gene Dependency	1.0	4.04868
MAX_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DPPA2	Pathway Commons Protein-Protein Interactions	1.0	null
CHAMP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59605
hsa-miR-526a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
BRD-K56354139	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49687
PTBP1	Pathway Commons Protein-Protein Interactions	1.0	null
HeLa-229 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.371
H3K4me2_Muscle Satellite Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inferior olive, principal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04662
H3K4me1_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
WE-48-PP43_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.375113
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20076
Lung adenocarcinoma_LUAD_TCGA-35-5375-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LY-294002-5233	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CA-48-SW47_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.267087
SW837	CCLE Cell Line Gene CNV Profiles	1.0	1.77856
STK40	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604877
GTEX-S3XE-0008-SM-3NM8O	GTEx Tissue Sample Gene Expression Profiles	1.0	0.91289
BRD-K07870648	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52101
BRD-K21996934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80498
7480_RPL8_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.725586
ARGLU1	Pathway Commons Protein-Protein Interactions	1.0	null
FAM162A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22981
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.625
SNU349	CCLE Cell Line Gene CNV Profiles	1.0	2.78952
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.22334
GTEX-WFJO-0008-SM-4LVN7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954808
KDM1A	ENCODE Transcription Factor Targets	1.0	null
BRD-K83272071	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02558
H3K27ac_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SH-4-54	DeepCoverMOA Drug Mechanisms of Action	1.0	0.2
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.830324
GSE66931,GSE73382_1_v_0_hira_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22401
GATA3_T47D_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Steatotic liver disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
GTEX-R55E-0726-SM-48FCZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0645
BRD-K58728497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03575
BRD-K22865069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24737
U1 snRNP	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.007
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_ABT-737_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157133
DPEP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06935
BRD-K77743611	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39215
ChIP_NANOG_18692474	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2986-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ZNF423	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3307
MED27	Pathway Commons Protein-Protein Interactions	1.0	null
PMC9237085-41467_2022_31238_MOESM4_ESM.xlsx-Table_4_MYC_BC_signature-HGNC_symbol_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
CA46	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.51631
hsa-miR-550a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.943946
BRD-K47690679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31016
GTEX-QLQW-0326-SM-447A8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09683
CARD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00528936
BRD-K71876816	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.88115
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K11652878	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.82413
GTEX-SSA3-0008-SM-47JWJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.954028
hsa-miR-548ak	TargetScan Predicted Conserved microRNA Targets	1.0	0.49473
POLR2AphosphoS5_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SC-81280 (NCOA2)	NURSA Protein Complexes	1.0	null
H3K4me1_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.74973
GSE216540_10_v_6_fulvestrant_human	RummaGEO Drug Perturbation Signatures	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3473-01A-01R-1193-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98794
HCC1493	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.834799
DRG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.33747
AA-48-XT80_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.28478
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.18248
Mesothelioma_MESO_TCGA-MQ-A4LP-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K75073699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03735
SIN3A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7454_RPL27A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.803744
hsa-miR-329	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
H3K27ac_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MCF7_S3I-201_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146151
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A5O9-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
EB1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.29294
TEN	DepMap CRISPR Gene Dependency	1.0	2.64602
SLC1A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00437572
BRD-K06220918	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1123
Ralfinamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.3
K562_AG-490_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158606
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-WL-A834-01A-11R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4952_KO_Zbtb2_ERP125292	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.43148
7491_RPP30_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57034
2545_EIF3B_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.547403
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.0248
NEUROD6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03805
Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.012
SF268	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.37988
K562_ABT-737_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172954
ELF5-23300383-T47D-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
NCIN87	DepMap CRISPR Gene Dependency	1.0	2.02845
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19798
Mitotic arrest phase fetal germ cell_Fetal gonad_Human	CellMarker Gene-Cell Type Associations	1.0	null
hsa-miR-556-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
FOXO3-22982991-MACROPHAGES-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-3914	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
GSE184892_6_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.95193
BRD-K58795356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36452
BRD-K63188051	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07392
preoptic region, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.893751
POLR2A_small intestine_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K18ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K58010565	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4082
Perturb_18606_KD_Lsm1_SRP327180	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	12.8005
UACC-893	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.11541
RL7	BioGPS Cell Line Gene Expression Profiles	1.0	1.25777
Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HO-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CDK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00327174
RCOR1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
Colon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
A549_SNS-314 Mesylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.019558
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00936
BRD-K23333192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51114
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.39755
upper (rostral) rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22774
hsa-miR-3679-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
CRCGN013_HEPG2_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.22573
Kidney Chromophobe_KICH_TCGA-KL-8332-11A-01R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K78813464	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04372
ES8	GDSC Cell Line Gene Expression Profiles	1.0	2.30959
GSE131649_6_v_10_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K50599016	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3932
CUX1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B4-01A-12R-A206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K85843964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19888
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A216-01A-11R-A155-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58075863	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21428
Lung adenocarcinoma_LUAD_TCGA-05-5423-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
U-698-M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.46695
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.053034
GTEX-WFJO-0626-SM-4LVMC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841737
LYVE1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00728649
BRD-K93101873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26285
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.878302
496100488_TCx_no dementia_no TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.09825
lymph node	HPA Tissue Gene Expression Profiles	1.0	1.38528
GRHL2-25758223-PLACENTA-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
496100320_PCx_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.31761
LC1SQ	DepMap CRISPR Gene Dependency	1.0	2.27538
BRD-K28165749	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10805
AU565	CCLE Cell Line Gene CNV Profiles	-1.0	-1.57925
POLR2A_kidney_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF16	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9688
BRD-K15833017	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10133
MEC1	DepMap CRISPR Gene Dependency	1.0	2.31705
7451_RPL24_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.639049
internal female genital organ	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.056405
HS695T	DepMap CRISPR Gene Dependency	1.0	2.96309
layer II of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.89307
ZNF320	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	195.978
hsa-miR-4778-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
H3K4me3_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
NELFE_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE131649_6_v_3_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
15220918-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
TBK1.DF	MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations	-1.0	null
GTEX-QVUS-0011-R10A-SM-3GIK3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.904801
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24571
PMC8530322-pone.0258316.s002.xlsx-GG_778_no-AA_778_no-Symbol_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE205550,GSE205552_2_v_1_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-4112-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sporoplasm	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.117
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.70969
MN-60	GDSC Cell Line Gene Expression Profiles	1.0	2.01147
GRHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2278
striatum_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.938858
BRD-K72800151	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.03332
PMC3526425-1471-2164-13-572-S3.xlsx-STAT6-STAT6_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-3973	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
PMC3470785-NIHMS377161-supplement-3.pdf-34-HOXA9_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
YY1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-5552-11A-01R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9378714-41467_2022_31999_MOESM10_ESM.xlsx-Supplementary_Data_7-Supplementary_Data_7_Collation_of_genes_possible_regulated_or_co-expressed_with_ELF5_ELF5	Rummagene Transcription Factor Associations 2026	1.0	null
KE-28-MO72_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.208344
MCF10DCIS.COM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.1154
SKRC31	CCLE Cell Line Gene CNV Profiles	1.0	1.45208
H3K4me3_G1E-ER4_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K27ac_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4074-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALDH6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635355
Anchored component of membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.639
C3A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.952978
CRCGN014_HEPG2_3H:B08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.8163
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XMK1-2026-SM-4B65K	GTEx Tissue Sample Gene Expression Profiles	1.0	0.896367
dorsolateral prefrontal cortex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.05756
H3K9ac_ES-E14_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
K562_PD98059_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0169866
TCF7L2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.6315
BRD-K65392756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23089
K562_Resveratrol_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170816
BRD-K86817746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02593
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47762331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00114
POLR2F	Pathway Commons Protein-Protein Interactions	1.0	null
OVCA 420	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849738
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-A5Y1-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18179
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58266
Liver hepatocellular carcinoma_LIHC_TCGA-ZS-A9CF-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125782_3_v_2_glutamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
temporal pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.908224
thyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
GSE236815_1_v_0_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K58843485	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.17448
GTF2B_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-5066-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83869
NCI-H2810	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.87479
eGFP-HDAC8_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K00010082	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56277
nucleolus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.781037
GSE192663_3_v_5_acly_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_MEL cell line_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01281
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4723-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
HT	CCLE Cell Line Gene Expression Profiles	1.0	1.70216
BRD-K74626943	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.93731
GTEX-RM2N-1326-SM-48FCW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97491
BRD-K34929471	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06461
H3K9ac_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K05432466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2684
PRDM14-21183938-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
H3K27ac_H1	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNU1077	DepMap CRISPR Gene Dependency	1.0	2.77236
BRD-K40061857	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41737
BRD-K00414849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34575
JHH-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10484
PKD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00557593
NCI-H2171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.949755
PMC8020666-pnas.2015855118.sd05.xlsx-LPS_4_ape-Ensemble_gene_id_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-VJYA-0726-SM-4KL1T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853353
colon	GTEx Tissue Gene Expression Profiles	1.0	1.17035
BRD-K52245873	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10188
BRD-K39639513	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38589
K562_Entinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133892
RFX5_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GATA3_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
magnocellular division of VA	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.56619
JARID1A-20064375-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
ZNF669	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04834
GTEX-U3ZM-0008-SM-4DXTQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1517
reproductive system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.052621
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ajmaline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14983
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.909094
eGFP-GATA2_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4729	TargetScan Predicted Conserved microRNA Targets	1.0	0.361556
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
K562_AZD1480_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0200149
BRCA1	ENCODE Transcription Factor Targets	1.0	null
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T6MN-0126-SM-32PLP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06884
NR2F2	ENCODE Transcription Factor Targets	1.0	null
MYBL2	ENCODE Transcription Factor Targets	1.0	null
CFPAC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.977282
orbital frontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64876
BRD-K18623962	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21243
Inflammation	CTD Gene-Disease Associations	1.0	1.19933
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE98831_1_v_0_brca1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EZH2_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
VMRCLCD	DepMap CRISPR Gene Dependency	1.0	2.11462
GSE119498_0_v_5_setd5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-XMK1-0001-SM-4B64F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35216
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-OHPM-2126-SM-3LK75	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917606
ELF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
THAP1	Pathway Commons Protein-Protein Interactions	1.0	null
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.840635
H3K4me3_cortical plate_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K9ac_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PPA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32475
SIN3A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FF-86-NH56_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201156
Esophagus - Mucosa	GTEx Tissue Gene Expression Profiles 2023	1.0	1.12036
HCFC1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TMMY-1326-SM-4DXU9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.955017
YY1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_Brain Cingulate Gyrus	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
snoutepidermis	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	-1.0	-0.890044
F-actin capping protein complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.89
GTEX-WFON-1426-SM-4LVMT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04429
H1_BMP4_Derived_Mesendoderm_Cultured_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.01403
4959_MED9_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.582214
8500_STAT6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511792
H3K79me2_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-0626-SM-4IHJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.829512
PEER	CCLE Cell Line Gene Expression Profiles	1.0	1.478
Exoribonuclease complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.913
GSE162739_8_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0172309
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.978961
Toc complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.99
TBP_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.45008
H3K9ac_heart_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
TAF1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.1158
GSE158834_7_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K99736408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17577
ZNF766	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.27998
GSE245134_2_v_3_atg5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MED1	Pathway Commons Protein-Protein Interactions	1.0	null
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21585
hippocampus (hippocampal formation)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15443
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A7CL-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K74978191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.64358
BRD-K51790412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00733
Perturb_13197_KO_HDAC3_ERP127280	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.85372
HES3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.19356
RANGAP1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE124932_2_v_1_sarm1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE131649_2_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38935
CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-1283	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
MAFK	ENCODE Transcription Factor Targets	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25648
STAT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.3311
PMC10070455-41598_2023_32568_MOESM3_ESM.xlsx-Genes_AA-genes_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
LF-94-HB11_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.231834
MAX_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1253
CA3 field, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.910868
EE-98-PF86_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.281568
anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.54195
GTEX-WHSE-0011-R1A-SM-3P5ZK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860122
BRD-K00909602	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.87075
CRCGN016_MCF10A.WT.HP_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.63646
POLR2A_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.976534
GSE133691_2_v_0_lgr5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.23362
3286_GART_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.688921
BRD-K56276074	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41633
BRD-K96807219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.51588
planum polare, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.958279
Perturb_8991_KD_EGR2_SRP407074	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-12.3358
EBF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EIF4A1	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN008_HEPG2_24H:N16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.28535
mediodorsal nucleus of thalamus_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839397
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF384	ENCODE Transcription Factor Targets	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
SCC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.919878
AIRE	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492697
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00151
chlortalidone-1581	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T5JC-0008-SM-4DM6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869304
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A78R-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91079447	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.69706
RPS3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35053
lymphnode_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.28556
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58469
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1049
neuro2a	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	0.826256
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.006
BRD-K57688676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.64261
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7105
Lung adenocarcinoma_LUAD_TCGA-44-2661-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110268_2_v_3_foxd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
7536_RPS6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.682704
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7593-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.67685
7476_RPL6_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.02657
496100518_HIP_no dementia_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.22086
GSE217541,GSE217543_0_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	1.0	null
MED19	Hub Proteins Protein-Protein Interactions	1.0	null
BRD-K74663731	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45299
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989993
ZDHHC17	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14076
intestine	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OXRK-1726-SM-3NB16	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52417
MAP1S	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09392
A549_Aminoglutethimide_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154663
Zymogen granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.722
GTEX-XGQ4-0126-SM-4AT4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13169
YY1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZFP14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	167.654
H3K4me3_megakaryocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.56439
H3K4me3_embryonic fibroblast_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_11_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
17880687-TableS3	GeneSigDB Published Gene Signatures	1.0	null
7441_RPL17_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.08554
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.90906
SCRT2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8581
TRIM28_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.703
GSE220520_6_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K52083268	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11581
IRF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.7552
KP4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.26599
hsa-miR-2276	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6512
orbital frontal cortex_37 yrs_M_12303	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.864698
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7596-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HS578T	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.26357
AMO1	CCLE Cell Line Gene CNV Profiles	-1.0	-1.41127
MYC-19030024-MESC-mouse	ChEA Transcription Factor Binding Site Profiles	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.14202
Proteinuria	CTD Gene-Disease Associations	1.0	1.08161
TBX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4389
III, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.23108
G44	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.11147
GSE202434,GSE202438_7_v_14_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K92446632	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.84232
7433_RPL11_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.500496
posteroventral (inferior) parietal cortex_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.95875
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.05954
BRD-K40646662	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30672
IRF1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K65399214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30626
ZNF143	ENCODE Transcription Factor Targets	1.0	null
PMC10800016-table_s3_20230913_ddad186.xlsx-DUX4-aff_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_2 yrs_F_12979	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.75396
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A5R3-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
MCF 10A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.8403
MED31	Pathway Commons Protein-Protein Interactions	1.0	null
hippocampus (hippocampal formation)_37 pcw_M_263195015	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.96991
GTEX-TKQ1-1026-SM-4GICL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00184
GSE240896,GSE240899_2_v_0_ccnt1_human	RummaGEO Gene Perturbation Signatures	1.0	null
COG2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.08826
laminin-11 complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.588
BRD-K93884191	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.82746
BRD-K53802078	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20508
H3K4me3_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.15675
EP300_HepG2_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SH3BP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00588708
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57176
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48956
Lung squamous cell carcinoma_LUSC_TCGA-66-2795-01A-02R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE110440_2_v_3_rad21_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HOXD12::ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9145
E2F4	ENCODE Transcription Factor Targets	1.0	null
BRD-K23299829	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08944
K562_Clevudine_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190733
RERFGC1B	DepMap CRISPR Gene Dependency	1.0	2.94862
A549_Pirarubicin_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147421
Head and Neck squamous cell carcinoma_HNSC_TCGA-UF-A719-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K11247495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66233
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-VUSG-0008-SM-4KL24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.08677
fat_a.V1	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.902026
GSE202603_3_v_2_bhlhe40_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MYF6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.4034
BRD-K56691168	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.14947
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
K562_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0235766
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00619
BRD-K69229416	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13062
H3K4me1_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4452	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.99187
paravermis of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.42181
doxorubicin_homo sapiens_gpl570_gse46493	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PIAS1_Depletion_GDS5076_12_human_MDA-MB 231 breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
4946_MED23_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.794814
H3K79me2_CH12.LX_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
PANC-08-13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.68527
Kidney renal papillary cell carcinoma_KIRP_TCGA-WN-A9G9-01A-12R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
REL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Nearest_Ensembl_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.04025
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XOTO-0726-SM-4B659	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.841569
GTEX-SNOS-1126-SM-4DM67	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31593
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-Q2AH-1226-SM-48TZL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01485
MXI1_CH12.LX_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125403_3_v_6_venetoclax_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_G1E_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
bj	HPA Cell Line Gene Expression Profiles	-1.0	-0.861959
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7919
GSE133683_1_v_5_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
T-98G cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.845
H3K27ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
apigenin-3257	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-RU72-0726-SM-46MUW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1105
MCF10A	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.774967
TAF1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RCOR1_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED18	Pathway Commons Protein-Protein Interactions	1.0	null
J82	CCLE Cell Line Gene CNV Profiles	1.0	2.43187
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.942734
Secretory granule membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.058
7566_RRP7A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.698267
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
miR-124_OE_GDS2657_770_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2984-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BATF	ENCODE Transcription Factor Targets	1.0	null
GTEX-XBEW-0002-SM-4AT5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0615
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0008-SM-4DM5L	GTEx Tissue Sample Gene Expression Profiles	1.0	0.845991
BRD-K39965317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55802
GTEX-Q2AG-0011-R9A-SM-2HMJ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11831
GTEX-QEG4-0226-SM-2S1PY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.9572
BRD-K32906083	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07789
BRD-K83312314	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04587
amygdaloid complex_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.49503
REST_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WRHU-1226-SM-4E3IJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06093
BRD-K00350773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63318
H3K4me3_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
K562_Altretamine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142614
umbilical artery	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.180286
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2527
MD-86-UW46_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.275248
GSE93674_2_v_0_ezh2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_bone marrow_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2806-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-FA-8693-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.826096
MED29	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-R55C-1426-SM-48FED	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64818
Lung squamous cell carcinoma_LUSC_TCGA-60-2709-11A-01R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
7466_RPL36_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.883354
BRD-K04195898	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28255
LPCAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00641804
GSE112761,GSE112767_4_v_0_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04063
Dmbx1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	19.4574
GSE169691_1_v_2_saha_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K75206417	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10439
ESR1-22446102-UTERI-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
Perturb_13195_KO_HDAC3_ERP127280	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	19.5229
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_BMS-911543_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0193084
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
PMC9590125-40478_2022_1453_MOESM3_ESM.xlsx-OLIG2_UNIQUE_DYS_GENES-NEUN_TLE_vs_TL_log2FoldChange_1_padj_0_1_OLIG2	Rummagene Transcription Factor Associations 2026	1.0	null
H3K79me2_MEL cell line_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SP1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ion binding	GO Molecular Function Annotations 2015	1.0	null
FA-88-II68_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.309343
Prostate adenocarcinoma_PRAD_TCGA-HC-A632-01A-11R-A29R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
subgranular zone of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0473
POLR2AphosphoS5_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DDX31	Pathway Commons Protein-Protein Interactions	1.0	null
3,5-Dichlorosalicylic acid	DeepCoverMOA Drug Mechanisms of Action	1.0	0.41
MAX_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K74261250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12816
YY1	ChEA Transcription Factor Targets	1.0	null
GTEX-X62O-0008-SM-46MU5	GTEx Tissue Sample Gene Expression Profiles	1.0	3.07179
Rectum adenocarcinoma_READ_TCGA-AG-3742-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Hepatobiliary disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
POLR2A_embryonic fibroblast_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fertilizedegg	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	1.0	1.57941
GSE93309_2_v_0_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
MED10	Pathway Commons Protein-Protein Interactions	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-RW-A67Y-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
amygdaloid complex_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.34757
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_1_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27ac_ES-Bruce4_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_4 mos_M_12296	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.839397
CRCGN016_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.78747
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TML8-1326-SM-4DXTO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.16897
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_K562_hg19_6	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_spleen_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4510-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56776985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.52747
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22995
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.694454
BRD-K30632097	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.67698
USF2	ENCODE Transcription Factor Targets	1.0	null
orbital frontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.99812
BRD-K57575504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.2066
K562_Aurora A Inhibitor I_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0200843
MYC-19079543-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-H7-8501-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_4276_KO_Smad2/Smad3_SRP132215	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.88722
BRD-K95016030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.10452
A549_MC1568_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0219841
VZ in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.976209
POLR2A_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
9482_UBA52_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.830035
H3K27ac_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K70357895	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49032
BRINP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.16794
SP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	139.068
BRD-K68298468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39403
fusiform gyrus, left, bank of the its	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00381
NCI-H441	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.70321
BRD-K26393435	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.24363
BRD-K09100418	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24481
BRD-K51322795	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08902
hsa-miR-506	TargetScan Predicted Conserved microRNA Targets	1.0	0.175726
CRCGN017_MCF10A.WT.HP_24H:K24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0257
ZNF683	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00660495
POLR2A_K562_hg19_7	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DC-51-WE27_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.319789
RCOR1	ENCODE Transcription Factor Targets	1.0	null
NUP54	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056391
7445_RPL21_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.622076
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-V955-1126-SM-4JBH3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878347
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.16511
CHD9	Pathway Commons Protein-Protein Interactions	1.0	null
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE148066,GSE157787_2_v_1_n4bp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5909
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE86021_0_v_3_crenolanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PML_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K79065821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15871
POLR2A_K562_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RELA_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fallopian tube	HPA Tissue Protein Expression Profiles	1.0	1.37932
BV-173	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K92826631	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.76025
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Adipocyte	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-0.967886
blood vessel	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.060225
5548_NDUFAF5_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.53437
amygdaloid complex_19 yrs_F_12832	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.92017
GSE211286_7_v_5_tcf12_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
K562_Cimetidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0199795
BRD-K01095342	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34914
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X5EB-0526-SM-46MVP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.838701
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4162
BRD-K59093791	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35678
Lung disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	1.668
Ptf1a	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	49.1413
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K10317744	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56427
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-362-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
IRF1_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68206
BRD-K89471250	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10518
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.471655
H3K4me1_placenta_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K75007044	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18143
EP300_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Enhanceosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.961
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0544
posteroventral (inferior) parietal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.45087
H3K4me3_liver_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_GM15510_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNMC-1426-SM-2XCFM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.910773
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
orbital frontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03583
POLR2AphosphoS2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-MEL-28 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.793
PABPN1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00656222
CD28	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00542038
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
GP5D	DepMap CRISPR Gene Dependency	1.0	2.09414
GSE200839,GSE233826_5_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
AB-33-EM56_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.27971
K562_M344_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.02018
GSE148263_6_v_0_trim3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K53241408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10084
GSE137325_2_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LY-294002-6945	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFG7-0001-SM-3P61S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981449
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.70809
H3K4me3_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K44344720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14101
hippocampus (hippocampal formation)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.28083
GTEX-TKQ1-0008-SM-4DXSO	GTEx Tissue Sample Gene Expression Profiles	1.0	0.986258
TAF7	ENCODE Transcription Factor Targets	1.0	null
BRD-K24453679	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37222
496100583_PCx_dementia_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.02343
NCCSTCK140	CCLE Cell Line Gene CNV Profiles	-1.0	-1.47418
COX7B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542351
POLR2A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE126463_5_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_bone marrow macrophage_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34748
GTEX-QCQG-0226-SM-48U28	GTEx Tissue Sample Gene Expression Profiles	1.0	1.28223
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81S-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-548c-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
ACIN1	Pathway Commons Protein-Protein Interactions	1.0	null
GSE143512,GSE143513_0_v_1_nr4a3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0188149
FANCA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00693487
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18779
PPIG	Pathway Commons Protein-Protein Interactions	1.0	null
GTF2F1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-3398-01A-01R-1107-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K27320944	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.06702
GTEX-SIU7-0526-SM-3NM8I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19866
inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.59705
YY1_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
mefexamide-1438	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_GM12865_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K86912219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27089
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO824	DepMap CRISPR Gene Dependency	1.0	2.37614
PMC11263707-41419_2024_6896_MOESM4_ESM.pdf-14-TCF7L2_TCF7L2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	0.86851
HT144SKINFV1	DepMap CRISPR Gene Dependency	1.0	2.12956
RNF220	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07374
hsa-miR-3146	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
MYC_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K16888026	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.63785
6219_PES1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.768565
GTEX-POMQ-0008-SM-48TE7	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00082
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2115
BRD-K95147720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41686
GTEX-OIZI-1126-SM-3NB1F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.872653
POLR1E	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2518
K562_AR-42_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.013541
ventrolateral prefrontal cortex_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.882211
HCFC1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-37-3792-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TTN	Pathway Commons Protein-Protein Interactions	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A3QE-01A-21R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_lung_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_KD_K562-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
primary motor cortex (area M1, area 4)_36 yrs_M_12302	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.22859
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TTF2-22483619-HELA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
DOHH-2	GDSC Cell Line Gene Expression Profiles	1.0	2.15344
GTEX-U3ZM-1626-SM-4DXSK	GTEx Tissue Sample Gene Expression Profiles	1.0	0.981976
DMS153	CCLE Cell Line Gene CNV Profiles	-1.0	-1.54544
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_kidney_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
DNM2	Pathway Commons Protein-Protein Interactions	1.0	null
Lipid storage disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.742
NFIC_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
FOXA2	ENCODE Transcription Factor Targets	1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64684
RFX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6736
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K70148257	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.26026
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OVCA420	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TP53	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.972415
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K88281646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13206
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39885
miR-124_OE_GDS2657_771_human_HepG2 cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
H3K27ac_Mobilized CD34 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.051
CF-87-AS90_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.268534
eGFP-NR4A1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
DAUDI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.5311
GSE242290_1_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
NDUFC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433303
Preribosome	CM4AI U2OS Cell Map Protein Localization Assemblies	1.0	null
NCI-H2595	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.873562
A549_CYC116_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0136588
MCF7_BMS-536924_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175038
DDX20	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K07602825	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.62998
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE217115_2_v_5_alectinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K43852369	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34417
TP63-23658742-EP156T-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE186620_0_v_1_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
viscus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
431_AQR_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.596527
GSE131649_6_v_9_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Drug-Related Side Effects and Adverse Reactions	CTD Gene-Disease Associations	1.0	1.36648
GSE152441,GSE152442_6_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K62800316	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69035
RELA	ENCODE Transcription Factor Targets	1.0	null
GTEX-U3ZG-0001-SM-47JYF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17603
MED9	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.0524
GTEX-XQ8I-1126-SM-4BOO2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03537
BRD4_01_311	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60414
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.020343
GTEX-SNOS-0008-SM-4DM6I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21066
GSE146156_1_v_3_tagap_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
JAK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29104
GSE186810,GSE186813_7_v_5_furin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
S107	DeepCoverMOA Drug Mechanisms of Action	1.0	0.24
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.76614
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A51H-06A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
JEKO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69255
ADH1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00554379
GTEX-NPJ8-0011-R8a-SM-2HMLG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.31691
DMS 454	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.984636
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.952813
TCF7L2_Panc1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76357
KYSE-270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.09395
MED16	Pathway Commons Protein-Protein Interactions	1.0	null
K562_Amisulpride_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0138808
orbital frontal cortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.29193
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.948538
CAPAN-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.54636
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549246
GSE216043_10_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
K562_Lapatinib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0205401
GSE205963_0_v_1_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE157594_0_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A2780	CCLE Cell Line Gene Expression Profiles	1.0	1.47479
FOXA1-27270436-VCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
SUM102PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.41135
BRD-K07501326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43057
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3365-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03959
PMC9974104-jci-133-159940-s017.xlsx-GT3-INCP-GATA3_Co-down-Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01362
MAX	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00935885
ERO1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540264
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
BRD-K64939364	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.57043
BRD-K59491482	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58534
BRD-K47197953	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10253
TBL1XR1	ENCODE Transcription Factor Targets	1.0	null
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED14	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-XMK1-0326-SM-4B652	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.896489
LILRA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00663546
pheniramine-1910	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
4945_MED22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.536825
K562_Rigosertib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157125
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.44827
GTEX-PSDG-1526-SM-48TCY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01902
U2AF1	Pathway Commons Protein-Protein Interactions	1.0	null
H3K14ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PSMD14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.17323
GTEX-NL3H-0011-R1a-SM-48TDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973035
BRD-K72694472	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.9093
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36527
ELK1::HOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.4792
orbital frontal cortex_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.70231
BRD-K80577041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58622
TAF1_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NANOG-18692474-MEFS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K74129999	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37631
HS-SULTAN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.05524
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MS4A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00671478
BRD-K09863466	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01652
BRD-K39206254	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00858
BRD-K07390518	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06949
GSE171177,GSE171181_1_v_2_e7107_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MLS0315771	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.51
JUN	ChEA Transcription Factor Targets	1.0	null
MYC_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.857118
BRD-K11844807	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00678
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80715
MOLT4	CCLE Cell Line Gene Expression Profiles	1.0	1.58999
CRCGN016_MCF10A.WT.HP_24H:C22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.33218
EGR1	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-AK-3451-01A-02R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.963394
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16284
FOXC1	JASPAR Predicted Transcription Factor Targets	1.0	null
496100395_TCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.5663
PMC4609150-13073_2015_228_MOESM2_ESM.xlsx-TP53-Gene_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
protein binding	GO Molecular Function Annotations 2015	1.0	null
HDAC8_02_51	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.60301
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28037
GTEX-XYKS-2126-SM-4E3IB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16631
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2754-01A-01R-0980-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_brain_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
SMC3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MALME 3M	BioGPS Cell Line Gene Expression Profiles	-1.0	-1.98938
GTEX-S4Z8-2026-SM-3K2A9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97246
POLR2AphosphoS5_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TBP_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K54332480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.36655
BRD-K39179354	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12103
BD-96-HO33_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.235096
CRCGN011_HEPG2_24H:K11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.14235
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ESR1	ChEA Transcription Factor Targets	1.0	null
GSE175787_11_v_2_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MYC-19915707-AK7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
LY334370	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
BRD-K35441510	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.37088
layer III of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.44848
BRD-K04143388	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32858
occipital neocortex_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.01193
MYBL2_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SIN3A_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TRIM28	ENCODE Transcription Factor Targets	1.0	null
TF-77-DW08_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.200869
Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1I0-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
POLR2A_K562_hg19_8	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K25203350	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.6218
GSE226439,GSE226441_6_v_2_hnf4g_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE206870,GSE206872_3_v_5_ascl1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
K562_Droxinostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153685
GSE131649_6_v_0_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
MCF7_Daphnetin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0126656
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2I	Pathway Commons Protein-Protein Interactions	1.0	null
5089_NIFK_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514153
GTEX-OIZG-1126-SM-2HMIU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887934
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.25903
UBE3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20757
SPI1_GM12891_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K57498440	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06086
esr2_15280152_c57bl6_mice_soleus_skeletal_muscle_lof_mouse_gpl81_gds791	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.8131
MDAMB453	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.13308
GTEX-VUSH-0004-SM-3P61T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71567
BRD-K21986392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08787
15902281-TableS1e	GeneSigDB Published Gene Signatures	1.0	null
AOC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41359
SK-MEL cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.735
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03707
NANOG-18692474-MESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K72414522_AZD-5438_LNCAP_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF281	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	172.731
GTEX-S7SE-0008-SM-33HB1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.971822
NCI-H1838	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.21042
GSE163297_0_v_2_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07914894	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03192
CCDC71	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00499125
BRD-K35462787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79508
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.958838
K562_Givinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143174
GSE127790_9_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DHX8	Pathway Commons Protein-Protein Interactions	1.0	null
Perturb_4576_KO_Haspin_SRP271373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.65265
GSE186810,GSE186813_3_v_5_furin_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VZ in caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45138
CD19+_BCells(neg._sel.)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.44376
NPIPA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04644
PPP5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00406707
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_G1E-ER4_mm9_3	ENCODE Histone Modification Site Profiles	1.0	null
EP300_K562_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PRPF38A	Pathway Commons Protein-Protein Interactions	1.0	null
928 MEL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.901764
A549_Gandotinib_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121137
H2AFZ_T-cell acute lymphoblastic leukemia_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59347
gastrointestinal tract	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
APOE	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19285
GSE164874_5_v_3_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
2988_FBL_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.900393
HDAC1	ENCODE Transcription Factor Targets	1.0	null
HSPD1	Pathway Commons Protein-Protein Interactions	1.0	null
KASUMI1	CCLE Cell Line Gene Expression Profiles	1.0	1.43849
BRD-K77290793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01435
POLR2A_MCF-7_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.65503
Penis_Foreskin_Melanocyte_Primary_Cells_skin01	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.15132
mRNA_NIPBL_20720539	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.12829
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2761
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.3107
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.53431
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0258596
GPHA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.15934
amygdaloid complex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.65756
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.849738
GTEX-UPIC-0002-SM-3NMDC	GTEx Tissue Sample Gene Expression Profiles	1.0	2.18639
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.916189
SUM149PT	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.14928
NCI-H196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.876214
TRIM28_HEK293_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-T6MN-0011-R9A-SM-32QOZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01663
CRCGN014_HEPG2_3H:N04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.0968
GTEX-NFK9-1626-SM-3LK5J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.952085
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.07659
sirolimus-921	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WK11-2426-SM-3NMAA	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33988
hippocampus (hippocampal formation)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.36728
H2AFZ_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-66-2768-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K15602285	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5806
CRCGN015_MCF10A.TP53.M_24H:O22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.31305
GTEX-V1D1-0003-SM-3NMDP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32097
LIPF	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070561
PMC9061835-41523_2022_425_MOESM1_ESM.xlsx-S3_Differential_GEX-Table-S3_Differential_expression_analysis_results_for_SOX10-high_versus_SOX10-low_TNBCs_from_the_TGCA_and_METABRIC_expression_datasets_SOX10	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UJHI-1126-SM-4IHLN	GTEx Tissue Sample Gene Expression Profiles	1.0	0.856545
layer VI of area 35c	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.70496
H3K4me3_CH12.LX_mm9_5	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-548ac	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
GTEX-X638-0003-SM-47JZ1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19355
A549_Tazemetostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0185312
BRD-K14399036	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30062
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_4_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_GM12891_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IF-01A-11R-A33J-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MED15	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K77875023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29354
7569_RRS1_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.557609
BRD-K40621788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10764
H3K4me3_testis_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K47417426	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.17809
HOXB4-20404135-EML-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
PIAS1_KD_GSE44024_133_human_breast cancer cells	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	null
POLR2A_thymus_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K59100858	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.42354
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ABI3BP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00770285
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K85821470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05357
Perturb_9779_KD_Gas41_SRP110498	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.76744
YY1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
7492_RPP38_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.511515
15656903-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
SNRPD1	Pathway Commons Protein-Protein Interactions	1.0	null
PADI6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00552233
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
KYSE-450	COSMIC Cell Line Gene Mutation Profiles	1.0	null
K562_Valproic acid sodium salt_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0176495
GTEX-XQ3S-0926-SM-4BOPI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826885
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE127790_6_v_2_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
bmi1_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.273808
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5138
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.3922
FBL	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K02921955	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01702
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K60713831	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05854
ELK1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1	ENCODE Transcription Factor Targets	1.0	null
diflunisal-1908	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
bronchus	HPA Tissue Protein Expression Profiles	1.0	1.37932
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3WB-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Post-Traumatic Stress Disorder	DisGeNET Gene-Disease Associations	1.0	null
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.15361
YY1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_liver_mm9_2	ENCODE Histone Modification Site Profiles	1.0	null
Organelle lumen	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.895
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.16133
BRD-K12107412	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25433
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A0C8-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7861-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KP-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12109
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23127
H3K4me3_olfactory bulb_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
ABL1_mutant_24_GDS4046	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.83621
REST_SK-N-SH_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
REST_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cingulate gyrus, frontal part, left, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.22718
KYSE270	CCLE Cell Line Gene Expression Profiles	-1.0	-1.52437
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.576
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.47223
GSE152432_6_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K76680796	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20023
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
H3K4me2_K562_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-T2IS-0226-SM-32QPH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945468
Bone marrow	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.077
trichostatin A-6340	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ChIP_H3K36me3_18692474_mouseESC	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	1.0	null
K562	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.971083
AD-16-HL96_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.261827
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
IPO7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36733
18081427-TableS7	GeneSigDB Published Gene Signatures	1.0	null
BRD-K68009914	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23976
BJAB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.52984
IDH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00615109
GSE159967_3_v_0_arid5a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fasudil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145038
GTEX-XBED-0003-SM-47JWP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37619
GTEX-S7SF-1926-SM-4AT5B	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843403
BRD-K88890050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.305
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain - Cerebellar Hemisphere	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.864955
anterior (rostral) cingulate (medial prefrontal) cortex_13 yrs_F_12831	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.0185
POLR2A_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0008-SM-48TE9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03348
transition metal ion binding	GO Molecular Function Annotations 2015	1.0	null
BRD-K48145537	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00645
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19P-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Motesanib Diphosphate_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175358
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.8935
CMSS1	Pathway Commons Protein-Protein Interactions	1.0	null
Zymogen granule	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.149
Perturb_5350_OE_Dux_SRP201141	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.59046
RNASE11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09662
H3K4me3_Bone Marrow Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9079
breast	HPA Tissue Protein Expression Profiles	-1.0	-0.979197
H3K4me3_Adult Kidney	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
9667_USP4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.652112
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
basolateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.897689
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20641
ELL2	Pathway Commons Protein-Protein Interactions	1.0	null
CRCGN015_MCF10A.TP53.M_24H:K08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.1608
KDM5B-21448134-MESC-MOUSE	ChEA Transcription Factor Binding Site Profiles	1.0	null
LAMA84	CCLE Cell Line Gene Expression Profiles	1.0	1.43769
UMRC7	DepMap CRISPR Gene Dependency	1.0	3.00323
MYF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59584
H3K9ac_Breast Myoepithelial Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XUZC-1326-SM-4BRV2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95399
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.831605
Perturb_5362_KO_Dux_SRP237568	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.21534
GSE71385_1_v_0_cdk8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2659
valproic acid_homo sapiens_gpl570_gse14973	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CORL279	CCLE Cell Line Gene Expression Profiles	-1.0	-1.71145
hsa-miR-30d	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
CIART	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.31724
NO10	DepMap CRISPR Gene Dependency	1.0	3.41023
HDAC1_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
inferior nucleus of pulvinar	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.970692
BRD-A16313205	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0511
POLR2A_MCF-7_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210841
MDA-MB-330	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sarcoma_SARC_TCGA-WK-A8XS-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-410	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
K562_BRD4770_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0151925
PRR5L	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00792082
K562_Sodium Phenylbutyrate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148077
H3K4me3_thymus_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
CUX1	ENCODE Transcription Factor Targets	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
7431_RPL10A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622955
NCIH2342	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67256
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.21139
Rectum adenocarcinoma_READ_TCGA-AG-3725-11A-01R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K56188108	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05423
BRD-K69808609	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.89036
H2AFZ_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A 438079	DeepCoverMOA Drug Mechanisms of Action	1.0	0.65
POLR2AphosphoS5_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05544
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
LUZP1-20508642-ESCS-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
CRCGN011_HEPG2_24H:O02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.19105
H3K36me3_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PA-75-VL17_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.475708
BRD-K86722849	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24427
MYOD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3273
inferolateral temporal cortex (area TEv, area 20)_15 yrs_M_12299	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.34097
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.38354
POFUT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00816679
BRD-K04614055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07907
dorsal thalamus_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.02652
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14756
GTEX-QEL4-1426-SM-447AC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.855867
GTEX-RWS6-0526-SM-4GIAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39978
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-8005-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
PLAG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	98.6111
GATA3_SH-SY5Y_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EFM-192A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.963786
RCC4	CCLE Cell Line Gene CNV Profiles	1.0	2.08875
H3K4me3_HepG2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	1.0	1.89962
A549_Droxinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0135759
hsa-miR-548ab	TargetScan Predicted Conserved microRNA Targets	1.0	0.517189
pcgf2_17452456_medulloblastoma_lof_human_gpl570_gds2724	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.338951
GSE235066_4_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.TP53.M_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.43631
10400_ZNF497_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.0489
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Theophylline	CTD Gene-Chemical Interactions	1.0	null
hsa-miR-548a-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.474009
PMC12866144-mmc3.xlsx-Sheet1-Table_S2_List_of_genes_that_comprehend_the_TP53_AML_signature_generated_in_this_manuscript_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
ARFGEF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40386
PRPF40A	Pathway Commons Protein-Protein Interactions	1.0	null
EF-80-OD07_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.299071
BRD-K01605333	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.80852
KA-29-AB08_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.407943
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.7491
VZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.34445
GTEX-OXRK-1326-SM-3NB1A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.902622
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.76238
mRNA_NRIP1_19796622	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
GSE126621,GSE126920_1_v_0_dppa4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoma_burkitts(Daudi)	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.08703
BC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE201239_3_v_4_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K9ac_HepG2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25053
CDC23	Pathway Commons Protein-Protein Interactions	1.0	null
BRD-K44675576	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85398
H3K4me3_Stomach Smooth Muscle	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CALU6	DepMap CRISPR Gene Dependency	1.0	3.07575
u937	HPA Cell Line Gene Expression Profiles	1.0	0.972391
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
GTEX-SNMC-1026-SM-4DM7K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.29187
GSE179974_3_v_1_carboplatin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Nasopharyngeal carcinoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.887
ZKSCAN1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981625
MON1A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00722073
BRD-K12517207	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4981
7461_RPL34_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.769889
BRD-K99116119	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01122
GSE124375_13_v_0_chd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
anterior orbital gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.968919
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.39362
BRD-A24643465_homoharringtonine_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC3669416-pone.0064838.s001.xls-mHTT-HOXB3_HOXB3	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Thalidomide_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0251232
GTEX-R55F-1426-SM-2TF53	GTEx Tissue Sample Gene Expression Profiles	1.0	0.955555
H3ac_myocyte_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
MK-6892	DeepCoverMOA Drug Mechanisms of Action	1.0	0.27
K562_Mesna_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182023
AFF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.51668
POLR2AphosphoS5_G1E_mm9_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MSTO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00647643
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF1_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K23598860	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22088
7463_RPL35_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.543893
NR2F2_K562_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IKZF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K14706855	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23658
BRD-K74933734	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20437
NELFE_MEL cell line_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
5750_NOP58_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.514931
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K40265664	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22429
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89611
SYK_druginhibition_285_GSE43510	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	2.24184
Prostate adenocarcinoma_PRAD_TCGA-G9-6362-11A-01R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
E2F1	ChEA Transcription Factor Targets	1.0	null
TAF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QMRM-1226-SM-447C6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942594
Perturb_4575_OE_Haspin_SRP271373	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.94846
JUND_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K14ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
SNRPD2	Pathway Commons Protein-Protein Interactions	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43288
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IRF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	47.9724
CMAS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.36568
CRCGN015_MCF10A_48H:B22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-3.25074
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
PRDM14	ChEA Transcription Factor Targets	1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154043
rectum	HPA Tissue Protein Expression Profiles	1.0	1.37932
BRD-K72833997	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81345
Lung epithelium cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.842
HEK 293 T-rex    	BioGPS Cell Line Gene Expression Profiles	1.0	1.50588
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Fluorouracil_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157487
inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16201
H3K36me3_ES-E14_mm9_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OOBK-2126-SM-3LK5T	GTEx Tissue Sample Gene Expression Profiles	1.0	0.965746
NFE2L2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.22208
H3K4me3_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K60052521	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47961
ventrolateral prefrontal cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.31603
SNU-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-3.0049
6625_PPIE_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.581955
H3K9ac_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX10	JASPAR Predicted Transcription Factor Targets	1.0	null
ARID3A_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28414977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03573
Skin Cutaneous Melanoma_SKCM_TCGA-FR-A3YO-06A-11R-A239-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GTEX-TKQ2-1826-SM-33HB2	GTEx Tissue Sample Gene Expression Profiles	1.0	0.945464
MZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.30982
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
K562_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0153886
CRCGN016_MCF10A.WT.HP_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.40068
inferior frontal gyrus, opercular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.06859
nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
COV362	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.96644
GSE114013,GSE114014_0_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EJ-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11165526-ADVS-11-2310146-s002.pdf-30-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
MHHNB11	CCLE Cell Line Gene Expression Profiles	-1.0	-1.49369
BRD-K09160804	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.96441
GSE198165,GSE198166_7_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cochlear nuclei, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.13868
GTEX-SUCS-0002-SM-3NMAJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68433
ventrolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19197
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
RSL1D1	Pathway Commons Protein-Protein Interactions	1.0	null
PMC12619835-41467_2025_66007_MOESM8_ESM.xlsx-Classical_KLF5_peaks-Gene_Name_1_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H441	GDSC Cell Line Gene Expression Profiles	-1.0	-1.9585
BRD-K88820027	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06014
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A101D	GDSC Cell Line Gene Expression Profiles	-1.0	-1.8415
7432_RPL10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.651074
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.996987
TYK-NU.CP-R	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.855657
SG in temporal polar cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.40955
NONO	Pathway Commons Protein-Protein Interactions	1.0	null
GSE153836_14_v_5_fluoxetine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10290283-biol-2022-0622-sm3.pdf-78-PURA_PURA	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A79248021	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10401
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MM253	DepMap CRISPR Gene Dependency	1.0	2.41069
GSE134375_4_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE232631_5_v_2_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_23 yrs_M_12300	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.959677
BRD-K23434564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5611
STAT1-20625510-HELA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
FOXM1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HUG1N	CCLE Cell Line Gene CNV Profiles	-1.0	-2.11693
ELF1_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cerebellar cortex_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05701
WD-62-UB45_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.329074
10623_ZNF774_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.26831
CRCGN016_MCF10A.TP53.M_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-4.5132
GSE80819_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
17660535-TableS4c	GeneSigDB Published Gene Signatures	1.0	null
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.68621
GSE158834_7_v_13_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Thalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014253
BL5589 (MYBL2)	NURSA Protein Complexes	1.0	null
MICALL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21956
primary auditory cortex (core)_13 pcw_M_12888	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.842333
GTEX-PLZ6-1426-SM-2S1OQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.278
A549_Quercetin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152198
cerebellar cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.899894
SLU7	Pathway Commons Protein-Protein Interactions	1.0	null
496100324_FWM_no dementia_TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15445
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TAF7_K562_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16718
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-J2-A4AE-01A-21R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.12816
TBL1XR1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
scriptaid-6896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN015_MCF10A_48H:E13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.57387
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MF-06A-11R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
WWC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42515
BRD-K06261202	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35229
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S33H-0826-SM-4AD5Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14486
BRD-K43364707	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3162
H3K4me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
A549_Quisinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0112716
RASL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.14014
GTEX-WFG8-2426-SM-3GILL	GTEx Tissue Sample Gene Expression Profiles	1.0	0.929993
RBBP5	ENCODE Transcription Factor Targets	1.0	null
CMTM7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0067747
BRD-K77824583	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19936
BRD-K57938735	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.58442
JC-02-ZR15_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219449
BRD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00773141
H3K4me1_spleen_mm9_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ELF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BA-06-RE84_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.277434
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09916
GSE229309,GSE229314_4_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-875-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
CRCGN017_MCF10A.WT.HP_24H:K07	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-6.23535
GTEX-PLZ5-1126-SM-3P613	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11377
BRD-K70286959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.24146
BRD-K97732674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01631
RAJI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.981847
SCLC22H	DepMap CRISPR Gene Dependency	1.0	2.07299
1152_CAD_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.572174
pineal_night	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.01173
BRD-K89514545	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.59951
EEF1A1	Hub Proteins Protein-Protein Interactions	1.0	null
DM3	CCLE Cell Line Gene Expression Profiles	-1.0	-1.72828
BRD-K87781745	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14921
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null