association	dataset	threshold value	standardized value
GSE238005_5_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE202434,GSE202438_6_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE227592_8_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
ATF3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.0132
Basal ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE234637_3_v_0_ikzf1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GAB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.42422
PMC7553775-elife-61287-supp1.xlsx-Muller_2014_DREAM_bound_genes-Genes_KCNIP3	Rummagene Transcription Factor Associations 2026	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.941764
GSE149621_0_v_1_olaparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
CSNK1A1L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06143
Nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
p1	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.699
GSE176008_7_v_5_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE175787_13_v_9_rhoc_human	RummaGEO Gene Perturbation Signatures	1.0	null
MLX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.04039
SOX21	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.2336
GSE215086_8_v_0_batf_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE227592_2_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE158969_1_v_0_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_7_v_6_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SUOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.31033
GSE199204,GSE211619_4_v_0_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
10442_ZNF554_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.587982
SYPL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.72712
GSE195559_8_v_4_notch1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UNCX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3679
CHST10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00554
GSE159893_2_v_0_genistein_human	RummaGEO Drug Perturbation Signatures	1.0	null
p190	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.652
ZNF582	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5256
pre-B cell receptor complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.616
GSE217132_0_v_1_pfkfb4_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MATN4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.02908
E2F4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.4329
CDX4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.5534
NACA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.47383
PGR	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.7303
GSE213588_8_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
9469_TYW3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.600553
SOCS6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36029
ZNF354A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.6168
LATS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.09687
Brain stem	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8191339-mmc1.xlsx-Table_S3_DE_genes-LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
1918_CSTF3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.512114
GSE221327_5_v_9_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ETV4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9873
MIXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3085
GSE234637_3_v_0_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE197571_2_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
POU6F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.2241
MEF2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	51.6875
HOXA10	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	46.0475
EMX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.4891
496100549_FWM_no dementia_TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.86556
PMC9038526-mmc1.xlsx-postCOVID_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
FBLN2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.12902
7173_RBM39_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.63108
TFAP4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.8759
PMC5029704-oncotarget-07-24326-s006.xlsx-Sheet1-Genes_that_are_downregulated_in_low_TET1_compared_to_high_TET1_TET1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC11329632-41419_2024_6969_MOESM3_ESM.pdf-79-ZZZ3_ZZZ3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE143994_2_v_1_ythdf1_human	RummaGEO Gene Perturbation Signatures	1.0	null
6550_POLR2I_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.891446
GSE169356_0_v_3_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HES6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.409
GSE95077_1_v_2_amiloride_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PTTG1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03727
GDAP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.10665
GSE175787_5_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE213228_4_v_0_irak2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
chr2_113442421_T_G_b38	GTEx eQTL 2025	1.0	1.60283
PMC6357748-aau9223_Table_S1.xlsx-CD4_T_-_LPS-Unnamed_0_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
6552_POLR2K_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.04781
SOX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.7326
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
Head	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE176008_7_v_3_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Subtelomeric heterochromatin	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.661
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_7_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
ETV7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.3719
POU2F1::SOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	38.2382
ZBTB26	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7658
DNAAF9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04502
9686_UTP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.03627
GSE222758_0_v_3_clofazimine_human	RummaGEO Drug Perturbation Signatures	1.0	null
beta-N-acetylhexosaminidase complex	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.192
ZBED1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2057
ABHD17C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05689
STMN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.41455
7422_RPAP1_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.863445
496100315_TCx_no dementia_TBI_86_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.44976
ZNF384	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	123.686
MSX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.6672
PMC11979751-table_s1_trajectoryderivation_elad055.xlsx-Cluster_DE_Genes_Summary-Cluster_2_AP2_Up_GTF3A	Rummagene Transcription Factor Associations 2026	1.0	null
GSE227592_6_v_3_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140936,GSE140938_0_v_1_slfn11_human	RummaGEO Gene Perturbation Signatures	1.0	null
2307_DNASE1L1_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.576773
ONECUT3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	77.4711
GSE213588_9_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE210101,GSE210114_6_v_9_urod_human	RummaGEO Gene Perturbation Signatures	1.0	null
Plasmodesma	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.875
TMEM181	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.28719
ARL4D	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07573
1605_CHTF8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.506562
TSHZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.24312
GSE120612_7_v_3_etoposide_human	RummaGEO Drug Perturbation Signatures	1.0	null
ZFP90	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.2019
GSE168918_1_v_0_tmprss4_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE82032_3_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE153907,GSE153908_0_v_1_azathioprine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
5927_OGDH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.969589
GSE230744,GSE237803_5_v_2_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
3916_HOXC6_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.691638
PSMA4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.52395
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_filtered-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE246660_1_v_0_glycerol_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE158834_11_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE103122_0_v_1_puromycin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC4149371-pone.0105180.s010.xls-NANOG-GENE_NANOG	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2263127-pone.0001816.s001.xls-E2F3_down_Bild-Symbol_E2F3	Rummagene Transcription Factor Associations 2026	1.0	null
GAPVD1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36814
HLF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7333
PMC9013128-NIHMS1795992-supplement-4.xlsx-501mel_ARID2_KO_Downregulated-Gene__name_ARID2	Rummagene Transcription Factor Associations 2026	1.0	null
ETV2::DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5597
GSE134375_3_v_2_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
RARA::RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9835
COL4A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.09717
Cerebral hemisphere	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
ELK1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.5478
Cerebral cortex	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE200430_1_v_0_sema3d_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE169356_0_v_5_ivermectin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE182181_1_v_0_ricolinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC12396377-jcb_202307079_tables1.xlsx-Fig_1C_i_-_iii_right-y_TFEB_KO_LLOMe_VS_WTLLOMe_UP_TFEB	Rummagene Transcription Factor Associations 2026	1.0	null
GSE237984_1_v_0_magi1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Frontal lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.136
FADS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.79656
TOMM7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.24644
MLYCD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21915
NUDT7	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.21792
GSE213588_8_v_12_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ARNT::HIF1A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.2212
ETS1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.7085
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-GeneID_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE258991_1_v_4_enzalutamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Occipital lobe	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.001
496100338_HIP_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.44711
MSC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.3007
GSE158969_1_v_2_trastuzumab_human	RummaGEO Drug Perturbation Signatures	1.0	null
Fallopian Tube	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.06109
RARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.1526
SALL3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36997
SLC43A2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.12201
GSE213228_1_v_5_irak2_human	RummaGEO Gene Perturbation Signatures	1.0	null
FOXL1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.7725
ENHO	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.36188
Depressive symptom (sleep problems) (binary trait)	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
GSE158834_12_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MRPL28	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.03597
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Gene_Name_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
PMC9974104-jci-133-159940-s019.xlsx-GT3-INCP-GATA3_co-bound_genes-Gene_Symbol_GATA3	Rummagene Transcription Factor Associations 2026	1.0	null
SEZ6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.23831
LBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3487
GSE213588_10_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE119978,GSE180930_6_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
tissues, cell types and enzyme sources	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1	Rummagene Transcription Factor Associations 2026	1.0	null
TLX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6461
FOXC1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.9817
GSE158834_11_v_8_palm_human	RummaGEO Gene Perturbation Signatures	1.0	null
10029_ZC3H8_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.678521
ZNF211	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	33.7733
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_Jurkat-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
TGIF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4046
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-version_2_4_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE201309_5_v_7_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
4299_KCNMB3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.562936
GSE239688_4_v_1_canagliflozin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Connective tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
TP63	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.9256
chr2_113475406_T_C_b38	GTEx eQTL 2025	1.0	1.17838
SOX14	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0814
POU4F2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.8234
MCF7_Altretamine_100nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0143715
PMC8586238-41467_2021_26788_MOESM6_ESM.xlsx-S2A_CDE_genes-S2A_CDE_-_genes_of_the_two_CCD_genes_RUNX2	Rummagene Transcription Factor Associations 2026	1.0	null
SEC24C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.29021
GSE111247_2_v_7_temozolomide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
6549_POLR2H_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.620249
K562_BMS-754807_10nM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0182123
KHK	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.92228
PMC8979909-13353_2022_690_MOESM1_ESM.xlsx-ESR1_targets-genes_ESR1	Rummagene Transcription Factor Associations 2026	1.0	null
FERD3L	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	32.9019
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-genename_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
BARX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.1972
SLX9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30177
GSE201668_0_v_1_ncor2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE217552_3_v_4_fisetin_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE76425_0_v_10_lenalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE207122_1_v_0_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNF2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.25644
GSE133927_1_v_3_meox1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE114883_0_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
RNF6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.37225
GSE107594_0_v_1_hmga2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
UBE2M	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.77301
GTEx Esophagus 20-29 vs 70-79	GTEx Tissue-Specific Aging Signatures	-1.0	-7.17274
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_HOXC6-gene_HOXC6	Rummagene Transcription Factor Associations 2026	1.0	null
9400_TTK_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.622748
GSE133516_0_v_1_kat7_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NTHL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.48374
MAP3K4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.08612
Brain - Cortex	GTEx Tissue Gene Expression Profiles 2023	1.0	2.15539
TCF7L2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.2034
GSE153871_4_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE213588_8_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE197571_3_v_1_foxm1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE172016_2_v_1_paclitaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
Spleen	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.62072
10202_ZNF207_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.538434
ATF2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.8244
GSE137325_3_v_0_copanlisib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-DDX5_17_KD_HEK293-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE178907_0_v_3_fkrp_human	RummaGEO Gene Perturbation Signatures	1.0	null
2858_FAM136A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.510578
MAPKAPK3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46628
PMC3470785-NIHMS377161-supplement-3.pdf-646-NFYA_NFYA	Rummagene Transcription Factor Associations 2026	1.0	null
GSE57871_5_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
PRAME	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1811
PDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.3561
GSE157894_1_v_0_cystine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218060_2_v_6_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7934233-13059_2021_2293_MOESM8_ESM.xlsx-Fibroblast_ATF1-gene_ATF1	Rummagene Transcription Factor Associations 2026	1.0	null
FOSL1::JUND	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4772
JUN::JUNB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.433
GSE199204,GSE211619_4_v_1_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
NDUFS1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.27036
ATF4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.109
PMC8851354-Table_6.xlsx-STAT3-bound_genes_GM12878-Supplementary_Table_6_STAT3-bound_unique_genes_in_GM12878_cells_STAT3	Rummagene Transcription Factor Associations 2026	1.0	null
GSE213588_10_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE230744,GSE237803_0_v_3_hira_human	RummaGEO Gene Perturbation Signatures	1.0	null
10755_NON-TARGETING_NON-TARGETING	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.584466
FOSB::JUN	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.6028
Brain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
CDX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.6434
ZSCAN5C	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.2618
Cells - Cultured fibroblasts	GTEx Tissue Gene Expression Profiles 2023	1.0	1.20457
496100611_FWM_no dementia_no TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.9796
EN1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.9476
GSE134375_3_v_5_stat3_human	RummaGEO Gene Perturbation Signatures	1.0	null
DRGX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2065
2313_DNM2_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.602379
PMC11906621-41598_2025_93656_MOESM6_ESM.pdf-6-ZNF267_ZNF267	Rummagene Transcription Factor Associations 2026	1.0	null
GSE218060_2_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE227698_2_v_4_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE138789_0_v_1_metformin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE218060_1_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9529122-pone.0274785.s002.xlsx-S1_Table-S1A_Table_Differentially_expressed_genes_in_HeyA8_overexpressin_ZNF521_vs_HeyA8_control_cells_ZNF521	Rummagene Transcription Factor Associations 2026	1.0	null
Whole body	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MTHFS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.0126
Vermiform appendix	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.877
PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_1h-Nearest_Ensembl_HSF1	Rummagene Transcription Factor Associations 2026	1.0	null
Prostate gland	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.125
RORA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	49.9133
GSE202434,GSE202438_15_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
9680_UTP14A_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.867644
Cigarettes smoked per day in Schizophrenia	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.569897
GSE114883_1_v_5_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7879
GSE201309_1_v_6_matrine_human	RummaGEO Drug Perturbation Signatures	1.0	null
TNFRSF1A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01009
BHLHE23	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.961
GSE158834_10_v_8_palmitic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
MEF2D	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.3499
6542_POLR2C_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.52493
PROP1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	29.384
RLIM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.26667
GSE220058,GSE220059_0_v_1_prrc2b_human	RummaGEO Gene Perturbation Signatures	1.0	null
chr2_113413043_C_T_b38	GTEx eQTL 2025	1.0	1.13585
PMC9038526-mmc1.xlsx-healthy_ctr_vs_LPS-symbols_98_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
chr2_113477901_G_C_b38	GTEx eQTL 2025	1.0	1.14459
SPIC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	37.2949
GSE98898_8_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE201309_5_v_3_matrine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FEV	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.3189
GBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.7848
4950_MED27_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.505817
GSE218060_1_v_4_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Symplast	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.8
RAX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.4985
WNK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.64968
KLLN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.23507
6862_PSMC5_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.979795
PMC7021771-41467_2020_14684_MOESM7_ESM.xlsx-CASZ1_ChIPseq_in_SMS-CTR_MEKi-Nearest_Ensembl_CASZ1	Rummagene Transcription Factor Associations 2026	1.0	null
HES2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8458
GSE235587_2_v_0_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE168798_0_v_1_isg15_human	RummaGEO Gene Perturbation Signatures	1.0	null
ZNHIT3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.73716
GSE202434,GSE202438_3_v_0_talazoparib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GADD45A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32563
GSE196962_4_v_3_parg_human	RummaGEO Gene Perturbation Signatures	-1.0	null
ISX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.078
METTL27	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.75938
CPD	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.138
RASIP1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.32884
Ganglion	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
GSE57871_6_v_10_vorinostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE235516_0_v_1_zdhhc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Metabolite levels	GWAS Catalog SNP-Phenotype Associations 2025	1.0	0.504576
nucleus	GO Cellular Component Annotations 2025	1.0	null
ERF::HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.7909
PAX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.2326
TBX19	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	26.3917
GSE152441,GSE152442_0_v_4_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
496100559_FWM_no dementia_no TBI_87_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.01622
ISL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.96004
GSE246660_1_v_0_lmo3_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE210662_3_v_0_znf165_human	RummaGEO Gene Perturbation Signatures	1.0	null
CREB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.7736
GSE218060_7_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Inward rectifying potassium channel	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	0.902
TCF7L1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	31.747
GSE218060_7_v_3_decitabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
SATB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	28.6678
PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK	Rummagene Transcription Factor Associations 2026	1.0	null
DUXA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.0364
PMC8791942-41398_2021_1766_MOESM7_ESM.xlsx-LPS_DEGs_Heatmap-hgnc_symbol_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
DCTN5	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.93541
PMC7606598-NIHMS1624889-supplement-1624889_Supp_Tab1-10.xlsx-S8_MR-JTI-geneid_NR3C2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE236497,GSE236500_1_v_0_pemrametostat_human	RummaGEO Drug Perturbation Signatures	1.0	null
2784_EXOC7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.715611
SYPL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.88749
CAMKV	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.17572
GSE227592_6_v_1_adar_human	RummaGEO Gene Perturbation Signatures	1.0	null
B-lymphoblast cell line	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	1.155
9457_TXNL4A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.562735
GSE235587_2_v_1_mitoxantrone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PATZ1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.32844
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_47_AR	Rummagene Transcription Factor Associations 2026	1.0	null
FAM204A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.40612
GSE233183,GSE233187_2_v_9_larp1_human	RummaGEO Gene Perturbation Signatures	1.0	null
7423_RPAP2_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.558671
GSE205729,GSE205731_2_v_1_tazemetostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
IRX3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04733
GSE110248_1_v_6_romidepsin_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE202434,GSE202438_6_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE131649_4_v_5_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
3537_GRINA_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.57146
1535_CFH_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.573757
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
VENTX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.9293
KIF14	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02342
GSE152441,GSE152442_7_v_5_folic acid_human	RummaGEO Drug Perturbation Signatures	1.0	null
RORC	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.0397
GSE216043_7_v_5_cisplatin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.041
POU4F1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.9425
FOXB1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	34.0288
STRBP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.59343
PRRX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.6196
GSE184892_7_v_3_trehalose_human	RummaGEO Drug Perturbation Signatures	-1.0	null
MSX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.0068
GSE94849_6_v_0_pinometostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ALX3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4282
SMARCD2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.35456
BHLHE22	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.547
GSE240439_1_v_2_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE202434,GSE202438_12_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC10149505-41392_2023_1393_MOESM2_ESM.xlsx-CPCMR-Hugo_Symbol_MEIS2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE199204,GSE211619_4_v_3_glutamine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
SHOX	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.05025
MDN1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.20388
GSE158834_7_v_3_palmitic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE140965_1_v_4_mybpc3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-GeneID_AR	Rummagene Transcription Factor Associations 2026	1.0	null
6794_PRPF38A_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.688155
GSE216413_1_v_0_gata3_human	RummaGEO Gene Perturbation Signatures	1.0	null
496100356_TCx_probable Alzheimer's disease_TBI_84_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.15583
PCDHB9	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.46203
GSE212330_1_v_0_azacitidine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE210476_11_v_3_rutaecarpine_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE213588_10_v_5_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_EC109_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE135514_8_v_5_dasatinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GBX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	15.5977
GSE182680,GSE182683_10_v_4_dexamethasone_human	RummaGEO Drug Perturbation Signatures	-1.0	null
ETV6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.0254
NKX6-1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.5737
PRKCA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.04573
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_2_AR	Rummagene Transcription Factor Associations 2026	1.0	null
GSE169152_3_v_6_ibrutinib_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE174701_5_v_8_maml3_human	RummaGEO Gene Perturbation Signatures	1.0	null
RALA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.01529
GTEx Ovary 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	1.0	5.32002
PKNOX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.9591
PMC12000322-41419_2025_7601_MOESM9_ESM.xlsx-H3122-AR_somatic_filtered_PASS-Unnamed_60_AR	Rummagene Transcription Factor Associations 2026	1.0	null
TGIF2LY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.5862
PMC12685885-Table1.xlsx-Table_S9-Du_PanCancer_SOX6_TrsFib_SOX6	Rummagene Transcription Factor Associations 2026	1.0	null
TWIST1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.0011
GSE106170_1_v_0_nap1l3_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CREB3L3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02277
PMC10859382-41392_2024_1740_MOESM3_ESM.pdf-13-JUND_JUND	Rummagene Transcription Factor Associations 2026	1.0	null
SBF1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.65574
SDF2L1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.055
NR1H2::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.24
DHX29	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	3.13131
PROB1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.65775
PMC10602967-18_2023_4927_MOESM3_ESM.xlsx-MBNL1_KD_HFE-145-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
RXRG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.9984
PMC2530868-gb-2008-9-7-r111-S5.xls-Inc_hgu133_AAG-AA-Unnamed_1_TEAD1	Rummagene Transcription Factor Associations 2026	1.0	null
CREM	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.006
GSE242290_3_v_2_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Telencephalon	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PFKFB3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.38249
GSE230263,GSE230265_0_v_1_runx1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE131649_4_v_11_hemin_human	RummaGEO Drug Perturbation Signatures	1.0	null
YBEY	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.54493
9420_TUBB_P1	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.547315
ZNF558	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	84.1084
intracellular membrane-bounded organelle	GO Cellular Component Annotations 2025	1.0	null
Antler	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.702
496100367_FWM_no dementia_TBI_78_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-3.6218
Midbrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
PMC8102197-41375_2021_1146_MOESM2_ESM.xlsx-genelists-MOLM13_ChIP_DOT1L_VTP_Dn_150_Krivstov_et_Al_DOT1L	Rummagene Transcription Factor Associations 2026	1.0	null
FUT4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.18689
Nerve - Tibial	GTEx Tissue Gene Expression Profiles 2023	1.0	0.949209
PHOX2A	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	27.2497
SOX18	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.81
6652_PPP1R10_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.81839
chr2_113462478_T_C_b38	GTEx eQTL 2025	1.0	4.11993
PMC11185845-NIHMS1996282-supplement-Table_S1.xls-TableS1_txt-Kasumi_miR130_KD_AR	Rummagene Transcription Factor Associations 2026	1.0	null
DLX6	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.4841
HOXD9	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1026
RUNDC3A	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1583
496100327_PCx_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.31458
PMC5689001-supp_061432.117_Supplemental_Table_1.xlsx-A_Seq_KD_cassette_exons-Unnamed_1_AR	Rummagene Transcription Factor Associations 2026	1.0	null
ZNF652	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.2929
GRHL2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.30399
GSE241622_1_v_0_ythdc2_human	RummaGEO Gene Perturbation Signatures	-1.0	null
CLDN10	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.114
FOXC2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	40.0399
GSE119978,GSE180930_3_v_8_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
Adipose tissue	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	1.0	1.033
10455_ZNF567_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.856997
SRY	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.25
GSE155031_5_v_3_dextran_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC10037107-JEM_20221755_TableS6.docx-0-IL4-p_E382Q-STAT6_targets_in_Jurkats_1_STAT6	Rummagene Transcription Factor Associations 2026	1.0	null
9905_XRCC3_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.515215
POU4F3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	43.0433
RARA::RXRA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.5217
TGIF2LX	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.3242
1910_CSRNP3_P1	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	1.45675
496100348_TCx_probable Alzheimer's disease_no TBI_79_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.15034
K562_SGI-1776 free base_1µM_24h	Sci-Plex Drug Perturbation Signatures	1.0	0.0189745
RARA	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	60.7125
PAX8	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.9878
RPRM	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.93212
PMC9338531-13046_2022_2445_MOESM18_ESM.xlsx-AASE_A549_KD-geneSymbol_AR	Rummagene Transcription Factor Associations 2026	1.0	null
PMC2866657-pone.0010547.s001.xls-ERG-high-GENES_DOWNREGULATED_IN_ERGhigh_ERG	Rummagene Transcription Factor Associations 2026	1.0	null
RPAIN	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00217
PPARG	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.5357
GSE203060_0_v_1_kdm4c_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE70935_1_v_0_cyfip1_human	RummaGEO Gene Perturbation Signatures	1.0	null
TMCO6	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.00597
GSE160765_2_v_1_twist1_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE235390_4_v_0_lurbinectedin_human	RummaGEO Drug Perturbation Signatures	1.0	null
TAOK2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.47383
SPDL1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.06897
Anterior pharynx	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	1.0	0.658
RORB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.3043
PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4	Rummagene Transcription Factor Associations 2026	1.0	null
PMC12209767-bcd-25-0099_supplementary_table_s2_suppst2.xlsx-C_DEGs_RNA-seq-Supplementary_table_S2C_List_of_differentially_expressed_genes_in_IGHUND_vs_IGH_GCB_MB2_DE_DLBCL_HGBCL-DH-BCL2_-BCL6_BCL6	Rummagene Transcription Factor Associations 2026	1.0	null
SLMAP	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.02586
ZNF35	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	21.1255
PMC10534007-Table_2.xlsx-S5_unique_up_MSC_B-721_elements_included_exclusively_in_BFTC905_MSC_up_MSC	Rummagene Transcription Factor Associations 2026	1.0	null
496100485_PCx_possible Alzheimer's disease_no TBI_100+_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.12468
DLX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	14.0214
PMC9229595-Table_2.xlsx-LPS_subset_IX-Unnamed_15_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE206729_5_v_0_trps1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
8109_SLC7A6OS_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.667555
RAX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	22.4082
chromosome, subtelomeric region	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	1.0	1.173
GSE119978,GSE180930_3_v_1_cisplatin_human	RummaGEO Drug Perturbation Signatures	1.0	null
HEY2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.8411
GSE168473_0_v_1_isoniazid_human	RummaGEO Drug Perturbation Signatures	1.0	null
GTEx Esophagus 20-29 vs 60-69	GTEx Tissue-Specific Aging Signatures	-1.0	-17.9094
GSE227698_2_v_1_g0s2_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE140651,GSE140653_2_v_6_med1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
Substantia nigra	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
RCOR3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84112
6060_TENT4B_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.574135
PBX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	19.191
496100659_PCx_no dementia_no TBI_90-94_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.01613
GSE213588_9_v_13_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ONECUT1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.3776
GSE202434,GSE202438_8_v_5_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
GSE135030_3_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
7393_RNF4_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.524573
Central nervous system	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
Muscle - Skeletal	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.59899
Minor Salivary Gland	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.47402
MYF5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.3409
GSE233679_5_v_9_nicotinamide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
FOXD3	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	82.3107
TGIF1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	25.6552
PMC11703355-IEPI_A_2435244_SM8871.xlsx-Table_S2-SMYD2_LF_K_LTF	Rummagene Transcription Factor Associations 2026	1.0	null
ZBTB26	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02879
GSE135030_11_v_9_fludarabine_human	RummaGEO Drug Perturbation Signatures	1.0	null
PMC11426526-ppat.1012555.s014.xlsx-DEG_DC_C91-PL_LPS_vs_DC_JK_LPS-Unnamed_5_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE242290_3_v_10_glutathione_human	RummaGEO Drug Perturbation Signatures	1.0	null
Brain - Spinal cord (cervical c-1)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-1.60714
PMC10242447-mmc2.xlsx-TI_DEGs-Table_S1_TIGs_Comparison_between_each_trained_monocyte_sub-population_T3m_LPS_with_monocytes_T0_LPS_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
MEF2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	23.3311
7424_RPAP3_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.612358
C1orf226	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.03041
OTX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.4238
GSE228017_0_v_1_parthenolide_human	RummaGEO Drug Perturbation Signatures	-1.0	null
Forebrain	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	1.0	4.0
MRTO4	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.94735
EMX1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	24.2225
FOXD2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	42.1005
PMC7041704-JEM_20180649_TableS1.xlsx-shared_LPS_induced_genes-Unnamed_6_IRF6	Rummagene Transcription Factor Associations 2026	1.0	null
GSE118548_1_v_2_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
NKX2-5	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	17.2691
chr2_113458385_G_C_b38	GTEx eQTL 2025	1.0	1.44626
496100323_FWM_possible Alzheimer's disease_TBI_90-94_M	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	-1.0	-2.73572
OLIG1	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	20.8313
GSE221327_5_v_0_clpp_human	RummaGEO Gene Perturbation Signatures	-1.0	null
TBXT	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.7045
TPGS2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.19748
CSGALNACT2	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-3.25121
GSE118548_1_v_0_trametinib_human	RummaGEO Drug Perturbation Signatures	1.0	null
ERF	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	18.5328
RHOA	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.1202
RSC1A1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.00719
GSE189609_1_v_2_hax1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE152441,GSE152442_0_v_3_folic acid_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PMC7529806-41467_2020_18638_MOESM7_ESM.xlsx-Supplementary_Data_4-Supplementary_Data_4_TG_of_EPAS1_EPAS1	Rummagene Transcription Factor Associations 2026	1.0	null
GSE233647_2_v_0_docetaxel_human	RummaGEO Drug Perturbation Signatures	1.0	null
1441_CDK7_P1P2	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	1.0	0.648503
GSE202434,GSE202438_8_v_1_talazoparib_human	RummaGEO Drug Perturbation Signatures	1.0	null
CDX2	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.5998
ADCYAP1R1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	-1.0	-2.07249
GSE80537_3_v_2_adhfe1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
QSOX1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.22032
496100358_HIP_no dementia_TBI_95-99_F	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	1.0	2.32689
ZSCAN4	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	35.213
PTGIS	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.84222
ATF7	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	16.1965
GSE175787_11_v_6_rhoc_human	RummaGEO Gene Perturbation Signatures	-1.0	null
NOC4L	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13745
GSE135350_3_v_6_dexamethasone_human	RummaGEO Drug Perturbation Signatures	1.0	null
7164_RBM22_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.954545
chr2_113449829_T_C_b38	GTEx eQTL 2025	1.0	1.65767
GSE98898_7_v_1_hoxa1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE126463_1_v_3_pomalidomide_human	RummaGEO Drug Perturbation Signatures	1.0	null
RARB	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	30.7117
Brain - Anterior cingulate cortex (BA24)	GTEx Tissue Gene Expression Profiles 2023	-1.0	-2.50091
1083_NEPRO_P1P2	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	1.0	0.872332
GSE218060_1_v_0_decitabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE57871_1_v_2_vorinostat_human	RummaGEO Drug Perturbation Signatures	-1.0	null
PHOX2B	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	44.1404
Sleep duration	GWAS Catalog SNP-Phenotype Associations 2025	1.0	1.0
ATP6V0D1	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.13281
GSE163297_0_v_1_doxorubicin_human	RummaGEO Drug Perturbation Signatures	-1.0	null
GSE218819_3_v_4_kdm5b_human	RummaGEO Gene Perturbation Signatures	-1.0	null
HOXB13	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	39.21
GSE182185_0_v_1_pstk_human	RummaGEO Gene Perturbation Signatures	-1.0	null
MEF2C	JASPAR Predicted Human Transcription Factor Targets 2025	1.0	61.134
LLPH	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.64776
PMC6996923-elife-46981-supp4.xlsx-KO_Up_Only_Vs_OCT4-Column_ID_POU5F1	Rummagene Transcription Factor Associations 2026	1.0	null
ELF3	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	1.0	2.02064
GSE153871_1_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null
chr2_113489746_C_A_b38	GTEx eQTL 2025	1.0	1.51368
PMC3702285-cddis2013211x6.pdf-9-ZNF813_ZNF813	Rummagene Transcription Factor Associations 2026	1.0	null
PMC8569982-41065_2021_205_MOESM1_ESM.xlsx-mono_THP1_a2b_tpm1-gene_GLI2	Rummagene Transcription Factor Associations 2026	1.0	null
GSE238005_0_v_3_c9orf72_human	RummaGEO Gene Perturbation Signatures	1.0	null
GSE229309,GSE229314_0_v_1_elavl1_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE203329_2_v_1_mettl5_human	RummaGEO Gene Perturbation Signatures	-1.0	null
GSE153871_5_v_2_cytarabine_human	RummaGEO Drug Perturbation Signatures	-1.0	null