association	dataset	threshold value	standardized value
GSE77108_5_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
abnormality of nervous system morphology	GWASdb SNP-Phenotype Associations	1.0	0.091377
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.11426
inferolateral temporal cortex (area TEv, area 20)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.881799
GSE162276_4_v_0_rosiglitazone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEP3_DN_AA_DN-D-HEP3_DN_AA_DN_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC3930188-813067.f1.pdf-160-ZNF529_ZNF529	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-T6MN-0011-R11A-SM-32QOX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.41252
GSE206729_2_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XQ8I-0626-SM-4BOPT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.942154
Lung squamous cell carcinoma_LUSC_TCGA-58-8390-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
VSIG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543337
Sinonasal undifferentiated carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.402
outer CP in primary auditory cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.48922
Cognition Disorders	CTD Gene-Disease Associations	1.0	1.05721
H3K79me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
lateral parabrachial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.914264
GSE223008_7_v_3_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN014_HEPG2_24H:L16	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.34532
trichostatin A-7047	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
endometrium	HPA Tissue Gene Expression Profiles	1.0	1.26765
GTEX-XAJ8-0006-SM-46MVM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.18213
GTEX-WZTO-1026-SM-3NM9P	GTEx Tissue Sample Gene Expression Profiles	1.0	0.95104
PE01	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.19222
BRD-K41492504	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04334
PMC9894241-pnas.2211429119.sd05.xlsx-G2_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956724
GSE215155_0_v_1_golph3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-1912	TargetScan Predicted Conserved microRNA Targets	1.0	0.069137
heterocycle metabolic process	GO Biological Process Annotations 2015	1.0	null
Vagina	GTEx Tissue Gene Expression Profiles 2023	1.0	1.51801
A549_Tanespimycin_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0171926
BRD-K27584103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33705
GSE148321,GSE169423_2_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC33	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02227
GSE94849_7_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_9_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN013_HEPG2_24H:K01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.27205
BRD-K85493820_KM 00927_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN013_HEPG2_24H:K04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.00951
male reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_fibroblast of foreskin _hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
dorsal thalamus_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.836507
GTEX-S7SF-0001-SM-3K2BE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922588
retina	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.915394
Perturb_5260_KD_Ubn2_SRP323703	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	18.284
VAESBJ	DepMap CRISPR Gene Dependency	1.0	2.07567
GSE158834_10_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
alcohol dependence	GWASdb SNP-Disease Associations	1.0	0.716372
H3K4me3_BE2C_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-129-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.082179
GSE103068_0_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
COLO741_SKIN	CCLE Cell Line Proteomics	1.0	4.70772
H3K27ac_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
tardbp_19910924_hek293e_lof_human_gpl570_gds3730	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.385455
GSE95302_2_v_3_tamoxifen_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE118794_0_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lung cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.135
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14059
BRD-K63107801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03405
GTEX-X585-0011-R11B-SM-46MUZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2934
intracellular	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-REY6-0626-SM-2TF4G	GTEx Tissue Sample Gene Expression Profiles	1.0	0.952193
Kidney Chromophobe_KICH_TCGA-KL-8340-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-429	TargetScan Predicted Conserved microRNA Targets	1.0	0.828473
CRCGN017_MCF10A.WT.HP_24H:P06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3581
CHD1-26751641-CHIP-SEQ-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE162739_2_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZFP42	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6775
GSE233679_12_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
pentetic acid-5629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-49-4506-01A-01R-1206-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_5047_KO_SYTL3_ERP126655	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
SYNRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79422
GTEX-OXRN-0005-SM-2I5EU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36498
Prostate adenocarcinoma_PRAD_TCGA-KK-A8ID-01A-11R-A36G-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
intracellular membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
BRD-K51370144	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77473
GSE211983_0_v_2_nicotine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
medial habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.52804
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.91025
cerebellar cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.952911
cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ELF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00690245
Maraviroc	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.34
EPLC272H	CCLE Cell Line Gene CNV Profiles	-1.0	-1.38326
H3K4me3_foreskin fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K03479638	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16428
USF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_Ramelteon_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0136767
Brain Lower Grade Glioma_LGG_TCGA-HT-7884-01B-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NUDT18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65701
H3K4me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A112-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
trichostatin A-5802	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HOXD12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.521
GSE120413,GSE120447_0_v_1_bap1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K67120755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10828
BRD-K00590556	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03321
GSE167324_2_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Tie2 kinase inhibitor_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175035
trichostatin A-1234	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCO2	CCLE Cell Line Gene CNV Profiles	1.0	1.36308
Colorectal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.041
GTEX-X62O-0005-SM-46MV1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09766
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.24249
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3316-01A-01R-0864-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2832-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A52729710	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02047
Brain - Putamen (basal ganglia)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.00196
SNU349	DepMap CRISPR Gene Dependency	1.0	4.79428
FOXA2_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4718-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Disease of anatomical entity	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
hsa-miR-203	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
Prostate adenocarcinoma_PRAD_TCGA-YJ-A8SW-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K05841284	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12317
GTEX-XBEC-1526-SM-4AT68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.859361
GSE221327_6_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A-CA-04-2009(H1N1)_18hour_23935999_GSE47962	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.62532
GSE112860_0_v_2_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
substantia nigra, reticular part	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03985
biological_process	GO Biological Process Annotations 2015	1.0	null
CEBPA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8858
NB6	DepMap CRISPR Gene Dependency	1.0	2.66565
A549_Tazemetostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0162968
H3K4me1_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE136742,GSE136744_0_v_3_setd2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
cell part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
rnf2_20805357_u2os_osteosarcoma_lof_human_gpl570_gse23035	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.407183
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46B-01A-31R-A250-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE178255_2_v_4_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206516,GSE206518_3_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
metrizamide-4156	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K72175798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80179
GSE216043_7_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
cingulum bundle, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	3.26578
BRD-K64424704	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.04268
GTEX-P44H-0006-SM-2XCFB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.970742
GSE169205_0_v_8_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RAD21	ENCODE Transcription Factor Targets	1.0	null
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.2768
trichostatin A-6874	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K31510624	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1075
OAW42	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15389
BRD-K27881453	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4991
HCT-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Thyroid	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.47088
GSE211128_7_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-T6MO-0006-SM-32QOU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.9838
stratum radiatum of rostral CA1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.27909
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.5881
tropicamide-2309	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TMMY-0005-SM-33HBN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.994938
Perturb_6669_KO_FGFR3/FGFR4_SRP386785	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.48612
whole body	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
inflammatory bowel diseases	GAD Gene-Disease Associations	1.0	null
GTEX-OIZH-1826-SM-2YUNP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23824
trichostatin A-6064	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
granular layer of rostral dentate gyrus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.25094
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
SW 780	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.61939
dorsolateral prefrontal cortex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.855165
GSE113106_2_v_5_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WFON-0526-SM-4LVLY	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893739
GSE223008_7_v_1_calhm6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_12_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MDA-MB-134-VI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.62383
GSE200673,GSE200691_1_v_5_hmga2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE210101,GSE210114_11_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SG in inferolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.52123
BRD-K70200818	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47655
BRD-K99198579	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11851
H3K4me3_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE95771_0_v_4_ruxolitinib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K15380626	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15506
posteroventral (inferior) parietal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.840366
trichostatin A-1793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PIK3C2G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00408901
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.08292
A549_CUDC-907_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0105229
GSE191015_1_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSS	DepMap CRISPR Gene Dependency	1.0	4.05314
PMC11358472-41467_2024_51851_MOESM4_ESM.xlsx-Sheet1-Supplementary_Table_4_gene_expression_levels_for_323_genes_connected_to_EWS-WT1_in_JN-DSRCT1_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE113734_3_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
TRIM24	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00530762
KDM3B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29372
GSE205070_2_v_5_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-XGQ4-0005-SM-4AT5U	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.00239
BRD-K48670593	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11248
GTEX-RM2N-1926-SM-48FCU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00699
GSE199899_3_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144838_7_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-VUSG-0003-SM-3NMDK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.882227
GSE202434,GSE202438_4_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_H54_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A549_BMS-911543_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189226
morphological abnormality of the central nervous system	GWASdb SNP-Phenotype Associations	1.0	0.1043
gonad	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE193993_1_v_6_sstr2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_5_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MAX	ENCODE Transcription Factor Targets	1.0	null
A549_Selisistat_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0117605
GSE128730_7_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE178292_0_v_3_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A1PV-01A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pou5f1::Sox2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.0928
BRD-K57382977	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1025
GSE130690,GSE130692_2_v_0_sirt6_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K39400123	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.32537
chronic colitis	GWASdb SNP-Phenotype Associations	1.0	0.390642
CTCF_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K58614056	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.47568
TEAD4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.11
GTEX-OXRL-0426-SM-3NM97	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826336
BRD-K15098674	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68469
SNU46	DepMap CRISPR Gene Dependency	1.0	3.41739
PMC9314667-Table_1.xlsx-Regulons-TFAP2A_TFAP2A	Rummagene Transcription Factor Associations 2026	1.0	null
biological regulation	GO Biological Process Annotations 2015	1.0	null
CD71+_EarlyErythroid	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.5631
PHA-00851261E-3965	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of primary metabolic process	GO Biological Process Annotations 2015	1.0	null
Carbohydrate metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.022
H3K4me3_choroid plexus epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SR-786	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.9465
GSE185944_5_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PC-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.83839
icSARS CoV_30Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.3195
GSE210101,GSE210114_7_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TADA2B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.78377
blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051566
GSE76425_0_v_12_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE203158_5_v_13_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EWSR1-negative small round cell tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
H2AFZ_astrocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XMD1-0006-SM-4AT4Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.51321
hsa-miR-4452	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE142210_9_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Ro 28-1675	DeepCoverMOA Drug Mechanisms of Action	1.0	0.3
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4986-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cyclin/CDK positive transcription elongation factor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.286
TAF1_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K9ac_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
FOXO4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.1465
U87MG	DepMap CRISPR Gene Dependency	1.0	2.70301
BRD-K03461876	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13929
GSE193541_0_v_2_nifurtimox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
icSARS CoV_36Hour_None_GSE37827	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.41301
NFE2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00873226
PDE2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570628
GSE94849_1_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.16159
GTEX-QMRM-0005-SM-3NB2A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21915
GTEX-XLM4-0005-SM-4AT4P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69073
hsa-miR-29a	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
GSE157555,GSE157556_0_v_1_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Momelotinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147256
GTEX-S4Q7-1026-SM-4AD75	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20561
GSE125782_0_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_3_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-5927-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEL-JUSO	GDSC Cell Line Gene Expression Profiles	-1.0	-1.80116
cerebrovascular disease	GWASdb SNP-Disease Associations	1.0	1.06118
GTEX-QEG4-0006-SM-2I5FY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10371
GTEX-U4B1-1926-SM-3DB9E	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27971
nutrition disease	GWASdb SNP-Disease Associations	1.0	0.341572
BRD-A19500257_geldanamycin_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3910	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
BRD-K06489778	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35639
GSE185519_1_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SIHA	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE206516,GSE206518_2_v_4_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.19538
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3929
Immune system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.026
hsa-miR-224	TargetScan Predicted Conserved microRNA Targets	1.0	0.03694
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EF-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K46400317	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08959
ESO26	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.05346
BRD-K06049932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43288
GSE137818_2_v_6_brca2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
trichostatin A-3791	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K45190659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.32905
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70P-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
mometasone-2896	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAMOS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854821
BRD-K69932463_AZD8055_A673_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MED28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.69324
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZP-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE125007,GSE125008_10_v_0_uhrf1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Yy1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	17.8335
IGR1_SKIN	CCLE Cell Line Proteomics	1.0	2.44105
GSE88819_0_v_9_tug1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
DPP4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00506911
GSE226316_3_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-520a-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
PMC5474565-onc2016488x2.xlsx-Table_S4_MLL_Target_Genes-MV4-11_MLL_wt_target_genes_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-W5X1-0006-SM-3GIJZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10034
WM1799_SKIN	CCLE Cell Line Proteomics	1.0	4.41239
GSE188832,GSE188835_0_v_1_irf4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SETBP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00543005
GTEX-RWS6-2326-SM-2XCB4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06768
Acute Myeloid Leukemia_LAML_TCGA-AB-2956-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-50-6591-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLTP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00558006
GTEX-X585-0002-SM-46MVA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.931258
HCC1500	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.20534
KCI-MOH1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.902318
GSE215086_5_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
pronetalol-4104	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE152699,GSE152723_3_v_2_vemurafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RUNX3_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
E2A	MotifMap Predicted Transcription Factor Targets	1.0	null
cyclothiazide	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.04104
MEG-01	GDSC Cell Line Gene Expression Profiles	-1.0	-1.62711
GTEX-T6MN-1226-SM-3NMA5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.89151
Primary hematopoietic stem cells G-CSF-mobilized Female RO_01508	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	1.0	1.17599
ESRRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549738
pancuronium bromide-4393	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.80827
DCK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09917
TEF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5742
NANOG	ENCODE Transcription Factor Targets	1.0	null
thrombocytosis	MGI Mouse Phenotype Associations 2023	1.0	null
CTCF_spleen_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
nucleus	LOCATE Curated Protein Localization Annotations	1.0	null
GSE107854_2_v_0_prmt5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE94849_7_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.58473
GSE147662_2_v_5_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
EW7	DepMap CRISPR Gene Dependency	1.0	2.17178
S100A13	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25611
GTEX-OHPK-0426-SM-3MJH3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.83349
GSE169356_2_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
VIIAt	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.896879
arcuate nucleus of hypothalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.62157
GTEX-WFG7-1826-SM-3GIL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2941
CRCGN011_HEPG2_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.07065
urogenital system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
BRD-K15567136_-666_SKB_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nucleic acid binding	GO Molecular Function Annotations 2015	1.0	null
HCC2270	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37967
Ewing sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.46
PSMC3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10003
ATF2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7100-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sarcoma_SARC_TCGA-IF-A4AK-01A-21R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0074133
GSE134191_6_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE161170,GSE161268_0_v_2_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-WHSE-2926-SM-3NMBG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40209
GSE221327_8_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HCC1954	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.742933
Prostate adenocarcinoma_PRAD_TCGA-EJ-5515-01A-01R-1580-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-X62O-1626-SM-46MW9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.913046
decreased mean corpuscular volume	MGI Mouse Phenotype Associations 2023	1.0	null
H2AFZ_keratinocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MFE280_ENDOMETRIUM	CCLE Cell Line Proteomics	1.0	2.24391
KDM5B_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
citiolone-3930	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SMAD4	ChEA Transcription Factor Targets	1.0	null
H3K4me3_fibroblast of foreskin _hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Retinoblastoma cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.545
GRK7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00580968
Vitreous chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.185
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54034
CDK5	Kinase Library Serine Threonine Kinome Atlas	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-XJ-A9DX-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-0005-SM-32QPA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36058
GSE183113_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A1BL-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-7710-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE140997_4_v_8_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.82729
GSE175787_4_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_U-87 MG_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RTLS-0326-SM-2TF6A	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840374
GTEX-WH7G-0005-SM-3NMBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.97042
SW 1990	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27356
GTEX-U3ZG-0006-SM-47JWX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.78512
DV-90	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GTEX-XBED-2426-SM-4AT4O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13306
SUM185PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.20729
BT-20	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16705
H3K4me3_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
12829800-IntrinsicList	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_skeletal muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-TKQ1-1226-SM-4GICJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847979
GSE163240_3_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WHWD-0005-SM-3LK7D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.29844
Male reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
NCI-H1581	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SG in dorsomedial parietal cortex (area 7m)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.98894
BRD-K22812176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05443
Sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.411
CCND3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00327659
BRD-K98535230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25435
BL3106 (APC)	NURSA Protein Complexes	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-CU-A0YN-11A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
regulation of nucleic acid-templated transcription	GO Biological Process Annotations 2015	1.0	null
H3K4me3_cardiac mesoderm_hg19_8	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_keratinocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01361
VI, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.849755
posterior (caudal) superior temporal cortex (area 22c)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.07687
H2AFZ_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CXCR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00630407
RETREG3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.5665
ARPE-19 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.781
GSE193249_0_v_1_gpx8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PNU-0230031-3629	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-OXRP-0006-SM-2I3FN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.32264
Reproductive system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.157
GTEX-SNOS-0006-SM-32PLH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31442
hsa-miR-324-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.283838
YA-78-MS95_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219228
H2AFZ_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
prostate	GTEx Tissue Gene Expression Profiles	1.0	1.18506
Olfactory neuroblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
TTC14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.34588
flucytosine-6450	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
azlocillin-3468	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-T8EM-1826-SM-4DM7F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04315
GTEX-RWSA-0005-SM-2XCAO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.07162
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Retinal vascular disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.404
trichostatin A-4436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PLZ6-1126-SM-3P5ZR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44481
GSE239578_5_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H522	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.01716
GSE148657_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:J21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0025
H3K4me3_SK-N-MC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE210101,GSE210114_6_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Selinexor _SHP-77	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00679062
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	76.4296
PMC9508118-42003_2022_3857_MOESM6_ESM.xlsx-a-Classification_of_camel_SON_basal_genes_-_transcription_factors_SON	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12499388-ADVS-12-e01774-s002.xlsx-Table_S1-Table_S1_Differentially_Expressed_Genes_between_wild-type_and_TET3-knockout_PANC-1_cells_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF157	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.0896
A549_Roscovitine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0195684
amygdaloid complex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.854209
Lung adenocarcinoma_LUAD_TCGA-44-2666-01A-01R-0946-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K20253608	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11957
GSE192870_2_v_0_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inferior frontal gyrus, triangular part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.868885
adrenal gland	HPA Tissue Protein Expression Profiles	1.0	0.950484
SW 480	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.18462
GSE180200,GSE180201_2_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_BMS-911543_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144047
PMC12455829-11658_2025_792_MOESM8_ESM.xlsx-2_DDIT3_IP_vs_BRG1_IP-Unnamed_2_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
Small cell sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.191
REST_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE226355,GSE226357_3_v_4_ybx1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GTEX-T8EM-0006-SM-3DB71	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.002
8305C	DepMap CRISPR Gene Dependency	1.0	2.07626
PHF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0592
BRD-K59491389	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.33778
KCNC4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00738119
GSE114013,GSE114014_1_v_3_itraconazole_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE81803,GSE81912_3_v_5_fmr1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158632_3_v_4_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SJXC-1226-SM-4DM78	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977817
GTEX-RNOR-0005-SM-2TF4Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09878
GSE203158_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.956711
GTEX-X4LF-0006-SM-3NMCO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15637
KHM-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.16913
GTEX-X4EO-0006-SM-3P5ZF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916251
NCI-H1651	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57389
hsa-miR-20b	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
CPLX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00687667
GSE219195_1_v_5_rbm12_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-3123	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
BRD-K39752756	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03066
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cellular_component	LOCATE Predicted Protein Localization Annotations	1.0	null
cellular_component	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-RWSA-2026-SM-47JX8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.32706
cerebral hemisphere	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
VI, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.959773
H3K4me1_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4696	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
niflumic acid-5490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC5967331-41467_2018_4384_MOESM4_ESM.xlsx-Sup_data1_with_CCF_txt-Gene_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH69	CCLE Cell Line Gene CNV Profiles	1.0	1.74552
GSE137653_2_v_3_siglecf_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-Q734-0006-SM-2I3FJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09133
GTEX-XBED-0726-SM-4GIAR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21845
diphenylpyraline-6061	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE199899_4_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
EBC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.21697
BRD-K19220233_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2917-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A3PJ-01A-21R-A220-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
KMS-21BM	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.05129
GTEX-REY6-1226-SM-48FDR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.913947
nucleus	LOCATE Predicted Protein Localization Annotations	1.0	null
CFAP410	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08146
GSE205070_2_v_9_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
sertaconazole-6811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cell part	LOCATE Predicted Protein Localization Annotations	1.0	null
A549_PFI-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0187413
GSE244710_3_v_2_srsf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Sox5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.0323
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE229973_3_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WY7C-0006-SM-3NB3L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.53115
MDAMB134VI	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.26149
POLR2A_GM19099_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BC-54-ON71_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.237358
A549_MLN8054_100nM_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0126781
GTEX-WZTO-2826-SM-3NM8P	GTEx Tissue Sample Gene Expression Profiles	1.0	2.04639
PMC9894241-pnas.2211429119.sd05.xlsx-G7_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me2_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H2AFZ_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NUCKS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00378022
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.75633
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-GATA6_GATA6	Rummagene Transcription Factor Associations 2026	1.0	null
HS 936.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.940929
GSE125862_2_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T8EM-1526-SM-3DB7I	GTEx Tissue Sample Gene Expression Profiles	1.0	0.93183
temporal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.00032
GTEX-RU72-0011-R11A-SM-2TF6J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52737
cinchonine-2789	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K12011077	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04564
BRD-K11741103	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30074
alprostadil-4179	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE128076_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S7PM-0006-SM-3NM8C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04927
UBQLN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00498267
PMC9203705-bloodBLD2021014723-suppl2.xlsx-Supp_Table_7-Supplementary_Table_7_Top-list_genes_differentially_expressed_in_CDX2_UBTF_ALL_pvalue_10-7_and_log2_fold_change_3_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S4Q7-1326-SM-4AD74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.859515
BRD-K26838195_AST1306_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H2BK15ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE217552_3_v_2_fisetin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RM2N-0006-SM-2TF5H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58683
BICR10	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COV644	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31185
GSE135030_3_v_10_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Mucoepidermoid carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.193
Yohimbine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
MAFK_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K62612761	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40606
PCI30	DepMap CRISPR Gene Dependency	1.0	2.62506
brain stem	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
MYEOV	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00653063
hsa-miR-498	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.940433
SKCO1	CCLE Cell Line Gene CNV Profiles	-1.0	-3.00341
Uterine Carcinosarcoma_UCS_TCGA-N5-A4RU-01A-31R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-TML8-0001-SM-3NMAF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.977
GSE158197_6_v_10_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
endopiriform nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.21627
GSE152432_3_v_0_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Blastoderm	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.774
BRD-K02130563_S1030_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TMEM209	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46974
hsa-miR-4534	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
GSE168807_0_v_8_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF140	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.4859
REST_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Organ system cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
hsa-miR-4269	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
PRPF8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07427
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.01437
CTCF_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUJ4-0005-SM-4BOQ6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.63741
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6951-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A43076080	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29248
male reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
CARS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01471
GSE130383_2_v_0_gps2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4351-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
mediodorsal nucleus of thalamus_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.979072
inferolateral temporal cortex (area TEv, area 20)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.982982
primary motor cortex (area M1, area 4)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.917749
hsa-miR-4801	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
NR4A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00599563
COLO668	CCLE Cell Line Gene CNV Profiles	1.0	1.48741
GSE175787_11_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K06956443	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.23545
BRD-K91513229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43241
STAT3	ENCODE Transcription Factor Targets	1.0	null
GTEX-X585-0005-SM-46MV3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05099
H3K27ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
EP300_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE65617_0_v_4_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K68202742_trichostatin A_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
496100307_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.74738
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_D1_vs_D10-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
Clonidine (hydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0264624
Lung adenocarcinoma_LUAD_TCGA-99-7458-01A-11R-2039-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7617064-EMS151900-supplement-Extended_Data_Figure_7_Source_Data.xlsx-D23_NFIX-Logfold_change_threshold_1_0_1_NFIX	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K89399989	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46337
BRD-A77941182	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20849
icSARS CoV_60Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.02641
CTCF_keratinocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S33H-2326-SM-2XCB3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30191
GTEX-S33H-1626-SM-4AD68	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.903286
lateral ganglionic eminence_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.03547
OB-06-WW76_0.01uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.224835
MN-60	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-101	TargetScan Predicted Conserved microRNA Targets	1.0	0.568687
A549_Resminostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0128226
GSE226249_2_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.752
RPAIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3629
TP63	ChEA Transcription Factor Targets	1.0	null
ASPA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523693
Lung squamous cell carcinoma_LUSC_TCGA-85-8351-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11185762-media-2.xlsx-ATAC2wk_KD_V337M_intersect_peak-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150895,GSE150896_0_v_1_kif15_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RTLS-0006-SM-2TF58	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957592
BRD-K50443235	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.44641
496100448_TCx_possible Alzheimer's disease_no TBI_88_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.02718
BACH1	ENCODE Transcription Factor Targets	1.0	null
NUCB2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00604174
heterocycle biosynthetic process	GO Biological Process Annotations 2015	1.0	null
regulation of macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-4303	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
BRD-K21047238	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02716
GTEX-POMQ-1926-SM-3NB1Y	GTEx Tissue Sample Gene Expression Profiles	1.0	0.837654
GSE113329,GSE113335_2_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226249_0_v_4_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
alcoholism	GAD Gene-Disease Associations	1.0	null
primary motor cortex (area M1, area 4)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.897588
CTCF_keratinocyte_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of gingiva_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
17483311-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
BRD-K46082763	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01318
organic substance biosynthetic process	GO Biological Process Annotations 2015	1.0	null
BRD-A02481876_Importazole_EFO27_6.0_h_60.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE128730_3_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.97265
GSE111660_4_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Z8-0526-SM-4AD4T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922849
GSE188870,GSE188871_4_v_5_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
icSARS CoV_54Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.03279
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_1_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Tfcp2l1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	35.8813
lateral habenular nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.942274
H2AFZ_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A13J-11A-13R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAP3K11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00813011
Central nervous system embryonal tumor	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
BRD-K97365803_PI 828_HCC515_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4342-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164135,GSE164137_0_v_1_fbxw7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.849445
H3K4me3_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-NL4W-0006-SM-2I3GH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07966
Eccrine porocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.507
GTEX-WWYW-0005-SM-3NB3K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57595
GTEX-S3XE-0326-SM-4AD6L	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09148
BRD-K27671601	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.47647
GTEX-UPK5-0006-SM-3GAD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10894
H3K9ac_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE158834_12_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PWN1-1726-SM-2S1O9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02836
nimodipine-6480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
smooth muscle	HPA Tissue Protein Expression Profiles	1.0	0.950484
IX, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.53121
EHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00584049
BRD-K31806725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.56006
SLC6A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00549224
GSE207282_1_v_0_polydatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUZC-0005-SM-4BOQ8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.62326
GSE236486_1_v_2_arnt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-157	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05916
GSE188570,GSE188571_3_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_6094_KD_ZNF207_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE176008_8_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IMR-32	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.73422
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.0697
H3K4me1_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MAZ	ENCODE Transcription Factor Targets	1.0	null
BRD-K44613656	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13129
Inherited metabolic disorder	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.029
P2RY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11476
GTEX-P4PP-2026-SM-3P61N	GTEx Tissue Sample Gene Expression Profiles	1.0	2.0607
Sox1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.4874
BRD-A09719808_NCGC00188536-01_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-BI-A0VS-01A-11R-A10U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC12701967-ijmsv23p0161s1.pdf-37-ZNF187_ZSCAN26	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB	Rummagene Transcription Factor Associations 2026	1.0	null
RKO_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.85962
ICAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00351242
Brain Lower Grade Glioma_LGG_TCGA-DU-7010-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NAMALWA	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.38336
Vermiform appendix	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.079
nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
PMC12700815-41380_2025_3205_MOESM2_ESM.pdf-9-ZNF521_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TSE9-0011-R11A-SM-3DB7N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.62577
regulation of cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
H2BK120ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE149359_3_v_1_asap2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05970499	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45774
CTCF_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MAX_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
membrane-bounded organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
GSE158834_12_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC9203705-10.1182-2021014723_bloodbld2021014723-suppl2.xlsx-Supp_Table_5-Supplementary_Table_5_List_of_genes_identified_by_WGCNA_corresponding_to_the_CDX2_UBTF_cluster_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH211	CCLE Cell Line Gene CNV Profiles	1.0	1.86196
CHD1	ENCODE Transcription Factor Targets	1.0	null
IC-76-JU42_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239419
TTC1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35476
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-T_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.4057
CDC42SE2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00582612
Lung adenocarcinoma_LUAD_TCGA-50-5931-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hel	HPA Cell Line Gene Expression Profiles	-1.0	-1.30139
Cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.726
ZIM3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	50.694
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.59132
GPC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060292
GSE155162,GSE155169_1_v_2_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
USF1_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Childhood kidney cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.216
BRD-K48276655	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09012
MNDA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0062682
ae3	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.367
hsa-miR-3614-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
AC-35-CK01_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.202156
PMC10901781-41467_2024_46134_MOESM12_ESM.xlsx-Supplementary_Data_9-Supplementary_Data_09_Differential_expressed_genes_in_RUNX1-mutated_AML_RUNX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE181959_3_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Sirtinol_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015134
Kidney renal clear cell carcinoma_KIRC_TCGA-B4-5378-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE57871_6_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DHRS3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00643406
GSE174735_4_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
QA-07-KC40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219315
A-VN-1203-2004(H5N1)_Day4-10^4pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.90906
NCI-H82	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.0745
GSE103068_5_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RNOR-1426-SM-48FDJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.883299
SKM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.67607
BRD-K18558473	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.4444
H3K4me1_CD4+ CD25- CD45RO+ Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE195559_2_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-IQ-A61J-01A-11R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE242199_9_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.4847
harpagoside-7355	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H2023	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE116810_2_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN011_HEPG2_24H:G17	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.49755
GTEX-P4PQ-1026-SM-3NMCN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855759
HCC1143	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.18043
GSE175787_8_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
HADHB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13164
H3K4me3_cardiac mesoderm_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-FV-A3I0-01A-11R-A22L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36368568	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01132
GSE163920_1_v_0_sirt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CL-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.10402
hsa-miR-367	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
GSE162892_4_v_0_sox9_human	RummaGEO Gene Perturbation Signatures	1.0	null
HOXC13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.0339
CEBPB_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-NPJ7-2826-SM-2I3FU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.17904
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.23171
BRD-K13662825_dinaciclib_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cefprozil	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03428
GSE188870,GSE188871_4_v_3_kat7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HL-7533-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A19037878_trichostatin A_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE228106_3_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
LN-229	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.844958
GSE199606_1_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-653	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
Perturb_16_KO_Mga_SRP314000	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.88268
Lung squamous cell carcinoma_LUSC_TCGA-77-8008-01A-21R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CUL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01573
GSE133683_3_v_0_doxorubicin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U4B1-1426-SM-4DXTX	GTEx Tissue Sample Gene Expression Profiles	1.0	2.14378
GTEX-RNOR-0326-SM-2TF51	GTEx Tissue Sample Gene Expression Profiles	1.0	0.891833
periaqueductal gray substance, ventral portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.94631
PMC2873957-pone.0010709.s003.xls-OCT4-only_OCT4_motif_present_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC38	GDSC Cell Line Gene Expression Profiles	1.0	1.75442
PMC10247733-41408_2023_863_MOESM2_ESM.pdf-574-ZNF48_ZNF48	Rummagene Transcription Factor Associations 2026	1.0	null
A549_IOX2_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0144353
MAX_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-MH-A856-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1238	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
A549_Barasertib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0141369
GSE169205_0_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PFSK-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58515
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4345-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-5631-01A-01R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE226249_0_v_3_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7403583-41598_2020_69884_MOESM2_ESM.xlsx-Sheet1-Supplementary_Table_1_Differentially_Expressed_Genes_FDR_q_0_05_in_U2932_ROCK2_KD_vs_Scrambled_shRNA_Constrols_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144484_0_v_3_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U8XE-0726-SM-3DB8O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1567
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K88542817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39042
hsa-miR-4699-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
GSE158834_11_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
intercalated nucleus of medulla	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33218
plicamycin_homo sapiens_gpl570_gse25127	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K70305913	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53834
HLA-DRA	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00460375
GTEX-P44H-0526-SM-2XCF1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.23946
HCC38	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	2.00438
RPS6KA3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00644608
PDE4D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00853538
BRD-K57639176	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08872
nizatidin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.38686
inner CP in posterosuperior (dorsal) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.00774
H3K9ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A172_CENTRAL_NERVOUS_SYSTEM	CCLE Cell Line Proteomics	1.0	3.30552
BRD-K49371609_528116.cdx_MCF7_6.0_h_0.09_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4772-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.55165
GSE103068_5_v_3_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN012_HEPG2_24H:J23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.09865
H3K27me3_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-2.26647
GSE134191_2_v_5_metformin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CE-96-GH46_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.297061
BRD-K16670438	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46628
trichostatin A-7245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE221327_6_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-U3ZH-0002-SM-3NMDD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.872201
Prostate adenocarcinoma_PRAD_TCGA-G9-6367-01A-11R-1789-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE116810_5_v_4_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9618568-41467_2022_34255_MOESM4_ESM.xlsx-TAL1-Unnamed_0_TAL1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE184087_4_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
nifurtimox-7328	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HEP G2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.40472
GSE147943_0_v_3_cited2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS5_neural cell_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hippocampus (hippocampal formation)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.922073
TFAP2A	ChEA Transcription Factor Targets	1.0	null
Spindle cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.901
HFM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07451
ADRA1D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00678408
BRD-K23868551	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65286
BRD-A37645929	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.11983
paclitaxel_homo sapiens_gpl570_gse39042	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE44157,GSE44163_3_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_Adipose Nuclei	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE135030_8_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
N-acetylmuramic acid-4406	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210101,GSE210114_11_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-664	TargetScan Predicted Conserved microRNA Targets	1.0	1.26663
NOZ	DepMap CRISPR Gene Dependency	1.0	2.90173
PRSS8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10564
GTEX-WOFL-0006-SM-3TW8K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.84489
LY-294002-1641	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE77108_8_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
CHD2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	1.0	null
JHH6_LIVER	CCLE Cell Line Proteomics	1.0	2.88507
A549_ZM 447439_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0118816
AGO2_02_132	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.90689
GTEX-PW2O-1926-SM-2S1OB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838484
GSE207914_2_v_7_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE228430_1_v_3_fabp5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_7548_Mut_UPF1_SRP298492	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
BC-54-ON71_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.201293
GTEX-O5YT-0426-SM-3MJHD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.75771
PS-1145	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
HS578T	BioGPS Cell Line Gene Expression Profiles	1.0	1.07355
H3K4me3_GM12864_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SOX15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.9498
GSE142232,GSE142234_0_v_3_gcgr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3478
hsa-miR-4511	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GSE221327_6_v_2_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CD300A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00551653
smoothmuscle_8b	HPA Tissue Sample Gene Expression Profiles	1.0	0.938928
GSE180185_9_v_8_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE48812_9_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_PF-3845_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0196753
OSC-19	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Zinc finger, C2H2-like	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K61168922	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04444
BRD-K05889827	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19455
BRD-K47170544	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01987
GSE186460_0_v_2_baricitinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-SJXC-0326-SM-2XCFI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.73321
CREB1	ENCODE Transcription Factor Targets	1.0	null
GSE202434,GSE202438_3_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of mammary gland_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A706-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5261-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-8253-01A-11R-2287-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240027,GSE240030_1_v_2_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-OIZI-0426-SM-2XCEF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.37741
Perturb_10916_KO_Ghr_SRP269490	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.56129
hsa-miR-302e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
KPNYN	DepMap CRISPR Gene Dependency	1.0	2.77245
BRD-K64606589_-666_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Temsirolimus_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.016705
doxycycline-3479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-VJYA-1226-SM-3GIJ6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33734
GSE58724_3_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MS-0007-SM-2D7W1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1521
240min_BMP4 vs ctrl_hESC (Human) [19664995]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	-1.0	null
GSE80098,GSE80366_0_v_8_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE185519_6_v_2_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV5::FOXO1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.7248
Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-7872-01A-11R-2232-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE89767_4_v_5_cebpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0372
BRD-K77990919	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.31197
Perturb_9543_KO_Ucp1_SRP187003	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-6.06609
GSE144120_3_v_1_plcg2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE44157,GSE44163_1_v_0_nr6a1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A5BY-01A-31R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
major depressive disorder	GWASdb SNP-Disease Associations	1.0	0.675623
GSE129858,GSE129859_1_v_3_robo1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-TKQ2-0004-SM-3NMAC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.864558
GTEX-P4PQ-0005-SM-2HMKJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.13432
GSE149760_0_v_5_elof1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
TBP_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
IFNA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00809297
GSE235701,GSE261434_2_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM5C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00472286
biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Fluorouracil	CTD Gene-Chemical Interactions	1.0	null
metencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_BE2C_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
U-937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18476
nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
MCC26	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4676-3p	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
H3K9ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE188570,GSE188571_5_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-302d	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE112860_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
locus ceruleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.830074
GTEX-PLZ6-0006-SM-33HBZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.32813
organic substance metabolic process	GO Biological Process Annotations 2015	1.0	null
PAX5_GM12892_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_fibroblast of skin of abdomen_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
HCC1937	DepMap CRISPR Gene Dependency	1.0	2.76639
SK-MM-2	COSMIC Cell Line Gene CNV Profiles	1.0	2.12703
GSE81803,GSE81912_0_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.985907
BRD-K53221607	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28681
Extraskeletal myxoid chondrosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.139
intracellular organelle	LOCATE Curated Protein Localization Annotations	1.0	null
Perturb_7551_KD_KDM2A_SRP300429	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE184087_2_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
LIVF001-022	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.87975
GSE77108_8_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MRC2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00693509
HCC-366	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE211128_9_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TOPBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45249
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5241
GSE135350_2_v_7_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2066	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-XPT6-0326-SM-4B66V	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825905
Lung squamous cell carcinoma_LUSC_TCGA-98-8021-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE146982_7_v_6_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF215	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.29869
GSE232558_0_v_1_fbxl12_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K38615104_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-146b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.23348
BARHL2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0316
GSE141143_1_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.836712
GSE116810_5_v_3_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
Endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
15(S)-15-methylprostaglandin E2-7521	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE216043_10_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TUHR14TKB	DepMap CRISPR Gene Dependency	1.0	3.00868
COPG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00681856
GTEX-T5JW-0426-SM-4DM7M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.843319
PMC8384902-mmc5.xlsx-H128_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
MAZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H2AFZ_fibroblast of lung_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SW1116	CCLE Cell Line Gene CNV Profiles	-1.0	-1.4086
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20Q-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
semustine-7487	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_MK-0752_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228991
disease of metabolism	GWASdb SNP-Disease Associations	1.0	0.08225
CP in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.54676
GSE174751_0_v_1_postn_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.72953
GSE226091,GSE226092_0_v_4_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K13852343	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45561
GSE142210_4_v_0_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE226285_3_v_1_glutathione_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-WXYG-0005-SM-3NB3M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79942
QNZ	DeepCoverMOA Drug Mechanisms of Action	-1.0	-1.19
OVCAR-5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06287
HPRT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00441598
GSE144838_2_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.653
LF-94-HB11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.217621
lateral nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.878785
POLR2A_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE176008_4_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE173810_4_v_1_igf2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
supraoptic nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.863658
GTEX-XQ3S-0006-SM-4BOQ4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.0217
LENEP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00509724
gliclazide-2870	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF780B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01791
OCI-LY-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.8422
GSE112763,GSE112767_4_v_1_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BALL-1	COSMIC Cell Line Gene CNV Profiles	1.0	2.12703
GSE168458_1_v_3_disulfiram_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_Panc1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE160373_8_v_7_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE126463_0_v_2_arid2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.3116
H3K4me3_CD14-positive monocyte_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE57871_8_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_15272_KD_Tardbp_SRP254218	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.60277
GSE201270,GSE201272_5_v_3_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K27600134	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59665
PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RCCFG2	DepMap CRISPR Gene Dependency	1.0	2.37316
PMC8016886-41419_2021_3630_MOESM6_ESM.xlsx-Sheet1-Table_S5_Differentially_expressed_genes_identified_between_HOXC6-low_and_HOXC6-high_expression_CRCs_using_TCGA_cohort_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_1_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
substance-related disorder	GWASdb SNP-Disease Associations	1.0	0.150802
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7404-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
1min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
FKBP9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00624733
JHH1_LIVER	CCLE Cell Line Proteomics	1.0	2.06728
disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039342
PMC9170821-JCMM-26-3183-s001.xlsx-Oligo_DAPI_ERG_VaD_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
congenital heart disease	GWASdb SNP-Disease Associations	1.0	0.438494
GSE84148,GSE96938_3_v_1_nrros_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
VCAP	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXA2	ChEA Transcription Factor Targets	1.0	null
GSE176008_4_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
overnutrition	GWASdb SNP-Disease Associations	1.0	0.412083
GTEX-PLZ6-0326-SM-3P61J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.33314
WDR26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30526
BRD-K10404799	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14783
UBC	Pathway Commons Protein-Protein Interactions	1.0	null
TYRO3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00506112
WSU-FSCCL	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.31084
HSPA9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24827
PROX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00491947
GSE214931_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PX3G-0426-SM-48U1C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.88267
GSE189683_1_v_2_rif1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
rna metabolic process	GO Biological Process Annotations 2015	1.0	null
DMS 79	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.940729
PANC0203_PANCREAS	CCLE Cell Line Proteomics	1.0	2.90271
Varespladib	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.37
GTEX-Q2AH-0005-SM-33HBR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.54323
bonemarrow_6c	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.4264
BRD-K17743125_S1085_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Carmofur_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0199351
atractyloside-3435	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_PFI-1_10然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0170552
Bladder Urothelial Carcinoma_BLCA_TCGA-E5-A4TZ-01A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_0_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CTCF_GM06990_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE135350_3_v_5_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
JJN-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27608
SIGIRR	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00373769
GSE169205_3_v_6_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE122509,GSE122513_2_v_0_ibrutinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K12867552_THM-I-94_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3925-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.274552
PMC10350897-j_biol-2022-0528-S1.pdf-191-ZNF385D_ZNF385D	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PROC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490986
intracellular part	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
NCI-H446	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.824777
GSE202434,GSE202438_13_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
EHEB	GDSC Cell Line Gene Expression Profiles	-1.0	-1.52345
cyclopenthiazide-7325	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-K51215422	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06343
GSE127916_1_v_4_nras_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FOXP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.8647
GSE160083,GSE160084_2_v_0_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-TMZS-0001-SM-3P61Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.828842
Larotrectinib sulfate_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0209647
GSE149903_0_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
valproic acid_homo sapiens_gpl570_gse14973	GEO Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.33203
central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.70348
GTEX-REY6-1126-SM-48FDU	GTEx Tissue Sample Gene Expression Profiles	1.0	1.87514
GSE151412_2_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
precommissural nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.17481
BRD-K52924481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08763
GSE176008_0_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-VUSG-2826-SM-4KKZM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.908358
GSE171401_1_v_2_adnp_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventral posterior medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.3708
USF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
YY1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12835	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.94893
GTEX-N7MT-1226-SM-2D7W4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58445
BRD-K91120514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11306
BRD-A90462498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.97183
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.06005
GSE173997_1_v_0_clic4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-873	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
SMAD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.012819
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.53068
TYK-NU	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-Q2AG-2826-SM-2HMJQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58164
GSE200839,GSE233826_5_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC8567138-Table_2.xlsx-Sheet1-IGFBP5_AND_IGFBP7_NOT_IGFBP3_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN016_MCF10A.TP53.M_24H:P18	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.23607
Large intestine cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.04
rna biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Sarcoma_SARC_TCGA-MB-A8JL-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A84941884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.65046
H3K4me3_GM06990_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
trichostatin A-3979	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-Q734-0426-SM-48TZX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.870822
BRD-K84710243	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03219
GSE203181_0_v_1_phosphoramidon_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H1 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.997127
GSE210101,GSE210114_0_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102467_3_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Busulfan_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0234603
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4843-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14436020	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17583
GSE60691_2_v_1_glutamine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TBP	ENCODE Transcription Factor Targets	1.0	null
liver_a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.0184
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7367-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
496100461_PCx_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.0841
Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_MLN8054_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0169356
PPP2R2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00683661
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.0026
GSE134375_3_v_7_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8746
Female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-MM-A564-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Eccrine acrospiroma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.521
GTEX-QXCU-0126-SM-2TC5Q	GTEx Tissue Sample Gene Expression Profiles	1.0	0.948569
GSE100316_7_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
VI, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.978267
hsa-miR-3134	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
BHLHA15	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.0364
NRF1	ENCODE Transcription Factor Targets	1.0	null
BL4508 (SMARCAD1)	NURSA Protein Complexes	1.0	null
trichostatin A-5940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-TMMY-1026-SM-4DXTI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.48409
GSE112174_5_v_7_runx1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T6MO-0003-SM-3NMAG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.851934
gastrointestinal system disease	GWASdb SNP-Disease Associations	1.0	0.086869
Skin Cutaneous Melanoma_SKCM_TCGA-FW-A5DX-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.58546
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-DHT_AR_ASO_super_enhancers-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ventral medial nucleus of thalamus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.13628
Lung squamous cell carcinoma_LUSC_TCGA-98-A53A-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE233679_5_v_3_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CTCF_GM19240_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K56645451	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05091
GSE125014_6_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_TMP195_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143282
PMC12119949-41467_2025_60269_MOESM3_ESM.xlsx-FOXA2-TR_FOXA2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE215086_0_v_1_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
layer IIIa of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.74252
H3K4me3_HCT116_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Respiratory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.127
SP1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P4QR-0006-SM-2I5GN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0723
H3K27ac_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-REY6-0726-SM-2TF4M	GTEx Tissue Sample Gene Expression Profiles	1.0	0.996206
BRD-K12867552_THM-I-94_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCK81_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	3.57301
BRD-K62909976	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.78951
ZFP14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40908
USF1_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HORMAD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570213
GSE210101,GSE210114_1_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9174882-EMMM-14-e15816-s004.xlsx-MYC_GeneSigs-DANG_REGULATED_BY_MYC_UP_MYC	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Fasudil_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132561
H3K4me3_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE220520_1_v_7_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GSE150055_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_4489_KO_Rnu11/Trp53_SRP309496	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	5.77002
Zinc finger, C2H2	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-A70931301	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.92752
GSE121198,GSE129779_0_v_1_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-4504	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5B-Up_H3K4me3_DPY30_KD-Unnamed_12_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TCF21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3097
GSE158834_12_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851853
POLR2AphosphoS5_HCT116_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE143830_0_v_1_trex1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POLR2AphosphoS5_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC6742760-41467_2019_12079_MOESM10_ESM.xlsx-Data_S8-Supplementary_Data_8_Target_genes_of_FOXA1-bound_enhancers_FOXA1	Rummagene Transcription Factor Associations 2026	1.0	null
HCC2688	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37967
Acute Myeloid Leukemia_LAML_TCGA-AB-2927-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2PI-01A-11R-A18M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
co-dergocrine mesilate-2793	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K41999717	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.69145
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_1_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
CEBPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.07274
GSE152937_12_v_7_slc16a13_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SLBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05518
BRD-K79551673	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.33113
BRD-K81217407	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09411
TEAD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6118
ARFRP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00353221
GTEX-RM2N-0326-SM-48FD8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.85685
ciclosporin-4411	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Vemurafenib_SNU-1	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00726322
metabolic process	GO Biological Process Annotations 2015	1.0	null
NUT midline carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	2.7
GSE112860_0_v_4_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC6591464-Table_4.xlsx-Sheet_1-Non-AIRE_regulated_genes_random_set_1_AIRE	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_epithelial cell of proximal tubule_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
SMC3	ENCODE Transcription Factor Targets	1.0	null
SW 620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.983349
GSE145639_1_v_6_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
JC-06-ED36_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.228734
PAX3_01_26	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.65935
Endocrine system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.069
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.54743
GSE100316_3_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-200c	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
GSE225656_2_v_3_tsc2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8948606-7488708.f2.docx-6-HSFX1_HSFX1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-A46G-01A-31R-A26U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ACLY	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00491204
H3K4me3_cardiac mesoderm_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-O5YT-1826-SM-32PK9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07027
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.86633
GSE232558_0_v_2_fbxl12_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE113106_2_v_4_dnm2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Supplementary_Figure_15l-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
Crus II, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.985091
PMC2768459-6605275x5.xls-Hoja1-Supplementary_Table_S2_Differentially_expressed_genes_within_the_ESR1-negative_BRCA1_tumors_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
vincamine-3976	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
YY1	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE85874_3_v_1_kdm5c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-P44H-1026-SM-3NM96	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953503
outer CP in posterior parahippocampal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.0464
ventrolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.15831
H3K9ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
internal female genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.39438
HCC1954	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
GSE206516,GSE206518_5_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
UPMD1	DepMap CRISPR Gene Dependency	1.0	2.13501
IRF2BPL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13374
outer CP in primary visual cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35018
icSARS CoV_48Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.703001
GSE115542_5_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6997-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Connective tissue cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.105
GSE164757,GSE164759_4_v_0_trametinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
mediodorsal nucleus of thalamus_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.37085
GSE169205_0_v_5_sirt5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-S7-A7WQ-01A-12R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-NPJ8-1826-SM-2YUNC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15139
GTEX-NL3H-0011-R11A-SM-2I3E6	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826709
H3K4me3_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
stratum pyramidale of rostral CA2	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.831839
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.58869
A549_PHA-680632_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.015364
spleen	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
H3K4me3_cardiac fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE71674,GSE71676_0_v_2_cbfa2t2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CTCF_fibroblast of upper leg skin_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KCNE3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00554291
Lung disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.053
Brain Lower Grade Glioma_LGG_TCGA-CS-6186-01A-12R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K41202439	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03869
BRD-A76904477	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11293
GSE142210_4_v_7_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE238116_1_v_0_egr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8384902-mmc5.xlsx-H889_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
MAFF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.6519
cellular macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
POU3F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.1428
hsa-miR-511	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
DNAJC2	ChEA Transcription Factor Targets	1.0	null
thrombocytosis	IMPC Knockout Mouse Phenotypes	1.0	null
BRD-K56272400	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.76088
A549_Mercaptopurine_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163714
GSE68155_3_v_2_gpr3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49262
frontal pole, right, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02077
MAP3K12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548302
BRD-K61681480	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01751
GSE165682_2_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K27me3_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-106a	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
CCDC102A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21017
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.29248
H3K4me3_fibroblast of skin of abdomen_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-SSA3-0005-SM-32QOT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4584
increased erythrocyte cell number	MGI Mouse Phenotype Associations 2023	1.0	null
heterocyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
SK-CO-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.90841
W chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.522
SARS-CoV MA15_Day1-PFU-10^3_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.82144
tonsil	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
GSE213588_8_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE94849_3_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHF8	ENCODE Transcription Factor Targets	1.0	null
GSE111660_2_v_5_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Triptolide cytotoxicity	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.609691
PMC8571097-41588_2021_941_MOESM3_ESM.xlsx-Supplementary_Table_2-Supplementary_Table_2_List_of_KMT2A_fusion_oncoprotein_target_genes_in_each_sample_KMT2A	Rummagene Transcription Factor Associations 2026	1.0	null
Cloxacillin (sodium)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0295977
SNU-175	COSMIC Cell Line Gene Mutation Profiles	1.0	null
PSG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00511928
H3K4me3_Panc1_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_8_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PIGW	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00719133
POLR2AphosphoS5_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-4657	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
CHD2	ENCODE Transcription Factor Targets	1.0	null
BRD-K81418486_vorinostat_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MYC_endothelial cell of umbilical vein_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
HEC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
EA-39-YN88_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.210778
GTEX-TSE9-0005-SM-4DXUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.49641
hsa-miR-372	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.16589
GSE188570,GSE188571_3_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NANOG	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00493086
GSE190322,GSE190324_3_v_4_rbm4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K53639581	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29371
hsa-miR-24	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
H3K4me3_fibroblast of gingiva_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
netilmicin-3524	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K36me3_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
arcuate nucleus of the hypothalamus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.93862
Ileocecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.079
CP-690334-01-4380	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
etiocholanolone-4764	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
clemizole-4695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
19171046-tableS1a	GeneSigDB Published Gene Signatures	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7261-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K90697694	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10638
BRD-K36725646	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27053
PMC8390679-41467_2021_25186_MOESM5_ESM.xlsx-HOXD4-Unnamed_2_HOXD4	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OXRO-0006-SM-2I5EM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35347
SLC30A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35677
oxymetazoline-2278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6193
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A7PX-01A-51R-A352-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_cardiac muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K63757821	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.30368
GSE77108_0_v_9_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_12_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CLU	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598799
hsa-miR-384	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K85775326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41362
A549_Anacardic Acid_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0145372
QIMR-WIL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.48954
GSE165307_3_v_0_gfi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SIN3A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
MICALL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00602918
CMTR2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06449
pilocarpine-3300	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K32145037	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.29822
POLR2A_HGPS cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K87209752	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00845
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.2771
OVMIU	DepMap CRISPR Gene Dependency	1.0	2.46827
Kidney renal papillary cell carcinoma_KIRP_TCGA-B3-4103-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MST1R	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00497612
A2058	COSMIC Cell Line Gene Mutation Profiles	1.0	null
USF1_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A75409952_wortmannin_HA1E_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_cardiac fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
behavioral abnormality	GWASdb SNP-Phenotype Associations	1.0	0.104698
BRD-K11942486	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05331
GSE70499_3_v_7_bmal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182179_2_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN010_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.05561
FADU	CCLE Cell Line Gene CNV Profiles	-1.0	-1.99755
Lung adenocarcinoma_LUAD_TCGA-44-6774-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-N7MS-0526-SM-4E3JP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02121
MHHNB11	DepMap CRISPR Gene Dependency	1.0	3.67332
H3K4me3_HCT116_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
citiolone-6031	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K67390061	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43603
SRF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.2513
TCF12_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SMAD3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555091
G140	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.0096
hsa-miR-4666-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
GTEX-SN8G-0006-SM-32PLD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.27483
CEP170	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06232
GSE139455_2_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K12867552_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE125014_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_WI38_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
organelle	GO Cellular Component Annotations 2015	1.0	null
MAGOH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0983
hsa-miR-20a	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
DKMG	DepMap CRISPR Gene Dependency	1.0	3.33183
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-381	TargetScan Predicted Conserved microRNA Targets	1.0	0.419947
GSE92457_7_v_8_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC3369932-pgen.1002751.s021.pdf-0-SMAD5_SMAD5	Rummagene Transcription Factor Associations 2026	1.0	null
NRBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00609842
hsa-miR-548b-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
Cecum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.079
H3K4me1_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE144838_7_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.709
MYC_01_237	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.59127
organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GSE111385_0_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEG5-1226-SM-447AR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19176
Prostate disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
TXK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07761
KDM4C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2982
intestinal disease	GWASdb SNP-Disease Associations	1.0	0.30055
morphological abnormality of the gastrointestinal tract	GWASdb SNP-Phenotype Associations	1.0	0.132838
Perturb_1745_KO_Tet2/Tet3_SRP063091	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.23059
proglumide-3972	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_4_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-UPIC-0005-SM-3GACV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42792
endometrium_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.00419
PMC6718408-41467_2019_11884_MOESM6_ESM.xlsx-TAD_genes_ST-EPN-RELA-Unnamed_4_RELA	Rummagene Transcription Factor Associations 2026	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A3HL-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN012_HEPG2_24H:G14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3599
H3K4me1_Colonic Mucosa	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
CRCGN017_MCF10A.WT.HP_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4162
GSE145790_0_v_1_bruceantin_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Mocetinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152202
Perturb_8746_OE_KRTAP106_SRP131095	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
A549_Anacardic Acid_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131
hexamethonium bromide-1901	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE160304,GSE163392_4_v_3_zswim8_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE111660_1_v_3_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PFDN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0717
NEPRO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04087
primary auditory cortex (core)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.837939
GTEX-Y8E5-0006-SM-47JWQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7364
POLR2A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-6978-01A-11R-1949-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SW 1116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31125
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-RUSQ-1926-SM-2TF6K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07953
GSE199606_3_v_0_csf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Reproductive system disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
intracellular organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
RUNX3	ENCODE Transcription Factor Targets	1.0	null
Nervous system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.217
superficial layers of caudal presubiculum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.23193
GTEX-XBED-0006-SM-47JXO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39185
GSE148657_3_v_1_cd44_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-A02799884	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	5.18237
GSE133516_0_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XPVG-0006-SM-4B65Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.04352
GSE111385_0_v_1_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NAMALWA	CCLE Cell Line Gene CNV Profiles	1.0	1.73273
cefotiam-3319	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE205687_1_v_0_mta1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
C170	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54034
POU3F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	69.3492
NCI-H596	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61956
cellular aromatic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
NCI-H2126	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-2.07695
Lung adenocarcinoma_LUAD_TCGA-64-5779-01A-01R-1628-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TRIM29	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00607623
STAT3_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE255432_7_v_3_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TNPO2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04615
hsa-miR-2277-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.107229
Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M6-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PGM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00601268
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-Q1-A73O-01A-11R-A32P-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC10809641-DataSheet3.pdf-434-ZNF529_ZNF529	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QXCU-0926-SM-48FEP	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00022
H3K4me3_fibroblast of upper leg skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE176008_7_v_2_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
JP-4-043	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.57361
BRD-K50212643	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.01719
GSE77178_5_v_3_ccnd1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE57871_11_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE118077_4_v_2_sprr5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.647
MMP26	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00588573
Perturb_2635_KD_TRIM46_SRP323434	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.98614
GSE211226_1_v_0_sirpa_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Sweat gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.195
paracetamol-5384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SMC3_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
tissues, cell types and enzyme sources	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-VJYA-0005-SM-3P5ZD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.30554
DMAC2L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47844
SIN3A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Panobinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00997317
Lung squamous cell carcinoma_LUSC_TCGA-O2-A5IB-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ETS2	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE132369,GSE132371_2_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
crohn's disease	GWASdb SNP-Disease Associations	1.0	0.821119
PMC10800016-table_s5_20230913_ddad186.xlsx-FvsC_-_DUX4_I-Unnamed_1_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
FER	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00445579
GSE210388_2_v_0_ror2_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70549064_EI-156_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-NL3H-0006-SM-2I3FW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.69499
Multilymphoid progenitor cell_Umbilical cord blood_Human	CellMarker Gene-Cell Type Associations	1.0	null
GSE163240_2_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RBBP5	ENCODE Transcription Factor Targets	1.0	null
FOXA1-27270436-LNCAP-HUMAN-PROSTATE-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-REY6-2126-SM-48FD9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.97838
GSE128730_7_v_5_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K43969492	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74377
CD8_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-2.05281
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WVLH-0011-R11A-SM-3MJFO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96088
cell type cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.043803
H3K4me3_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-UTHO-0006-SM-3NMCC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20026
trichostatin A-3868	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_JNJ-7706621_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164564
dentate gyrus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.14551
BRD-K69393995	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49898
VIIIB, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.991047
KYSE-70	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.37967
GTEX-T5JW-0003-SM-3NMAD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05625
RCOR1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_mus musculus_gpl4134_gse23072	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PARP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00455477
NCI-H2227	GDSC Cell Line Gene Expression Profiles	1.0	1.47524
hippocampus (hippocampal formation)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.930678
BRD-K64135153	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11387
GSE164874_5_v_4_prednisolone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:O10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.32025
CD105+_Endothelial	BioGPS Human Cell Type and Tissue Gene Expression Profiles	-1.0	-1.03492
GSE134191_3_v_1_metformin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R53T-2026-SM-3GIJF	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20486
ATF3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589985
COIL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00445
Alcoholism	dbGAP Gene-Trait Associations	1.0	0.090111
TOP2B_drug inhibition_GSE1417_341_human_HeLa	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	null
BRD-A55025683	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.02073
GSE129186,GSE129223_0_v_1_aicda_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.57389
H3K4me3_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
cytoplasmic part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
BRD-K82968130	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36581
BRD-A28219573	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.53751
NCI-H2030	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.64508
cinchocaine-4149	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE159937_2_v_0_tfcp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GRANTA-519	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.62856
CP67-MEL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE102467_3_v_2_pazopanib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF100	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79352
GTEX-XUW1-1126-SM-4BONZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04489
Disease	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
GSE216238,GSE216241_0_v_1_tonsl_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-8508-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE210662_2_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_bronchial epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K27me3_mononuclear cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RWS6-0005-SM-2XCAN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36351
GSE242199_6_v_11_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE178714_5_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hindbrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-X8HC-0006-SM-46MV6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37738
GSE158834_2_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_SK-N-SH_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MHHCALL2	CCLE Cell Line Gene CNV Profiles	1.0	1.57057
TAF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11195
iPS-18 Cells	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	-1.0	-0.91796
BRD-K22229373	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.13314
GSE161846,GSE161849_4_v_0_smarca4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE242199_9_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-A01848933	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.5139
GSE182179_5_v_4_kdsr_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NCI-H1355	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.07726
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
Perturb_15611_KO_Nampt_SRP065603	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.43643
HOXB8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1244
HCC4011	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46296
Lung squamous cell carcinoma_LUSC_TCGA-34-5928-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TCF4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0060127
BRD-K71253424	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.34739
PMC6225799-annrheumdis-2018-213524supp003.xlsx-Activated-state-LPS-Gene_Symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN008_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.88035
metamizole sodium-3929	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTF2F1	ENCODE Transcription Factor Targets	1.0	null
GSE174701_4_v_3_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MTX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03657
H3K4me3_keratinocyte_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
INO80B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09875
POU5F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2819
BRD-A35588707_TENIPOSIDE_MDST8_6.0_h_1.25_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE88819_3_v_12_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE130396_7_v_6_braf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GCAT	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0100061
CTCF_fibroblast of mammary gland_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney Diseases	CTD Gene-Disease Associations	1.0	1.02821
A549_Lomustine_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147659
mental depression	GWASdb SNP-Disease Associations	1.0	0.439515
bonemarrow_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.92348
HUP-T4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.22933
trichostatin A-5981	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-A5RC-01A-11R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE128730_3_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary motor cortex (area M1, area 4)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.45633
GSE182179_0_v_3_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K25923961	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13514
GSE149124,GSE149128_3_v_0_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
santonin-3877	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
picrotoxinin-2816	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hippocampus (hippocampal formation)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.07544
Mesothelioma_MESO_TCGA-NQ-A57I-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE77108_4_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXP3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5823
GSE211128_4_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K90264208	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.14081
GSE135350_2_v_1_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
binding	GO Molecular Function Annotations 2015	1.0	null
GSE173201_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMK1-0005-SM-4B665	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22311
fosfosal-4823	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-S7SF-0006-SM-3K2B6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23023
BACH2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.8652
RPL12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24077
forebrain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-T5JC-0005-SM-4DM7B	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39478
Bladder Urothelial Carcinoma_BLCA_TCGA-GU-A42Q-01A-11R-A23W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205630_0_v_1_gmds_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RTLS-1326-SM-46MUN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.926067
BRD-K35788497	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06871
primary auditory cortex (core)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.24254
hsa-miR-4667-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
Sarcoma_SARC_TCGA-FX-A76Y-01A-11R-A355-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-FU-A3EO-11A-13R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185519_3_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6707
GTEX-RU72-2626-SM-4GIE1	GTEx Tissue Sample Gene Expression Profiles	1.0	0.869222
RRM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00940241
GSE80098,GSE80366_0_v_5_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Sorafenib Tosylate_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156189
CRCGN014_HEPG2_24H:F22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.20266
GTEX-T5JC-2326-SM-32PMR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.86502
NCI-H2081	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.878994
GSE166783_8_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8387919-mmc2.xlsx-ST9_NEUROG3_bound_TF_genes-Unnamed_2_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
CRCGN016_MCF10A.WT.HP_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.22603
PMC8384902-mmc5.xlsx-H2107_PROX1_ChIP-Symbol_PROX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE119694_1_v_0_lifr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ventricular (matrix) zone of cerebellum	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.958416
TP63-22573176-HFKS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
CTCF_GM12875_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CACNG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00570889
GSE158834_1_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K41563239	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52755
GSE242199_9_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K64606589_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE226249_5_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
regulation of metabolic process	GO Biological Process Annotations 2015	1.0	null
SARS-dORF6_0Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	-1.0	-1.5369
GTEX-NFK9-0006-SM-3GACS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39386
KASUMI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27
trichostatin A-7503	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
molecular_function	GO Molecular Function Annotations 2015	1.0	null
GSE166914_1_v_0_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
17426248-TableS2a	GeneSigDB Published Gene Signatures	1.0	null
POU3F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	58.9409
GTEX-QDT8-3026-SM-32PKB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.47716
Diabetes mellitus	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.031
BRD-K35544244	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00021
EP300_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.0229
orbital frontal cortex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1734
GTEX-P4QT-2026-SM-3NMCJ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.889162
GSE210101,GSE210114_8_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
IV, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.895683
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
2793_EXOSC6_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.45775
regulation of macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
KHK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00494261
GSE116810_5_v_1_selinexor_human	RummaGEO Drug Perturbation Signatures	1.0	null
MHH-NB-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.45431
Sarcoma_SARC_TCGA-DX-A2IZ-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PGM2L1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00627546
trichostatin A-5822	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NSA2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.17675
NCI-H889	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.17701
A549_Pelitinib_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0150009
GTEX-WH7G-1726-SM-4LVKY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61814
Brain Lower Grade Glioma_LGG_TCGA-DU-7304-02A-12R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE101767_1_v_0_wdr11_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN010_HEPG2_24H:K09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.47561
SNU213	CCLE Cell Line Gene CNV Profiles	-1.0	-1.48875
Ankylosing Spondylitides_macrophage_GSE11886	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.41316
NUGC-3	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-3679-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
SU-DHL-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.45822
PMC6713698-109_2019_1809_MOESM2_ESM.xlsx-AR-PCOS-Gene_List_AR	Rummagene Transcription Factor Associations 2026	1.0	null
spinal trigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888873
BRD-K36557327	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53151
GSE158834_0_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleic acid-templated transcription	GO Biological Process Annotations 2015	1.0	null
metergoline-5344	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE123943_1_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-YA-A8S7-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K91766181	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07304
orbital frontal cortex_4 mos_M_12890	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.849546
H3K4me3_H7_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
organelle	LOCATE Curated Protein Localization Annotations	1.0	null
SHSYSY+RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.29304
loperamide-1949	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_12649_KD_DIRC3_SRP191422	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
seminal vesicle	HPA Tissue Protein Expression Profiles	1.0	0.950484
Hematopoietic system	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.026
GSE138938_1_v_2_foxp2_human	RummaGEO Gene Perturbation Signatures	1.0	null
L-Eflornithine (monohydrochloride)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0172908
BRD-K65494150	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63543
CRCGN016_MCF10A.TP53.M_24H:F14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.94654
gossypol-6058	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_LNCaP clone FGC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-X261-0011-R11A-SM-4E3JY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.11234
hsa-miR-4485	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Prestwick-642-2815	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-3074-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.065994
anthraquinone	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65005
BRD-K19457629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39186
hippocampus (hippocampal formation)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.64365
OCILY3	CCLE Cell Line Gene CNV Profiles	1.0	1.89436
H2722	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K79090631_CGP-60474_LNCAP_3_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Dux	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.2031
GTEX-POMQ-1426-SM-3P61D	GTEx Tissue Sample Gene Expression Profiles	1.0	0.962261
hsa-miR-3919	TargetScan Predicted Conserved microRNA Targets	1.0	0.145356
liver	HPA Tissue Gene Expression Profiles	-1.0	-1.03749
PMC9911396-41467_2023_36178_MOESM11_ESM.xlsx-Sheet1-Genes_in_10kb_vicinity_of_ZBTB12_ChIP-seq_peaks_hic_ZBTB12	Rummagene Transcription Factor Associations 2026	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A49A-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97746859	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39075
GSE94011_0_v_1_pias3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
RNF5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31747
TRNT1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47991
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A3IB-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Gene_Name_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K14813155	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51787
GSE176008_8_v_1_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
macromolecule metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE162892_4_v_5_isox_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SK-LU-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-R55E-0426-SM-2TC65	GTEx Tissue Sample Gene Expression Profiles	1.0	0.864057
CHLA90	DepMap CRISPR Gene Dependency	1.0	2.55321
H3K4me3_cardiac mesoderm_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
GSE115542_2_v_1_digoxin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
trichostatin A-7285	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K39185798	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.7459
PMC4387713-supp_gad.255984.114_Table_S3.xlsx-S3A-Down_Dpy30_KD-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A83387524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.01888
NCIH358_LUNG	CCLE Cell Line Proteomics	1.0	3.34143
CEBPB_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
KURAMOCHI	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31185
H3K4me3_Caco-2_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE93309_1_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12319_KD_PRMT1_SRP165280	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE233049_1_v_3_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-BF-A3DJ-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_6095_KD_ZNF207_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GTEX-P4PP-0005-SM-2HMKX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.19021
PMC9894241-pnas.2211429119.sd05.xlsx-G3_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-RVPV-0011-R11A-SM-2TF6F	GTEx Tissue Sample Gene Expression Profiles	1.0	1.82663
intracellular organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
Lung squamous cell carcinoma_LUSC_TCGA-43-7658-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Blood Pressure	DisGeNET Gene-Phenotype Associations	1.0	null
PRTN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00600261
MAZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE112763,GSE112767_0_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Ivermectin_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	-1.0	-0.0173379
sitosterol-4154	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE242199_6_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
betonicine-6063	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
2-PMDQ	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13998
BRD-K17889110	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.42973
BRD-K68705041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.72863
DCAF15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47879
BRD-K48407262	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30313
H3K4me3_kidney epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_A549_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Squamous cell carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.48
sulfafurazole-5622	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_A549_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
PANX1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00550189
Perturb_10180_KO_Atrx_SRP282433	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.29802
A549_SRT1720 HCl_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0175383
HDAC2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Abnormalities, Drug-Induced	CTD Gene-Disease Associations	1.0	1.14302
GSE193402_0_v_1_imatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1500	CCLE Cell Line Gene CNV Profiles	1.0	2.34768
GSE158834_11_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
karakoline-6059	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE180200,GSE180201_3_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-451b	TargetScan Predicted Conserved microRNA Targets	1.0	0.072324
GSE210101,GSE210114_7_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TFAP2A-17053090-MCF7-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
HOXC11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3336
IGR-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
AQP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00921062
A549_UNC0631_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0147035
H3K27me3_CD14-positive monocyte_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PHA-00851261E-3857	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K83012560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11566
GTEX-V1D1-0006-SM-3NMCE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22685
PK45H	DepMap CRISPR Gene Dependency	1.0	3.08668
GTEX-XQ8I-0006-SM-4BOQ5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.70889
Kidney renal papillary cell carcinoma_KIRP_TCGA-A4-7828-01A-11R-2139-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
tissues, cell types and enzyme sources	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.049827
H3K4me3_astrocyte of the spinal cord_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
PMC3348545-NIHMS263168-supplement-3.pdf-403-MBD1_MBD1	Rummagene Transcription Factor Associations 2026	1.0	null
MC116	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30973
GPX5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00505012
H3K4me3_WI38_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70N-01A-12R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-OOBK-0005-SM-2YUMG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47888
LS1034	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.879386
GSE226285_3_v_1_nr0b1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201270,GSE201272_5_v_1_mybl2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
inflammatory bowel disease	GWASdb SNP-Disease Associations	1.0	0.391529
PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-MECP2-toNode_MECP2	Rummagene Transcription Factor Associations 2026	1.0	null
SUP-B15	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22337
BRD-K47599758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43952
CTCF_GM12878_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
EM-2	GDSC Cell Line Gene Expression Profiles	-1.0	-1.83821
GSE125219,GSE125221_3_v_8_arid1a_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XLM4-2926-SM-4AT59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.76814
heart muscle	HPA Tissue Protein Expression Profiles	1.0	0.950484
hsa-miR-186	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
USF1	ENCODE Transcription Factor Targets	1.0	null
GTEX-OIZG-0005-SM-2HMJC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.2693
JURKAT, CLONE E6-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.15487
Rifaximin	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.45
acquired metabolic disease	GWASdb SNP-Disease Associations	1.0	0.138243
primary visual cortex (striate cortex, area V1/17)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.68036
VIIIA, left, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.832789
GTEX-P44H-0011-R11A-SM-2XCER	GTEx Tissue Sample Gene Expression Profiles	1.0	2.90907
endometrium_5a	HPA Tissue Sample Gene Expression Profiles	1.0	0.911094
salicyl-alcohol	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08164
GTEX-WEY5-0006-SM-3GIKG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3774
GTEX-QDVN-0006-SM-48U1R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.63618
GTEX-OHPK-0006-SM-2HMKH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.79894
MXI1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
LS123	CCLE Cell Line Gene CNV Profiles	-1.0	-1.36778
GTEX-WVLH-2926-SM-3MJG5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53754
SLC22A23	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00766479
POU2F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	57.4671
LIPC	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00622451
H3K9ac_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BE-27-RQ61_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203619
thioperamide-5635	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
parabigeminal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.924502
TAF7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09224
H3K27ac_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ITPKB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00623384
GTEX-O5YT-0007-SM-32PK7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.7167
GSE163240_3_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE111385_2_v_3_tgfbr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
sp1_22099172_dental_follicle_cell_gof_human_gpl11532_gse31628	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.127219
DND-41	COSMIC Cell Line Gene Mutation Profiles	1.0	null
aromatic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-ZP-A9D2-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MKN-74	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944635
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JA-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SZ in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.21089
KP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10818
GSE158834_12_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K07160586	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32267
H2BK12ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-K30121969	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0503
RBFOX3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0066907
GTEX-Q2AG-0005-SM-33HBX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.12312
SW 900	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16718
amygdaloid complex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.62452
primary metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE135030_11_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
LY-294002-5937	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_astrocyte of the cerebellum_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE217405_3_v_2_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.5678
Kidney renal papillary cell carcinoma_KIRP_TCGA-P4-A5ED-01A-11R-A28H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216538_7_v_4_mrs2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BABAM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39733
GTEX-XUYS-0002-SM-47JXL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.860693
SOX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.9122
GNAT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00523689
BRD-K03662481	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.74274
FLI1::FOXI1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.4959
BRD-K96893659	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.1345
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42673
GSE227891_5_v_0_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Daphnetin_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154795
HCC78	DepMap CRISPR Gene Dependency	1.0	2.67757
GSE158834_11_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Cytarabine_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0282688
GTEX-WYVS-2426-SM-3NMA9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.894719
GSE165682_2_v_5_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_12_v_9_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K38904629	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.09903
occipital pole, left, lateral aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-3.09898
primary motor cortex (area M1, area 4)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.863335
GTEX-X638-0005-SM-47JX6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09112
GBP7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00393793
HCC1428	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.22125
Kidney renal papillary cell carcinoma_KIRP_TCGA-AL-3467-01A-02R-1351-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-VM-A8CA-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
H3K56ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE85874_4_v_1_kdm5c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
ISLR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.16119
GSE213588_10_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Myosin VII complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.714
HARA	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7994
Lung squamous cell carcinoma_LUSC_TCGA-85-6175-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-539	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
Neuro D	MotifMap Predicted Transcription Factor Targets	1.0	null
biperiden-3321	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RN-01A-12R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-HD-7831-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A12166214	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.45662
GTEX-Q734-0326-SM-48U15	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855861
Prestwick-674-3614	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_9544_KO_Ucp1_SRP187003	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-4.1885
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A94Z-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE102505_6_v_0_tunicamycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
gallbladder	HPA Tissue Protein Expression Profiles	1.0	0.950484
isocorydine-2780	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MOLM-13	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Zinc finger C2H2-type/integrase DNA-binding domain	InterPro Predicted Protein Domain Annotations	1.0	null
BRD-K69659917	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56127
Thymus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.27
SOX2-21211035-LN229-GBM	ChEA Transcription Factor Targets 2022	1.0	null
POLR2AphosphoS5_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PWCY-0005-SM-33HBP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.91128
LBH-589	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.3679
GSE192663_3_v_2_acly_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
EA-18-FP00_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.239105
GSE76425_0_v_7_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-888	TargetScan Predicted Conserved microRNA Targets	1.0	0.997906
methylergometrine-6704	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_H7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE131161_5_v_0_rarres1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-U3ZH-1626-SM-3DB74	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967564
FPGS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00339806
GSE179693,GSE179694_4_v_2_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CHRNA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00563809
internal female genital organ	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
abnormality of the cerebral vasculature	GWASdb SNP-Phenotype Associations	1.0	0.302217
hsa-miR-195	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GTEX-QDT8-1026-SM-43V6X	GTEx Tissue Sample Gene Expression Profiles	1.0	0.861242
REST	ENCODE Transcription Factor Targets	1.0	null
BRD-A69786436	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51736
POLR2AphosphoS5_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242049_1_v_0_glutathione_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
caudal subdivision of paraventricular nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.65976
oculomotor nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.927064
GSE140997_4_v_3_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Q7-0006-SM-3K2AT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.37982
TOR4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.58498
GSE153137,GSE153140_2_v_1_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
POU5F1B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	55.8301
abnormality of cardiac morphology	GWASdb SNP-Phenotype Associations	1.0	0.15536
GSE174701_4_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
SNU-81	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K67484361	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39141
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.04906
BRD-K81418486_vorinostat_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
GTEX-S32W-2426-SM-2XCAT	GTEx Tissue Sample Gene Expression Profiles	1.0	0.883209
GSE224004,GSE224005_0_v_8_chd4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Brain - Cerebellum	GTEx Tissue Gene Expression Profiles 2023	1.0	1.88416
abnormality of the large intestine	GWASdb SNP-Phenotype Associations	1.0	0.274757
BRD-K93316985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85763
CRLF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00481
epiandrosterone-3306	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac fibroblast_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
ATF2_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Mesothelioma_MESO_TCGA-LK-A4O7-01A-11R-A34F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE174701_5_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_cardiac mesoderm_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
GSE48812_9_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
KMS26	CCLE Cell Line Gene CNV Profiles	1.0	1.55042
CRCGN008_HEPG2_24H:H01	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0194
hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.842605
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A2I2-01A-11R-A180-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CAMK2D	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00566384
GSE173307,GSE173391_0_v_1_rgcc_human	RummaGEO Gene Perturbation Signatures	1.0	null
whole body	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
POLR2AphosphoS5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE160083,GSE160084_2_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8224457-MSB-17-e9760-s005.xlsx-C_Ctrl_v_HMGB1-KD_IMR90-Gene_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DD-75-HY40_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.517725
PIP5K1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00712346
Sarcoma_SARC_TCGA-3B-A9HR-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K52300725	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.6598
5869_NUDT21_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.35157
caudal ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19232
Lung squamous cell carcinoma_LUSC_TCGA-77-7141-01A-11R-2045-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12175788	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.94284
DHRS9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00425187
peripheral blood	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.332661
ETNK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0065351
Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A3WV-01A-11R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
temporal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.69966
H3K4me3_choroid plexus epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDVJ-1926-SM-2S1PJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.7952
GSE77108_3_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Perturb_78_KD_BAP18_SRP074464	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.79722
primary auditory cortex (core)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.27403
LNCAP	BioGPS Cell Line Gene Expression Profiles	1.0	1.1871
ANXA5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0038142
BRD-K88328128	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0185
ticlopidine-1895	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R55C-0005-SM-3GAE9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.06197
inner CP in posteroinferior (ventral) parietal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.997169
EZH2_myotube_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE234514,GSE234516_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XMK1-1026-SM-4B65H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.68801
laterorostral part of entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.00226
SOX2	ChEA Transcription Factor Targets	1.0	null
endogenous depression	GWASdb SNP-Disease Associations	1.0	0.675623
CAMK2G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00373927
GTEX-O5YV-0006-SM-2I5GX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11481
A549_Fluorouracil_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0148641
PLPP3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00752694
Cranial nerve malignant neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.077
FA-80-DR66_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	1.0	0.211456
PrefrontalCortex	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.878209
KMS18	DepMap CRISPR Gene Dependency	1.0	3.1701
GSE140997_2_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE189859,GSE189861_4_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE101239_4_v_2_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleic acid metabolic process	GO Biological Process Annotations 2015	1.0	null
corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
COV504	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.983042
MAC2A	DepMap CRISPR Gene Dependency	1.0	3.24633
YY1_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
fenbufen-4743	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-374c	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
BRD-K85965830	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55494
H3K4me3_brain microvascular endothelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
liver_c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.950393
MAX_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-8120-01A-11R-2241-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_GM12878_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE199606_1_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PAX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.862
H3K4me3_SK-N-SH_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2227	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.39876
PMC10319804-41467_2023_38747_MOESM9_ESM.xlsx-KHSRP_KD_genes_up-gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
HOXC9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5994
GTEX-N7MS-2526-SM-2D7W3	GTEx Tissue Sample Gene Expression Profiles	1.0	1.72345
OVCAR4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.5977
BRD-K20987582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5374
BRD-K60837711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.02828
Eptifibatide	DeepCoverMOA Drug Mechanisms of Action	1.0	0.31
DNAJC2-21179169-NT2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
abnormality of the nervous system	GWASdb SNP-Phenotype Associations	1.0	0.616892
NRF2-31884422-A549-HUMAN-LUNG-CARCINOMA	ChEA Transcription Factor Targets 2022	1.0	null
hematopoietic system	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.051337
SU8686	CCLE Cell Line Gene CNV Profiles	-1.0	-2.07525
V, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.10577
GTEX-X4XY-0526-SM-46MW1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.07769
BRD-K81418486_vorinostat_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K36170758	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39295
RBM47	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00495939
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-880-ZNF207_ZNF207	Rummagene Transcription Factor Associations 2026	1.0	null
GSE88819_11_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71737889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49677
HT115_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	5.3705
AF4-28076791-SEM-HUMAN-BLOOD-LEUKEMIA	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-WFG7-0005-SM-3GIKM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43614
Probenecid	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.74
H3K4me3_endothelial cell of umbilical vein_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
deep layers of olfactory entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.977964
GTEX-WCDI-0005-SM-3NB2M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.48544
PMC10123531-NIHMS1874945-supplement-Table_S6.xlsx-SOX2_BCAT_cobound_peaks-Gene_Name_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.916535
GSE57871_11_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RERF-LC-KJ	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.46296
Nfat5	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	25.4466
GTEX-POMQ-0426-SM-3P61G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2354
RT-112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854821
BMS-911543	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
CTCF_GM19238_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NRL	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.5569
BRD-A39646320_H7270_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KG-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1341
HEY1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00618293
BRD-K54233340_Dorsomorphin dihydrochloride_U937_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H4K5ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
BRD-A31916785	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.2844
ANKMY2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.25384
GTEX-QCQG-0006-SM-2S1OW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06174
FOXA3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0675
H3K4me2_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE245270_1_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K32231853	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.03801
SP1	ENCODE Transcription Factor Targets	1.0	null
A549_Abexinostat_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0121853
LXR-22292898-THP-1-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
hsa-miR-16	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
BRD-K47471281	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8705
NCI-H146	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-Q2AG-1126-SM-48U1P	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.83319
ARID4A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.3251
MAFF	ENCODE Transcription Factor Targets	1.0	null
GSE178292_0_v_2_melphalan_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_12_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217405_3_v_2_osimertinib_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
nocodazole-2239	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE112860_3_v_6_prdm16_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
spiradoline-4375	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Regorafenib_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0240607
Perturb_15396_KD_CSN5_SRP316687	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	6.28678
BRD-K01152687	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.40398
icSARS CoV_12Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.2645
AU565	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.08664
L-363	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.52321
GSE193258,GSE193259_5_v_3_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
G-361	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00288
DDX25	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79514
GANAB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.43044
GTEX-OIZI-0005-SM-2XCED	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08994
flumethasone-pivalate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26267
VIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.96586
upper (rostral) rhombic lip_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.19706
hsa-miR-3617	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
HIPK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00597998
GTEX-X4XX-0005-SM-3NMCS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22854
BT549	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.708486
CRCGN010_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.32556
metal ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE207135_1_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE166783_1_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMC8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0063417
GSE207787_3_v_2_pdha1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Sarcoma_SARC_TCGA-DX-A1KY-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K79048835	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.503
GSE130715_1_v_0_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP3_01_290	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	2.70802
BRD-A19037878_trichostatin A_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
H3K27ac_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_Ellagic acid_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0242239
GTEX-WFG7-0926-SM-4LMK7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.937813
CRIP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.51607
BRD-K90806964	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.02108
RPAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02647
GSE180200,GSE180201_5_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K21470524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03588
GSE239688_2_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9618568-41467_2022_34255_MOESM6_ESM.xlsx-TAL2-Unnamed_0_TAL2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-WH7G-0826-SM-4LVMR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848046
Pheochromocytoma and Paraganglioma_PCPG_TCGA-W2-A7HF-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K21680192_mitoxantrone_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
malignant glioma	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.354868
VIIB, right, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.21904
hsa-miR-424	TargetScan Predicted Conserved microRNA Targets	1.0	0.248923
GSE146982_7_v_6_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
SMAD3-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-3646	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
UACC257	DepMap CRISPR Gene Dependency	1.0	3.43073
BRD-K35491869	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28982
hsa-miR-32	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
GSE226091,GSE226092_0_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
tobacco use disorder	GAD Gene-Disease Associations	1.0	null
SOX2-21211035-LN229-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
HCC1395	CCLE Cell Line Gene CNV Profiles	-1.0	-1.43726
trichostatin A-7105	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
NCI-H146	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.14059
crohn's disease	GWASdb SNP-Phenotype Associations	1.0	0.71647
GSE151829,GSE151831_5_v_8_aire_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
59M	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.20053
GSE231799_3_v_4_nfkbie_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
raubasine-2898	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WRHU-0006-SM-3MJF6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.863979
H2AFZ_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_5_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FLI1	ChEA Transcription Factor Targets	1.0	null
15090461-Table1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K19702946	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31013
GSE80098,GSE80366_0_v_4_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
metamizole sodium-6030	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE125014_6_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SIU8-0006-SM-2XCE5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.957872
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2873-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE126776_0_v_1_pelp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
JUN-21703547-K562-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE200839,GSE233826_2_v_0_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Gastrointestinal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.188
IL1RAPL2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00501403
GSE102467_1_v_0_pazopanib_human	RummaGEO Drug Perturbation Signatures	1.0	null
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.8588
18504433-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
PMC12663032-mmc7.xlsx-Supp_T6-Supplemental_Table_6_Dual_treated_vs_vehicle_treated_MSC_top_DEGs_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
Prestwick-1083-6357	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_6488_OE_circAKT3_SRP216548	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SOX10	MotifMap Predicted Transcription Factor Targets	1.0	null
BRD-K24382357	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.20091
ovary	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Malignant Neoplasm	DisGeNET Gene-Disease Associations	1.0	null
GTEX-XMD3-0006-SM-4AT5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10322
GSE227127_1_v_0_diclofenac_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K09635314_-666_CL34_6.0_h_80.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.4578
JAM3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00524193
KIF21A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05589
regulation of biological process	GO Biological Process Annotations 2015	1.0	null
GTEX-XOT4-0326-SM-4B66S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.879244
GSE178255_3_v_0_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
piromidic acid-4398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MZ in caudal perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.893021
POLR2AphosphoS5_neural cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NCIH889	CCLE Cell Line Gene CNV Profiles	1.0	2.03092
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-992-ZNF418_ZNF418	Rummagene Transcription Factor Associations 2026	1.0	null
Lung adenocarcinoma_LUAD_TCGA-55-7914-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ILF2_02_152	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.32193
hsa-miR-4469	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE148193_1_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
17426248-TableS2b	GeneSigDB Published Gene Signatures	1.0	null
GSE185944_0_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC9314667-Table_1.xlsx-Regulons-SOX4_SOX4	Rummagene Transcription Factor Associations 2026	1.0	null
hydroquinine-2767	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5435-01A-01R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-NK-A5CX-01A-11R-A26W-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
T-T	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.73787
GSE135030_11_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE167324_1_v_0_eif4e_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE182921_0_v_1_slit2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60024823	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04132
trimethadione-4165	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE144484_0_v_1_mllt6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K91654198	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.79775
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938591
CARD8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00843556
KMS-11	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.902669
Organ system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.505
GSE114284_2_v_3_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE235701,GSE261434_2_v_3_enasidenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MEWO	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K27ac_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SC-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.30973
GSE140997_10_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MAFF_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE174701_5_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SUDHL10	DepMap CRISPR Gene Dependency	1.0	3.27876
GSE158834_11_v_9_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213588_8_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K08458391	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12246
doxazosin-3363	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-UPJH-0006-SM-3GACW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.980423
PMC12119949-41467_2025_60269_MOESM3_ESM.xlsx-CTCF-TR_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-MR-A8JO-01A-12R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Sensory system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.252
H3K4me3_endothelial cell of umbilical vein_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
A549_PFI-1_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152675
H3K4me3_GM06990_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN015_MCF10A_48H:O23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01154
A549_Fasudil_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0174921
Staphylococcus aureus nasal carriage (intermittent)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.61549
endometrium_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.15786
cellular_component	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
colonrectum_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.00208
hsa-miR-29c	TargetScan Predicted Conserved microRNA Targets	1.0	0.053794
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-T2IS-0011-R11A-SM-32QPC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74018
BHLHE40	ENCODE Transcription Factor Targets	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4326-01A-01R-1289-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QDT8-0326-SM-32PL1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.09381
GSE174701_4_v_7_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
KLE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.925399
GTEX-WFG7-2326-SM-3GIKV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884268
Perturb_926_OE_Scnn1b_SRP272854	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	3.94733
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.44243
SW1417	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.80378
CDK13	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00593531
CREB1_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TOP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00413505
GSE245270_2_v_4_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XUW1-0726-SM-4BOP5	GTEx Tissue Sample Gene Expression Profiles	1.0	0.854979
BRD-K73587666	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.39819
GSE94849_6_v_2_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC8901773-41598_2022_7986_MOESM3_ESM.xls-PIO_vs_LPS-Gene_symbol_ENSEMBL_ID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPM-0006-SM-2HMKU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.57768
hsa-miR-520d-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
YY1	ENCODE Transcription Factor Targets	1.0	null
BRD-K10959171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15508
GSE142210_4_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE178714_5_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PX3G-0826-SM-48TZS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962358
uterine cervix	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE81803,GSE81912_4_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
MOLP-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	1.0	null
C-33 A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859535
GSK2636771	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.24
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Supplementary_Table_2A_Contrast_ATF4-def_control_vs_HCT116_control_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
ACAA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00525691
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7369-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-R53T-0005-SM-3GADK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11952
H3K4me2_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE123943_4_v_3_sox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
6-bromoindirubin-3'-oxime-7044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
14695196-Table4	GeneSigDB Published Gene Signatures	1.0	null
BRD-K52592505	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10233
GSE103068_5_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HOXC10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7536
SG in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.973046
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-S341-1926-SM-3K2BA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840061
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T6C_mageckTFkoscreen_wo_BATF3-gene_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
flurbiprofen-6472	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ES4	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-1.9294
MYCL	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.41738
valproic acid-458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-15b	TargetScan Predicted Conserved microRNA Targets	1.0	0.154935
GSE151083_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SNU61	CCLE Cell Line Gene CNV Profiles	-1.0	-1.51113
NR3C2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8403
EZH2_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
OCI-AML5	COSMIC Cell Line Gene Mutation Profiles	1.0	null
G-402	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.27034
probucol-5626	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE157383_3_v_2_abemaciclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Fasudil_10然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0209638
Artery - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	1.53506
Ar	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	27.3557
abnormality of the intestine	GWASdb SNP-Phenotype Associations	1.0	0.208144
Perturb_11964_KO_BATF_SRP401628	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-17.7545
BCL2A1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552318
Sarcoma_SARC_TCGA-WK-A8XQ-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
RERF-GC-1B	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.27356
Perturb_8930_KD_ELL_SRP275788	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
hsa-miR-139-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.37496
OVCAR-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.19944
ion binding	GO Molecular Function Annotations 2015	1.0	null
GSE223908,GSE223909_1_v_3_serpinb3_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2AphosphoS2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UPJH-0626-SM-4IHJN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.0106
IL1R1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00592997
endocrine gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GSE122425_1_v_0_nsun2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-W5X1-2826-SM-3GILM	GTEx Tissue Sample Gene Expression Profiles	1.0	1.27269
AK5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00520113
CRCGN014_HEPG2_3H:P19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.08661
GSE144838_4_v_3_egfr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
skmel24	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.571
HCC1937	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.05588
CRCGN015_HEPG2_48H:L03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.22757
BRD-A37056613	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34786
GSE226316_0_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
mammillary body, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.69339
MHH-ES-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.6512
SK-NEP-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
stroke	GWASdb SNP-Phenotype Associations	1.0	0.929673
10min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
VMRC-LCD	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03673
Skin Cutaneous Melanoma_SKCM_TCGA-D9-A4Z5-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
11823860-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
nucleus coeruleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.03052
BRD-K81463178	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.39212
CTCF_endothelial cell of umbilical vein_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-QVJO-1325-SM-2S1QX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53152
ATP1A3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00598749
GTEX-U412-0006-SM-3DB8J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.25409
BRD-K33805195	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1556
GSE178714_1_v_4_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KARPAS-1106P	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.89867
nes	HPA Cell Line Gene Expression Profiles	1.0	1.36716
orbital frontal cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.42463
OUMS23	CCLE Cell Line Gene CNV Profiles	-1.0	-1.3772
cetuximab_homo sapiens_gpl570_gse21483	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE229468,GSE229471_2_v_1_znf587_human	RummaGEO Gene Perturbation Signatures	1.0	null
POLR2A_HeLa-S3_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE249404_0_v_1_oxytocin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Prostate carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
BRD-K81418486_vorinostat_HCC515_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
30min_BMP4 vs ctrl_hESC (Human) [19664995]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	-1.0	null
GTEX-OIZH-2026-SM-3NB1M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.84323
NUDT11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.44824
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4770-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A17658676	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52219
GSE193258,GSE193259_2_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
A549_Mesna_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0132944
UACC893	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45533
Perturb_13976_KO_H3f3a/H3f3b_ERP109384	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	8.85631
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-01A-12R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE165071,GSE165072_1_v_0_dexamethasone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
SP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.33117
regulation of rna metabolic process	GO Biological Process Annotations 2015	1.0	null
CLEC6A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00504732
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-AR_ASO_super_enhancers-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Perturb_5647_KD_JQ1_SRP142503	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-2.24901
BRD-K16976282	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04595
H3K4me1_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
abnormality of the abdominal organs	GWASdb SNP-Phenotype Associations	1.0	0.062297
G111	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12165
prostate_4a	HPA Tissue Sample Gene Expression Profiles	1.0	1.10885
mepenzolate bromide-6024	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SIN3A	ENCODE Transcription Factor Targets	1.0	null
GSE162892_4_v_0_isox_human	RummaGEO Drug Perturbation Signatures	1.0	null
transcription, dna-templated	GO Biological Process Annotations 2015	1.0	null
tranexamic acid-2248	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
prostate_4b	HPA Tissue Sample Gene Expression Profiles	1.0	1.2712
heliotrine-6035	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE126127_5_v_4_prmt1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE175787_11_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-4481	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
BRD-K08927194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.43014
GR-ST	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Perturb_1736_OE_NHD13_SRP068420	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.81678
PMC11328671-jitc-12-4-s003.pdf-446-ZNF488_ZNF488	Rummagene Transcription Factor Associations 2026	1.0	null
clidinium	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11919
GTEX-S32W-0426-SM-4AD6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.967174
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
scriptaid-6919	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
WM-115	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.1893
Perturb_13399_KD_PBX1_SRP302267	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	10.0563
PPP2R5D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.26709
BRD-K34604755	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33844
GSE206516,GSE206518_6_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-SYMBOL_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-1212	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Thymus gland disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.267
GSE143847_2_v_3_inhba_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE174498,GSE174500_2_v_7_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Telmisartan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
A549_Disulfiram_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158997
H3K4me3_fibroblast of pedal digit skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0006-SM-4B64T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20136
Rhabdoid cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
IF-87-AU84_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.21348
KDM4A	ENCODE Transcription Factor Targets	1.0	null
Perturb_7745_KD_RRP6/DIS3_SRP062389	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.3914
GSE202434,GSE202438_9_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-QLQW-0005-SM-2S1RA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.25218
pepstatin-4790	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NOD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00457633
PMC8423434-mmc7.xlsx-SOX2_HENSM-Genes_n_2733_SOX2	Rummagene Transcription Factor Associations 2026	1.0	null
PDK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00821694
GSE210101,GSE210114_1_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
19204204-SupplementaryTable6	GeneSigDB Published Gene Signatures	1.0	null
H3K4me3_BJ_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-POMQ-2026-SM-2S1OD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907889
H2AFZ_skeletal muscle myoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XUW1-0005-SM-4BOQ7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.960043
GSE210101,GSE210114_0_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
G122	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.834524
Spleen	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.026
furafylline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18139
GSE158834_0_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
whole body	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.049844
upper (rostral) rhombic lip_8 pcw_M_13058	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.879146
abnormality of the urinary system	GWASdb SNP-Phenotype Associations	1.0	0.966449
KCNQ2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00564795
GSE57871_8_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K48899005	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.56277
NB10	DepMap CRISPR Gene Dependency	1.0	2.88946
obesity	GWASdb SNP-Disease Associations	1.0	0.560729
dinoprost-3308	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Oil secretion	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.761
BRD-K21680192_mitoxantrone_HEPG2_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A19037878_trichostatin A_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3I6-01A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PDK3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00783352
BRD-K40452322	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.31681
GTEX-OIZI-0526-SM-2XCEG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.907396
Liver hepatocellular carcinoma_LIHC_TCGA-5C-A9VG-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL1576 (ESCO1)	NURSA Protein Complexes	1.0	null
GSE147876,GSE147877_2_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR1_T47D_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K28467941	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05461
GSE210101,GSE210114_11_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FUT4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00604457
bone marrow	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
naproxen-6096	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZBTB7A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	GO Cellular Component Annotations 2015	1.0	null
A549_Linifanib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0184266
Prestwick-559-2877	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
POLR2A_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
STAT3	JASPAR Predicted Transcription Factor Targets	1.0	null
Disease of cellular proliferation	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.704
Pancreatic adenocarcinoma_PAAD_TCGA-RB-A7B8-01A-12R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Body Mass Index	dbGAP Gene-Trait Associations	1.0	0.304966
RGS7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00672121
BRD-K69396470	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11717
phenothrin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.83969
GSE48812_2_v_6_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
hsa-miR-363	TargetScan Predicted Conserved microRNA Targets	1.0	0.187098
A549_Tazemetostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0190602
GSE226249_2_v_8_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KM-H2	GDSC Cell Line Gene Expression Profiles	-1.0	-2.36203
ventrolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.1277
ATF2	ENCODE Transcription Factor Targets	1.0	null
GJA8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0056739
GTEX-TMMY-0426-SM-33HBB	GTEx Tissue Sample Gene Expression Profiles	1.0	0.858217
GTEX-WEY5-2226-SM-3GILQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838002
GTEX-RU72-1126-SM-2TF6H	GTEx Tissue Sample Gene Expression Profiles	1.0	0.862577
GTEX-PWCY-1426-SM-48TCT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.00659
GTEX-RN64-1826-SM-48FDV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.983496
BRD-U51951544_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K11874023	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.139
GSE122101,GSE122103_3_v_1_ssu72_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
TRIB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.35627
BHLHE40_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE258991_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.04478
lymph node	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
KU 55933	DeepCoverMOA Drug Mechanisms of Action	1.0	0.78
GTEX-U3ZN-0226-SM-3DB8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922529
GTEX-WRHK-0005-SM-3MJF5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35826
BRD-K76985713	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77785
BRD-K14139166	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08662
GSE126463_0_v_2_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
HCC1569	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.880377
Heart Defects, Congenital	CTD Gene-Disease Associations	1.0	1.26021
BRD-K30943140	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05419
Brain Lower Grade Glioma_LGG_TCGA-E1-A7YV-01A-11R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BUB1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00421528
H3K4me3_cardiac mesoderm_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K90127324	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21683
procyclidine-3330	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4813-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN014_HEPG2_24H:P23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.06816
PLXNC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669224
GSE233049_2_v_0_atf3_human	RummaGEO Gene Perturbation Signatures	1.0	null
ALOX12	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00551192
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	1.0	null
idoxuridine-1899	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K81418486_vorinostat_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE138815,GSE138817_0_v_2_kdm6a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A549_JQ1_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0132023
A549_Quisinostat_100nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00924992
SARS-CoV MA15_Day1-PFU-10^4_None_GSE33266	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.13017
H3K4me3_fibroblast of villous mesenchyme_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PMC10592471-NIHMS1912771-supplement-2.xlsx-NR2F1-Ind-Downregulated_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-TML8-1626-SM-32QOO	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01652
GSE139455_2_v_3_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE74251_2_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-T2IS-2926-SM-32QPO	GTEx Tissue Sample Gene Expression Profiles	1.0	2.27996
GSE173201_2_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.922966
SNU-1040	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K54420800	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0016
BRD-K57042334	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05914
BRD-K81418486_vorinostat_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-S4P3-0006-SM-3K2AW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28754
Nuclear cyclin-dependent protein kinase holoenzyme complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.231
BRD-K43389698_BMS-387032_PC3_24_h_0.12_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SBNO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45307
NCI-H929	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.909456
Lung adenocarcinoma_LUAD_TCGA-50-8459-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
primary auditory cortex (core)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.34607
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.27608
hsa-miR-1913	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
male reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
primary somatosensory cortex (area S1, areas 3,1,2)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.5847
organic cyclic compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
AB-71-CI37_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.289172
CRH	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00466351
ZD 7288	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
GSE122990,GSE123061_0_v_1_urod_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasal vestibule	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.57
L-363	GDSC Cell Line Gene Expression Profiles	-1.0	-1.96161
PMC12464728-HSR2-8-e71283-s003.docx-24-700_OVOL2_1_OVOL2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-1185	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
Lung squamous cell carcinoma_LUSC_TCGA-58-8393-01A-11R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Sorafenib Tosylate_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228753
HCC515	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00688
BRD-K26612358	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.16283
17177833-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GTEX-S4P3-0326-SM-4AD6P	GTEx Tissue Sample Gene Expression Profiles	1.0	1.02066
SMAD3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-PSDG-0005-SM-3GADC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.21163
trichostatin A-4565	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XBEW-0006-SM-4AT4E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32316
HBL-100	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.78538
BRD-K32282076	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15393
BRD-A41916216	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.19935
CTCF_B cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cochlear nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.27096
neomycin-2229	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27me3_CD4+ CD25- CD45RA+ Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
MELHO	DepMap CRISPR Gene Dependency	1.0	2.31254
Golgi cisterna membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.953
HOXD10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8392
primary visual cortex (striate cortex, area V1/17)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.902322
JUND_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE149124,GSE149128_2_v_1_cdk7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K71262871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53082
Testis	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.86439
PMC4580625-pone.0138726.s006.xlsx-Immune_molecular_modules-IRF8_mod_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S32W-1926-SM-4AD63	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.867609
brain	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE113329,GSE113335_3_v_4_taf6l_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-56-5898-01A-11R-1635-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CW-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.58302
BRD-A73909368_-666_MCF7_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE166783_3_v_2_tp53_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_KW-2449_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0164442
Liver hepatocellular carcinoma_LIHC_TCGA-ED-A97K-01A-21R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE144231_2_v_1_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-AR_ASO_super_enhancers-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
cell part	LOCATE Curated Protein Localization Annotations	1.0	null
H3K4me2_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-DC-6156-01A-11R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_7672_KD_UPF1_SRP267245	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.8752
GTEX-SJXC-2026-SM-4DM6N	GTEx Tissue Sample Gene Expression Profiles	1.0	1.60776
Liver hepatocellular carcinoma_LIHC_TCGA-5R-AA1D-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GABRA2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046969
CRCGN017_MCF10A.WT.HP_24H:P08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4613
H3K4me3_fibroblast of lung_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Eccrine sweat gland neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.501
TCF3	ENCODE Transcription Factor Targets	1.0	null
GSE157555,GSE157556_0_v_6_foxa2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE118794_5_v_4_zmynd8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE236280_0_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A89354030	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.92325
PMC12455829-11658_2025_792_MOESM8_ESM.xlsx-2_DDIT3_IP_vs_BRG1_IP-Supplementary_Table_7_Transcription_factors_DDIT3	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A06837695	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41168
GE-47-OO30_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.213898
BRD-K04010869_PROSTAGLANDIN A1_CL34_6.0_h_1.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-U4B1-0006-SM-3DB8E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11767
hsa-miR-495	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851853
EP300_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
TCF12_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K78126613_MENADIONE_NCIH596_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4680-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
GSE239844_11_v_10_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-G2-A2EL-01A-12R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_11_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Amisulpride_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0182885
H3K4me3_fibroblast of lung_hg19_6	ENCODE Histone Modification Site Profiles	1.0	null
mRNA_PRDM14_20953172	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	-1.0	null
H4	GDSC Cell Line Gene Expression Profiles	1.0	1.55812
18631401-TableS3	GeneSigDB Published Gene Signatures	1.0	null
FOXF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1549
Bladder Urothelial Carcinoma_BLCA_TCGA-BL-A3JM-01A-12R-A21D-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Adrenocortical carcinoma_ACC_TCGA-P6-A5OG-01A-22R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE143944_1_v_0_ribociclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer CP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.22355
valproic acid_homo sapiens_gpl6883_gse26940	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE185944_2_v_4_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SP in ventrolateral prefrontal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.832234
BE2-M17	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.53843
MAX_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PSMD12	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.30069
GSE210885_2_v_1_klf4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140997_4_v_5_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
orbital frontal cortex_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.908216
GTEX-N7MS-0626-SM-2YUN7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.884608
Hs-683	Sanger Dependency Map Cancer Cell Line Proteomics	-1.0	-2.00979
mediodorsal nucleus of thalamus_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885932
GSE130676_0_v_1_suds3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SLC25A2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00529504
MAFK_HepG2_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
14695196-Table2	GeneSigDB Published Gene Signatures	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B6-01A-21R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K06543683_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE225869_2_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174498,GSE174500_2_v_8_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTSW	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00612607
GTEX-VJWN-0005-SM-3GIKF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.997205
hsa-miR-92a	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
PMC10363146-41598_2023_38681_MOESM1_ESM.pdf-489-LEF1_LEF1	Rummagene Transcription Factor Associations 2026	1.0	null
nucleus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
496100474_FWM_possible Alzheimer's disease_TBI_89_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.65011
VIIIB, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.07638
cellular metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-U8XE-1526-SM-4E3HT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911317
GSE171837_0_v_3_bortezomib_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K23860926	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.20966
GTEX-UTHO-2926-SM-3P5Z9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.51193
testis	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K15426523	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08494
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-OOBJ-1026-SM-3NB2L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.916631
dehydrocholic acid-1940	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ES4	DepMap CRISPR Gene Dependency	1.0	2.32148
YY1	JASPAR Predicted Transcription Factor Targets	1.0	null
hsa-miR-3928	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
GSE42805,GSE42811_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
etynodiol-6479	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE242199_2_v_0_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.432
colecalciferol-3298	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_9_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K55940699	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13155
H3K4me3_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
9798_BUD23_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.33685
lorglumide-6456	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-TKQ2-0006-SM-33HBH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.14571
Endocrine gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.223
BOK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.62666
Lung adenocarcinoma_LUAD_TCGA-L9-A443-01A-12R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PWOO-0006-SM-2I3E3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.67848
endometrium_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.18803
GTEX-VUSG-0126-SM-4KL1X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00215
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.2768
SR 3335	DeepCoverMOA Drug Mechanisms of Action	1.0	0.5
GTEX-U3ZN-0006-SM-3DB7Y	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.19193
Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-7842-01A-11R-A32Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-B8-4143-01A-01R-1188-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.09799
SOX2-21211035-LN229_GBM-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
azacyclonol-5398	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CRCGN011_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.58955
PMC12003887-41467_2025_58921_MOESM16_ESM.xlsx-Figure_4a-Figure_4a_Average_normalized_activities_of_1_358_TRs_in_ESR1-knockout_experiments_analyzed_for_both_up-_and_down-regulated_gene_sets_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
VIIIA, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.89725
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7890-01A-12R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE164874_5_v_0_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE174701_1_v_2_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CDKN1C	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00478366
HCC1359	CCLE Cell Line Gene CNV Profiles	-1.0	-1.62854
hsa-miR-4436b-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
V, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.987177
methoxsalen-3302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K27ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K79090631_CGP-60474_MCF7_24_h_1.11_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE57871_5_v_12_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ATP6V1F	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07374
GSE132369,GSE132371_1_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fatty Liver	CTD Gene-Disease Associations	1.0	1.07234
FOXA2	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-15a	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
Carcinoma	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
GSE149903_6_v_1_myd88_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE213588_8_v_7_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_11_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_3_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CD4_Naive_Primary_Cells	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.28497
reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Paranasal sinus cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.273
HOXB9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0723
GSE158834_0_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
hydralazine-2311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE209911_0_v_1_ncstn_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cimetidine-1884	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SW948	COSMIC Cell Line Gene Mutation Profiles	1.0	null
TOLEDO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.889918
A549_Lenalidomide_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141488
BRD-K25147028	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08205
GSE206108_1_v_0_bhlhe22_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZBTB32	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.156
PMC12119949-41467_2025_60269_MOESM3_ESM.xlsx-ZBTB7A-TR_ZBTB7A	Rummagene Transcription Factor Associations 2026	1.0	null
NCIH2126	CCLE Cell Line Gene CNV Profiles	-1.0	-2.36905
GSE158632_3_v_0_oxyquinoline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-T6MN-2526-SM-32PMN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.61329
MITF-21258399-MELANOMA-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GTEX-RU72-0006-SM-2TF65	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08965
disease	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039036
inferior rostral gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.839614
GSE220668_0_v_1_ncapg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
VIIIA, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.20369
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.4675
GTEX-T5JW-0005-SM-3GADE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.68875
OVOL1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00660635
CW-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K79090631_CGP-60474_BT20_3_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
0225151-0000-6384	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hydralazine-3621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE208254_4_v_5_irf8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC4266008-mmc3.xlsx-iPS-MSC_vs_MSC-Unnamed_24_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.70272
POU1F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.8875
postcentral gyrus, left, superior lateral aspect of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.916817
Heart - Left Ventricle	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.14416
GTEX-V1D1-1926-SM-4JBGX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03464
H3K4me1_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_1213_KO_Zfp580/Sp3_SRP302435	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.26582
smoothmuscle_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.12984
hsa-miR-335	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
GSE169356_2_v_4_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K27me3_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SK-OV-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.922787
GSE185519_1_v_5_gilteritinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
denatonium benzoate-5480	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
MAX_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PVOW-0626-SM-2XCF6	GTEx Tissue Sample Gene Expression Profiles	1.0	1.39642
A549_BMS-265246_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0159679
PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_1_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-3.09549
GSE227592_8_v_3_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S33H-1826-SM-4AD65	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19782
ACTR2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00600284
LY2	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-1.04821
RECQL4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00489789
LBP9  (Tcfcp211)	MotifMap Predicted Transcription Factor Targets	1.0	null
GTEX-T6MO-1926-SM-32QOJ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.173
UBA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.49526
Cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
hsa-miR-662	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
cerebellum_12 pcw_F_12960	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.994377
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-Gene_SymbolH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K74311661	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30103
BRD-K13390322_HY-50940_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K47535493	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.06763
H3K4me1_Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Fetal Death	CTD Gene-Disease Associations	1.0	1.54086
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.7077
BRD-K72238567_656402-250MG_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.042
GSE229102_1_v_0_nr2f6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Crus II, left, lateral hemisphere	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.922204
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3323-01A-02R-1325-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN017_MCF10A.TP53.M_24H:D15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.15264
GTEX-POYW-0006-SM-2XCF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.852194
hsa-miR-3692	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.48184
hsa-miR-105	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.40969
GSE226355,GSE226357_1_v_0_ybx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147662_2_v_4_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC5640240-ppat.1006668.s013.xlsx-MAX_ChIP_shEP400-1-Unnamed_6_MAX	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-QMR6-0011-R11A-SM-32PKK	GTEx Tissue Sample Gene Expression Profiles	1.0	2.33036
MAN1B1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00410799
HPAC	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.02452
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-5971-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_fibroblast of the aortic adventitia_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abducens nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18023
BRD-K02708799_GSK-1059615_HA1E_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ESR1_T47D_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-YL-A8SB-01A-31R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K02130563_S1030_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.31511
Acute Myeloid Leukemia_LAML_TCGA-AB-2933-03A-01T-0734-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE198165,GSE198166_7_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12130184-12276_2025_1441_MOESM5_ESM.pdf-2-NFATC1_NFATC1	Rummagene Transcription Factor Associations 2026	1.0	null
CB-31-UO16_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.203964
oxyphenbutazone-6844	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
HCC-15	COSMIC Cell Line Gene Mutation Profiles	1.0	null
trichostatin A-6439	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-U8T8-0005-SM-3DB8F	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4619
H3K9ac_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE123958,GSE123959_0_v_1_mta1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GM12878	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-1.29349
disease of anatomical entity	GWASdb SNP-Disease Associations	1.0	0.072127
SNU-475	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.967685
hsa-miR-302a	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
HCC2218_BREAST	CCLE Cell Line Proteomics	1.0	4.39842
FOXH1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4897
GSE85995_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
A549_Streptozotocin_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0139132
PHLDA1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17379
BRD-K81418486_vorinostat_A549_24.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.958235
GSE213588_8_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:P09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0922
hsa-miR-182	TargetScan Predicted Conserved microRNA Targets	1.0	0.047969
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
LB996-RCC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
OVCAR-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.48437
BRD-A84816049	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19346
BRD-K22701871	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46251
GTEX-PX3G-0006-SM-33HBQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.887497
PMC2866657-pone.0010547.s003.xls-ERG_corr-Genes_correlated_anticorrelated_to_ERG_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
CHD1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Cell type cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
Lung adenocarcinoma_LUAD_TCGA-NJ-A4YQ-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE142210_2_v_10_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
5286656-889	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-A24524033	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.68645
GSE213588_8_v_4_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A13122391_16-HYDROXYTRIPTOLIDE_LOVO_6.0_h_0.08_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE189789_0_v_1_oridonin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10349775-432_2022_4445_MOESM1_ESM.pdf-24-NFATC4_NFATC4	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB7A	ENCODE Transcription Factor Targets	1.0	null
GSE85874_4_v_5_kdm5c_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
SMAD3-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
A549_ENMD-2076_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0146261
GTEX-R55F-0005-SM-2TF4W	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77556
POLR2G_02_09	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.90689
TF1	DepMap CRISPR Gene Dependency	1.0	2.27026
GSE125014_1_v_5_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HCC1534	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.10755
H3K4me3_epithelial cell of proximal tubule_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135030_8_v_7_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE224969,GSE224971_0_v_7_chtop_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD4-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE229580_2_v_1_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_10_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Quinidine (15% dihydroquinidine)_Hs 766T	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00368659
BRD-K85475457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.67869
H3K4me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE178714_5_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PDE6G	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00818023
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8XJ-01A-11R-A37O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-PX3G-2026-SM-48U1H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.26296
GSE149264,GSE149267_4_v_3_trp53_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
639-V	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_kidney epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29549246	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41863
BCL6B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.714
GSE115395_2_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
STAT6	MotifMap Predicted Transcription Factor Targets	1.0	null
CLDND2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0187
GSE196671_5_v_0_obox4_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K43789905	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.13258
Brain - Amygdala	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.940454
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4974-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00300115	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.72402
GSE157777_2_v_0_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
A-673	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.84667
GSE255680_1_v_3_igf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_WERI-Rb-1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K17743125_belinostat_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phenacetin-2832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LEO1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.45558
primary auditory cortex (core)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.26901
BRD-K82362034	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.59745
Prostate	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02703
M059K	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.41012
GSE229468,GSE229471_0_v_3_znf587_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung adenocarcinoma_LUAD_TCGA-53-7813-01A-11R-2170-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
female reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
GTEX-X4XY-0006-SM-46MV2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01451
SG in rostral perirhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.52875
Prostate adenocarcinoma_PRAD_TCGA-EJ-7317-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Genetic disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.08
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q4-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dna binding	GO Molecular Function Annotations 2015	1.0	null
A549_Entacapone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0196645
prostate_4c	HPA Tissue Sample Gene Expression Profiles	1.0	0.995283
Brain Lower Grade Glioma_LGG_TCGA-DU-8161-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Cilostamide	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.32
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_5_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-X4EO-0126-SM-3P5YN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10672
BRD-K42385001	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14904
dl-alpha tocopherol-3256	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores	1.0	0.039475
regulation of cellular macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
ECGI10	CCLE Cell Line Gene CNV Profiles	-1.0	-2.47044
POLR2A_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-UJMC-1926-SM-3GADS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893074
GSE113734_1_v_0_qprt_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE125014_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC9240038-41467_2022_31337_MOESM5_ESM.xlsx-Sheet1-CTCF_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-A8YO-01A-11R-A37K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bucladesine-842	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE74251_2_v_1_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-N7MT-1426-SM-3LK5M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.18166
hepg2	HPA Cell Line Gene Expression Profiles	-1.0	-1.23548
GSE207863_0_v_1_hdac5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
depression	GWASdb SNP-Phenotype Associations	1.0	0.578934
abnormality of cardiovascular system physiology	GWASdb SNP-Phenotype Associations	1.0	1.55293
DTX2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13693
CPSF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.42643
RAD21_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7382-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE167373_0_v_3_rbfox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Perturb_12647_KD_Dirc3_SRP191022	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
GSE120612_7_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H1930	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.2272
posterior (caudal) superior temporal cortex (area 22c)_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.03856
SUM52PE	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	-1.0	-0.939584
hippocampus (hippocampal formation)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.27894
cell part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
H3K4me3_fibroblast of villous mesenchyme_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE146982_7_v_1_gpd1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
primary auditory cortex (core)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.897855
pancreas_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.12473
H3K4me3_cardiac mesoderm_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-QDT8-0011-R11A-SM-32PKD	GTEx Tissue Sample Gene Expression Profiles	1.0	2.67338
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7398-01A-11R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-REY6-0005-SM-2TF54	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03274
BRD-K69840642_HDAC6 inhibitor ISOX_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
JHH-7	COSMIC Cell Line Gene Mutation Profiles	1.0	null
SU-DHL-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
blood	GTEx Tissue Gene Expression Profiles	-1.0	-1.67875
GTEX-OXRK-0006-SM-2HML1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39676
H3K4me3_LNCaP clone FGC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
CA11	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00574343
GTEX-X4EP-0005-SM-3P5ZE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.77996
COLO-824	GDSC Cell Line Gene Expression Profiles	1.0	1.64111
GSE228106_0_v_5_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207514,GSE207515_0_v_3_acetylcysteine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
KDM5B	ENCODE Transcription Factor Targets	1.0	null
16536878-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
GSE81803,GSE81912_2_v_1_fmr1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
anterior (rostral) cingulate (medial prefrontal) cortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.2179
P30-OHK	COSMIC Cell Line Gene Mutation Profiles	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.00886
H2AFZ_mammary epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
T3M4	CCLE Cell Line Gene CNV Profiles	-1.0	-1.67213
NCI-H2009	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03673
GTEX-SIU8-0326-SM-2XCDR	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04576
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC10154349-41418_2023_1142_MOESM6_ESM.xlsx-Sheet1-Supplementary_data_3_Genes_positively_correlated_with_HOXC13-AS_in_skin_granular_cells_correlation_coefficients_cor_0_FDR_0_05_HOXC13	Rummagene Transcription Factor Associations 2026	1.0	null
ZFHX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.05902
GSE200839,GSE233826_2_v_4_tnrc18_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me1_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
piretanide-3567	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_4360_KO_CEP83_SRP379856	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	2.35667
regulation of nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
CHRFAM7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00736542
Golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	1.0	1.395
NURR1	MotifMap Predicted Transcription Factor Targets	1.0	null
rescinnamine-2785	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12878_hg19_5	ENCODE Transcription Factor Binding Site Profiles	1.0	null
A-Vietnam-1203_CIP048_RG3-2004(H5N1)mutPB2-627E_12Hour_None_GSE43203	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.13696
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A80L-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
finasteride-6062	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE154767_2_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-POMQ-0006-SM-33HBY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01354
Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81Q-01A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PIM2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00772578
Irf1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	42.7174
CRCGN012_HEPG2_24H:C20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.96501
GSE216273,GSE216292_0_v_1_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
urinary system disease	GWASdb SNP-Disease Associations	1.0	0.229092
BRD-K64531971	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25515
BRD-K10133810	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.52452
GTEX-RU72-1426-SM-46MUF	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.961126
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.90653
BL4488 (KDM5C)	NURSA Protein Complexes	1.0	null
Adenocarcinoma	CTD Gene-Disease Associations	1.0	1.06225
H3K4me3_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
AB-30-CR11_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.285215
vascular disease	GWASdb SNP-Disease Associations	1.0	0.249197
mcf7	HPA Cell Line Gene Expression Profiles	-1.0	-0.834834
GTEX-XOTO-2926-SM-4B65G	GTEx Tissue Sample Gene Expression Profiles	1.0	1.52795
hsa-miR-522	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE100316_7_v_1_mtor_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A2LA-01A-11R-A18C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Lymph node	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.112
Perturb_4314_KO_Hdac4_SRP219834	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	4.29849
GSE160077,GSE160084_3_v_0_bin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K86797399_pracinostat_PC3_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE187006_0_v_1_valproic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE193258,GSE193259_2_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN015_MCF10A.TP53.M_24H:L19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.075
epitiostanol-4788	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-T2YK-0005-SM-32QOV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.98493
GSE175787_13_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
all	GWASdb SNP-Phenotype Associations	1.0	0.056825
GSE143944_2_v_3_ribociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WOFM-1626-SM-3MJFX	GTEx Tissue Sample Gene Expression Profiles	1.0	0.949049
A549_G007-LK_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0173324
SIMA	GDSC Cell Line Gene Expression Profiles	1.0	2.01224
macromolecule biosynthetic process	GO Biological Process Annotations 2015	1.0	null
PMC6347712-pnas.1812449116.sd06.xlsx-iPSC_IRF7_48h_rest_RNAExpress-Gene_IRF7	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_Breast vHMEC	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
intracellular organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
Neurosphere_Cultured_Cells_Ganglionic_Eminence_Derived	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.827958
GSE189772,GSE189773_3_v_2_fbxo11_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE122067_2_v_1_mtch2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN008_HEPG2_24H:M13	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.0468
GSE103068_0_v_4_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF_Q1_vs_Q4-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
KMS-26	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.33792
PKN3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00603105
ESR1_T47D_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
0min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
4805_MAP2K7_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.35718
upper limb region of M1	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.4237
GSE217541,GSE217543_3_v_2_tet1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NAE1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.80528
POLR2AphosphoS5_SK-N-MC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE233679_6_v_10_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
CKMT2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00433205
GTEX-UPK5-1526-SM-4JBJA	GTEx Tissue Sample Gene Expression Profiles	1.0	0.82842
GSE235701,GSE261434_0_v_1_enasidenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BL4172 (NCRNA00153)	NURSA Protein Complexes	1.0	null
josamycin-1950	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
ME-31-RM40_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.305395
nicotinic acid-3381	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE180185_7_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_AT9283_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0186479
Poisoning	CTD Gene-Disease Associations	1.0	1.19509
POLR2A_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PDE-9i	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.98
GSE207978_1_v_0_rai1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SW 1463	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.927894
HOXD8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1982
Perturb_9511_KO_Rorc_ERP109443	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.34092
GSE195663_0_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RPE1SS48	DepMap CRISPR Gene Dependency	1.0	2.28468
GSE246195,GSE246305_1_v_0_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-RWSA-1426-SM-47JXA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.888933
GTEX-QV44-2226-SM-447A3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.825681
male reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
DMS 53	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.42065
NFIL3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.022
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE185519_4_v_0_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me1_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE239688_2_v_3_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RNOR-2226-SM-2TF5O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57896
A549_Dacinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163314
oral mucosa	HPA Tissue Protein Expression Profiles	1.0	0.950484
SMAD4-21741376-HESCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
BRD-A64374397	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.54199
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.24074
GSE139455_0_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney Chromophobe_KICH_TCGA-KL-8327-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SMARCD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.22386
GTEX-PW2O-0426-SM-48TCC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20622
U-2932	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.83398
GTEX-XOT4-0005-SM-4B64S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1155
NCI-H1869	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.903527
BRD-K47536398	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15369
naringenin-3278	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
urapidil-6455	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
intracellular	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
YY1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Obesity_Muscle - Striated (Skeletal) (MMHCC)_GSE5109	GEO Signatures of Differentially Expressed Genes for Diseases	-1.0	-1.28446
ZFAND2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00434213
NCI-H209	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.24552
SET-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.03008
GSE174735_1_v_3_il22_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE242199_6_v_7_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Tolvaptan	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.66
GSE128333_2_v_1_tcf4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMARCA4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00613032
HCC1428	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.944883
GATA3-26560356-CHIP-SEQ-TH2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE114883_0_v_2_romidepsin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CTCF_GM12892_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE114992,GSE114993_0_v_5_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE86507,GSE86509_4_v_1_hoxb7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE102486,GSE102490_1_v_5_setdb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70578146_dactinomycin_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5195-01A-02R-1426-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE147664_0_v_1_arid1b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
MS4A6E	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00545376
GSE175787_5_v_0_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4586-01A-01R-1443-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_epithelial cell of esophagus_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Weight Loss	CTD Gene-Disease Associations	1.0	1.26669
intracellular part	GO Cellular Component Annotations 2015	1.0	null
Nr2e1	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.619
H3K4me1_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE185944_2_v_3_pth1r_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_16609_KO_Larp7_SRP189392	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	6.1032
CALU-3	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.840604
BRD-A55411938	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.25369
IRF4-20064451-CD4+T-MOUSE	ChEA Transcription Factor Targets 2022	1.0	null
medial ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.956724
GTEX-R55E-0011-R11A-SM-2TC6I	GTEx Tissue Sample Gene Expression Profiles	1.0	2.01585
NCI-H2110	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31185
pretectal region	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.851751
Brain Lower Grade Glioma_LGG_TCGA-FG-6692-01A-11R-1896-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hl60	HPA Cell Line Gene Expression Profiles	-1.0	-2.39936
CEBPZOS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02682
A549_Pracinostat_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.012115
IM-95	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CF-24-KQ98_0.1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.234674
SW 48	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09469
TC-71	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.03828
hsa-miR-1273d	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
A549_UNC0631_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0229284
KMBC2	DepMap CRISPR Gene Dependency	1.0	2.11975
BRD-K66248685	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.53782
GSE226115,GSE226116_2_v_0_doxorubicin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NCI-H2198	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.53434
A549_Mesna_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0158554
PTGDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691938
GSE168171,GSE168173_0_v_1_ddx41_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
outer SZ in lateral temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.952747
H3K9ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
A549_UNC0379_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0166775
H3K4me3_mammary epithelial cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE105406_0_v_3_ptcd1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NBN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.4847
PMC12768487-NIHMS2129409-supplement-4.xlsx-2D_3D_TFEA_shared-TFEA_for_siSIRT3_TFE3	Rummagene Transcription Factor Associations 2026	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.32514
POLR2AphosphoS5_U-87 MG_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE157960_2_v_3_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
talampicillin-3515	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE137653_4_v_0_siglecf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131680_1_v_0_macroh2a1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE133516_5_v_2_kat7_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K68008192	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09178
cell part	GO Cellular Component Annotations 2015	1.0	null
GSE174701_4_v_0_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXP2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.2755
increased erythrocyte cell number	IMPC Knockout Mouse Phenotypes	1.0	null
GSE96641_5_v_0_esrp2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-PVOW-0006-SM-3NMB8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.36982
Laryngeal cancer cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.09
thioproperazine-2236	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5669_KD_Yy1_SRP281855	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
GTEX-X4XX-2926-SM-3NMB1	GTEx Tissue Sample Gene Expression Profiles	1.0	1.38205
amygdaloid complex_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.20397
BRD-K83527041	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25014
KCNN4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00347849
Lung squamous cell carcinoma_LUSC_TCGA-90-A4ED-01A-31R-A24Z-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
FOXA1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.7229
A549_Streptozotocin_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0157127
C20orf96	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.39552
GSE164874_5_v_9_prednisolone_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW1783	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE58724_1_v_0_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WEY5-0001-SM-3P61Z	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.826607
ZNF8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.2639
cingulum bundle, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.13441
BRD-K02708799_GSK-1059615_A375_24_h_0.37_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K10776934	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.07496
hsa-miR-373	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
primary motor-sensory cortex (samples)_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.05726
20460542-SuppTable1	GeneSigDB Published Gene Signatures	1.0	null
BRD-K94411351	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.41024
hsa-miR-4745-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
hsa-miR-1271	TargetScan Predicted Conserved microRNA Targets	1.0	0.039622
GSE120612_4_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
MYC_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE167546_1_v_2_atrx_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5893-01A-11R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
cerebellar cortex_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.858334
KARPAS-620	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.09832
TAF1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-194	TargetScan Predicted Conserved microRNA Targets	1.0	0.32519
Sarcoma_SARC_TCGA-FX-A2QS-01A-11R-A21T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Neurotoxicity Syndromes	CTD Gene-Disease Associations	1.0	1.11116
GTEX-T6MN-0326-SM-32PMK	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22748
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5710-01A-11R-1672-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QCQG-1926-SM-2S1PI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97974
isocorydine-6843	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
ADCK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590393
GSE140200_1_v_0_trim59_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Lymphoid tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.026
GTEX-U3ZH-0005-SM-3DB72	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.08043
BRD-K63375777	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.81178
inflammation of the large intestine	GWASdb SNP-Phenotype Associations	1.0	0.390642
GSE101336_1_v_0_decitabine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12634441-41375_2025_2771_MOESM7_ESM.xlsx-RNAseq-Table_S2_Bulk_RNA-seq_GATA2_vs_control_Only_p-adj_0_05_GATA2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K15879529	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.85649
18818702-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
A549_Meprednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160634
BRD-K19662956	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.65225
Malignant olfactory nerve neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.186
EWS502	DepMap CRISPR Gene Dependency	1.0	3.39975
CSNK2A3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52114
POU2F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.939
WC-16-IR43_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.212104
PMC8065135-41467_2021_22068_MOESM6_ESM.xlsx-E_MYOG_binding_in_downreg-Unnamed_1_MYOG	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-U3ZM-0926-SM-4DXSW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.06366
HNT-34	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01022
GSE162276_4_v_0_pparg_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE214931_1_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cellular process	GO Biological Process Annotations 2015	1.0	null
Rectum adenocarcinoma_READ_TCGA-F5-6702-01A-11R-1830-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K38615104_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE200352_9_v_6_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-4cell_CTCF-Unnamed_2_CTCF	Rummagene Transcription Factor Associations 2026	1.0	null
ADRA2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00425398
GSE77108_4_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
VZ in hypothalamic portion	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.39649
KYSE-450	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.06466
Perturb_12901_KD_ZBP1_SRP298473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	16.1815
Corpus callosum	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	2.067
endocrine gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
mafenide-2287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
docosahexaenoic acid ethyl ester-664	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE210505_0_v_1_sox1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-655	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
COLO-704	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.09898
delavirdine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0517
GSE214382,GSE214383_1_v_2_ascl1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE180200,GSE180201_15_v_6_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K49345010	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.48
GSE231720,GSE231724_2_v_1_setd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112860_0_v_8_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE169356_2_v_1_ivermectin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE100863,GSE100864_3_v_0_tet2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FARAGE	DepMap CRISPR Gene Dependency	1.0	2.51129
GSE142684_3_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NR3C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	52.5393
FOXP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00478529
hsa-miR-582-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.165047
GSE180200,GSE180201_5_v_11_qpctl_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE155162,GSE155169_1_v_0_buparlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PRPF19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17142
GSE186471_1_v_2_carnosol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Prestwick-664-6033	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1937	CCLE Cell Line Gene CNV Profiles	-1.0	-1.87576
GTEX-RWSA-0926-SM-47JXW	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13648
ets_00000000_2008_ovarian_cancer_cells_gof_human_gpl6244_gse21129	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.110159
TAF1_HeLa-S3_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE198165,GSE198166_8_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K79090631_HY-11009_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3671	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
GTEX-XYKS-0005-SM-4BRUD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15771
BRD-K43918582	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18094
hsa-miR-3138	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GSE165560_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.1389
posteroventral (inferior) parietal cortex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.856039
H3K4me3_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_5_v_4_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_fibroblast of mammary gland_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K82517280	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.85781
BACH1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NTPCR	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.07454
GTEX-WH7G-0002-SM-4LVN9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832023
BRD-A19037878_trichostatin A_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE233679_6_v_4_nicotinamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
piracetam-5462	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
frontal pole, left, medial aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.38574
KMOE-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
CRCGN008_HEPG2_24H:K02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	4.3004
MRPL18	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28098
EZH2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
nasopharynx	HPA Tissue Protein Expression Profiles	1.0	0.950484
POLR2AphosphoS5_endothelial cell of umbilical vein_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BFTC-905	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31125
Retinal microvascular endothelial cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.519
H3K4me2_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
TAS1R2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00433892
GTEX-SJXC-0426-SM-2XCFH	GTEx Tissue Sample Gene Expression Profiles	1.0	0.8371
GSE57871_6_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
regulation of transcription, dna-templated	GO Biological Process Annotations 2015	1.0	null
CLEC12A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00777776
GTEX-SNOS-0326-SM-4DM6C	GTEx Tissue Sample Gene Expression Profiles	1.0	0.941714
Cervix - Ectocervix	GTEx Tissue Gene Expression Profiles 2023	-1.0	-0.683463
POLR2A_MCF 10A_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
PMC5557398-13045_2017_515_MOESM1_ESM.xlsx-S8-DUX4_SpecDMCs-Unnamed_3_DUX4	Rummagene Transcription Factor Associations 2026	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SP-A6QH-01A-21R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE58724_1_v_4_oxymetholone_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
striatum_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.33518
NCIH1963	CCLE Cell Line Gene CNV Profiles	1.0	2.18
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A4NB-01A-12R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
NALM-6	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.63207
GSE181959_1_v_2_dextran_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11447041-41598_2024_74391_MOESM2_ESM.xlsx-A_ATF4-def_vs_HCT116_ctrl-Unnamed_2_ATF4	Rummagene Transcription Factor Associations 2026	1.0	null
orbital frontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.97882
GTEX-PVOW-2626-SM-32PL8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.12921
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.8193
amygdaloid complex_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.39901
H3K4me2_mammary epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
SUM 229PE	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.839162
Acute Myeloid Leukemia_LAML_TCGA-AB-2843-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
20min_EGF vs ctrl_HeLa (Human) [17081983]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	1.0	null
BRD-K86914375	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08501
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZT-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Streptozotocin_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0228251
CRCGN011_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.85635
CDK14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00446159
H3K9ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GCH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.4641
GTEX-TKQ1-0006-SM-33HBI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04183
GSE158834_12_v_13_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SE-15-AV21_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.222956
Perturb_6639_KD_ZBP1_SRP298473	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
amygdaloid complex_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.40306
GSE224096_3_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
cell	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
786-0	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-A18497530_EI-293_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-570	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
hsa-miR-1303	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.2992
RPMI2650	DepMap CRISPR Gene Dependency	1.0	3.84783
gigantocellular reticular nuclei	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.29314
GSE108495_1_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
MAX_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K99545815_HY-10459_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3660	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
BRD-K15591233	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14664
MAFK	ENCODE Transcription Factor Targets	1.0	null
Perturb_7199_KD_MED26_SRP164752	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20N-11A-11R-A14Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Female reproductive gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
SG in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-2.8411
GTEX-XBEC-0006-SM-4AT5T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.47769
GSE57871_1_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RI1	CCLE Cell Line Gene CNV Profiles	1.0	2.96116
JUND	ENCODE Transcription Factor Targets	1.0	null
Perturb_5056_OE_MERVL_SRP161512	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-10.691
Disease of anatomical entity	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.462
H3K4me3_fibroblast of upper leg skin_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
POLR2A_endothelial cell of umbilical vein_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular organelle	GO Cellular Component Annotations 2015	1.0	null
BRD-K37698302	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.5235
GTEX-R3RS-0005-SM-3GAEH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4226
H3K4me3_Caco-2_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
ep16	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.868
hsa-miR-4639-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.265648
PMC12917211-Table1.xlsx-Table_S13-Table_S13_Gene-level_perturbation_statistics_from_the_virtual_KLF5_knockout_model_in_malignant_ductal_cells_KLF5	Rummagene Transcription Factor Associations 2026	1.0	null
basolateral nucleus (basal nucleus)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.833106
GTEX-WL46-0011-R11A-SM-3MJFT	GTEx Tissue Sample Gene Expression Profiles	1.0	1.71169
GSE154767_4_v_0_adam10_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me3_GM12866_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE140997_10_v_7_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nasal cavity cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.328
MYC_MCF 10A_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Rectum adenocarcinoma_READ_TCGA-EI-7004-01A-11R-1928-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE158834_0_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
BOD1L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23365
hsa-miR-302b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE147876,GSE147877_4_v_7_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE158834_10_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_CD4 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
PMC8016886-41419_2021_3630_MOESM4_ESM.xlsx-Sheet1-Table_S3_Differentially_expressed_genes_identified_between_NC_and_HOXC6-OE_HCT116_cell_lines_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
HCC60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.938591
COLO-684	COSMIC Cell Line Gene Mutation Profiles	1.0	null
etilefrine-4415	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-O5YW-0006-SM-3LK6E	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24414
GTEX-XUYS-0005-SM-47JZ2	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.922447
GTEX-OHPN-0005-SM-2YUML	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17989
GTEX-OOBJ-0426-SM-3NB1S	GTEx Tissue Sample Gene Expression Profiles	1.0	0.875902
IRF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.30023
KMM-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00288
Perturb_3783_KD_SAP130_SRP041162	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
SOX12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8975
Bladder	GTEx Tissue Gene Expression Profiles 2023	1.0	3.19272
hsa-miR-154	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
SPZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.43441
NCI-H510A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.34423
GSE210101,GSE210114_4_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE96641_1_v_4_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_145_KD_Kdm5c_SRP255034	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	1.35655
PMC9745835-supp_079195.122_Supplemental_Table_1.xlsx-ADAR-KD-Gene_name_AR	Rummagene Transcription Factor Associations 2026	1.0	null
dorsolateral prefrontal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.10042
GSE242083,GSE242098_2_v_4_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_8_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_0_v_3_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-OXRL-0005-SM-3LK6A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35392
hsa-miR-641	TargetScan Predicted Conserved microRNA Targets	1.0	0.111118
PMC6113333-41598_2018_31192_MOESM11_ESM.xlsx-Sheet1-H1_NFIC_NFIC	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12827430-41467_2025_67591_MOESM6_ESM.xlsx-Figure_4f-FOSL2_ChIP_WT-exclusive_genes_FOSL2	Rummagene Transcription Factor Associations 2026	1.0	null
KELLY	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.854121
GTEX-PLZ5-0006-SM-2S1NZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.1831
SARS-CoV_60Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.91439
GSE210101,GSE210114_2_v_3_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
U266B1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.993577
GSE118077_1_v_8_sprr5_human	RummaGEO Gene Perturbation Signatures	1.0	null
Lung adenocarcinoma_LUAD_TCGA-L4-A4E5-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BL1754 (MED23)	NURSA Protein Complexes	1.0	null
helveticoside-6047	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC202	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	0.71742
GTEX-XAJ8-1226-SM-47JYS	GTEx Tissue Sample Gene Expression Profiles	1.0	0.847386
BRD-K45520793	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.0822
Internal male genital organ	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
III, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	2.14877
BRD-K22503835_-666_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
acepromazine-2769	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE104508_0_v_1_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BC-54-ON71_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.316767
NCI-H209	GDSC Cell Line Gene Expression Profiles	1.0	2.00177
amygdaloid complex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.11857
GSE242083,GSE242098_3_v_0_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
estradiol-5238	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7331-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE193354_0_v_1_saraf_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hypertension	GWASdb SNP-Disease Associations	1.0	1.68619
Sweat gland benign neoplasm	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.076
guaifenesin-4371	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
substance dependence	GWASdb SNP-Disease Associations	1.0	0.251068
hsa-miR-144	TargetScan Predicted Conserved microRNA Targets	1.0	0.436802
hippocampus (hippocampal formation)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.31082
GSE180200,GSE180201_3_v_0_qpctl_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE114553_0_v_1_lhx6_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K69520171	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.64378
GTEX-XQ3S-2526-SM-4BOOG	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3937
COR-L47	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.71317
GSE142210_9_v_8_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K79090631_CGP-60474_A375_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-3664-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.9207
GSE197564,GSE198513_2_v_0_mettl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.20954
klf4_17017123_rko_gof_human_gpl96_gds1942	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.205624
GSE142210_9_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QMRM-0626-SM-447BQ	GTEx Tissue Sample Gene Expression Profiles	1.0	0.853586
outer CP in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.35403
BRD-K54233340_Dorsomorphin dihydrochloride_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-2681	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
IGSF10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00547429
GBP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00801889
GSE84922,GSE84924_0_v_1_sall4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_0_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_1_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Nfatc2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.7052
GSE87617_1_v_0_ascl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_4_v_8_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZBTB7A_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE158197_0_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	89.0493
D425	DepMap CRISPR Gene Dependency	1.0	6.76972
GSE239578_1_v_7_cxadr_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-BC-4073-01B-02R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_6_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WL46-2826-SM-3LK81	GTEx Tissue Sample Gene Expression Profiles	1.0	1.74997
BRD-K54660148	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.81962
GTEX-QEL4-1326-SM-447AD	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.934513
GTEX-R55D-1426-SM-48FEN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831329
endometrium_8b	HPA Tissue Sample Gene Expression Profiles	1.0	2.31712
BRD-K44227013_ponatinib_HA1E_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4721	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.7397
Tazarotene1	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
H3K27ac_osteoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
VZ in midlateral extrastriate cortex (area 19)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.960967
MOLT-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LIM1215	COSMIC Cell Line Gene Mutation Profiles	1.0	null
FOXO6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.3386
H3K4me3_SK-N-MC_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE70935_1_v_5_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
acacetin-6044	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
H3K4me3_cardiac muscle cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
ML-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.39925
abnormality of brain morphology	GWASdb SNP-Phenotype Associations	1.0	0.169142
shsy5y	HPA Cell Line Gene Expression Profiles	1.0	0.88982
harmol-2900	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HEC-1-A	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.857967
BT-474	COSMIC Cell Line Gene Mutation Profiles	1.0	null
KNS-62	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16652
H3K4me3_MCF-7_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2M7-06A-11R-A18U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K14070721	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	4.20111
SKMG1	DepMap CRISPR Gene Dependency	1.0	5.24212
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-A8LB-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-Q2AI-0006-SM-2I3FG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.07048
HCC1162	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.18372
intracellular part	LOCATE Curated Protein Localization Annotations	1.0	null
GTEX-WOFM-1326-SM-3MJFR	GTEx Tissue Sample Gene Expression Profiles	1.0	0.924288
Pancreatic adenocarcinoma_PAAD_TCGA-IB-7893-01A-11R-2204-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
COLO 699	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.00288
GSE166315_5_v_4_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
ELAVL1	Pathway Commons Protein-Protein Interactions	1.0	null
CRTAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.005301
GSE210655_3_v_0_cisplatin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K79me2_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-OHPK-2026-SM-3MJH7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.866336
primary auditory cortex (core)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.85827
GTEX-WHSB-0005-SM-3LK7C	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59731
GSE57871_5_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_Adipose Derived Mesenchymal Stem Cell Cultured Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
HCC1395	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.13404
CEBPB	ENCODE Transcription Factor Targets	1.0	null
GTEX-UJMC-0005-SM-3GACU	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.3916
FXYD2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00762859
BRD-K81418486_vorinostat_EFO27_6.0_h_11.1_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K28347985	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04334
hydroxyamphetamine	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.80627
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4814-01A-01R-1277-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
abnormality of the cardiovascular system	GWASdb SNP-Phenotype Associations	1.0	0.155624
cell	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
DOV13	DepMap CRISPR Gene Dependency	1.0	4.30339
hsa-miR-4526	TargetScan Predicted Conserved microRNA Targets	1.0	0.136254
Perturb_17328_KO_Dis3_SRP278122	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.31555
Kidney Chromophobe_KICH_TCGA-KN-8423-01A-11R-2315-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-Nearest_Ensembl_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
PML	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0072279
BRD-K12884811	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08314
gentamicin-2245	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K84800135	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.05128
GSE202434,GSE202438_7_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PCK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00614137
SARS-BatSRBD_24Hour_23935999_GSE47960	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.20208
alcuronium chloride-4409	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
guanfacine-5621	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCIMY7	CCLE Cell Line Gene CNV Profiles	1.0	1.39987
tonzonium bromide-6457	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC7346435-12864_2020_6860_MOESM6_ESM.xlsx-H1_ZF_Oocyte_Specific-GeneH_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
GSE144838_1_v_5_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me2_A549_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE129241_4_v_0_valproic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_fibroblast of lung_hg19_7	ENCODE Histone Modification Site Profiles	1.0	null
NCI-H2196	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	2.24289
FOXA2-19822575-HepG2-human	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE210662_3_v_1_znf165_human	RummaGEO Gene Perturbation Signatures	-1.0	null
KPL-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.18944
BRD-K83872468	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36901
Belumosudil (mesylate)_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0115826
BRD-K49419779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21207
abnormality of the gastrointestinal tract	GWASdb SNP-Phenotype Associations	1.0	0.096689
SU-DHL-4	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.19049
DPP9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05929
GSE216043_7_v_0_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A54389315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.01834
medioventral part of putamen	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.63645
8666_TAF5_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.1063
PMC12048643-44318_2025_409_MOESM3_ESM.xlsx-regulonTargets-TEAD2_TEAD2	Rummagene Transcription Factor Associations 2026	1.0	null
hsa-miR-17	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
GSE174701_1_v_6_maml3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12879	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08751
Embryo Loss	CTD Gene-Disease Associations	1.0	1.2013
GSE193258,GSE193259_5_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R55E-0006-SM-2TC5G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.947793
hsa-miR-25	TargetScan Predicted Conserved microRNA Targets	1.0	0.199275
H3K4me3_cardiac mesoderm_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
CHD2_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
CL14	CCLE Cell Line Gene CNV Profiles	-1.0	-1.76886
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6950-01A-11R-1915-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain_Germinal_Matrix	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	1.47966
Brain Lower Grade Glioma_LGG_TCGA-DH-A669-02A-11R-A31N-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
Perturb_14237_KO_Tet1_SRP237910	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-3.16375
GTEX-X4XX-0011-R11A-SM-46MWQ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.40472
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MS-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
18172295-SuppTable4	GeneSigDB Published Gene Signatures	1.0	null
BRD-A19037878_trichostatin A_VCAP_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE160373_6_v_4_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WRHU-1326-SM-4E3K7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.838916
Spinalcord	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.02662
GSE206516,GSE206518_2_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
496100494_HIP_no dementia_TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.05825
RGS14	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00563572
SG in midinferior temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.3878
posteroventral (inferior) parietal cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.76259
amiodarone-5618	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZR-75-30 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.906
MZ in rostral midinferior temporal cortex (area 36)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.11173
0317956-0000-3858	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K30467307	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.35017
FOXD1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.8
CRCGN011_HEPG2_24H:C23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.46495
PMC6151027-12864_2018_5080_MOESM3_ESM.xlsx-D1-D3_643_AR-DEGs-Symbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE226249_0_v_6_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DMS53	CCLE Cell Line Gene CNV Profiles	1.0	1.53855
thiamazole-4372	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
RAPGEF6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00620375
BRD-A81392774	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.55726
CR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00490125
GTEX-XBED-2526-SM-47JYD	GTEx Tissue Sample Gene Expression Profiles	1.0	0.994119
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_2_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
H2AFZ_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-P5-A5EX-01A-12R-A28M-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
BRD-K80972048	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.61872
TBK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00579945
BRD-K27638063	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43332
BRD-K69528787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27406
GTEX-WYVS-0006-SM-3NMA7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.969839
BRD-K80782159	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11748
Respiratory system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.215
trichostatin A-1891	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158834_1_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7925-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE240027,GSE240030_1_v_4_atrx_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-HB-A3YV-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HW-8322-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Fetalbrain	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.3671
BRD-K89923892	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.70019
DAUDI	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE230573_1_v_0_dcaf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE130396_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
fulvestrant-7490	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
DLG2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00537159
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-6873-01A-11R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1406
H3K27ac_A549_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive gland	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
CTCF_choroid plexus epithelial cell_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE167886_2_v_0_chd7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HS 695T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.49584
Leukemia	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.098
CRCGN017_MCF10A.WT.HP_24H:N09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.5425
GSE178227_1_v_0_tet1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE111247_0_v_8_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
AD-66-NV75_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.284439
H2AFZ_osteoblast_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ERBB3_drugactivation_31_GDS4361	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.19763
BRD-K57184137	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.8015
dorsal subdivision of VLC	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.16662
GSE128730_0_v_2_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
colitis	GWASdb SNP-Phenotype Associations	1.0	0.390642
dorsorostral division of MFC (area 32)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.58714
regulation of biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE205070_1_v_4_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.03449
POLR2A_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE186647,GSE217288_2_v_4_hnrnpc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MM77	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4689
POLR2AphosphoS5_HCT116_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-4741-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
USF1_ECC-1_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cation binding	GO Molecular Function Annotations 2015	1.0	null
Body Height	DisGeNET Gene-Phenotype Associations	1.0	null
CRCGN008_HEPG2_24H:H15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.4545
GSE227592_4_v_1_adar_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE147876,GSE147877_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
HMV-II	COSMIC Cell Line Gene Mutation Profiles	1.0	null
COV434	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2003
Lung adenocarcinoma_LUAD_TCGA-55-A494-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC8948659-ADVS-9-2104491-s013.xlsx-Sheet1-Supplemental_Table_9_related_to_Figure_7_Differential_genes_highly_correlated_with_TP53_deletion_in_H929_cells_by_RNA-seq_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.1821
ONS76	DepMap CRISPR Gene Dependency	1.0	2.53644
H3K4me2_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Prostate-luminal cell of prostate epithelium	Tabula Sapiens Gene-Cell Associations	1.0	9.87064
SMKR1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00654988
CREG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29784
A3/KAW	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.89867
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.8324
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE213588_10_v_6_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ZNF143_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE104508_0_v_3_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K03624299	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.99435
dihydroergocristine-2895	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC12323057-13148_2025_1945_MOESM2_ESM.xlsx-17-Supplementary_Table_17_Overview_of_number_of_targets_genes_shared_with_THRB_THRB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE94849_6_v_4_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K56ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-A5GH-01A-11R-A27Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PYM1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16214
membrane-bounded organelle	GO Cellular Component Annotations 2015	1.0	null
CXCR5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00517484
GYPB	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00929231
BRD-K26127722	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.143
GSE147662_3_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
parthenolide-2885	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7611-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
streptozocin-6098	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE48812_2_v_1_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-XXEK-0005-SM-4BRWJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.66656
FOXA2_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
SJRH30	COSMIC Cell Line Gene Mutation Profiles	1.0	null
LIVF001-007	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27039
BRD-K66541877	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.13865
ZM 336372	DeepCoverMOA Drug Mechanisms of Action	1.0	0.29
Sarcoma_SARC_TCGA-MO-A47R-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K36736230	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14794
GSE142210_9_v_6_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE231720,GSE231724_3_v_0_setd2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
FADU	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.61956
HNF4	MotifMap Predicted Transcription Factor Targets	1.0	null
HOXC12	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.696
A549_G007-LK_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0181788
CRCGN017_MCF10A.WT.HP_24H:O14	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.4124
A549_ITSA-1_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0154884
19204204-SupplementaryTable9	GeneSigDB Published Gene Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.829865
SU-DHL-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K79me2_HeLa-S3_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
MOLM-16	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.09776
lateral mammillary nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.48397
TAF7_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
locus ceruleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.20625
ARHGEF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10198
tinidazole-3430	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7616
GTEX-S7SE-2526-SM-2XCDL	GTEx Tissue Sample Gene Expression Profiles	1.0	2.07515
NR2C1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2431
GSE157777_2_v_3_foxa3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
decreased mean corpuscular volume	IMPC Knockout Mouse Phenotypes	1.0	null
nucleus	GO Cellular Component Annotations 2015	1.0	null
LK2	DepMap CRISPR Gene Dependency	1.0	2.10753
dorsolateral prefrontal cortex_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.42136
progesterone-3287	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Adult_Liver	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.870145
nucleobase-containing compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
B cell_Kidney_Human	CellMarker Gene-Cell Type Associations	1.0	null
HCC38	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.851853
GSE155567_1_v_0_cd33_human	RummaGEO Gene Perturbation Signatures	-1.0	null
cellular nitrogen compound biosynthetic process	GO Biological Process Annotations 2015	1.0	null
GSE147366_1_v_4_med13_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE77108_6_v_2_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
Uterine Carcinosarcoma_UCS_TCGA-NA-A5I1-01A-21R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE234340_1_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE112762,GSE112767_2_v_0_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.4444
inferolateral temporal cortex (area TEv, area 20)_11 yrs_F_12289	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.25502
ventrolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.52006
GSE255432_6_v_0_imeglimin_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Perturb_4407_KD_DDX3X_SRP299259	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	20.0
Sox17	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	21.2997
ESR1	ENCODE Transcription Factor Targets	1.0	null
hsa-miR-3198	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.921135
BRD-K08036779	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.55733
PMC9894241-pnas.2211429119.sd05.xlsx-G6_REST-Dataset_S6_Differentially_expressed_genes_in_G1-G8_REST	Rummagene Transcription Factor Associations 2026	1.0	null
GSE179002_3_v_8_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_AG-490_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0163727
PMC12518476-10067_2025_7574_MOESM8_ESM.xlsx-Sheet1-Down_regulated_DEGs_of_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Tobacco Use Disorder	HuGE Navigator Gene-Phenotype Associations	1.0	null
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.6421
hsa-miR-4789-5p	TargetScan Predicted Conserved microRNA Targets	1.0	0.454769
brain	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K69035249	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.19487
G130	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.864792
GTEX-P78B-1326-SM-3P611	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.03583
HDQP1_BREAST	CCLE Cell Line Proteomics	1.0	4.77126
GSE69869_0_v_1_panobinostat_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.WT.HP_24H:P20	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03398
LNCAP-CLONE-FGC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_fibroblast of pedal digit skin_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
G112	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.47084
GSE147662_0_v_1_nicotinamide_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
Musculoskeletal system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.176
GSE94849_1_v_5_pinometostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
Sarcoma_SARC_TCGA-X6-A8C7-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE221327_10_v_11_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Nr2f6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	50.7798
BRD-K96101240	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.18908
GSE193993_1_v_7_sstr2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
USF1_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE242199_9_v_5_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CALU1_LUNG	CCLE Cell Line Proteomics	1.0	2.38562
NCI-H1793	COSMIC Cell Line Gene Mutation Profiles	1.0	null
HA-E2F1_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-TSE9-2926-SM-3DB77	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57107
GTEX-T2IS-2026-SM-4DM6W	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03471
terconazole-4407	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-PWO3-0005-SM-2I5FS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.51564
HCC1143	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.11374
SMAD3-30307970-HCASMC-HUMAN-CORONARYARTERY	ChEA Transcription Factor Targets 2022	1.0	null
Microglial cell_Brain_Human	CellMarker Gene-Cell Type Associations	1.0	null
cerebellar cortex_21 pcw_M_12886	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.50064
GSE123002_0_v_1_srsf3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
primary somatosensory cortex (area S1, areas 3,1,2)_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.55784
GTEX-OHPL-2026-SM-3TW8R	GTEx Tissue Sample Gene Expression Profiles	1.0	0.830783
GSE148692,GSE148695_2_v_0_satb2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IZ in caudal midinferior temporal cortex (area TF)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.25945
H3K4me3_fibroblast of the aortic adventitia_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K25933460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.15335
GSE112760,GSE112767_1_v_5_ddx6_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
rifabutin-4527	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
valproic acid-5574	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Rucaparib_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0124456
organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
PMC8554124-DataSheet2.XLSX-57-CEBPD_CEBPD	Rummagene Transcription Factor Associations 2026	1.0	null
GSE198165,GSE198166_8_v_10_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K05096562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.03575
SHSYSY-RA	BioGPS Cell Line Gene Expression Profiles	1.0	1.22853
PBXIP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00523544
MC-IXC	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE242083,GSE242098_2_v_5_med1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S341-0006-SM-3NM8D	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.36221
BRCA1	ENCODE Transcription Factor Targets	1.0	null
STS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0051937
BRD-K02759046	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63314
ZNF367	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00621123
GSE140074_1_v_0_kif20a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE139455_4_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
antimycin A-5472	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
abnormality of the genitourinary system	GWASdb SNP-Phenotype Associations	1.0	0.073397
60min_BMP4 vs ctrl_hESC (Human) [19664995]	SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands	-1.0	null
SKMM2	CCLE Cell Line Gene CNV Profiles	1.0	2.62685
Gonad	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
KCL-22	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MSANTD4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14351
GTEX-SSA3-0526-SM-32QPL	GTEx Tissue Sample Gene Expression Profiles	1.0	1.21547
GSE224311_3_v_2_chaetocin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
occipital pole, left, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02844
HSC3	CCLE Cell Line Gene CNV Profiles	-1.0	-1.45039
Super elongation complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.929
C32TG	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.87922
carboplatin	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.28706
Perturb_796_KO_Tnfaip3_SRP332632	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-19.699
fulvestrant-985	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
EZH2	ENCODE Transcription Factor Targets	1.0	null
BRD-K02066524	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22885
H3K4me3_mammary epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-XOTO-0326-SM-4B66K	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20957
PLEC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.58435
GSE127205_1_v_0_asf1a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
METAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.10897
BRSK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555434
IGROV-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GTEX-VUSG-0526-SM-4KL22	GTEx Tissue Sample Gene Expression Profiles	1.0	1.01888
SMPD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522312
superior occipital gyrus, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.31482
BRD-K84924563_6-diazo-5-oxo-l-norleucine_DV90_6.0_h_40.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
propafenone-2871	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MDA-MB-330	COSMIC Cell Line Gene CNV Profiles	-1.0	-3.29865
Perturb_6087_KD_XRN2_SRP271175	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-4.96048
HEATR9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00442275
GSE225869_2_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Prostate adenocarcinoma_PRAD_TCGA-M7-A720-01A-12R-A32O-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-EJ-7327-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PTGS1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00438061
nalbuphine-2225	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7103-01A-21R-2016-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
SOX4	MotifMap Predicted Transcription Factor Targets	1.0	null
17910759-TableS5	GeneSigDB Published Gene Signatures	1.0	null
NB17	DepMap CRISPR Gene Dependency	1.0	5.64402
GSE96649_1_v_2_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XXEK-1126-SM-4BRUX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.833531
GSE226249_0_v_1_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-N7MT-0007-SM-3GACQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.962423
BL555 (TRIM28)	NURSA Protein Complexes	1.0	null
BRD-K53257131	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18756
hsa-miR-300	TargetScan Predicted Conserved microRNA Targets	1.0	0.389112
external granular (germinal) layer of upper rhombic lip	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.837925
Kidney renal clear cell carcinoma_KIRC_TCGA-CZ-5465-01A-01R-1503-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
iodixanol-3362	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE158834_12_v_4_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
sulfacetamide-1695	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PCLAF	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.01887
GTEX-QVJO-0006-SM-2S1RC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.83832
GSE174498,GSE174500_2_v_1_asparaginase_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K9ac_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
calcium folinate-3442	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
USF2	ENCODE Transcription Factor Targets	1.0	null
BRD-K56041932	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.14291
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A498-01A-11R-A24H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MAX_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
COR-L279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.00905
GSE228894_0_v_1_rnmt_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27me3_CD8 Memory Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-SIU7-0001-SM-3NMAW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894539
17616640-TableS3	GeneSigDB Published Gene Signatures	1.0	null
8661_TAF1_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	2.33149
EW-18	GDSC Cell Line Gene Expression Profiles	1.0	1.53955
GSE158834_2_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
mexiletine-3862	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE206984_1_v_0_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ITPR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96556
Hypothalamus	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	0.880228
BRD-K22503835_Scriptaid_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-43-6143-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE239844_11_v_2_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
head	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
FXR	MotifMap Predicted Transcription Factor Targets	1.0	null
FOXA2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.5197
SU.86.86	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.68424
DDAH2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0079847
animal	TISSUES Text-mining Tissue Protein Expression Evidence Scores	1.0	0.049844
CRCGN016_MCF10A.TP53.M_24H:M09	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.41335
cromoglicic acid-3475	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-4438	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
HDAC2	ENCODE Transcription Factor Targets	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A3EV-06A-11R-A20F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC7265345-41598_2020_65638_MOESM5_ESM.xlsx-3_E2F2-Gene_E2F2	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-2A-A8VL-01A-21R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_B cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE196117_6_v_0_clarithromycin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-OHPL-0006-SM-3MJHB	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.64831
JEG-3	GDSC Cell Line Gene Expression Profiles	-1.0	-2.22039
animal	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GTEX-XUJ4-0004-SM-4BOQE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.978307
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-PLZ6-1626-SM-3NB23	GTEx Tissue Sample Gene Expression Profiles	1.0	0.878955
GSE100316_0_v_6_mtor_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
USF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GR79236	DeepCoverMOA Drug Mechanisms of Action	1.0	0.95
GTEX-W5X1-0001-SM-3P61V	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.965122
H3K4me3_Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
icSARS CoV_36Hour_23365422_GSE33267	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	0.66431
GTEX-WHSE-0011-R11A-SM-3P5YY	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03994
hsa-miR-4731-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.159923
MAFK_HepG2_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-A75409952_wortmannin_MDST8_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE131161_2_v_6_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
EE-03-SG02_1uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.214301
VZ in caudal subicular cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.21735
CACHD1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00500239
tolbutamide-4362	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
appendix	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
BRD-K16526787	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11335
PHF8_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
cellular_component	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-PLZ5-0426-SM-3P612	GTEx Tissue Sample Gene Expression Profiles	1.0	1.30673
Eccrine sweat gland cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.428
BSX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3011
pentoxyverine-4649	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-77-8145-01A-11R-2247-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE160083,GSE160084_1_v_3_tamoxifen_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
253J-BV cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.952
A549_AMG-900_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0131578
GSE147959,GSE147960_5_v_3_stat1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
nitrogen compound metabolic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-146a	TargetScan Predicted Conserved microRNA Targets	1.0	0.226173
GSE191015_0_v_3_gsdmb_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QGP-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.859535
GSE166536_0_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE246184,GSE246195_0_v_1_sin3a_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QDVJ-0005-SM-2TC5X	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.01064
IGFBP5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00752975
NCIH1385	CCLE Cell Line Gene CNV Profiles	1.0	1.32898
cytoplasm	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
astrocytes	BioGPS Cell Line Gene Expression Profiles	1.0	1.5047
GTEX-POYW-0426-SM-2XCEV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.826461
GSE117212,GSE117214_0_v_1_zbtb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ROS50	DepMap CRISPR Gene Dependency	1.0	4.85667
GSE215086_4_v_7_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
T84	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.31185
SIG-M5	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.01349
GTEX-VUSH-0005-SM-3NB2H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.59877
EC-62-OE64_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.219856
FLI1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
H3K4me1_CD4+ CD25- Th Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213588_10_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF7	ENCODE Transcription Factor Targets	1.0	null
19096012-TableS5	GeneSigDB Published Gene Signatures	1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-A3-3367-01A-02R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Kidney renal papillary cell carcinoma_KIRP_TCGA-G7-6797-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K58149231	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.83991
IZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.965535
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.13612
GTEX-X5EB-1826-SM-4E3K8	GTEx Tissue Sample Gene Expression Profiles	1.0	2.71617
PMC3728595-srep02327-s1.pdf-15-ZNF527_ZNF527	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A20256229	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.70129
trichostatin A-6886	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_Cyclocytidine HCl_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0143624
BRD-K59930979	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.22653
BRD-A97270959	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.26856
BBLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.0432
GTEX-S33H-0005-SM-2XCAL	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15927
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-4837-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-0006-SM-2XCFE	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.23822
Recycling endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.85
PMC12179407-MCO2-6-e70261-s004.xlsx-up_TET3-KO_PQ_vs_Cas9_PQ-Unnamed_10_TET3	Rummagene Transcription Factor Associations 2026	1.0	null
ATP6V0E1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.00597
OlfactoryBulb	BioGPS Human Cell Type and Tissue Gene Expression Profiles	1.0	1.78556
EZH2_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE175787_4_v_7_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K98510376	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58307
Cobimetinib_SW 1088	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0249622
RUNX1	ChEA Transcription Factor Targets	1.0	null
GSE76425_0_v_5_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
duodenum_4c	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.839686
GTEX-S3XE-0526-SM-4AD4G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.865186
GSE120612_6_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
LY 487379	DeepCoverMOA Drug Mechanisms of Action	1.0	0.49
H3K4me3_retinal pigment epithelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K64055457	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06657
CRCGN011_HEPG2_24H:L12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.9521
H3K4me3_HEK293_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
hsa-miR-4475	TargetScan Predicted Conserved microRNA Targets	1.0	0.140752
CTCF_GM10248_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
liver_d	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.22917
BRD-K87901124	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86224
GSE207914_2_v_6_nudt7_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
COLO 678	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01588
CIC-rearranged sarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.476
16273092-TableS1e	GeneSigDB Published Gene Signatures	1.0	null
GTEX-V955-0005-SM-3P5ZC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.5463
JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.1889
BARX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.8383
GSE219103,GSE219104_0_v_1_progesterone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
Other source	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.5
Gastrointestinal system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.121
Reproductive system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE205070_1_v_6_mertk_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
RPMI 8226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.29548
A549_Avagacestat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0148048
GTEX-XMK1-2426-SM-4B66I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19175
Fetal_Brain_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.841467
GTEX-OXRL-1826-SM-2YUMV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.989527
H3K4me1_CD4+ CD25- IL17+ PMA-Ionomcyin stimulated Th17 Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GTEX-R53T-0326-SM-48FEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17296
A549_Quisinostat_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00947127
BRD-A20305532	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.36799
GSE114284_2_v_0_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K60127720	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49663
ampyrone-6845	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
chlorpropamide-5391	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-UJHI-0006-SM-3DB8H	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.981215
GSE130715_1_v_3_budesonide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A97N-01A-11R-A38B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE114992,GSE114993_0_v_3_irf5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE198165,GSE198166_9_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Prostate adenocarcinoma_PRAD_TCGA-HC-7819-11A-01R-2118-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-324-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
serotonin-3311	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
MAFA	MotifMap Predicted Transcription Factor Targets	1.0	null
GSE239844_11_v_9_crizotinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
SW 403	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.865884
GSE140997_4_v_6_nsun6_human	RummaGEO Gene Perturbation Signatures	1.0	null
dorsolateral prefrontal cortex_26 pcw_F_12949	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.989166
GSE135030_3_v_1_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
nucleus	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
GTEX-OIZF-0006-SM-2I5GQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.05331
CDCA3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.39502
A549_Resminostat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0123575
H3K4me3_GM12878_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
A549_JNJ-7706621_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0146707
GSE133764_2_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-QESD-0006-SM-2I5G6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.31105
GTEX-NPJ8-0526-SM-3MJHN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.53297
GSE210101,GSE210114_4_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193258,GSE193259_9_v_15_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE152432_6_v_4_zrsr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.899504
GTEX-TMZS-0006-SM-3DB8G	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09302
H3K4me1_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K80198069	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.05022
BRD-K85357344	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.17021
trichostatin A-1951	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SDS	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00583688
GSE208141,GSE208142_2_v_3_cocaine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-X5EB-0006-SM-46MV5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.34076
GSE144838_1_v_8_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
IV, right, paravermis	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.28753
GSE123861_1_v_0_sin3a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BE-13	GDSC Cell Line Gene Expression Profiles	-1.0	-1.4574
Perturb_15492_KD_MYC_SRP279303	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	11.6891
GPR141	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00548899
NTERA-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.9953
PMC4196925-pone.0109760.s005.xlsx-Supp_Table_1_Genes_in_immune_mo-IRF8_mod_IRF8	Rummagene Transcription Factor Associations 2026	1.0	null
GSE77108_6_v_9_saha_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-R45C-0006-SM-3GAD6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.14004
GSE158834_1_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SP in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.885693
GSE57871_11_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Lower respiratory tract disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.047
PMM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.0056432
TASK1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
NB17	GDSC Cell Line Gene Expression Profiles	1.0	1.44031
frontal pole, right, superior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.833314
RBX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29954
central gray of the pons, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.27645
Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EH-01A-11R-A36F-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K70511574_sunitinib_MCF7_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PMC9160255-41467_2022_30710_MOESM4_ESM.xlsx-AR_specific_regulated_genes-SYMBOL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
3-CPMT	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.34796
Perturb_16403_KO_Grpel1_SRP363877	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-9.41457
lateral habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.82218
CRCGN010_HEPG2_24H:G15	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39996
BRD-K18562194	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1641
POU2F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	67.0459
BRD-K17743125_belinostat_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_4971_KD_Mthfd2_SRP149554	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-7.11307
Brain Lower Grade Glioma_LGG_TCGA-DU-8164-01A-11R-2256-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
B4GALT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16184
anterior (rostral) cingulate (medial prefrontal) cortex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-2.03244
mood disorder	GWASdb SNP-Disease Associations	1.0	0.321468
MAX_A549_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE120612_4_v_5_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-DAY1_SOX17_peaks-Gene_Name_SOX17	Rummagene Transcription Factor Associations 2026	1.0	null
GSE150895,GSE150896_0_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-SNOS-0926-SM-4DM7A	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.831388
BRD-K95666495	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.18884
BRD-K83994491	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.21545
PMC9038526-mmc1.xlsx-postCOVID_LPS_vs_healthy_L-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
diltiazem-1532	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
A549_JQ1_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0133855
cingulate gyrus, retrosplenial part, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.835862
BRD-M16762496_S1205_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
telencephalon	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
pepstatin-3264	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50053371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57325
H3K4me3_HeLa-S3_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
15220918-TableS1a	GeneSigDB Published Gene Signatures	1.0	null
SUPHD1	CCLE Cell Line Gene CNV Profiles	1.0	1.78412
TC-32 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.888
GTEX-RUSQ-0326-SM-47JWS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2386
BRD-K85853281_-666_HEPG2_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Lung adenocarcinoma_LUAD_TCGA-62-8399-01A-21R-2326-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K98474331	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.66559
PMC12640707-NIHMS2124006-supplement-Supplemental_tables.xlsx-Supplemental_Table_S5-Supplemental_Table_S5_Genes_commonly_downregulated_in_both_clones_of_ZFX-depleted_HEK293T_cells_in_Ni_et_al_2020_ZFX	Rummagene Transcription Factor Associations 2026	1.0	null
golgi apparatus	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
CRCGN008_HEPG2_24H:I19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2792
ncoa_22072566_ly2_lof_human_gpl570_gds4095	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.014784
STAT3	MotifMap Predicted Transcription Factor Targets	1.0	null
PHOX2A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.24729
BRD-K91564773	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5333
urogenital system	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K68202742_trichostatin A_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A549_TGX-221_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0206507
CTCF_SK-N-SH_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lateral ganglionic eminence_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.49501
POLR2A_A549_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
H3K4me3_retinal pigment epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-RU72-2926-SM-2TF66	GTEx Tissue Sample Gene Expression Profiles	1.0	1.25146
paracentral lobule, posterior part, left, bank of cingulate sulcus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.26884
GSE246053_4_v_3_hnf4a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PANX2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00492236
GSE165682_0_v_1_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
NXPE3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.83482
A549_ITSA-1_10nM_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0141694
occipital neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.93614
parathyroid gland	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
GTEX-SE5C-0006-SM-4BRW5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.56653
GSE184399_0_v_3_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
OPM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.836333
BRD-K48325920	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12055
ACHN	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58455
GTEX-WK11-0006-SM-3NB3J	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09304
GTEX-Q2AG-0011-R11A-SM-2HMKZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.65447
SKM-1	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71438
hsa-miR-4255	TargetScan Predicted Conserved microRNA Targets	1.0	0.103424
gland	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
A549_Zileuton_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0177558
GTEX-T5JC-0011-R11A-SM-32PMB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.96549
A549_Meprednisone_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0142673
broxyquinoline	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0624
PMC9170821-JCMM-26-3183-s001.xlsx-Astro_DAPI_ERG_VaDadj_vs_NC-Gene_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Ellagic acid_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0134241
PAX5	ENCODE Transcription Factor Targets	1.0	null
GSE103068_0_v_7_volasertib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CRCGN015_MCF10A.TP53.M_24H:E24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.56945
PMC2866657-pone.0010547.s003.xls-ESE3_corr-Genes_correlated_anticorrelated_to_ESE3_EHF	Rummagene Transcription Factor Associations 2026	1.0	null
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9253
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Nurr1_modulation_mediates_neuroprotective_effects_of_statins_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
Laryngeal squamous cell carcinoma cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.212
NOLC1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00386779
NCIH747	CCLE Cell Line Gene CNV Profiles	-1.0	-1.7149
NCI-H2461	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.04889
LMO1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00522417
PMC10785552-13059_2023_3149_MOESM7_ESM.xlsx-RNAseq_HOXA9_rescue-Table_S6_The_DEGs_in_in_RBM5_KO_cells_with_HOXA9_overexpression_relative_to_RBM5_KO_control_HOXA9	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-UPK5-1426-SM-4JBHH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.97189
BRD-A07952294	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.72293
COLO680N	CCLE Cell Line Gene CNV Profiles	-1.0	-1.84027
solasodine-3924	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
chlorhexidine-1942	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
trichostatin A-4458	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-4304	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE213588_9_v_1_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CTCF_GM19239_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
functional abnormality of the gastrointestinal tract	GWASdb SNP-Phenotype Associations	1.0	0.225295
P53-21459846-SAOS-2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE158834_1_v_5_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE190235_0_v_2_foxo3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of cellular process	GO Biological Process Annotations 2015	1.0	null
GSE234340_10_v_2_muc2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-U00779237_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K98374711	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.06969
PMC8384902-mmc5.xlsx-H128_ASCL1_ChIP-Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
trichostatin A-4302	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Neuroendocrine carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.025
H3K4me2_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
CRCGN012_HEPG2_24H:C19	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.07065
PMC7498599-41467_2020_18508_MOESM11_ESM.xlsx-ICM_JUN-Unnamed_3_JUN	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227891_5_v_3_ethanol_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
inner SZ in ventromedial extrastriate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.86429
HCC1954	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K4me3_HEK293_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Perturb_4829_KD_Rrp40_SRP150410	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.82208
epididymis	HPA Tissue Protein Expression Profiles	1.0	0.950484
BRD-K35442564	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.23238
GSE210101,GSE210114_2_v_10_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC2820592-NIHMS144142-supplement-8.xls-LMS_SAM_2-GENES_HIGHLY_EXPRESSED_IN_GROUP_II_LMS_TP63	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-PLZ4-0006-SM-2S1NY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00207
GSE182179_0_v_1_kdsr_human	RummaGEO Gene Perturbation Signatures	1.0	null
dentate gyrus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.54575
primary somatosensory cortex (area S1, areas 3,1,2)_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.53586
GSE57871_11_v_9_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE128730_3_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE139975_3_v_0_rnf2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE202434,GSE202438_10_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
MWP complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.694
GTEX-WVLH-0006-SM-3MJF7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18308
HCC1599	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	1.0	1.27704
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A3MA-01A-11R-A213-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K31034311	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.04992
BRD-K40367360	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58619
GSE196104,GSE196106_3_v_1_vsx2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-RWS6-2426-SM-2XCB9	GTEx Tissue Sample Gene Expression Profiles	1.0	0.835137
GTEX-X638-0426-SM-47JY2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.04679
BRD-K97410356	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.27521
BRD-A31962514	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73001
PAN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03212
PMC10703699-41588_2023_1554_MOESM3_ESM.xlsx-T6D_mageckTFkoscreen_with_BATF3-gene_BATF3	Rummagene Transcription Factor Associations 2026	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.0199
GSE166315_1_v_0_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_PHA-680632_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0160045
hsa-miR-618	TargetScan Predicted Conserved microRNA Targets	1.0	1.45615
NB-4	COSMIC Cell Line Gene Mutation Profiles	1.0	null
ISTMEL1	DepMap CRISPR Gene Dependency	1.0	2.2949
paracentral lobule, anterior part, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.02088
BRD-K81418486_vorinostat_PC3_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE197555_0_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-A71001587	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.51034
FOXS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.6658
SK-MM-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.69041
TAF1	ENCODE Transcription Factor Targets	1.0	null
BRD-K23960050	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41756
Intestinal cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.038
GTEX-S95S-1026-SM-4B64M	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2854
GSE184087_0_v_1_tert_human	RummaGEO Gene Perturbation Signatures	1.0	null
intracellular part	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
Dhori Virus_24Hour_20090954_GSE17400	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.87507
SBC-3	Sanger Dependency Map Cancer Cell Line Proteomics	1.0	2.62448
BRD-A61522392	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.90482
PMC8755441-mmc3.xlsx-IRF1-UP-Symbol_IRF1	Rummagene Transcription Factor Associations 2026	1.0	null
liver	GTEx Tissue Gene Expression Profiles	-1.0	-1.2014
PMC3644282-1471-2164-14-110-S3.xls-Contextual_Gene_Set_TCGA-GBM-TFAP2C_TFAP2C	Rummagene Transcription Factor Associations 2026	1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EE-A20H-06A-11R-A18S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
striatum_16 pcw_M_12287	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.43565
Reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.194
abnormality of the abdomen	GWASdb SNP-Phenotype Associations	1.0	0.056707
MK 886	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
Gata3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	23.2036
K-562	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.75211
cervical carcinoma cell	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
levcycloserine-4346	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-XV7Q-0005-SM-4BRWI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973001
DHRS7B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.3048
BL5990 (ZNF592)	NURSA Protein Complexes	1.0	null
PDE7A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00542024
benzamil-6056	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE207611,GSE207612_0_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-XQ8I-1926-SM-4BOOK	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.894391
GSE215351,GSE215794_2_v_3_kdm8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Perturb_18557_KD_miR466c_SRP319883	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	2.81088
BRD-K04968881	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.10587
GSE214212_2_v_0_chd6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K03884263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.10847
GTEX-QVUS-2926-SM-3GIJB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.51793
Skin Cutaneous Melanoma_SKCM_TCGA-ER-A19T-01A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE112763,GSE112767_4_v_5_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
HEL	DepMap CRISPR Gene Dependency	1.0	3.12027
GSE210101,GSE210114_7_v_10_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE215086_0_v_2_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ZNF532	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38606
GTEX-O5YV-0626-SM-3LK64	GTEx Tissue Sample Gene Expression Profiles	1.0	1.14509
vagina	HPA Tissue Protein Expression Profiles	1.0	0.950484
GSE95077_5_v_3_amiloride_human	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN017_MCF10A.WT.HP_24H:O21	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.28995
mammillary body, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.09106
H2BK120ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE167474_2_v_0_naa40_human	RummaGEO Gene Perturbation Signatures	-1.0	null
rostral division of VL	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.01941
RKO	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.53031
H3K4me3_NT2-D1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Selinexor _LOX-IMVI	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.00598508
Dabigatran	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.41
RBBP5_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
A549_Pracinostat_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0139418
hsa-miR-101	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
HCC56	CCLE Cell Line Gene CNV Profiles	-1.0	-1.33387
Sarcoma_SARC_TCGA-HB-A43Z-01A-11R-A24X-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE208634_1_v_0_doxycycline_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE74251_0_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
POLR2A_A549_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
intracellular part	LOCATE Predicted Protein Localization Annotations	1.0	null
A549_AT9283_10然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0110099
JUN	ChEA Transcription Factor Targets	1.0	null
MXI1	ENCODE Transcription Factor Targets	1.0	null
malformation of the heart and great vessels	GWASdb SNP-Phenotype Associations	1.0	0.165903
EP300	ENCODE Transcription Factor Targets	1.0	null
GTEX-WFON-1726-SM-4LVMQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.92713
PMC11192681-11033_2024_9703_MOESM1_ESM.xlsx-ZFP_genes_expression_vs_methyla-Relationship_between_C2H2-ZNF_gene_expression_and_DNA_methylation_ZKSCAN7	Rummagene Transcription Factor Associations 2026	1.0	null
gata3_21892208_mda_mb_231_gof_human_gpl570_gds4080	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	-1.0	-0.014374
endometrium	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
GSE193258,GSE193259_9_v_0_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ESR1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.0727
IGROV1	BioGPS Cell Line Gene Expression Profiles	1.0	1.08888
H3K4me3_B cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Lung adenocarcinoma_LUAD_TCGA-69-7978-01A-11R-2187-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE223241_2_v_0_cdkn2a_human	RummaGEO Gene Perturbation Signatures	-1.0	null
methocarbamol-2274	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
LN464	DepMap CRISPR Gene Dependency	1.0	2.75202
GSE116810_2_v_0_selinexor_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Gland	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4803-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K97472167	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.41685
BRD-K86797399_pracinostat_A549_24_h_10_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
FOXA2-19822575-HEPG2-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE71468,GSE76476_0_v_1_rbfox1_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10592471-NIHMS1912771-supplement-7.xlsx-D-Enh_vs_AA-all_DE-Aza_atRA_DE_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OHPN-0011-R11A-SM-2I5FM	GTEx Tissue Sample Gene Expression Profiles	1.0	0.876533
MAP3K19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00480641
BRD-K57014223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.63211
GSE199606_3_v_0_ricin_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE135030_3_v_0_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
heart disease	GWASdb SNP-Disease Associations	1.0	0.197541
Bladder Urothelial Carcinoma_BLCA_TCGA-GC-A3WC-01A-31R-A22U-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
POLR2A_MCF-7_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE142684_0_v_1_prdm16_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
PRAM1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00556261
Y-27632-832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE224096_1_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE77108_6_v_7_saha_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A03898562	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.16983
GSE211357_1_v_3_atg7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
azathioprine-5627	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CRCGN017_MCF10A.WT.HP_24H:N23	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.5493
hsa-miR-93	TargetScan Predicted Conserved microRNA Targets	1.0	0.714812
GSE65617_5_v_1_aire_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KIF20B	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35062
PMC10550934-41467_2023_41927_MOESM4_ESM.xlsx-degenes_beatAML_CEBPA-NT_Fig1c-Gene_Symbol_CEBPA	Rummagene Transcription Factor Associations 2026	1.0	null
SU-DHL-8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.897435
GSE138001_0_v_3_rorb_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152734,GSE152735_2_v_0_pbrm1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MOLP-8	COSMIC Cell Line Gene Mutation Profiles	1.0	null
POLR2A_HeLa-S3_hg19_4	ENCODE Transcription Factor Binding Site Profiles	1.0	null
NEDD9	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0046305
PTPRG	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.16668
ACHN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.893039
IM-9	GDSC Cell Line Gene Expression Profiles	-1.0	-1.58457
Belumosudil (mesylate)_CHP-212	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0143651
SOX10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6268
H3K4me3_fibroblast of lung_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE206729_3_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
piribedil-3512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-6488-01A-12R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Pheochromocytoma and Paraganglioma_PCPG_TCGA-SR-A6MX-06A-11R-A35L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
GSE126402_2_v_0_tal1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
19204204-SupplementaryTable5	GeneSigDB Published Gene Signatures	1.0	null
GSE116930,GSE116935_1_v_6_hes7_human	RummaGEO Gene Perturbation Signatures	1.0	null
Pramipexole	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
GSE158834_12_v_13_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-497	TargetScan Predicted Conserved microRNA Targets	1.0	0.181316
CA7	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00635912
NRF1_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-HT-7879-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A549_Cyclocytidine HCl_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0151104
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2899-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me1_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
Mobilized_CD34_Primary_Cells_Female	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	-1.0	-0.87993
GSE158458_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRMT5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00525505
GTEX-X15G-0005-SM-3NMDA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.02221
racecadotril-2774	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-SUCS-0006-SM-4DM59	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.81506
Acute Myeloid Leukemia_LAML_TCGA-AB-2866-03A-01T-0736-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC-56	COSMIC Cell Line Gene Mutation Profiles	1.0	null
central nucleus of inferior colliculus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.33541
dydrogesterone-2811	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K34318928	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.43057
OC-314	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Sox6	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	26.1205
conotruncal defect	GWASdb SNP-Phenotype Associations	1.0	0.572823
JUND_H1-hESC_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-XOTO-0826-SM-4B65O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923109
Perturb_11912_KD_Arntl2_SRP063609	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-5.28097
Lung adenocarcinoma_LUAD_TCGA-95-A4VN-01A-11R-A262-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
15489324-TableS2	GeneSigDB Published Gene Signatures	1.0	null
GSE235066_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Busulfan_1然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.014945
NANOG_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
15489886-TableS1b	GeneSigDB Published Gene Signatures	1.0	null
Liver hepatocellular carcinoma_LIHC_TCGA-DD-A1EH-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CRCGN015_HEPG2_48H:I06	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39564
GSE195663_7_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
occipital pole, left, inferior aspect	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.87962
H3K4me3_WERI-Rb-1_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
NCI-SNU-16	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE165682_0_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
TCF3_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
hsa-miR-1278	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
MINO	CCLE Cell Line Gene CNV Profiles	1.0	1.451
BRD-K13672060	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61857
GTEX-WZTO-0006-SM-3NM9T	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.09879
GTEX-WQUQ-0006-SM-3MJF4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.963863
MED15	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.21468
AN3-CA	GDSC Cell Line Gene Expression Profiles	1.0	1.59662
PMC10592471-NIHMS1912771-supplement-4.xlsx-D-HEp3_DN_NR2F1_ind_DN-D_HEP3_DN_NR2F1_Ind_DN_NR2F1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-S7SE-0011-R11A-SM-2XCDD	GTEx Tissue Sample Gene Expression Profiles	1.0	1.64427
DMS-53	COSMIC Cell Line Gene CNV Profiles	1.0	2.12703
SHISA8	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0402
tretinoin-849	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
UBC	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13957
Adrenocortical carcinoma_ACC_TCGA-OR-A5J2-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
A-VN-1203-2004(H5N1)_Day4-10^3pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	1.53718
altizide-6089	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE225869_3_v_0_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-V955-2626-SM-3NM9F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.898703
growth abnormality	GWASdb SNP-Phenotype Associations	1.0	0.477852
outer SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.05583
CCN2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00652395
GSE189859,GSE189861_1_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
bonemarrow_6a	HPA Tissue Sample Gene Expression Profiles	-1.0	-2.24535
GSE135030_11_v_5_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary auditory cortex (core)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.34088
GSE217694_4_v_0_pold1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXD11	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3198
GTEX-TKQ2-0426-SM-4DXUO	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.855948
BRD-A63590986	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.34108
BRD-K79555196	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.2926
anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.07596
MITF	ChEA Transcription Factor Targets	1.0	null
GTEX-Q2AH-2026-SM-2S1PX	GTEx Tissue Sample Gene Expression Profiles	1.0	1.03001
Lung squamous cell carcinoma_LUSC_TCGA-56-6545-01A-11R-1820-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Bladder Urothelial Carcinoma_BLCA_TCGA-DK-A1AB-01A-11R-A13Y-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
bonemarrow_5a	HPA Tissue Sample Gene Expression Profiles	-1.0	-1.48729
GSE140997_4_v_1_nsun6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-34-2600-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-XOTO-2826-SM-4B65I	GTEx Tissue Sample Gene Expression Profiles	1.0	1.94707
GTEX-PWO3-1026-SM-2I5F2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.15622
Disease of metabolism	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.007
hsa-miR-520e	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GTEX-X88G-0006-SM-47JX5	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.46823
Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A70R-01A-11R-A35K-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K83544408	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30182
CST6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00650659
H2AFZ	ENCODE Transcription Factor Targets	1.0	null
GSE178714_1_v_0_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE160001,GSE160670_0_v_2_lapatinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
RCC-FG2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
RCOR1	ENCODE Transcription Factor Targets	1.0	null
Glucose Intolerance	CTD Gene-Disease Associations	1.0	1.09892
P-TEFb complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.316
JSC-1	COSMIC Cell Line Gene Mutation Profiles	1.0	null
BRD-K02113016_AZD2281 (KU59436)_NCIH2073_6.0_h_44.4_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
SKMEL19	DepMap CRISPR Gene Dependency	1.0	2.32016
Kidney renal clear cell carcinoma_KIRC_TCGA-B0-5108-01A-01R-1420-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC4989457-13073_2016_339_MOESM3_ESM.xls-MITF-_SURVIVAL-hugo_id_MITF	Rummagene Transcription Factor Associations 2026	1.0	null
POLR2A_GM12878_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
methylbenzethonium chloride-3850	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE158834_1_v_6_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
RUNX1-21571218-MEGAKARYOCYTES-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
NCI-H630	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE221327_8_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Male reproductive organ cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
PFKFB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00680066
GSE229580_0_v_3_creb1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K42435237	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.30761
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TT-01A-11R-A38C-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE184399_0_v_2_cnot1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC11336098-41598_2024_70235_MOESM1_ESM.pdf-117-ZBTB14_ZBTB14	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242199_6_v_3_ntrk2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Thymic carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.551
GSE165647_2_v_1_cry2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE216274,GSE216292_4_v_2_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227698_5_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD4-21741376-HESC-HUMAN	ChEA Transcription Factor Binding Site Profiles	1.0	null
GSE139455_7_v_6_stat3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_foreskin fibroblast_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
PL-21	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.25286
HIVEP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00562989
hsa-miR-4311	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
BRD-K11795542_-666_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
H3K4me3_WI38_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_GM12865_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE226316_1_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE193282_2_v_0_cd44_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
HT1197_URINARY_TRACT	CCLE Cell Line Proteomics	1.0	2.4972
GSE188382_4_v_0_sirt5_human	RummaGEO Gene Perturbation Signatures	1.0	null
PMC12697342-jem_20250471_tables3.xlsx-ileal_M-ILF_2_TBRC-Gene_FOXK2	Rummagene Transcription Factor Associations 2026	1.0	null
cognitive disorder	GWASdb SNP-Disease Associations	1.0	0.110126
BRD-K68202742_trichostatin A_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CEACAM19	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00532372
LMNB2_02_191	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	1.0	3.45943
17297478-SuppTable2	GeneSigDB Published Gene Signatures	1.0	null
SAP30_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ID2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00352521
NCI-H226	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.00509
HL-60	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.48338
PLPBP	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00669124
KASUMI1	DepMap CRISPR Gene Dependency	1.0	3.71565
Kidney renal clear cell carcinoma_KIRC_TCGA-B2-A4SR-01A-11R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
inferior occipital gyrus, right, superior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-1.62245
H3K27ac_endothelial cell of umbilical vein_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
abnormal emotion/affect behavior	GWASdb SNP-Phenotype Associations	1.0	0.292737
BRD-A84923154	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.40632
18451145-TableS1	GeneSigDB Published Gene Signatures	1.0	null
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.22
GSE118548_1_v_3_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE112763,GSE112767_4_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
(+/-)-catechin-3351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Z chromosome	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.165
hsa-miR-92b	TargetScan Predicted Conserved microRNA Targets	1.0	0.205675
BRD-K43911180	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.12784
GTEX-X3Y1-0006-SM-3P5ZG	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.33439
A549_Valproic acid sodium salt_100nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0210882
parietal neocortex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.65901
GRIK2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00589138
H3K4me2_CD14-positive monocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE135350_2_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE239688_2_v_5_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amygdaloid complex_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.857392
18713946-TableS3	GeneSigDB Published Gene Signatures	1.0	null
Rectum adenocarcinoma_READ_TCGA-AG-3732-11A-01R-1660-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
MEST	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00465915
GSE118765_1_v_5_rreb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Sox7	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	22.1654
inner CP in subgenual (subcallosal) cingulate cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-0.888844
H3K4me3_fibroblast of lung_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-85-8288-01A-11R-2296-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-RVPU-0005-SM-2TF6L	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.18414
H3K4me3_WI38_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
bone marrow	HPA Tissue Gene Expression Profiles	-1.0	-1.86579
MPHOSPH6	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00520806
GSE151612_4_v_11_pracinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me1_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K06507315	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.77777
BRD-K61662457_CAY10594_A549_6.0_h_20.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hippocampus (hippocampal formation)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.05153
BRD-K23453536	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.08913
Uterine Carcinosarcoma_UCS_TCGA-N8-A4PQ-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
molt4	HPA Cell Line Gene Expression Profiles	-1.0	-0.887371
GTEX-U3ZH-0626-SM-4DXT3	GTEx Tissue Sample Gene Expression Profiles	1.0	0.912942
gastrointestinal inflammation	GWASdb SNP-Phenotype Associations	1.0	0.308909
SAP30	ENCODE Transcription Factor Targets	1.0	null
HT-115	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-106b	TargetScan Predicted Conserved microRNA Targets	1.0	0.670641
Abnormalities, Multiple	CTD Gene-Disease Associations	1.0	1.13484
BRD-K83475223	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25911
BRD-K55927371	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.73332
GTEX-P44H-2426-SM-2XCEJ	GTEx Tissue Sample Gene Expression Profiles	1.0	3.85224
BRD-K47113219	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15846
MAFK_IMR-90_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-P78B-0005-SM-2I5GM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20593
GTEX-S4Q7-0003-SM-3NM8M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.973525
Rectum adenocarcinoma_READ_TCGA-F5-6464-01A-11R-1736-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE205070_2_v_7_mertk_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-WHSE-0006-SM-3NMBW	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.72266
Uterine Carcinosarcoma_UCS_TCGA-N9-A4Q7-01A-11R-A28V-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
A549_Fedratinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0273454
GSE111247_0_v_13_temozolomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ER to Golgi transport vesicle membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.586
posteroventral (inferior) parietal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.7243
P30-OHK	GDSC Cell Line Gene Expression Profiles	-1.0	-1.41602
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-R55D-0006-SM-3GIJS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.06415
hsa-miR-548an	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
A549_Divalproex Sodium_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0186107
LOUNH91	DepMap CRISPR Gene Dependency	1.0	4.72652
GTEX-XQ3S-0001-SM-4B64K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.832535
GTEX-OOBJ-0826-SM-3NB2K	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.923479
EVI2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00547168
Brain Lower Grade Glioma_LGG_TCGA-DU-7013-01A-11R-2027-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
ALPK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00474391
H3K4me3_epithelial cell of esophagus_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WFJO-0005-SM-3GIKY	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22282
GSE197948_2_v_0_atp7b_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
496100543_FWM_probable Alzheimer's disease_TBI_78_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26056
GTEX-QEG4-1126-SM-2S1P7	GTEx Tissue Sample Gene Expression Profiles	1.0	0.995472
Perturb_4600_KO_Mettl3_SRP048598	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	20.0
PMC3921136-CIN-13-2014-021-s001.pdf-227-ZNF443_ZNF443	Rummagene Transcription Factor Associations 2026	1.0	null
CLASP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.81809
head	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
Lung adenocarcinoma_LUAD_TCGA-44-7661-01A-11R-2066-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GALNT3	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0073451
HS 852.T	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.2892
BRD-K79232672	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.09513
GSE76425_0_v_3_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9160255-41467_2022_30710_MOESM6_ESM.xlsx-DHT_AR_ASO_super_enhancers-ENSEMBL_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6403-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CTBP2-25329375-LNCAP-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE166308_1_v_0_pim1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
bromopride-6037	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
TTLL11	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.48673
BRCA1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
BRD-K17175263	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.16513
Salivary gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.461
sulfadimethoxine-3441	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
inner SZ in superolateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.45085
H3K4me1_CD4 Naive Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-D6-6515-01A-21R-1873-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
H3K4me3_Pancreatic Islets	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE206729_5_v_1_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC8816731-41388_2021_2128_MOESM8_ESM.xlsx-TF_Upregulated_by_SNAIL1-Unnamed_2_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-SNOS-1026-SM-4DM4Y	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19438
RANBP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21543
BRD-K70917163_6-amino-1-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone MLS000052933-02_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PEAK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00555517
GTEX-U3ZN-0726-SM-4DXT5	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12705
SCN1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0070954
PDSS2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00644198
Liver hepatocellular carcinoma_LIHC_TCGA-CC-A1HT-01A-11R-A131-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PMC9218776-ADVS-9-2104640-s002.xlsx-SIM_-_Nurr1-Unnamed_1_SIM2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-A06232236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.5254
Tranilast_KATO III	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0139058
GTEX-R55E-2526-SM-2TC6H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12595
primary motor cortex (area M1, area 4)_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.41682
CRCGN015_MCF10A.TP53.M_24H:E22	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.0908
pancreas	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
REST_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-RVPV-0006-SM-2TF6Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.28741
PIP5K1B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00439016
GSE249098_3_v_0_mthfd1l_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE258991_1_v_0_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0439
GSE211126_1_v_0_hapln1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
A549_Dasatinib_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0215918
fulvestrant-5235	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-520c-3p	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
caudal ganglionic eminence	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.11091
GTEX-XOTO-0011-R11B-SM-4B64O	GTEx Tissue Sample Gene Expression Profiles	1.0	1.57788
Adrenocortical carcinoma_ACC_TCGA-OR-A5J1-01A-11R-A29S-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K00363054	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.27608
hsa-miR-639	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.809003
primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12837	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.920303
GTEX-UPIC-0926-SM-4IHLV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.91451
Skin Cutaneous Melanoma_SKCM_TCGA-D3-A1Q5-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-SNMC-0926-SM-4DM5U	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44831
Diabetic retinopathy	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.441
GRANTA519	CCLE Cell Line Gene CNV Profiles	1.0	1.40578
GTEX-S3XE-1326-SM-4AD4H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.2452
GTEX-QCQG-1326-SM-48U24	GTEx Tissue Sample Gene Expression Profiles	1.0	1.43595
SG in posterior frontal cortex (motor cortex)	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.52599
GSE203267_0_v_1_alkbh5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TMEM127	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54265
BRD-K49042040	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.49907
cefamandole-3436	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CTCF_GM12865_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
estradiol_homo sapiens_gpl570_gds3283	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE165682_4_v_5_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158834_2_v_5_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
amiodarone-3296	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
latamoxef-5609	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
EW-24	GDSC Cell Line Gene Expression Profiles	1.0	1.99049
Retinal disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.243
HCC2998	COSMIC Cell Line Gene Mutation Profiles	1.0	null
striatum_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	2.08654
BRD-K99034771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.15929
GSE158431_5_v_7_pioglitazone_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-U8XE-1226-SM-4E3HN	GTEx Tissue Sample Gene Expression Profiles	1.0	1.3003
hsa-miR-3926	TargetScan Predicted Conserved microRNA Targets	1.0	0.241055
CRCGN016_MCF10A.TP53.M_24H:L10	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.6035
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CTCF	ENCODE Transcription Factor Targets	1.0	null
anterior amygdaloid area	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.04675
hsa-miR-548p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.965816
tetralogy of fallot	GWASdb SNP-Disease Associations	1.0	0.668836
Brain Lower Grade Glioma_LGG_TCGA-DB-5280-01A-01R-1470-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Perturb_3969_KO_S100A2_SRP344838	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	-1.0	-20.0
OLIG2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.8311
GSE112762,GSE112767_1_v_3_dgcr8_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
Pancreatoblastoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.294
POLR2A_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
sirolimus-5204	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
NCI-H650	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H2BK20ac_H9	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
inner SZ in midlateral temporal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	0.925505
GSE113385_0_v_1_six1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
fastigial nucleus, left	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	0.990756
TAF7_H1-hESC_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
lobelanidine-2897	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTF2F1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE124920_1_v_2_prmt1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Z8-0006-SM-3K2AQ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.22503
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4789-01A-01R-1305-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
LRP2	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00608629
Perturb_9140_KD_NR3C2_SRP165263	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	4.87296
GTEX-WYJK-0005-SM-3NMA1	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.868036
SMAD3	ChEA Transcription Factor Targets	1.0	null
thiamphenicol-glycinate	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.31886
GSE132369,GSE132371_3_v_0_cccp_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE217452_3_v_1_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
TCF12	ENCODE Transcription Factor Targets	1.0	null
GTEX-R55E-1126-SM-48FDZ	GTEx Tissue Sample Gene Expression Profiles	1.0	1.22438
GSE242049_1_v_0_txndc5_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K29077209	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.3774
POU1F1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00581589
GSE245270_2_v_5_isoproterenol_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Spindle cell rhabdomyosarcoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.16
GTEX-XPT6-0006-SM-4B66Q	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.4417
GTEX-T6MN-0005-SM-32PLJ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.43947
GSE193258,GSE193259_9_v_6_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-K03321770	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.04911
GSE199899_1_v_0_diethylnitrosamine_mouse	RummaGEO Drug Perturbation Signatures	1.0	null
CRCGN008_HEPG2_24H:C24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.39025
NR0B2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.7851
GSE226249_0_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_16605_KO_Bend2_SRP357909	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-1.33327
GSE198165,GSE198166_6_v_3_zfp266_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K4me3_mononuclear cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-V955-0004-SM-3NMDH	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.933721
A549_MLN8054_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0159625
abnormality of nervous system physiology	GWASdb SNP-Phenotype Associations	1.0	0.05999
animal	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
PMC8816731-41388_2021_2128_MOESM8_ESM.xlsx-TF_Upregulated_by_SNAIL1-Unnamed_1_SNAI1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE131161_2_v_4_rarres1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K9ac_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
central nervous system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	1.53602
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
LRRC61	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45403
GTEX-QVUS-0006-SM-3GAE8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17371
CRCGN008_HEPG2_24H:F03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.1392
BRD-K60389305	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33855
BRD-K19868817	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.00949
RPSA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.18883
GTEX-S4Q7-1526-SM-3K2AG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.978174
GSE206270_2_v_3_lsm14b_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
inferolateral temporal cortex (area TEv, area 20)_21 yrs_F_13057	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.04622
GTEX-T5JC-0326-SM-4DM5C	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36228
GTEX-QLQ7-0005-SM-2S1QP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.24638
NCI-H1092	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	1.69248
GSE198165,GSE198166_0_v_4_zfp266_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
eldeline-6026	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BEC	DeepCoverMOA Drug Mechanisms of Action	1.0	0.46
mediodorsal nucleus of thalamus_10 mos_M_12977	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.57375
GTEX-N7MS-0011-R11A-SM-2HMJS	GTEx Tissue Sample Gene Expression Profiles	1.0	1.41041
BRD-A19037878_trichostatin A_NEU_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
OCIMY5	CCLE Cell Line Gene CNV Profiles	1.0	1.67752
rolipram-6449	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
trichostatin A-6709	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
HCC1171	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.986634
H3K4me3_fibroblast of dermis_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K29838935	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.29308
cerebellar cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.885
Hidradenoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.005
PMC9490101-mmc3.xlsx-Sheet1-Supplementary_Table_3_Differentially_expressed_genes_in_CASC11_KD_MHCC-97H_cells_AR	Rummagene Transcription Factor Associations 2026	1.0	null
EEF1A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.13564
GTEX-OIZH-0005-SM-2HMJN	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.5293
GSE88819_3_v_8_tug1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Hematologic cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.104
PMC8384902-mmc2.xlsx-3_ASCL1_high_subtype-Gene_Symbol_ASCL1	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_B cell_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
Chamber of the eye	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.147
cerebral lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K27ac_myotube_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
acepromazine-6832	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
17297478-SuppTable6	GeneSigDB Published Gene Signatures	1.0	null
GSE212312_2_v_3_fbxw7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
carboxy-terminal domain protein kinase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.279
GTEX-T8EM-0426-SM-4DM7E	GTEx Tissue Sample Gene Expression Profiles	1.0	0.917316
Prostate cancer	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
TFAP2A-17053090-MCF-7-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE200352_9_v_3_pparg_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
SMAD2/3-21741376-EPCS-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE186633_1_v_0_chd1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC12769604-13402_2025_1147_MOESM6_ESM.xlsx-Table_S4_3_Venn-Tumor_AND_Prognosis_NOT_Scissor_NR4A2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-OOBJ-0006-SM-2I3F4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.11144
ASAH1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24436
P31-FUJ	GDSC Cell Line Gene Expression Profiles	-1.0	-2.95498
GSE139911_0_v_4_dnmt3a_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GSE171837_3_v_1_bortezomib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-NPJ8-0007-SM-2D7VX	GTEx Tissue Sample Gene Expression Profiles	-1.0	-3.46684
RPE1SS119	DepMap CRISPR Gene Dependency	1.0	3.47656
GSE116580_0_v_1_smug1_human	RummaGEO Gene Perturbation Signatures	1.0	null
hsa-miR-96	TargetScan Predicted Conserved microRNA Targets	1.0	0.045136
GSE125014_1_v_3_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Kidney renal clear cell carcinoma_KIRC_TCGA-BP-4991-01A-01R-1334-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE121824,GSE121826_0_v_8_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
BRD-K81418486_vorinostat_A549_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE142210_3_v_1_panobinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QEG5-0006-SM-2I5FZ	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.35219
GSE158834_11_v_3_palm_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Skin Cutaneous Melanoma_SKCM_TCGA-EB-A44R-06A-41R-A266-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
medial habenular nucleus, right	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.19996
Sarcoma_SARC_TCGA-SG-A6Z7-01A-12R-A32Q-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Colorectal mucosa	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
chlortalidone-6800	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
ovary_8a	HPA Tissue Sample Gene Expression Profiles	1.0	1.00494
GSE135030_11_v_2_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC6242972-41467_2018_6699_MOESM5_ESM.xlsx-Sheet1-Supplementary_Data_2_Significantly_up-_and_down-regulated_genes_adj_P_Val_0_05_upon_TBX2_knockdown_in_the_IMR-5_75_cell_line_TBX2	Rummagene Transcription Factor Associations 2026	1.0	null
GTEX-R55F-1226-SM-2TF59	GTEx Tissue Sample Gene Expression Profiles	1.0	1.35907
BTBD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.14136
CC-17-JL38_10uM	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	-1.0	-0.204236
CRCGN015_MCF10A.WT.HP_24H:G03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	-1.0	-2.08642
PMC5352226-elife-20488-fig4-data5.xls-tfnames-ADNP_ADNP	Rummagene Transcription Factor Associations 2026	1.0	null
A549_Divalproex Sodium_10nM_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0156881
MX-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.897401
posteroventral (inferior) parietal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.846303
amygdaloid complex_4 yrs_M_12298	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.00565
HEL	GDSC Cell Line Gene Expression Profiles	-1.0	-1.71955
PIK3R5	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540482
BRD-K54233340_Dorsomorphin dihydrochloride_VCAP_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE60837_0_v_3_bcl9_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
OPM-2	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE176008_0_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_foreskin fibroblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
vitexin-4413	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-576-5p	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.880544
pancreas	GTEx Tissue Gene Expression Profiles	-1.0	-0.897544
PANK1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00471431
GSE220806_1_v_3_progesterone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NR1I3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.6085
POLR2A_HeLa-S3_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE178113,GSE178116_0_v_1_atrx_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CR-7368-01A-11R-2132-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
hsa-miR-1252	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.20993
Pirenzepine	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
PMC7378211-41598_2020_69015_MOESM3_ESM.xlsx-EWS-WT1_rep1_testp-7_annotatedp-ID_WT1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE125153_1_v_0_bcl3_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-XGQ4-0004-SM-4AT5S	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.15732
EW-22	GDSC Cell Line Gene Expression Profiles	1.0	1.68354
GTEX-R3RS-0526-SM-3GADG	GTEx Tissue Sample Gene Expression Profiles	1.0	0.922033
GSE151412_2_v_3_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
membrane-bounded organelle	LOCATE Curated Protein Localization Annotations	1.0	null
BRD-K42333498	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.00885
NLK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47134
CAY10683	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.35
GSE211128_2_v_0_angptl4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE60217_1_v_2_inosine_human	RummaGEO Drug Perturbation Signatures	1.0	null
H2BK12ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Prenatal Exposure Delayed Effects	CTD Gene-Disease Associations	1.0	1.07518
hsa-miR-200b	TargetScan Predicted Conserved microRNA Targets	1.0	0.90397
hexetidine-3318	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K50177754	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.08742
oxybenzone-5410	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.25823
BRD-K96567801	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.46738
GSE148321,GSE169423_0_v_1_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
abnormality of the vasculature	GWASdb SNP-Phenotype Associations	1.0	0.11708
BRD-K96945247	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21734
GTEX-QMR6-1326-SM-32PLB	GTEx Tissue Sample Gene Expression Profiles	1.0	2.59595
GTEX-WRHU-0626-SM-3MJFI	GTEx Tissue Sample Gene Expression Profiles	1.0	0.968425
CRCGN016_MCF10A.TP53.M_24H:P12	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	3.35675
GSE193588_1_v_0_pax3_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
KP2	CCLE Cell Line Gene CNV Profiles	-1.0	-1.78427
GSE96641_1_v_2_esrp2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
UM-UC-9 cell	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.279
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me1_CD4+ CD25+ CD127- Treg Primary Cells	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
GSE213153_1_v_0_ulixertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.20367
posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.875766
prostate	HPA Tissue Gene Expression Profiles	1.0	0.98838
iocetamic acid-4425	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
phenotypic abnormality	GWASdb SNP-Phenotype Associations	1.0	0.540309
GSE165682_4_v_3_ptbp1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
quinethazone-4351	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-WFON-0005-SM-3NMC9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-2.19372
BRD-K87909389_HY-10005_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
hsa-miR-29b	TargetScan Predicted Conserved microRNA Targets	1.0	0.050854
COLO205_LARGE_INTESTINE	CCLE Cell Line Proteomics	1.0	2.13031
eucatropine-3935	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
L-NIL	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
artery disease	GWASdb SNP-Disease Associations	1.0	0.321908
GSE152666,GSE152668_2_v_1_carm1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-QEL4-1226-SM-447A4	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.869361
CRCGN013_HEPG2_24H:K03	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.3216
BRD-K58876832	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.86884
Kidney renal papillary cell carcinoma_KIRP_TCGA-DZ-6135-01A-11R-1965-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DB-5279-01A-03R-2347-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
OCI-LY-10	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.11906
GSE208350_4_v_1_fgfr1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CRCGN015_HEPG2_48H:H04	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.03472
Perturb_15413_KD_KDM3B_SRP187702	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.52102
GSE178255_2_v_7_tlr4_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
cardiovascular system disease	GWASdb SNP-Disease Associations	1.0	0.213302
hsa-miR-21-5p	MiRTarBase microRNA Targets	1.0	null
H3K4me3_skeletal muscle cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE206516,GSE206518_0_v_7_ptdss2_human	RummaGEO Gene Perturbation Signatures	1.0	null
striatum_24 pcw_M_12288	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.979087
KU812	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.47556
GTEX-S3XE-1826-SM-3K2B4	GTEx Tissue Sample Gene Expression Profiles	1.0	1.10655
Kidney renal papillary cell carcinoma_KIRP_TCGA-B9-5155-01A-01R-1592-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
TAF1_SK-N-SH_hg19_2	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GIMEN	DepMap CRISPR Gene Dependency	1.0	2.09088
OLIG3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9312
PMC9203705-bloodBLD2021014723-suppl2.xlsx-Supp_Table_5-Supplementary_Table_5_List_of_genes_identified_by_WGCNA_corresponding_to_the_CDX2_UBTF_cluster_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
primary visual cortex (striate cortex, area V1/17)_17 pcw_F_12880	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	0.941868
YY1_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-60-2695-01A-01R-0851-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-QESD-2026-SM-447BI	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.04379
GTEX-POYW-1126-SM-48TCI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.12212
GTEX-XMD1-0011-R11A-SM-4AT5J	GTEx Tissue Sample Gene Expression Profiles	1.0	1.1588
SSB	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.55587
GSE178714_1_v_7_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
amygdaloid complex_13 pcw_M_12820	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	0.993219
BRD-K17349619_HLI 373_HT115_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Brain Lower Grade Glioma_LGG_TCGA-DU-6405-01A-11R-1708-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
disease	GWASdb SNP-Disease Associations	1.0	0.058879
corpus callosum	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.60775
GSE166536_1_v_2_docetaxel_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_astrocyte of the spinal cord_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
GSE195559_3_v_7_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CJUN-26792858-CHIP-SEQ-BT549-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
GSE115395_2_v_1_enzalutamide_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K85493820_KM 00927_A549_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Ascl2	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	53.0729
A549_Decitabine_1然_72h	Sci-Plex Drug Perturbation Signatures	1.0	0.0125649
H3K4me3_brain microvascular endothelial cell_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S33H-1226-SM-4AD69	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.842123
tetralogy of fallot	GWASdb SNP-Phenotype Associations	1.0	0.572823
TMD8	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	1.54172
AGS	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-0.89867
Perturb_9654_KD_HMGB2_SRP306591	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	5.3492
RNF10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21046
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.26809
GSE135030_3_v_4_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE256181_2_v_3_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
acetohexamide-1707	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
Ospemifene	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.33
PMC6097700-pgen.1007515.s008.xlsx-S2_Table-S2_Table_SATB2_Cort_gene-set_list_SATB2	Rummagene Transcription Factor Associations 2026	1.0	null
HEPACAM	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552403
GSE127790_13_v_3_zcchc8_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-NPJ7-0011-R11A-SM-2I3E8	GTEx Tissue Sample Gene Expression Profiles	1.0	1.44215
HIPK2_defectivemutant_29_GDS4233	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	1.0	1.83851
GTEX-TMMY-0526-SM-33HBC	GTEx Tissue Sample Gene Expression Profiles	1.0	1.20496
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1Z0-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GTEX-W5WG-0006-SM-3GIJT	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.17954
496100527_FWM_possible Alzheimer's disease_no TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.19236
halcinonide-6040	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GSE213588_9_v_11_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.3127
SUDHL4	DepMap CRISPR Gene Dependency	1.0	3.83977
SLC16A10	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00540785
GSE135030_3_v_6_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Vdr	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	15.8998
GSE158834_0_v_4_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POU3F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	59.9671
posterior (caudal) superior temporal cortex (area 22c)_8 yrs_M_12981	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-0.894727
GSE142210_2_v_5_panobinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE120612_7_v_1_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WFG8-0006-SM-3GIKS	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.44941
lorglumide-5619	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-QDVN-2326-SM-2S1PF	GTEx Tissue Sample Gene Expression Profiles	1.0	0.893262
A549_Dacinostat_1然_72h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0152254
BRD-K96799727_-666_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
central glial substance	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	1.0	1.45411
GSE161302,GSE161304_1_v_2_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-RU1J-0006-SM-2TF6M	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.10521
SLF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2663
Nut Midline Carcinoma	DisGeNET Gene-Disease Associations	1.0	null
GTEX-TKQ2-1726-SM-4DXUP	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.975696
BRD-M34385771	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-4.18102
A549_Azacitidine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0130356
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
amygdaloid complex_9 pcw_M_12833	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.11223
GTEX-R55C-1826-SM-3GADI	GTEx Tissue Sample Gene Expression Profiles	1.0	1.05782
GSE198380_0_v_1_phgdh_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE226091,GSE226092_3_v_1_sall1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ME-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.1968
rilmenidine-6512	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
TEF-1	MotifMap Predicted Transcription Factor Targets	1.0	null
GULP1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00409975
LIG1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00691976
Disease of cellular proliferation	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	1.0	0.504
CNPY3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13755
SLVL	COSMIC Cell Line Gene Mutation Profiles	1.0	null
Lung squamous cell carcinoma_LUSC_TCGA-33-4587-01A-11R-2125-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE101239_5_v_1_valproic acid_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
TAF1_ECC-1_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE144231_3_v_5_cxcr2_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
PMC10828394-41698_2024_509_MOESM1_ESM.pdf-127-ZNF431_ZNF431	Rummagene Transcription Factor Associations 2026	1.0	null
FOXK2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.9715
15520196-SuppTable3	GeneSigDB Published Gene Signatures	1.0	null
Zic3	JASPAR Predicted Mouse Transcription Factor Targets 2025	1.0	33.5391
RFXANK	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00590188
Vitreous humor	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.202
GTEX-RWS6-1326-SM-47JXB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13293
GSE217452_3_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
disease of mental health	GWASdb SNP-Disease Associations	1.0	0.07867
posterior (caudal) superior temporal cortex (area 22c)_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.16445
Brain Lower Grade Glioma_LGG_TCGA-VM-A8C9-01A-11R-A36H-07	TCGA Signatures of Differentially Expressed Genes for Tumors	-1.0	null
cerebellar cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.71057
PSMA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.45172
JHOS4	CCLE Cell Line Gene CNV Profiles	1.0	1.95862
GSE207135_2_v_0_sod2_human	RummaGEO Gene Perturbation Signatures	1.0	null
Adenocarcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.155
hsa-miR-3163	TargetScan Predicted Conserved microRNA Targets	1.0	0.193083
BRD-K91060460	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.88367
PMC4742856-srep20328-s7.xls-Sheet2-ZF_converted_to_Human_CREBZF	Rummagene Transcription Factor Associations 2026	1.0	null
H3K4me3_HeLa-S3_hg19_3	ENCODE Histone Modification Site Profiles	1.0	null
GSE193258,GSE193259_9_v_14_osimertinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K42296822	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.0876
Perturb_10675_KO_Jmjd6_SRP309362	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-2.36374
GSE175787_8_v_10_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
posterior (caudal) superior temporal cortex (area 22c)_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-0.886785
NFYC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.5064
SV2A	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00552915
GSE224096_2_v_0_cocaine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE157383_0_v_1_abemaciclib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC6484770-41388_2018_602_MOESM5_ESM.xlsx-down_P53_vs_con-Unnamed_1_TP53	Rummagene Transcription Factor Associations 2026	1.0	null
NCI-H1882	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.956637
Prostate adenocarcinoma_PRAD_TCGA-V1-A8MM-01A-11R-A37L-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K57507729	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.12714
2119_DDX3X_P1P2	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	1.0	1.10001
intracellular membrane-bounded organelle	COMPARTMENTS Curated Protein Localization Evidence Scores	1.0	0.098109
cerebral cortex	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
H3K4me3_fibroblast of lung_hg19_5	ENCODE Histone Modification Site Profiles	1.0	null
pancreas	HPA Tissue Gene Expression Profiles	-1.0	-1.00409
GSE126345_7_v_5_hcrt_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-6016-01A-11R-1686-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K12184916_NVP-BEZ235_A375_24_h_0.04_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
CENPA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12943
H3K4me1_Panc1_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
female reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
GTEX-U8XE-0005-SM-3DB8I	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.02823
BRD-K15800236	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.11504
Head and Neck squamous cell carcinoma_HNSC_TCGA-CQ-7072-01A-21R-A30B-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K30217326	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.32697
HAL-01	COSMIC Cell Line Gene Mutation Profiles	1.0	null
MHH-ES-1	GDSC Cell Line Gene Expression Profiles	1.0	1.42652
basal ventral medial nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.07018
regulation of cellular biosynthetic process	GO Biological Process Annotations 2015	1.0	null
COLO-792	COSMIC Cell Line Gene Mutation Profiles	1.0	null
H3K9ac_astrocyte_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-WHPG-0006-SM-3NMBV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.58875
NCI-H1568	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.16652
CRCGN015_HEPG2_48H:M08	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11598
kidney disease	GWASdb SNP-Disease Associations	1.0	1.10419
BRD-K79090631_CGP-60474_A375_24_h_3.33_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
isocarboxazid-3424	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
KARPAS-45	COSMIC Cell Line Gene Mutation Profiles	1.0	null
UBA6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.06659
GTEX-R55G-0626-SM-48FDB	GTEx Tissue Sample Gene Expression Profiles	1.0	1.13961
anterior (rostral) cingulate (medial prefrontal) cortex_30 yrs_F_12290	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.40569
GSE242096,GSE242098_1_v_0_med1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
hsa-miR-3670	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
VZ in caudal hippocampal proper	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.38488
GSE153137,GSE153140_2_v_0_mettl5_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BCAT1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00684315
H2AFZ_fibroblast of dermis_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
Female reproductive organ cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.034
CATSPER1	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00572264
levodopa-4394	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
regulation of rna biosynthetic process	GO Biological Process Annotations 2015	1.0	null
hsa-miR-3620	TargetScan Predicted Nonconserved microRNA Targets	1.0	0.843347
GSE188870,GSE188871_0_v_2_kat7_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
CGN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.94446
PMC8387919-mmc2.xlsx-ST9_NEUROG3_bound_TF_genes-Supplemental_Table_9_NEUROG3_bound_TFs_genes_NEUROG3	Rummagene Transcription Factor Associations 2026	1.0	null
foliosidine-6057	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
PTPN22	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	-1.0	-0.00470321
organic cyclic compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GSE256181_2_v_0_etv2_human	RummaGEO Gene Perturbation Signatures	1.0	null
ventrolateral prefrontal cortex_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.02532
reproductive system	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
Pemetrexed_AN3 CA	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	1.0	0.0250271
Perturb_642_KD_FASTKD1_SRP299834	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	1.0	1.87106
BRD-K91596921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.53842
GTEX-WFON-1626-SM-4LVMV	GTEx Tissue Sample Gene Expression Profiles	1.0	0.961387
Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZH-06A-11R-A18T-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE185519_4_v_7_gilteritinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEX-WZTO-0011-R11A-SM-4E3K9	GTEx Tissue Sample Gene Expression Profiles	1.0	1.81534
CRCGN015_MCF10A_48H:N11	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.11206
fluocinonide-3933	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
dorsolateral prefrontal cortex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.43503
GTEX-V955-0926-SM-4JBJ8	GTEx Tissue Sample Gene Expression Profiles	1.0	0.840974
MAP3K8	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00555547
H3K4me2_H1-hESC_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GSE128730_0_v_1_neratinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE121824,GSE121826_0_v_3_scaf8_human	RummaGEO Gene Perturbation Signatures	1.0	null
NCI-H1703	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	1.0	0.969735
H3K4me3_GM12864_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Immune system disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.0
GSE238116_3_v_2_egr1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GTEX-S4Z8-0626-SM-4AD6J	GTEx Tissue Sample Gene Expression Profiles	1.0	0.999672
dorsolateral prefrontal cortex_21 pcw_F_12365	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	1.0	1.08751
GSE233679_5_v_8_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
TOMM70	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.46643
NFYA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.121
hsa-miR-4476	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.0155
GSE226316_11_v_2_tead2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
ES-2	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.22667
GSE179002_2_v_7_caprin1_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
FNTA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.0389
organelle	LOCATE Predicted Protein Localization Annotations	1.0	null
NCI-H1648	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.01204
GSE43041,GSE43044_0_v_1_ldb1_mouse	RummaGEO Gene Perturbation Signatures	1.0	null
ZNF85	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.012
GTEX-R55G-0006-SM-2TC6O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.80916
sulfapyridine-6101	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
A-427	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.31941
hsa-miR-3613-3p	TargetScan Predicted Conserved microRNA Targets	1.0	0.17031
PMC12885947-44386_2025_32_MOESM1_ESM.pdf-23-ZNF469_ZNF469	Rummagene Transcription Factor Associations 2026	1.0	null
Inflammatory Bowel Diseases	dbGAP Gene-Trait Associations	1.0	0.449184
MDA-MB-330	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.46018
GSE158197_5_v_4_egfr_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
regulation of gene expression	GO Biological Process Annotations 2015	1.0	null
GSE235066_4_v_2_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A-VN-1203-2004(H5N1)_Day4-10^2pfu_22074594_GSE33263	GEO Signatures of Differentially Expressed Genes for Viral Infections	1.0	2.44362
GSE193258,GSE193259_9_v_13_osimertinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE130437_2_v_3_palbociclib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE226249_5_v_7_pirfenidone_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K17743125_S1085_NPC_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
GTEX-R53T-0426-SM-48FEM	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.829265
NCIH146	CCLE Cell Line Gene CNV Profiles	1.0	1.63389
CRCGN015_MCF10A_48H:G02	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.2401
uterus	TISSUES Curated Tissue Protein Expression Evidence Scores	1.0	null
BRD-K87909389_HY-10005_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE153354_0_v_1_tcf19_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE42805,GSE42811_1_v_0_cocaine_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
H3K4me3_GM12875_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K76691746	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.21545
GSE147876,GSE147877_2_v_6_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
A549_Quercetin_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0154123
KDM4A_H1-hESC_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-PW2O-0006-SM-2I3DV	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.89797
BRD-K54233340_Dorsomorphin dihydrochloride_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GTEX-WOFM-0005-SM-3MJF3	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.87074
CBP-20019798-JUKART-HUMAN	ChEA Transcription Factor Targets 2022	1.0	null
PMC10099894-NAN-49-0-s001.xlsx-GENIC_INTERSECT_VCF-MID_TBX1	Rummagene Transcription Factor Associations 2026	1.0	null
Acute Myeloid Leukemia_LAML_TCGA-AB-2929-03A-01T-0735-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
GSE254649_3_v_1_cstf2_human	RummaGEO Gene Perturbation Signatures	1.0	null
LGE-VZ border region	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	2.25292
GSE134412_0_v_1_siah2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
GTEX-S95S-0005-SM-2XCEC	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.39345
KRTCAP2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.068
FH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24949
A549_Prednisone_1然_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0155328
18310505-TableS7	GeneSigDB Published Gene Signatures	1.0	null
regulation of nucleobase-containing compound metabolic process	GO Biological Process Annotations 2015	1.0	null
GTEX-U3ZN-1026-SM-4DXTC	GTEx Tissue Sample Gene Expression Profiles	1.0	0.97535
PMC11192681-11033_2024_9703_MOESM1_ESM.xlsx-ZFP_genes_expression_vs_methyla-Unnamed_26_ZKSCAN7	Rummagene Transcription Factor Associations 2026	1.0	null
Glucose metabolism disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.028
Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7421-01A-11R-2081-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HCC2279	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.10224
GTEX-SJXC-0005-SM-2XCE7	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.42115
COLO 680N	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.38032
MALME3M	DepMap CRISPR Gene Dependency	1.0	2.67288
membrane-bounded organelle	COMPARTMENTS Experimental Protein Localization Evidence Scores	1.0	0.233497
HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	CCLE Cell Line Proteomics	1.0	2.35136
Viral cardiomyopathy_Myocardial tissue_GSE4172	GEO Signatures of Differentially Expressed Genes for Diseases	1.0	2.91835
H3K4me3_BJ_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
cefsulodin-4148	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
Perturb_5231_KO_Kmt5c_SRP194976	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	-1.0	-20.0
dorsal raphe nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.67285
MED19	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06735
H2AFZ_GM12878_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
ZNF143	ENCODE Transcription Factor Targets	1.0	null
GSE82032_3_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
BRD-A15530910_SDZ 21009_PC3_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
hsa-miR-520b	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.07142
RKN	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	-1.0	-1.03972
prostate	HPA Tissue Protein Expression Profiles	-1.0	-1.01523
FOXP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.6425
H3K4me3_A549_hg19_4	ENCODE Histone Modification Site Profiles	1.0	null
H3K4me3_fibroblast of pulmonary artery_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
Eye disease	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.23
prepositus hypoglossal nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.53315
hsa-miR-452	TargetScan Predicted Conserved microRNA Targets	1.0	1.11641
GTEX-XMD1-2826-SM-4AT5F	GTEx Tissue Sample Gene Expression Profiles	1.0	0.953245
FECH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.81011
RI-1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	2.07535
CP-690334-01-3823	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
BRD-K78867378_mw-A1-12_A375_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
organic cyclic compound binding	GO Molecular Function Annotations 2015	1.0	null
496100455_FWM_dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.20787
Head and Neck squamous cell carcinoma_HNSC_TCGA-CN-A6V3-01A-12R-A34R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
PLEKHA5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.86749
GTEX-VUSG-0006-SM-3GIK9	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.00136
BRD-K64800655_HY-11001_MCF7_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE235066_4_v_3_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Perturb_949_KO_Bhlhe40|Bhlhe41_SRP216680	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	1.0	13.012
GSE171486_4_v_6_ddx6_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE48812_2_v_10_sulforaphane_human	RummaGEO Drug Perturbation Signatures	1.0	null
H3K4me3_bronchial epithelial cell_hg19_2	ENCODE Histone Modification Site Profiles	1.0	null
BRD-K60149889	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.11721
Febuxostat	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.26
GTEX-NPJ7-0006-SM-3GACR	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.32465
GSE189859,GSE189861_0_v_2_idh1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
EJM	DepMap CRISPR Gene Dependency	1.0	4.70825
GSE114284_1_v_5_irf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE206729_4_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K27ac_skeletal muscle myoblast_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-P4PP-1026-SM-3NM9O	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.848151
Rumen epithelium	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.915
deep layers of caudal entorhinal cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	1.0	1.20018
hsa-miR-519d	TargetScan Predicted Conserved microRNA Targets	1.0	0.632343
GNF-5	DeepCoverMOA Drug Mechanisms of Action	1.0	0.39
MEIS2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.4282
CRCGN017_MCF10A.WT.HP_24H:P05	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.60458
GSE178714_1_v_2_smad2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
H3K18ac_IMR90	Roadmap Epigenomics Histone Modification Site Profiles	1.0	null
Pancreatic adenocarcinoma_PAAD_TCGA-HZ-7922-01A-11R-2156-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
STAT4	MotifMap Predicted Transcription Factor Targets	1.0	null
HS-578-T	COSMIC Cell Line Gene Mutation Profiles	1.0	null
hsa-miR-4491	TargetScan Predicted Conserved microRNA Targets	1.0	0.348832
GTEX-UTHO-0011-R11A-SM-3GIJE	GTEx Tissue Sample Gene Expression Profiles	1.0	1.58052
Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20R-11A-11R-A16R-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Depressive Disorder	CTD Gene-Disease Associations	1.0	1.01474
H2AFZ_CD14-positive monocyte_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GSE133764_1_v_0_chd2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE109285_5_v_2_glucagon_mouse	RummaGEO Drug Perturbation Signatures	-1.0	null
GTEX-QDVJ-0626-SM-48U1T	GTEx Tissue Sample Gene Expression Profiles	1.0	1.32118
cerebellum	TISSUES Experimental Tissue Protein Expression Evidence Scores	1.0	0.766457
pancreas_6b	HPA Tissue Sample Gene Expression Profiles	-1.0	-0.964905
MAX_A549_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
GTEX-S7SF-2126-SM-3K2B2	GTEx Tissue Sample Gene Expression Profiles	1.0	1.19066
Lung squamous cell carcinoma_LUSC_TCGA-85-8664-01A-11R-2403-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
CSNK2B	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.0041401
Pancreatic adenocarcinoma_PAAD_TCGA-H6-8124-01A-11R-2404-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
Nervous system cancer	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.014
GSE225869_3_v_0_cd44_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC12586484-41598_2025_22484_MOESM2_ESM.xlsx-Supplementary_Table_1-Supplementary_Table_1_DEGs_in_ATOH8-depleted_EVT_ATOH8	Rummagene Transcription Factor Associations 2026	1.0	null
TAF1_SK-N-SH_hg19_1	ENCODE Transcription Factor Binding Site Profiles	1.0	null
diflunisal-4794	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
SALL4_01_98	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	-1.0	-0.6026
POLR2A_GM12878_hg19_3	ENCODE Transcription Factor Binding Site Profiles	1.0	null
D502MG	DepMap CRISPR Gene Dependency	1.0	5.71786
sin3a_22783022_mcf7_lof_human_gpl570_gds4388	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	1.0	0.852346
A4/FUK	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-0.84847
MRS 1754	DeepCoverMOA Drug Mechanisms of Action	-1.0	-0.29
CHRNB4	LINCS L1000 CMAP CRISPR Knockout Consensus Signatures	1.0	0.00605322
GTEX-P4PP-0426-SM-3NM9H	GTEx Tissue Sample Gene Expression Profiles	1.0	1.36165
amygdaloid complex_40 yrs_F_12304	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	-1.0	-1.12959
GSE157555,GSE157556_4_v_7_foxa2_mouse	RummaGEO Gene Perturbation Signatures	-1.0	null
BRD-K61796560	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.1918
Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-K05250921	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.25202
BRD-A30758703	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.58298
BRD-K76942055	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.61446
4star	Roadmap Epigenomics Cell and Tissue Gene Expression Profiles	1.0	0.968579
BRD-K53104784	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.33022
GTEX-SIU7-0006-SM-2XCE6	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.52865
superior parietal lobule, right, inferior bank of gyrus	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	-1.0	-0.886439
A549_M344_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.00994703
CRCGN015_MCF10A.WT.HP_24H:D24	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	1.0	2.01115
GTEX-SSA3-0002-SM-3P61R	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.0178
Acute Myeloid Leukemia_LAML_TCGA-AB-2910-03A-01T-0740-13	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
dihydroergotamine-6840	CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
BRD-K64804596	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-3.19735
PURA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28823
GSE180185_9_v_5_setbp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
H3K4me1_GM12878_hg19_1	ENCODE Histone Modification Site Profiles	1.0	null
GTEX-S3XE-0006-SM-3K2AA	GTEx Tissue Sample Gene Expression Profiles	-1.0	-1.20113
Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-4078-01A-01R-1436-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
estradiol_mus musculus_gpl4134_gse23241	GEO Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
GSE147893,GSE147897_2_v_1_rbm4_human	RummaGEO Gene Perturbation Signatures	1.0	null
Parotid gland	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.22
A549_Roxadustat_10然_24h	Sci-Plex Drug Perturbation Signatures	-1.0	-0.0168639
MYC	ENCODE Transcription Factor Targets	1.0	null
BRD-A68009927_-666_HT29_6.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	1.0	null
PMC12464728-HSR2-8-e71283-s008.pdf-364-IRF3_IRF3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE128730_7_v_6_neratinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
Nasal cavity carcinoma	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	1.0	1.389
BRD-K11596967	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.4566
DB	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	1.0	0.958353
striatum_8 yrs_M_12841	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	-1.0	-1.11993
PMC9203705-10.1182-2021014723_bloodbld2021014723-suppl2.xlsx-Supp_Table_7-Supplementary_Table_7_Top-list_genes_differentially_expressed_in_CDX2_UBTF_ALL_pvalue_10-7_and_log2_fold_change_3_CDX2	Rummagene Transcription Factor Associations 2026	1.0	null
BRD-K91905575	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.49187
BRD-A24436948	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	-1.0	-5.39481
GSE113005_0_v_1_sorafenib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
urinary bladder	HPA Tissue Protein Expression Profiles	1.0	0.950484
Lung adenocarcinoma_LUAD_TCGA-50-5933-01A-11R-1755-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
BRD-A39506880	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.57316
Early endosome membrane	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.549
BRD-A19037878_trichostatin A_HCC515_24.0_h_10.0_um	LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
pempidine-6027	CMAP Signatures of Differentially Expressed Genes for Small Molecules	-1.0	null
CCDC174	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.11358
hippocampus (hippocampal formation)_13 pcw_F_12834	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	1.0	1.15305
TEAD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.8247
supraoptic nucleus	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.26098
SG in medial temporal-occipital cortex	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	-1.0	-1.18122
GTEX-WFG8-0001-SM-4LVN8	GTEx Tissue Sample Gene Expression Profiles	-1.0	-0.911213
GSE96649_1_v_0_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
POLR2A	ENCODE Transcription Factor Targets	1.0	null
SNU-C1	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles	-1.0	-1.12679
hsa-miR-302c	TargetScan Predicted Nonconserved microRNA Targets	1.0	1.13535
GSE210101,GSE210114_1_v_9_urod_human	RummaGEO Gene Perturbation Signatures	-1.0	null
body mass index	GAD Gene-Disease Associations	1.0	null
ALDH4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72227
Lung adenocarcinoma_LUAD_TCGA-05-4427-01A-21R-1858-07	TCGA Signatures of Differentially Expressed Genes for Tumors	1.0	null
HOP-92	COSMIC Cell Line Gene Mutation Profiles	1.0	null
GSE146982_7_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
BRD-K66734120	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	1.0	3.37466
GSE82110,GSE82299_1_v_0_acriflavine_human	RummaGEO Drug Perturbation Signatures	1.0	null
CORL95	CCLE Cell Line Gene CNV Profiles	1.0	1.66026
GSE189941_1_v_2_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE89729_0_v_1_ppard_human	RummaGEO Gene Perturbation Signatures	-1.0	null