association dataset threshold value standardized value MOLP-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0939 GSE63048_11_v_8_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null SZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.14316 U2OS DepMap CRISPR Gene Dependency 1.0 2.99223 SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null PMC9574515-mmc2.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null SUZ12-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null layer VI of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87709 NFE2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.7929 H3K9me3_megakaryocyte_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Sarcoma_SARC_TCGA-QC-A6FX-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null superficial stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33097 496100288_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.74268 HCC70 CCLE Cell Line Gene CNV Profiles -1.0 -1.70252 G44 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.28229 sensory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.046898 SUM 229PE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.943705 BRD-K91410469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10839 fluoxetine-6757 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null viscus TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.051642 Corpus epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.755 mantle zone of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.13221 Liver hepatocellular carcinoma_LIHC_TCGA-CC-A9FW-01A-11R-A37K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null JARID2-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null RMG-I Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.47939 SMAD4-21741376-HESC-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null periventricular stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25847 H3K4me1_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Ahr::Arnt JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 19.5 MDA MB435 BioGPS Cell Line Gene Expression Profiles 1.0 1.01404 CHAGOK1 CCLE Cell Line Gene CNV Profiles -1.0 -2.1663 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-ENSEMBL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null core of nucleus accumbens Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.97872 BRD-K28247259 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01175 paraventricular nuclei, right of thalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.920309 TCF7L2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.1712 anterior olfactory area, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71016 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Edinger-Westphal nucleus (accessory oculomotor nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.833829 ion binding GO Molecular Function Annotations 2015 1.0 null mRNA_GATA3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K29802265 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24957 lateral pallium Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14148 Acrosomal vesicle COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.267 PAX6-23342162-BETA-FORBRAIN-LENS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.TP53.M_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.19248 SNU182 DepMap CRISPR Gene Dependency 1.0 2.52005 gametocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.089542 Lateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.34697 fluphenazine-490 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Axonemal dynein complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.854 membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 tanespimycin-505 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null brain GTEx Tissue Gene Expression Profiles 1.0 1.07062 Prenatal Exposure Delayed Effects CTD Gene-Disease Associations 1.0 1.08019 ChIP_RNF2_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null UBE2D3 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K90697693 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34675 NFIC::TLX1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.5 PMC5655592__F4 PFOCR Pathway Figure Associations 2024 1.0 null H3K9me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-K4-A54R-11A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Edinger-Westphal nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.34419 BRD-K13798725 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33626 H3K4me1_liver_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SLFN5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.22435 STAT1-17558387-HELA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null LN428 CCLE Cell Line Gene Expression Profiles 1.0 1.57745 BRD-K08715132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51601 BRD-K84936524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08711 Orbital area, medial part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07478 CRCGN008_HEPG2_24H:I01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.05185 BRD-K86228587 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19262 H3K4me3_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null NCI-H2804 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25679 TEF-1 MotifMap Predicted Transcription Factor Targets 1.0 null BRD-K93496326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.22443 CH157MN CCLE Cell Line Gene Expression Profiles 1.0 2.30462 ubiquitin protein ligase activity GO Molecular Function Annotations 2025 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BA-5559-01A-01R-1514-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K28314528 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.65341 BRD-K08489825 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15312 heart GTEx Tissue Gene Expression Profiles -1.0 -1.0782 BRD-K56161792 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47398 spinalcordlower BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.23182 cytoplasm LOCATE Curated Protein Localization Annotations 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A3MR-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SERINC4 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.59355 REC-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.58292 CA4 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.33226 BRD-K57894545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24731 BRD-K56106571 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18519 BRD-K05789358 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89116 H3K4me1_placenta_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Bmi-1_KD_GDS2724_102_human_DAOY medulloblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K84235037 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.1188 superficial stratum of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.41132 Temporal association areas, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.4234 NCO2 CCLE Cell Line Gene CNV Profiles 1.0 1.93583 PPARA::RXRA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.768 globose nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 3.26578 POLR2A ENCODE Transcription Factor Targets 1.0 null H3K4me1_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Targets 2022 1.0 null Primary somatosensory area, mouth, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41129 Bladder Urothelial Carcinoma_BLCA_TCGA-CF-A47V-01A-11R-A23W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H847 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.08272 H3K4me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null GSE196104,GSE196106_2_v_0_vsx2_mouse RummaGEO Gene Perturbation Signatures -1.0 null central nucleus of inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.69666 reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.379626 isthmic part of the intermediate lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.28712 MZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1307 NURR1 MotifMap Predicted Transcription Factor Targets 1.0 null female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K98505253 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00939 CA4 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48764 Subiculum, dorsal part, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4058 KLM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36688 Embryonic cerebral cortex TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.564 CRCGN017_MCF10A.TP53.M_24H:C01 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.27665 H3K4me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null KLF5-20875108-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NKX2-3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9305 superficial stratum of r5BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83293 GSE183994_1_v_0_scml2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-K96379403 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20742 ChIP_SUZ12_18555785 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Autosomal recessive nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.175 hippocampus (hippocampal formation)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.47273 BRD-K70923850 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05694 nucleus of the stria terminalis, medial division, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25546 Piriform area, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17038 BRD-K08607520 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16928 SKNO1 DepMap CRISPR Gene Dependency 1.0 3.62487 MDA-MB-453 GDSC Cell Line Gene Expression Profiles -1.0 -1.42838 finger TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.782725 PMC10209342-mmc9.xlsx-UBE2D3_interactors-UBE2D3_interactors_used_for_Venn_Diagrams_from_MINT_STRING_UniProt_IntAct_BioGRID_SPEN Rummagene Transcription Factor Associations 2026 1.0 null PMC11263707-41419_2024_6896_MOESM6_ESM.pdf-78-ZNF329_ZNF329 Rummagene Transcription Factor Associations 2026 1.0 null 496100373_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.4815 DF-32-EL16_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.68555 PHC1-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K58971526 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.91843 BRD-K85357344 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08517 BRD-K82814367 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44587 CRCGN016_MCF10A.TP53.M_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.91233 Brain Lower Grade Glioma_LGG_TCGA-HT-7610-01A-21R-2090-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K62965224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15363 BRD-K89121101 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05801 POLR2AphosphoS5_G1E_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K48699175 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20606 UBE2W Pathway Commons Protein-Protein Interactions 1.0 null BRD-K86330848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37926 ChIP_RNF2_22325148 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null fasciola cinerea Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.12966 Sec61 translocon complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.912 PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K64742599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33168 CRCGN016_MCF10A.WT.HP_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.91256 CD8+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.02382 Male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 estradiol-365 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null imatinib-366 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Retrosplenial area, ventral part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83742 RUNX2 ChEA Transcription Factor Targets 1.0 null BRD-K19103068 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02254 BRD-K99131664 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48813 layer 2 of VPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07989 RCOR3 ChEA Transcription Factor Targets 1.0 null ZNF449 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.6393 184B5 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.848389 periventricular stratum of r9Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18182 Organelle membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Uvula (IX) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02245 dopamine-491 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null mantle zone of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56303 OV-90 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.88344 BRD-K30318008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24435 Adrenocortical carcinoma_ACC_TCGA-OR-A5KV-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null IGR-37 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82944 ESS-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K82145108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56192 periventricular stratum of r4Lim Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54612 CRCGN017_MCF10A.WT.HP_24H:O11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2546 TCF12/HEB-22897851-JUKARTE6-1-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PMC8724844-bt-30-1-98-supple2.xlsx-Hallmark_pathways-EGR2_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null Rectal Mucosa Donor 31 Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -2.08234 BRD-K43026564 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17731 MM1S CCLE Cell Line Gene CNV Profiles 1.0 1.52723 Temporal association areas Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65841 HELA BioGPS Cell Line Gene Expression Profiles -1.0 -0.897795 Perturb_14493_KO_Cnot4_SRP285155 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations 1.0 14.6316 RAC3-21632823-H3396-HUMAN ChEA Transcription Factor Targets 2022 1.0 null SUM52PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.505833 BRD-K40494117 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07413 Linear nucleus of the medulla Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02549 LMO2 ChEA Transcription Factor Targets 1.0 null dorsal thalamus_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.930882 KATO III Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.60587 Skin Cutaneous Melanoma_SKCM_TCGA-ER-A199-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC5655592__F4 PFOCR Pathway Figure Associations 2023 1.0 null 496100372_HIP_dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.74438 SG in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.36034 EOL-1-CELL COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K69699301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11465 SEPTIN7 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.22873 amygdaloid complex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43876 WIDR Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11949 UOK101 CCLE Cell Line Gene Expression Profiles 1.0 2.13088 MDA-MB-330 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852583 BRD-K11247495 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09352 Paraflocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.27524 H3K4me1_thymus_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K22584556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0245 layer 1 of InsCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22265 SU-DHL-4 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44503 BRD-K25149224 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77581 DEL CCLE Cell Line Gene CNV Profiles -1.0 -1.3719 TUHR10TKB DepMap CRISPR Gene Dependency 1.0 3.24634 superficial stratum of r10Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.17494 MDA-MB-415 COSMIC Cell Line Gene Mutation Profiles 1.0 null tongueepidermis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.879183 BRD-K80921954 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05129 female reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 CRCGN015_MCF10A.TP53.M_24H:C23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.6139 STAT3-24763339-IMN-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null FOXK2_02_31 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 4.05209 ZNF219 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.22365 Prostate adenocarcinoma_PRAD_TCGA-G9-6365-11A-01R-1789-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZFP281-27345836-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PA-TU-8902 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.36688 septohypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.11081 CRCGN016_MCF10A.WT.HP_24H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.6072 periventricular stratum of VTTh Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17132 BRD-K83562499 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70959 MERO83 DepMap CRISPR Gene Dependency 1.0 5.50969 BRD-K20009653 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82999 layer III of caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.47463 Pancreatic adenocarcinoma_PAAD_TCGA-US-A776-01A-13R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BICR18 CCLE Cell Line Gene Expression Profiles 1.0 1.509 primary visual cortex (striate cortex, area V1/17)_15 yrs_M_12299 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.22182 JHH-7 COSMIC Cell Line Gene Mutation Profiles 1.0 null Piriform area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21195 Medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26243 spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.18292 HEK 293 T-rex BioGPS Cell Line Gene Expression Profiles 1.0 1.89625 negative regulation of cellular process GO Biological Process Annotations 2025 1.0 null laterorostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.06891 TUFT1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.51092 OCIM1 CCLE Cell Line Gene Expression Profiles 1.0 3.40796 Entorhinal area, lateral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.09752 Endoplasmic reticulum membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 sodium phenylbutyrate-434 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02751 PMC11811132-41598_2025_89334_MOESM5_ESM.xlsx-SOX4-toNode_SOX4 Rummagene Transcription Factor Associations 2026 1.0 null Cul3-RING ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.146 VZ in caudal subicular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10977 superficial layers of olfactory entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.841748 Zinc finger, RING/FYVE/PHD-type InterPro Predicted Protein Domain Annotations 1.0 null Triangular nucleus of septum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.02968 RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K80575072 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35463 globus pallidus, internal segment, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.999304 superficial stratum of r1BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32153 KPL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49777 SUZ12-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null dorsal nucleus of the lateral lemniscus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82285 r3 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63037 CRCGN011_HEPG2_24H:L14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0188 NCI-H1781 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior (caudal) superior temporal cortex (area 22c)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28252 posteroventral (inferior) parietal cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.22871 BRD-K06181307 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66239 MKN-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.995061 laterodorsal part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.87098 integral component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 SW-48 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.888 SCA1_Knock-in_GDS1756_231_mouse_Cerebellum tissue - 4 weeks of age GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K02087489 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67033 GI-1 GDSC Cell Line Gene Expression Profiles 1.0 2.08547 BCL11A JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.3599 CORL279 CCLE Cell Line Gene CNV Profiles 1.0 1.96561 external part of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.48129 RCH-ACV COSMIC Cell Line Gene Mutation Profiles 1.0 null nervous system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042957 EBC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null Field CA3, stratum lacunosum-moleculare Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06559 UterusCorpus BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 0.831987 G111 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21727 IX, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 2.22673 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.9488 BRD-K06480376 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17597 SPI1 ChEA Transcription Factor Targets 1.0 null VCAP CCLE Cell Line Gene CNV Profiles -1.0 -1.37643 MCF7 CCLE Cell Line Gene CNV Profiles -1.0 -1.88315 BRD-K69294714 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70315 tolnaftate-4221 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null flufenamic acid-316 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null claustrum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.854413 pancreas BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.46784 superficial stratum of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.71016 BRD-K19752998 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.54463 CHL1DM DepMap CRISPR Gene Dependency 1.0 4.62006 TP63 ChEA Transcription Factor Targets 1.0 null periventricular stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.60835 homatropine-methylbromide LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51487 496100350_FWM_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.53859 RUNX1 ChEA Transcription Factor Targets 1.0 null triangular septal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52682 Lung squamous cell carcinoma_LUSC_TCGA-21-5782-01A-01R-1635-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Adrenocortical carcinoma_ACC_TCGA-P6-A5OF-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HT1376 DepMap CRISPR Gene Dependency 1.0 2.07918 SMAD3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null lateral habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -3.30461 membrane part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.044689 SMAD4-21741376-HESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K33967077 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3343 BRD-K69350885 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26948 FU97 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38104 Retrosplenial area, dorsal part, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33149 BRD-K44126416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26914 SCC-9 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12989 Bed nuclei of the stria terminalis, anterior division, oval nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.58433 wortmannin-506 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC8709578-elife-69843-supp2.xlsx-HSF1_KO_2_E2_30min-Nearest_Ensembl_HSF1 Rummagene Transcription Factor Associations 2026 1.0 null lateral ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.13652 CHD4-35695185-NICBASALROOTGANGLIA-MOUSE-EMBRYO ChEA Transcription Factor Targets 2022 1.0 null BRD-A76076412 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10233 organelle LOCATE Predicted Protein Localization Annotations 1.0 null superficial stratum of r8BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.40967 Brain Lower Grade Glioma_LGG_TCGA-TM-A84R-01A-21R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 2 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41746 BRD-K97624648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20313 DMS 79 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896616 BRD-K05286676 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20459 BRD-K15863674 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.36578 BRD-K89376690 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01993 Seminal plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.914 CRCGN016_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.22573 outer CP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.3254 GA-88-CF36_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.91166 Lung squamous cell carcinoma_LUSC_TCGA-63-A5MS-01A-11R-A26W-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null breast GTEx Tissue Gene Expression Profiles 1.0 1.54084 496100377_PCx_no dementia_no TBI_95-99_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40107 CLPP_KO_GSE40207_378_mouse_Testies GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null EA-18-FP00_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.90393 mRNA_POU5F1_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null negative regulation of nucleotide-binding oligomerization domain containing signaling pathway GO Biological Process Annotations 2023 1.0 null Endoplasmic reticulum subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Inferior olivary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05871 THBS3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.21487 Colo-678 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.125 testis TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.53554 MG-63 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12048 CREM ChEA Transcription Factor Targets 1.0 null Entorhinal area, medial part, dorsal zone, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.53186 BRD-K86721033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34308 Acute Myeloid Leukemia_LAML_TCGA-AB-3002-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nucleus of the lateral olfactory tract, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48481 H3K27me3_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ESR2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 39.0457 MOLM16 CCLE Cell Line Gene CNV Profiles 1.0 2.36077 VEGF_A_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null BRD-K37831546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.25274 BRD-K43388152 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.51025 NCI-H929 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03221 MTF2-20144788-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:L22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.08101 rostral subdivision of paraventricular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47298 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U6-01A-12R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K27me3_erythroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null RCOR1_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null dexamethasone_homo sapiens_gpl4133_gse42619 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.15598 CRCGN015_HEPG2_48H:D17 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.7204 Field CA2, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12515 BRD-K83966071 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4302 CRCGN008_HEPG2_24H:A06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2332 ubiquitin-protein transferase activity GO Molecular Function Annotations 2025 1.0 null negative regulation of cell cycle GO Biological Process Annotations 2023 1.0 null cerebellar cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.37702 posterior (caudal) superior temporal cortex (area 22c)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.83656 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H0-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CLPP_KO_GDS4791_104_mouse_testis GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NRK cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.111 RARA::RXRG JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.457 Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4223-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KHM1B CCLE Cell Line Gene CNV Profiles 1.0 1.6806 SNU119 CCLE Cell Line Gene Expression Profiles -1.0 -1.51778 Ebolavirus(EBOV)_2day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.30964 U266B1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.89007 EZH2-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null dorsal cortical nucleus of inferior colliculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.18866 JcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52971 Lingula (I) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.93907 BRD-K64404450 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01231 RNF2-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Spastic hemiplegia DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.075 PACADD161 DepMap CRISPR Gene Dependency 1.0 6.79562 ZNF675 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.3314 SLR21 CCLE Cell Line Gene Expression Profiles 1.0 2.25007 H3K4me3_brain_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K33953218 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43952 cingulum bundle, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -2.34733 inner SZ in primary visual cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.60784 intracellular part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 G96 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21831 OCI-AML5 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.75654 nucleus LOCATE Predicted Protein Localization Annotations 1.0 null Female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 SG in frontal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.96099 Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.3394 LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 PCDH12_Deficiency_GDS3415_577_mouse_Embryonic placentas (12.5 day) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null TET1-21490601-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null mRNA_TCF3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A7PW-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K98805845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.73772 Olig2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.8727 BRD-K37780492 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.50914 BRD-K04614055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10668 GB1 CCLE Cell Line Gene Expression Profiles -1.0 -1.60611 BRD-K71836501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.2036 H3K9me3_fibroblast of lung_hg19_2 ENCODE Histone Modification Site Profiles 1.0 null CSRP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.75291 BRD-K89687419 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50199 Arsenic CTD Gene-Chemical Interactions 1.0 null r9 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33203 GSE186460_3_v_6_baricitinib_human RummaGEO Drug Perturbation Signatures 1.0 null PC-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30375 BRD-K45112293 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.73615 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO Biological Process Annotations 2025 1.0 null Testis TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 NCI-H2795 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99794 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7418-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null KYSE270 CCLE Cell Line Gene Expression Profiles 1.0 1.36461 intermediate stratum of r7Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02449 Anterior olfactory nucleus, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.39119 H3K9me3_CH12.LX_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DU-A7TC-01A-21R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HSC-39 COSMIC Cell Line Gene Mutation Profiles 1.0 null DMRTA1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 18.0532 CREB3L1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 23.8041 Bladder Urothelial Carcinoma_BLCA_TCGA-BT-A20W-01A-21R-A14Y-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r2 part of anteroventral cochlear nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89212 HCC38 DepMap CRISPR Gene Dependency 1.0 2.14502 AU565 CCLE Cell Line Gene CNV Profiles -1.0 -1.3954 Asi complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.09 BRD-K85294251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.92854 cerebellar cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.24731 BRD-K80819226 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03022 Cerebellar mossy fiber COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.844 GSE65617_2_v_3_aire_mouse RummaGEO Gene Perturbation Signatures -1.0 null lateral superior olive Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05452 medial subdivision of central nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.10893 BRD-K00970182 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1215 Endomembrane system COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 ventrolateral prefrontal cortex_37 yrs_M_12303 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.60857 arm TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.72322 BRD-K80073743 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.33321 mRNA_SOX9_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null layer 3 of VPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03834 SUZ12-18974828-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null intrinsic component of membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 urogenital system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.232881 BRD-K78789413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.40055 Sarcoma_SARC_TCGA-DX-A23U-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cellular_component LOCATE Predicted Protein Localization Annotations 1.0 null animal TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null abducens nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.856045 BRD-K08389897 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04983 IRF4-20064451-CD4+T-MOUSE ChEA Transcription Factor Targets 2022 1.0 null H3K9me3_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ChIP_PHC1_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K28510065 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.44016 NCI-H1651 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852583 GSE199255,GSE199356_4_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null ventricular (matrix) zone of cerebellum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.846103 BRD-A63759745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08548 Lung adenocarcinoma_LUAD_TCGA-05-4398-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null amygdaloid complex_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.02676 BRD-K64483847 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02741 central GeneRIF Biological Term Annotations 1.0 null CRCGN016_MCF10A.TP53.M_24H:D15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03357 Retrosplenial area, ventral part, layer 2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.98582 Lung squamous cell carcinoma_LUSC_TCGA-22-1005-01A-01R-0692-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K01077691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20229 H3K4me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null KMS-34 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828364 CLPP_KO_GSE40207_388_mouse_testis GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null primary motor cortex (area M1, area 4)_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.06648 Superior olivary complex, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02947 KARPAS-45 COSMIC Cell Line Gene Mutation Profiles 1.0 null HCC1171 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953401 FOXP3_ABLATION_GDS2525_64_mouse_mature regulatory T cells (Treg) GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null striatum_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.07871 ATF2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 20.9395 BRD-K42333498 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19442 BRD-K98953346 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08781 C32TG Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02279 gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K46824282 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.46758 JURKAT CCLE Cell Line Gene Expression Profiles -1.0 -1.52298 Postsubiculum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.06037 Inferior colliculus, dorsal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44439 Down Syndrome_Brain_GSE5390 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.76771 primary somatosensory cortex (area S1, areas 3,1,2)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.62701 PK-59 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.49867 H-EMC-SS COSMIC Cell Line Gene Mutation Profiles 1.0 null HSOS1 DepMap CRISPR Gene Dependency 1.0 2.04842 CPC-N Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.63386 SUZ12-20075857-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K4me1_lung_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null posterior group of nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.10072 CRCGN015_HEPG2_48H:G19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4 COLO-704 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.20559 ChIP_EZH2_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRCGN011_HEPG2_24H:J13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.7889 Inner dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.074 DPY-21335234-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K89537738 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.48452 GSK3A_knockdown_203_GDS4305 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.39761 BRD-K61053165 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24236 C75 DepMap CRISPR Gene Dependency 1.0 3.75656 BRD-A75954196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14395 BRD-K87193132 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07941 UO31 BioGPS Cell Line Gene Expression Profiles -1.0 -1.87309 tissues, cell types and enzyme sources TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 JVM3 DepMap CRISPR Gene Dependency 1.0 2.07208 Entorhinal area, lateral part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0474 primary motor cortex (area M1, area 4)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.25282 endoplasmic reticulum membrane GO Cellular Component Annotations 2025 1.0 null Prostate adenocarcinoma_PRAD_TCGA-G9-6347-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mantle zone of AOD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.70566 IV, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.45226 HUNS1 CCLE Cell Line Gene Expression Profiles 1.0 1.36323 EED ChEA Transcription Factor Targets 1.0 null tuberomammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50965 SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null mediodorsal nucleus of thalamus_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.876979 intermediate stratum of r6Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05122 BRD-K28720546 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3037 TCF3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 28.2941 male reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.409731 monorden-489 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null membrane part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 OVTOKO CCLE Cell Line Gene Expression Profiles 1.0 1.86521 CRCGN016_MCF10A.TP53.M_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.79425 HS 294T Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.843807 Protease-associated domain, PA InterPro Predicted Protein Domain Annotations 1.0 null Lung adenocarcinoma_LUAD_TCGA-MN-A4N5-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TestisIntersitial BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.39854 subiculum, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.876244 TET1-21490601-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Autosomal recessive nonsyndromic deafness 68 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 2.32 orbital frontal cortex_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.35207 BRD-K56739005 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.71776 CX-1 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.565 Sarcoma_SARC_TCGA-X6-A7W8-01A-21R-A355-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ebolavirus(EBOV)_3day_PBMCs_17725815_GSE8317 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.14514 GSE153064,GSE153065_1_v_0_hdac3_mouse RummaGEO Gene Perturbation Signatures -1.0 null Lung adenocarcinoma_LUAD_TCGA-05-4426-01A-01R-1206-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null U-2932 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.04841 Reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 CTCF ENCODE Transcription Factor Targets 1.0 null 496100339_HIP_no dementia_TBI_79_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.40914 MZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.16474 VZ in septal region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.881215 gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 PMC10247733-41408_2023_863_MOESM2_ESM.pdf-581-ZNF878_ZNF878 Rummagene Transcription Factor Associations 2026 1.0 null pipenzolate LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26179 NB10 COSMIC Cell Line Gene Mutation Profiles 1.0 null RKN Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07601 putamen, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.847077 cell part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K54381125 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.05477 GSE122067_3_v_1_mtch2_mouse RummaGEO Gene Perturbation Signatures 1.0 null IZ in superolateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.00572 H3K27me3_T-cell acute lymphoblastic leukemia_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null MDA-MB-453 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K09863466 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.20063 sodium phenylbutyrate-408 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null cerebellar cortex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.06227 SUZ12-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null modification-dependent protein catabolic process GO Biological Process Annotations 2023 1.0 null dorsal part of JcP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19948 ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2025 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7784-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9387164-Table_2.XLSX-Sheet1-CLOCK_CLOCK Rummagene Transcription Factor Associations 2026 1.0 null NCIH929 CCLE Cell Line Gene CNV Profiles 1.0 1.60902 H3K9me3_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null SETDB1-19884255-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null JURKAT COSMIC Cell Line Gene Mutation Profiles 1.0 null SF268 COSMIC Cell Line Gene Mutation Profiles 1.0 null 496100368_PCx_probable Alzheimer's disease_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.68415 Postsubiculum, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01842 CRCGN016_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.24657 SIN3B ChEA Transcription Factor Targets 1.0 null VM-CUB-1 GDSC Cell Line Gene Expression Profiles -1.0 -1.54045 A172 BioGPS Cell Line Gene Expression Profiles -1.0 -0.875641 Crohn's disease_Intestine - Large Intestine - Colon (MMHCC)_GSE6731 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.69602 BRD-K26184956 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09051 CRCGN008_HEPG2_24H:C05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.2021 anterior hypothalamic area, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.35815 16651409-SuppTable5 GeneSigDB Published Gene Signatures 1.0 null CD56+_NKCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.44903 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A184-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K59185421 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.44038 TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null HEC-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null PRDM14 ChEA Transcription Factor Targets 1.0 null BRD-K19320442 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.57861 GSE144919,GSE145177_1_v_0_dazl_mouse RummaGEO Gene Perturbation Signatures -1.0 null YWHAH CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.80493 496100536_HIP_no dementia_no TBI_87_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.05117 superficial stratum of ERCx (cortical plate/marginal zone) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56303 Apical ectoplasmic specialization COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.513 BRD-K69854611 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01845 BRD-K25081075 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42672 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MR-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.040507 CCK-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null cerebellum BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.873801 UT7 CCLE Cell Line Gene CNV Profiles 1.0 2.89376 GSE164494_0_v_2_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures -1.0 null H3K9me3_skeletal muscle myoblast_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null Colonic epithelium cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.811 CL11 CCLE Cell Line Gene Expression Profiles -1.0 -2.00778 BRD-K95537020 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.34239 whole body TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K86722849 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.54959 CatSper complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.774 BRD-A35495382 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54369 NCIH520 CCLE Cell Line Gene CNV Profiles 1.0 1.50822 AU565 COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN016_MCF10A.TP53.M_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.8326 habenula (old epithalamus) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07873 Lymphoid Neoplasm Diffuse Large B-cell Lymphoma_DLBC_TCGA-GS-A9TV-01A-11R-A38C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null protein kinase inhibitor activity GO Molecular Function Annotations 2023 1.0 null BRD-K83820627 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49521 AR-19668381-PC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null magnocellular (medial) subparafascicular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17225 choroid plexus of the lateral ventricle Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.860636 Skin Cutaneous Melanoma_SKCM_TCGA-GN-A262-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null basomedial nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.1641 LUBAC complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.255 prostatitis DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.23169 UBE2D1 Pathway Commons Protein-Protein Interactions 1.0 null Lingula (I), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37995 ZFP14 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 66.5924 MCF-7 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.81161 CRCGN016_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.3415 NKX2-4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.6668 BRD-K61651560 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18078 LN18 DepMap CRISPR Gene Dependency 1.0 2.04752 Outer dynein arm COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.014 WM793B COSMIC Cell Line Gene Mutation Profiles 1.0 null CRCGN017_MCF10A.TP53.M_24H:K03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.45808 female reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null OCT4-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HL60 BioGPS Cell Line Gene Expression Profiles 1.0 1.28936 ASCL1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 60.2436 OPM-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896616 GCIY COSMIC Cell Line Gene Mutation Profiles 1.0 null PPARG ChEA Transcription Factor Targets 1.0 null NCI-H64 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K20028734 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14253 BRD-K03546460 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29293 NCI-H358 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38104 BRD-K30581008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26692 ETV1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.7557 F5 CCLE Cell Line Gene Expression Profiles 1.0 1.77536 GATA2_G1E_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null UBE2E1 Pathway Commons Protein-Protein Interactions 1.0 null NR-8383 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.661 hsa-miR-4315 TargetScan Predicted Nonconserved microRNA Targets 1.0 0.965816 GSE173810_4_v_6_igf2_mouse RummaGEO Gene Perturbation Signatures -1.0 null BRD-K34815008 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1519 Prp19 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.927 ciclosporin-261 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null uterus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.902906 Plagl1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 59.4648 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-VS-A8EC-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null forelimb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.475423 BRD-K21467089 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1684 BRD-K29768655 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23943 Hrd1p ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.548 TestisSeminiferousTubule BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.36809 r9 part of dorsal parvicellular reticular formation Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.61084 TP53-20018659-R1E-MOUSE ChEA Transcription Factor Targets 2022 1.0 null Accessory olfactory bulb, mitral layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.23891 TestisLeydigCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.1828 DB Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0939 DOV13 DepMap CRISPR Gene Dependency 1.0 2.22289 BRD-K11517399 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04547 Brain Lower Grade Glioma_LGG_TCGA-HT-8019-01A-21R-2404-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Prostate adenocarcinoma_PRAD_TCGA-EJ-7789-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 2 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12006 bed nucleus of stria terminalis, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.918585 PMC10330983-ab-22-0432-Supplementary-Table-11.pdf-165-ZHX3_ZHX3 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN015_MCF10A.WT.HP_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4342 H3K9me3_CH12.LX_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null CRCGN015_MCF10A.TP53.M_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1747 BRD-K03221986 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.80253 LYL1 ChEA Transcription Factor Targets 1.0 null periventricular nucleus, preoptic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.56436 primary somatosensory cortex (area S1, areas 3,1,2)_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.985308 Lingula (I), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.1761 anterior (rostral) cingulate (medial prefrontal) cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1421 SNU1079 DepMap CRISPR Gene Dependency 1.0 2.17782 ChIP_SUZ12_18692474 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ZR7530 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.45853 ventricular (matrix) zone of pons Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.920222 AR ChEA Transcription Factor Targets 1.0 null H3K4me1_erythroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null HCC1806 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.888365 Female reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 calmidazolium-486 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Prostate adenocarcinoma_PRAD_TCGA-HC-7080-01A-11R-1965-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus, external part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.91553 KM12 COSMIC Cell Line Gene Mutation Profiles 1.0 null Lung adenocarcinoma_LUAD_TCGA-95-7043-01A-11R-1949-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:P02 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.12785 PMC12005766-ADVS-12-2413120-s003.xlsx-VENN1-Table_S6_related_to_Figure_S6D_List_of_overlapping_DEGs_with_the_E3_or_DUB_gene_set_from_the_iUUCD_2_0_database_ZUP1 Rummagene Transcription Factor Associations 2026 1.0 null LOVO COSMIC Cell Line Gene Mutation Profiles 1.0 null S117 DepMap CRISPR Gene Dependency 1.0 2.03944 BRD-K10589286 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10538 BRD-K60052521 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47052 496100408_PCx_no dementia_TBI_85_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.33243 RCOR1 ENCODE Transcription Factor Targets 1.0 null CRCGN015_HEPG2_48H:J22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.87885 thyroid BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 1.04166 male reproductive system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.692697 IX, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.50147 Prostate adenocarcinoma_PRAD_TCGA-HC-7745-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null LCLC-97TM1 GDSC Cell Line Gene Expression Profiles -1.0 -1.58487 RVH421 DepMap CRISPR Gene Dependency 1.0 2.08824 496100434_HIP_no dementia_TBI_95-99_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 4.07112 ZNF175 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.4919 BRD-K42526449 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.25218 endocrine gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_K562_hg19_4 ENCODE Transcription Factor Binding Site Profiles 1.0 null NCIH1915 CCLE Cell Line Gene CNV Profiles 1.0 1.37564 female reproductive gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054808 binding GO Molecular Function Annotations 2015 1.0 null CRCGN015_MCF10A.WT.HP_24H:C21 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.93246 Entorhinal area, medial part, dorsal zone, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.48481 HCC366 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.879547 cerebellar cortex_4 mos_M_12296 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.955774 CRCGN015_MCF10A.TP53.M_24H:J23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.4847 periventricular stratum of r6Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44212 BRD-K45860594 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17782 SUDHL4 CCLE Cell Line Gene CNV Profiles 1.0 1.56282 Anterolateral visual area, layer 6b Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07478 BRD-K96154586 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17788 NCI-H446 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.02378 superior occipital gyrus, right, inferior bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.15456 Sarcoma_SARC_TCGA-DX-A7ER-01A-11R-A36F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JG-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN014_HEPG2_3H:K20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.05481 GATA2 ENCODE Transcription Factor Targets 1.0 null entorhinal cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56303 cation binding GO Molecular Function Annotations 2015 1.0 null L-363 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44503 BRD-K00973124 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06313 OVISE Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852583 Tubulobulbar complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.638 ATF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.026 Pyramus (VIII) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82845 BRD-K88720906 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.79906 CRCGN009_HEPG2_24H:D11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 7.4407 PMC3804941-supp_jem.20122709_JEM_20122709_TableS1.xlsx-Suppl_Table_1C-1772_genes-Table_S1_C_1_772_significantly_overexpressed_genes_during_AR_when_combining_p-values_at_FDR_20_AR Rummagene Transcription Factor Associations 2026 1.0 null CA1 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.02685 Nucleus sagulum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2466 PMC8175556-42003_2021_2140_MOESM6_ESM.txt--EGR2_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null NCI-H1915 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03319 intermediate stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.95858 intracellular part LOCATE Curated Protein Localization Annotations 1.0 null TP53 ChEA Transcription Factor Targets 1.0 null CD34+ BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.33926 lateral trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14147 BRD-K65561930 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.65148 HDAC6 ENCODE Transcription Factor Targets 1.0 null PHC1-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K97343426 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31153 Primary somatosensory area, upper limb, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12645 phenazopyridine-2537 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null lateral hypothalamic area, anterior region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.381 BRD-K22405104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27251 medial habenular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.51178 Retinoschisis_Retina_GSE5581 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -0.380495 NCIH2141 CCLE Cell Line Gene Expression Profiles -1.0 -1.80662 SUZ12_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K99077411 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32421 496100491_HIP_no dementia_no TBI_88_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 5.85418 Nodulus (X), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34312 S-117 GDSC Cell Line Gene Expression Profiles 1.0 1.9986 CAL-148 COSMIC Cell Line Gene Mutation Profiles 1.0 null H2AK5ac_H1 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null tetraethylenepentamine-405 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null SKOV3 CCLE Cell Line Gene CNV Profiles 1.0 1.81202 PMC8545815-Table8.XLSX-Sheet1-ZNF623_ZNF623 Rummagene Transcription Factor Associations 2026 1.0 null TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null AP-4 MotifMap Predicted Transcription Factor Targets 1.0 null autosomal recessive nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.951604 P30OHK DepMap CRISPR Gene Dependency 1.0 7.45462 germ cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.090799 OAW28 CCLE Cell Line Gene CNV Profiles -1.0 -1.72356 BRD-A33119430 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3045 SETDB1-19884255-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-H4-A2HQ-01A-11R-A180-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Glucose Intolerance CTD Gene-Disease Associations 1.0 1.01174 COLO 201 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.912762 gp2d TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.138 ubiquitin protein ligase activity GO Molecular Function Annotations 2023 1.0 null MDN1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas -1.0 -2.44617 supramammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.987345 BRD-K47541706 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06114 BRD-K54837058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.25878 H3K27me3_liver_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FD-A3B7-01A-31R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Anterior olfactory nucleus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.17981 COV318 CCLE Cell Line Gene Expression Profiles 1.0 1.36359 RUNX1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PMC7825356-8844261.f3.docx-155-CREB3L3_CREB3L3 Rummagene Transcription Factor Associations 2026 1.0 null SKMM2 DepMap CRISPR Gene Dependency 1.0 2.37916 BRD-K89232006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6033 MC116 COSMIC Cell Line Gene Mutation Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A4XB-01A-11R-A26U-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KHM-1B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.943705 VZ in hypothalamic portion Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 2.39442 Skin Cutaneous Melanoma_SKCM_TCGA-DA-A1HV-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Temporal association areas, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.14355 MZ in retrosplenial cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.08947 OCIM1 CCLE Cell Line Gene CNV Profiles 1.0 2.65495 H3K4me3_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null ChIP_SUZ12_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null droperidol-5690 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null nonsyndromic deafness DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.507273 AOB, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.49761 LS-180 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K81181894 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.31579 SPI1-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K62577212 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00119 amygdalostriatal transition area Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.987996 CA2 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.94467 primary auditory cortex (core)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.08622 ISTMEL1 DepMap CRISPR Gene Dependency 1.0 2.07884 female reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 CTCFL JASPAR Predicted Human Transcription Factor Targets 2025 1.0 38.2857 layer 1 of LPrP cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.31213 SIN3B-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K88003497 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05457 BRD-K41707029 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07742 Retrosplenial area, ventral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33149 GMS-10 GDSC Cell Line Gene Expression Profiles -1.0 -2.16287 LPIN1_OE_GDS2291_587_mouse_Liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null nfe2l2_15173550_liver_lof_mouse_gpl81_gds514 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations 1.0 0.199087 PPARG-20887899-3T3-L1 PREADIPOCYTE CELLS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Anterior olfactory nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17038 BRD-K90094729 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74537 BRD-K95822658 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24849 orlistat-6420 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GP-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PRKDC CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.54676 BRD-K29728947 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10625 BRD-K75177817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28475 SP in caudal midinferior temporal cortex (area TF) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.940179 NCI-H510A COSMIC Cell Line Gene Mutation Profiles 1.0 null hesperetin-6750 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Entorhinal area, medial part, dorsal zone, layer 4 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.35308 homolog GeneRIF Biological Term Annotations 1.0 null NOMO-1 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.089 JVM3 CCLE Cell Line Gene Expression Profiles -1.0 -1.63825 PPARG-20176806-THIOMACROPHAGE-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null mRNA_ASCL2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null layer II of area 35c Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.44081 CD14+_Monocytes BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.877999 Brain Lower Grade Glioma_LGG_TCGA-DH-A7UR-01A-11R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null EP300-20729851-FORBRAIN_MIDBRAIN_LIMB_HEART-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null NCIH1836 CCLE Cell Line Gene Expression Profiles -1.0 -1.45952 HGC-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21831 CLPP_KO_GDS4791_374_mouse_Testies GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null 496100619_HIP_no dementia_no TBI_84_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.46219 cellular_component GO Cellular Component Annotations 2015 1.0 null BRD-K03093950 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.03323 BRD-K43611837 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32599 doxorubicin_homo sapiens_gpl570_gse46493 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 BRD-K37774987 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.16937 CRCGN017_MCF10A.WT.HP_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.10525 Accessory olfactory bulb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56625 blastocysts BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.10628 estradiol-373 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K21897482 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66087 H3K4me3_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GRM CCLE Cell Line Gene Expression Profiles -1.0 -2.04951 BRD-K83553001 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02204 disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.042405 r9 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.17996 superficial stratum of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.89798 layer 6 of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19378 Lymphatic edema_Skin tissue_GSE4333 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.52323 intermediate stratum of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20089 Lateral reticular nucleus, magnocellular part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02156 fasudil-436 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null inner CP in dorsomedial extrastriate cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.43682 BRD-K18887540 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.41851 Brain Lower Grade Glioma_LGG_TCGA-TQ-A7RH-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2452 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.896616 superficial stratum of r10BM Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.76615 BRD-K45044525 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05363 Flocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -3.4095 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2GL-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Lung adenocarcinoma_LUAD_TCGA-50-5044-01A-21R-1858-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null frontal pole, right, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19646 integral component of membrane GO Cellular Component Annotations 2015 1.0 null RFX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.0404 Mesothelioma_MESO_TCGA-LK-A4NZ-01A-12R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K39476596 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.50295 Cortical amygdalar area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02848 BRD-K91506006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.38478 periventricular stratum of PcPV Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22508 ERBB2_knockdown_238_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.38773 basomedial nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.885959 Gonad TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 anterior (rostral) cingulate (medial prefrontal) cortex_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.12484 Hepatitis, Autoimmune_Hepatic Tissue_GSE867 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.66048 calnexin GeneRIF Biological Term Annotations 1.0 null Liver hepatocellular carcinoma_LIHC_TCGA-CC-A7IJ-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A17X-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Ectorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.503 RBBP5_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COLO800 DepMap CRISPR Gene Dependency 1.0 8.32862 A-431 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.97 stratum lacunosum-moleculare of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.38899 ZBTB26 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.2803 BRD-K44307624 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17961 dentate gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.87628 rostral ventrolateral reticular area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.41056 SUM149PT Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.848621 BRD-K08903301 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31888 primary auditory cortex (core)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.66698 prostate gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.085864 inner CP in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.20362 SNU1077 CCLE Cell Line Gene CNV Profiles -1.0 -1.49421 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A708-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null GSE199255,GSE199356_3_v_1_pds5a_mouse RummaGEO Gene Perturbation Signatures 1.0 null primary motor cortex (area M1, area 4)_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28252 PATU8988S DepMap CRISPR Gene Dependency 1.0 2.22466 DIFI DepMap CRISPR Gene Dependency 1.0 2.17316 NCI-H1993 COSMIC Cell Line Gene Mutation Profiles 1.0 null SUZ12-18692474-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K30812092 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.1036 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-6942-01A-21R-2016-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K02934881 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18961 PMC7818749-12931_2021_1617_MOESM1_ESM.xlsx-TBX4-SYMBOL_TBX4 Rummagene Transcription Factor Associations 2026 1.0 null MZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.96776 Gli2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 26.4579 H3K9me3_mammary epithelial cell_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K20735575 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49276 nucleus of the lateral olfactory tract Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17141 Mafg JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 22.6681 CRCGN015_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.57155 cell part LOCATE Curated Protein Localization Annotations 1.0 null olfactory bulb Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09197 Prostate adenocarcinoma_PRAD_TCGA-EJ-5511-01A-01R-1580-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K80945184 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6968 SW403 DepMap CRISPR Gene Dependency 1.0 5.26342 BRD-K00263786 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10233 RET_mutant_23_GDS3319 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.69126 ERBB2_knockdown_233_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.94173 midbrain reticular formation Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.955 PRC1_BMI_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null PATU8902 CCLE Cell Line Gene CNV Profiles -1.0 -1.69748 BRD-K84062787 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66025 VCP-NPL4-UFD1 AAA ATPase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.772 hydroxyzine-6660 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN015_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.1463 PMC10684125-cm9-136-2712-s001.xlsx-Sheet1-EGR2_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-A60J-01A-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCIH647 CCLE Cell Line Gene CNV Profiles -1.0 -1.33671 NIH:OVCAR-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.38104 KARPAS299 DepMap CRISPR Gene Dependency 1.0 2.71566 SUZ12 ENCODE Transcription Factor Targets 1.0 null BRD-K33177501 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07056 PMC8755441-mmc3.xlsx-IRF7-Up-SUZ12_IRF7 Rummagene Transcription Factor Associations 2026 1.0 null abducens motor nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.25847 BRD-K08427390 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.08838 periventricular stratum of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34792 ceforanide-6751 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Adrenocortical carcinoma_ACC_TCGA-OR-A5KY-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null UBE2D2 Pathway Commons Protein-Protein Interactions 1.0 null CBP-20019798-JUKART-HUMAN ChEA Transcription Factor Targets 2022 1.0 null NCIH1944 CCLE Cell Line Gene CNV Profiles -1.0 -1.46492 periventricular stratum of r5Ve Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00251 cell part COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 DB CCLE Cell Line Gene CNV Profiles 1.0 2.08134 BRD-K59188100 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17457 TP53-20018659-R1E-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null auditory system disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 0.167915 Developmental and epileptic encephalopathy 73 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.834 OV-56 COSMIC Cell Line Gene Mutation Profiles 1.0 null OCUM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00795 H3K4me1_erythroblast_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null BRD-A02501536 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69283 BRD-K24076516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.15505 H3K27me3_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC8709578-elife-69843-supp2.xlsx-MIX_Ctr-Gene_Name_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null mRNA_DLX3_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K18979455 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.55157 ChIP_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Gli1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 20.3877 Subiculum, ventral part, stratum radiatum Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.05962 TCF7-22412390-EML-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SUZ12-18555785-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K81619018 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.40277 PPP1R3E CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.84351 CRCGN015_MCF10A.TP53.M_24H:O22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28045 proteasomal protein catabolic process GO Biological Process Annotations 2025 1.0 null BRD-K80679698 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04789 BRD-K90316899 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15476 anterior nucleus of pulvinar Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.85702 PAX6 ChEA Transcription Factor Targets 1.0 null H3K27me3_heart_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K16717067 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.05885 PMC6347838-13046_2019_1042_MOESM3_ESM.xls-PRDM16_group_peak_anno-Gene_PRDM16 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K13551202 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.27945 BD-11-DV28_10uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.01562 BRD-K73608149 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11431 BRD-K86995890 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.30355 CRCGN015_MCF10A.TP53.M_24H:K10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.28255 RCM-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.11949 Liver hepatocellular carcinoma_LIHC_TCGA-CC-5263-01A-01R-A131-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null primary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.187507 Entorhinal area, medial part, dorsal zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6382 SUZ12-18555785-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041654 Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4882-01A-02R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB415 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.16992 TK Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.21831 Ebf4 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 34.6938 PMC12717993-MEC-34-e17796-s002.xlsx-ST12_WGS_RFMix_genes_2_anc-Unnamed_14_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null Cytoplasmic ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.89 Ebolavirus(ZEBOV)_6day_PBMCs_rhAPCtreated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 0.628137 BRD-K06997715 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13625 ChIP_SETDB1_19884255 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null r5 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30373 parvocellular part of the r9LRt Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07684 H3K4me3_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K30895360 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.66296 MEL-HO GDSC Cell Line Gene Expression Profiles -1.0 -1.50855 reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null GSE179031_0_v_2_foxp1_mouse RummaGEO Gene Perturbation Signatures -1.0 null enilconazole-5113 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K95096346 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11277 SP in perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.0356 A_CA_04_2009_7dayMOI-10^3_None_GSE37569 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.33438 BRD-K23553911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.5198 UBE2E3 Pathway Commons Protein-Protein Interactions 1.0 null PMC9327205-11658_2022_358_MOESM7_ESM.xlsx-K562-BP1-Symbol_DLX4 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.52553 Brain Lower Grade Glioma_LGG_TCGA-DU-8162-01A-21R-2256-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle LOCATE Predicted Protein Localization Annotations 1.0 null medial trapezoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.83244 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3AA-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null H3K4me1_kidney_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null periventricular stratum of PcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57553 H3K9ac_ES-Bruce4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null POLR2A_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null endocrine gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 RUNX2-24764292-MC3T3-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.WT.HP_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.35461 U20S BioGPS Cell Line Gene Expression Profiles 1.0 1.11868 CRCGN011_HEPG2_24H:L13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.92975 496100294_HIP_possible Alzheimer's disease_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.53549 CRCGN017_MCF10A.TP53.M_24H:O20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.36142 KMS27 CCLE Cell Line Gene CNV Profiles 1.0 1.65346 18537972-TableS3 GeneSigDB Published Gene Signatures 1.0 null Bed nuclei of the stria terminalis, anterior division, anteromedial area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20136 AOB, outer plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.15807 BRD-K20454972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02042 BRD-K48023456 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.1298 Urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Nrf1 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 44.2002 posterolateral cortical amygdaloid area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06063 semen TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.669657 BRD-K52956006 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01888 mantle zone of r7BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22655 CREM-20920259-GC1-SPG-MOUSE ChEA Transcription Factor Targets 2022 1.0 null characterization GeneRIF Biological Term Annotations 1.0 null BRD-K37000177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05096 GSE247764_5_v_2_nell2_mouse RummaGEO Gene Perturbation Signatures 1.0 null BRD-A62995832 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23957 FLI1 ChEA Transcription Factor Targets 1.0 null CX-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12048 BRD-K94037108 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.42945 FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Breast Cancer_Mammary Gland Tissue_GSE3744 GEO Signatures of Differentially Expressed Genes for Diseases -1.0 -1.3836 BRD-K42679315 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.24808 BRD-K66632266 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.47155 JM1 DepMap CRISPR Gene Dependency 1.0 5.26201 r5 part of ventral lateral lemniscal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0738 RNF2-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null MYC ENCODE Transcription Factor Targets 1.0 null intercalated nucleus of medulla Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.2014 DJ-1_KD_GDS3750_373_human_SH-SY5Y GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K97595801 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45642 Caput epididymis TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.53 negative regulation of cell cycle GO Biological Process Annotations 2025 1.0 null CORL279 CCLE Cell Line Gene Expression Profiles -1.0 -1.90677 GSE224969,GSE224971_0_v_5_chtop_mouse RummaGEO Gene Perturbation Signatures 1.0 null CRCGN015_MCF10A.WT.HP_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.00843 CD105+_Endothelial BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.15129 BRD-K88941096 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10304 mantle zone of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81382 BRD-K43364707 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.51748 SNU1214 CCLE Cell Line Gene CNV Profiles -1.0 -2.22349 KURAMOCHI COSMIC Cell Line Gene Mutation Profiles 1.0 null Endoplasmic reticulum COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Suprageniculate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0508 NCIH1836 CCLE Cell Line Gene CNV Profiles 1.0 2.03867 negative regulation of cellular process GO Biological Process Annotations 2023 1.0 null BRD-K46619710 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.96061 ERF::NHLH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 55.549 NCI-H146 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.852583 CRCGN013_HEPG2_24H:I15 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.34446 PMC8444148-NIHMS1529754-supplement-1529754_Tab_S2.xlsx-upregulated_in_ATF4OE_txt-RNA-seq_of_C3_ATF4_OE_and_C3_neurons_ATF4 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K22670776 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08149 BRD-M45350951 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02276 BRD-K87602457 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75296 UBB_KO_GDS3906_496_mouse_Testis - 28 Days GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Membrane COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 superficial stratum of VPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.04946 BRD-A17687311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.94614 MKN-74 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.42903 MEIS1 ChEA Transcription Factor Targets 1.0 null urogenital system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null SNU-81 COSMIC Cell Line Gene Mutation Profiles 1.0 null Head and Neck squamous cell carcinoma_HNSC_TCGA-BB-4224-01A-01R-1436-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K04546974 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04652 BRD-K31197843 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22142 mouse GeneRIF Biological Term Annotations 1.0 null male reproductive system TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null medial geniculate complex, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.11957 SIN3B-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null ZBTB20_Deficiency_GDS3718_517_mouse_Developing hippocampus GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null SG in caudal entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.17815 organelle membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.049979 urinary tract TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058131 Listeriosis DisGeNET Gene-Disease Associations 1.0 null kidney GTEx Tissue Gene Expression Profiles 1.0 0.861771 BRD-K86961579 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19811 Paraflocculus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29186 urethra TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.814397 NCI-H187 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.995061 choroid plexus of the fourth ventricle Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37528 PK59 CCLE Cell Line Gene CNV Profiles -1.0 -1.72901 anterior (rostral) cingulate (medial prefrontal) cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20931 ACTC1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.88016 posteroventral (inferior) parietal cortex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.03505 BRD-K31969867 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09232 Ectorhinal area/Layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61186 Uterine Carcinosarcoma_UCS_TCGA-NA-A4QW-01A-11R-A28V-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UMRC6 CCLE Cell Line Gene CNV Profiles -1.0 -1.4501 PL45 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828364 H3K4me1_megakaryocyte_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null metal ion binding GO Molecular Function Annotations 2015 1.0 null mediodorsal nucleus of thalamus_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.843287 BRD-K87781745 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.30432 BRD-A21584932 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13658 medial habenular nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.21335 GSE115542_5_v_3_digoxin_human RummaGEO Drug Perturbation Signatures -1.0 null r2 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.56959 RCC4 CCLE Cell Line Gene Expression Profiles 1.0 1.64448 MYC_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K65752097 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.4832 PPARG-20887899-3T3-L1-MOUSE ChEA Transcription Factor Targets 2022 1.0 null layer 1 of AOD cortex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.81382 PPARG JASPAR Predicted Transcription Factor Targets 1.0 null ELK1-22589737-MCF10A-HUMAN ChEA Transcription Factor Targets 2022 1.0 null RAPA_EARLY_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations -1.0 null primary somatosensory cortex (area S1, areas 3,1,2)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.53692 H3K4me1_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null whole body TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2A6-06A-11R-A18T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null SUZ12-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null PHC1 ChEA Transcription Factor Targets 1.0 null SNU-1040 COSMIC Cell Line Gene Mutation Profiles 1.0 null transition metal ion binding GO Molecular Function Annotations 2015 1.0 null Entorhinal area, lateral part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.12521 BRD-K14258088 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.04432 hippocampus (hippocampal formation)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.07255 primary somatosensory cortex (area S1, areas 3,1,2)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01313 posterior (caudal) superior temporal cortex (area 22c)_19 pcw_F_12885 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.832796 MF-11-EW49_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.393208 BRD-K87080069 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54794 cellular_component COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041183 DFCI024 CCLE Cell Line Gene Expression Profiles 1.0 2.00886 BRD-K34506374 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18136 testis BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 2.09859 BRD-K92444813 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64223 CDX2-19796622-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null urinary system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.058394 NCOR-22424771-293T-HUMAN ChEA Transcription Factor Targets 2022 1.0 null PRDM14-21183938-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TE-6 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K03902845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.99439 MKN74 CCLE Cell Line Gene CNV Profiles -1.0 -2.90856 CRCGN015_MCF10A.TP53.M_24H:M08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.30635 Ectorhinal area/Layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.36101 AOB, mitral cell layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57982 UBF1/2-26484160-CHIP-SEQ-FIBROBLAST-HUMAN ChEA Transcription Factor Targets 2022 1.0 null H3K4me1_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Pyramus (VIII), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.02569 Accessory olfactory bulb, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57644 Huntington's Disease_CNS - Brain (MMHCC)_GSE857 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.16823 BRD-K40057256 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.08542 SUM44PE Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.907415 BRD-K75426080 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23122 U178 CCLE Cell Line Gene Expression Profiles 1.0 1.68448 H3K4me3_small intestine_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null endoplasmic reticulum membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.479245 tretinoin_homo sapiens_gpl6244_gds4180 GEO Signatures of Differentially Expressed Genes for Small Molecules 1.0 null POLR2A_testis_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null ER ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.477 Hepatomegaly CTD Gene-Disease Associations 1.0 1.10803 H3K4me1_spleen_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null layer 3 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.38072 BRD-K63420290 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11194 mainolfactoryepithelium.MOE. BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.836512 IOMMLEE CCLE Cell Line Gene Expression Profiles 1.0 1.4014 RNF2 ChEA Transcription Factor Targets 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-QT-A5XJ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC8987207-DataSheet_1.xls-TF_targets_Fig_2A-E2A_Pre-Pro-B-Cells_ChIP-seq_TCF3 Rummagene Transcription Factor Associations 2026 1.0 null MDAMB436 DepMap CRISPR Gene Dependency 1.0 6.71236 BRD-K31230200 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.34585 SP in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.23386 LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN011_HEPG2_24H:I24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.3129 PMC5193459-pone.0168968.s009.xlsx-Dharmacon_OTP_siRNA_Area-Symbol_OTP Rummagene Transcription Factor Associations 2026 1.0 null MTF2 ChEA Transcription Factor Targets 1.0 null basal nucleus of meynert, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62212 BRD-K21927299 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.59823 CRCGN017_MCF10A.TP53.M_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.36754 NCIH1915 CCLE Cell Line Gene Expression Profiles -1.0 -1.61998 NCIN87 CCLE Cell Line Gene CNV Profiles -1.0 -1.77613 NRL_Deficiency_GDS2936_630_mouse_Retinas - 10 days GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K64266251 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.56218 CRCGN016_MCF10A.WT.HP_24H:E20 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.80221 Zic1::Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 29.5244 H3K4me1_heart_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null AQP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.18579 BRD-K06058625 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74273 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.29865 layer 1 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.41557 rostral division of OFCi (area 11) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.80897 MFE319 DepMap CRISPR Gene Dependency 1.0 2.66354 V, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.06787 TET1 ChEA Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A3JD-06A-11R-A20F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K33805195 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49069 BRD-K29039402 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.13969 PcPL part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.57669 GSE115542_5_v_4_digoxin_human RummaGEO Drug Perturbation Signatures -1.0 null amygdaloid complex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2441 ERBB2_knockdown_232_GSE8373 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -2.25885 mRNA_EOMES_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null POLR2A_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null EZH2-27304074-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null ESR1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.6647 BRD-K77023196 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14938 animal TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null BRD-K19411393 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6906 Ptf1a JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 48.6589 CML-T1 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K27me3_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null BRD-K52593146 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08929 PMC11237033-41419_2024_6873_MOESM3_ESM.xls-Supplementary_Appendix_2-EGR2_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null primary auditory cortex (core)_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.991886 Entorhinal area, medial part, dorsal zone, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.92756 interpeduncular nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.77589 HCC2279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.00694 BRD-K79329532 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1297 NCI-H1838 COSMIC Cell Line Gene Mutation Profiles 1.0 null amygdalohippocampal transition zone, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.56863 stratum oriens of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.881244 Manchette COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.159 BRD-K38424085 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75716 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6GZ-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CD19+_BCells(neg._sel.) BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.21357 BRD-K41876347 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.51373 PMC8481886-Table_2.xlsx-A_subsets-AF_MSC_MSC Rummagene Transcription Factor Associations 2026 1.0 null ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2023 1.0 null mRNA_SMAD4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null VZ in posterior parahippocampal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.893878 posterior (caudal) superior temporal cortex (area 22c)_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.81403 H3K4me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null PC3 DepMap CRISPR Gene Dependency 1.0 7.38547 animal TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054144 H3K4me1_cortical plate_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null GFI1_KO_GDS4204_147_mouse_HSC GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null NCI-H1650 GDSC Cell Line Gene Expression Profiles -1.0 -1.41789 H3K9me3_G1E-ER4_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null 8-MG-BA GDSC Cell Line Gene Expression Profiles 1.0 2.26125 urogenital system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K66659401 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.8968 PMC10641274-mmc2.xlsx-FOXK1_Insulin-ENSEMBL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K40474424 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.1147 COV362 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44073 BRD-K74211805 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21633 CRCGN011_HEPG2_24H:L03 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.8746 TC32 CCLE Cell Line Gene Expression Profiles 1.0 2.02499 20386565-TableS1 GeneSigDB Published Gene Signatures 1.0 null spermatid TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.672506 H3K9me3_megakaryocyte_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A2MH-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PMC9574515-mmc2.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null VZ in thalamic region Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.54273 GSE171712_0_v_1_scgb1a1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Nucleus of the lateral olfactory tract, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.1211 PCGF5 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.87188 lateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.03232 SNU-475 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.933297 PMC9574515-mmc1.xls-THP1_0_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null NEC8 COSMIC Cell Line Gene Mutation Profiles 1.0 null Mesothelioma_MESO_TCGA-SC-A6LP-01A-11R-A34F-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null thioridazine-417 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null PMC11221067-JCMM-28-e18520-s002.xlsx-Supplementary_Table_2-EGR2_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null AOB, internal plexiform layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.47446 molecular_function GO Molecular Function Annotations 2015 1.0 null MDAMB468 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.78742 BRD-K58044926 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.72675 BRD-K80724972 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11306 PMC11836325-41467_2025_56634_MOESM8_ESM.xlsx-gene_table_NGS5844-Supplementary_Data_6_Gene_targets_lost_in_resistant_cells_upon_FOSL1_knockdown_and_their_corresponding_hallmark_pathway_FOSL1 Rummagene Transcription Factor Associations 2026 1.0 null posteroventral (inferior) parietal cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.99849 H3K9me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null frontalcortex BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -0.853618 Brain Lower Grade Glioma_LGG_TCGA-DB-A75P-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null HBL-100 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.09293 A-431 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.44073 RCOR3-21632747-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K24047785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21126 YA-78-MS95_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.349226 posteroventral (inferior) parietal cortex_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.43118 BRD-K39223744 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.19014 TFAP2C JASPAR Predicted Transcription Factor Targets 1.0 null protein tyrosine kinase inhibitor activity GO Molecular Function Annotations 2023 1.0 null LOXIMVI COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-BP-5201-01A-01R-1426-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null KYSE-140 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me3_G1E-ER4_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Organelle subcompartment COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 Gracile nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.47734 cuneus, right, striate Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.19502 ventrolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.1742 periventricular stratum of r5Tr Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.30409 inner portion of medial ganglionic eminence Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.26929 Ppara JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 16.3728 Piriform area, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.47465 BRD-K83115435 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43258 496100344_HIP_probable Alzheimer's disease_TBI_100+_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.8197 BRD-K39460811 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.56206 subcuneiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.34739 KRAS.600.LUNG.BREAST_UP.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null PMC5006001-srep32069-s2.xls-Common_with_CREM-Genes_de-regulated_by_loss_of_CREM_and_Trf2_CREM Rummagene Transcription Factor Associations 2026 1.0 null PMC7300082-41598_2020_66556_MOESM11_ESM.xlsx-Supplementary_Table_10-EGR2_EGR2 Rummagene Transcription Factor Associations 2026 1.0 null Postpiriform transition area, layers 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32838 r9 part of the lateral reticular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0444 BACH1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.3049 H3K9me3_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null KLF5-25053715-YYC3-HUMAN ChEA Transcription Factor Targets 2022 1.0 null GRANTA-519 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K23342427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.431 Skin Cutaneous Melanoma_SKCM_TCGA-EE-A29C-06A-21R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-DB-A64W-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MTF2-20144788-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null HT1080 BioGPS Cell Line Gene Expression Profiles -1.0 -1.94323 COLO704 CCLE Cell Line Gene Expression Profiles -1.0 -2.04278 NCIH3255 CCLE Cell Line Gene Expression Profiles -1.0 -2.13311 496100359_PCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.42758 membrane COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 Fetal Brain Male Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles -1.0 -0.838956 r6 (gustatory) part of solitary complex Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.44158 mantle zone of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32286 Adrenocortical carcinoma_ACC_TCGA-OR-A5JD-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ChIP_SUZ12_18974828 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null CRCGN015_MCF10A.WT.HP_24H:K18 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.60693 Medial pretectal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.72935 SK-MES-1 GDSC Cell Line Gene Expression Profiles 1.0 3.42704 negative regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO Biological Process Annotations 2025 1.0 null USF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.7568 CPCN CCLE Cell Line Gene CNV Profiles 1.0 1.32762 KOPN-8 COSMIC Cell Line Gene Mutation Profiles 1.0 null KYSE-270 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913731 CRCGN016_MCF10A.TP53.M_24H:P23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.37285 internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null cerebellar cortex_3 yrs_F_12836 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.916496 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO Biological Process Annotations 2023 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A847-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null bed nucleus of the stria terminalis, medioseptal division Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21507 H3K4me3_iPS DF 6.9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null JARID2 ChEA Transcription Factor Targets 1.0 null head of caudate nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.1473 facial nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.885755 Brain Lower Grade Glioma_LGG_TCGA-CS-6670-01A-11R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN016_MCF10A.TP53.M_24H:K05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 8.3433 dorsolateral prefrontal cortex_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.00804 amygdaloid complex_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.950044 REC1 CCLE Cell Line Gene CNV Profiles 1.0 1.79577 thyroid GTEx Tissue Gene Expression Profiles -1.0 -1.02014 COLO 205 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25679 CMK86 CCLE Cell Line Gene Expression Profiles -1.0 -2.77372 H3K27ac_testis_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null NCI-H1573 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.939752 dorsal motor nucleus of the vagus (vagal nucleus) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.37615 TP63-23658742-EP156T-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null POR_KO_GDS1349_497_mouse_liver GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-FJ-A871-01A-11R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 4 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.22792 Nuclear inner membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.259 BRD-K72770355 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06498 spiperone-1559 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null medial preoptic nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.9339 BRD-K41307047 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14258 BRD-A89681034 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01927 EP300 ChEA Transcription Factor Targets 1.0 null BRD-K72609445 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.02485 arcuate nucleus of the hypothalamus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.62177 Uvula (IX), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0463 superior frontal gyrus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.848664 Anterolateral visual area, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4427 HIVEP3 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.62972 tissues, cell types and enzyme sources TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 CRCGN016_MCF10A.TP53.M_24H:P10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.89354 BRD-A25243629 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.95019 Prostate adenocarcinoma_PRAD_TCGA-QU-A6IL-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null MDAMB175VII Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.809579 NCI-H345 COSMIC Cell Line Gene Mutation Profiles 1.0 null male reproductive gland TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K81035073 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.69779 HCC193 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.44145 ZFYVE27 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.62777 Prostate adenocarcinoma_PRAD_TCGA-HC-8265-01A-11R-2263-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-FG-5964-01A-11R-1708-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null layer 6b of PaS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.41349 inferior colliculus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.09339 BRD-K60662039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.64627 BRD-K16560691 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.57849 SK-OV-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.24235 striatum_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.20252 Entorhinal area, lateral part, layer 2a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.37386 BRD-K88200990 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.14707 rostral part of entorhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979316 721_B_lymphoblasts BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -2.19008 ECC10 CCLE Cell Line Gene CNV Profiles 1.0 1.34807 dentate gyrus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.45866 Gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 Postsubiculum, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.30597 rostral ventral respiratory cell group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.49314 medioventral part of putamen Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -2.28857 BRD-K86998514 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.10536 Hedgehog signaling complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.534 intracellular part LOCATE Predicted Protein Localization Annotations 1.0 null BRD-K78697404 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.08988 BRD-K87277021 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16608 BRD-K48777375 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05381 medial mammillary nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3968 KP-N-YS COSMIC Cell Line Gene Mutation Profiles 1.0 null ZMPSTE24_Deficiency_GDS3775_506_mouse_Embryonic fibroblasts GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null TBX2-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null BRD-A90249268 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.19339 CRCGN016_MCF10A.WT.HP_24H:F05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.51203 PMC12529848-12967_2025_7217_MOESM3_ESM.xlsx-Table_S4-Table_S4_Associations_of_genetically_proxied_proteins_with_risk_of_atrial_fibrillation_by_MR-SPI_NR3C2 Rummagene Transcription Factor Associations 2026 1.0 null MDA-MB-415 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.99607 BRD-K75584297 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.17073 BRD-K00243272 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6401 BRD-K28351377 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.36056 raphe obscurus nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.898374 GSE131377_1_v_3_spocd1_mouse RummaGEO Gene Perturbation Signatures -1.0 null RBBP5 ENCODE Transcription Factor Targets 1.0 null Perturb_15981_KO_Ewsr1_SRP164692 PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations -1.0 -1.65983 CA3 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.57394 NCI-H522 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.02526 DBNDD1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.78191 interstitial nucleus of Cajal, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.08505 lateral hypothalamic area, mammillary region, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.67348 Brain Lower Grade Glioma_LGG_TCGA-QH-A6X8-01A-12R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K95153427 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03481 Bed nuclei of the stria terminalis, anterior division, juxtacapsular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.2246 ChIP_H3K27me3_17603471_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K36090848 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52615 male reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 BRD-K97452545 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16922 PMC12823428-43587_2025_1018_MOESM3_ESM.xlsx-ST12-Supplementary_Table_12_Main_mendelian_randomisation_results_of_plasma_proteins_on_delirium_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null CRCGN016_MCF10A.WT.HP_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.64424 Brain Lower Grade Glioma_LGG_TCGA-S9-A6U2-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intracellular organelle part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.0418 H3K4me3_limb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null Brain Lower Grade Glioma_LGG_TCGA-RY-A840-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null X, left, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.05318 BRD-K92644013 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26504 U266B1 CCLE Cell Line Gene CNV Profiles 1.0 1.77466 Uvula (IX), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.01802 mRNA_TUBA1A_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K73689413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06529 AOB, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.5258 BRD-K34405227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.38358 NCIH2172 CCLE Cell Line Gene Expression Profiles 1.0 1.3881 BRD-K41009039 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.49064 intracellular part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.040992 Brain Lower Grade Glioma_LGG_TCGA-FG-A6J1-01A-11R-A31N-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null RAF1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.17238 SNU1076 CCLE Cell Line Gene CNV Profiles -1.0 -1.58 preoptic BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.66293 primary visual cortex (striate cortex, area V1/17)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.20881 Ebolavirus(ZEBOV)_7day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -0.158689 TBX4-33478486-IMR90-HUMAN-LUNG ChEA Transcription Factor Targets 2022 1.0 null BRD-K70594121 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09384 SG in granular insular cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.50041 BRD-K71184289 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.21469 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5888-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H2198 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.960026 anterior (rostral) cingulate (medial prefrontal) cortex_18 yrs_M_12984 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.876979 PMC11589140-41416_2024_2881_MOESM1_ESM.pdf-474-ZNF844_ZNF844 Rummagene Transcription Factor Associations 2026 1.0 null HCC1195 CCLE Cell Line Gene CNV Profiles -1.0 -2.25101 Ebolavirus(ZEBOV)_6day_PBMCs_rNAPc2treated_21987740_GSE24943 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.37383 pallidal islands of Calleja Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19619 ticlopidine-4074 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null amygdaloid complex_3 yrs_M_12980 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.54017 IV, left, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.12568 GATA2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.8353 Pheochromocytoma and Paraganglioma_PCPG_TCGA-RM-A68W-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRCGN015_MCF10A.TP53.M_24H:C14 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.02195 LYL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null embryonic stem no feeder BioGPS Mouse Cell Type and Tissue Gene Expression Profiles -1.0 -1.72049 H3K36me3_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null Retrosplenial area, ventral part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.0037 male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null mantle zone of JcPD Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.20089 BRD-K32251128 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.17719 polymorphic layer of rostral subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.18031 BRD-K31010207 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.23574 P31FUJ CCLE Cell Line Gene CNV Profiles 1.0 1.39744 nicotinic acid-6702 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Brain Lower Grade Glioma_LGG_TCGA-TM-A84H-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NFIB JASPAR Predicted Human Transcription Factor Targets 2025 1.0 46.9878 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO Biological Process Annotations 2023 1.0 null SW 403 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.913731 CRCGN014_HEPG2_3H:K23 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.28427 LOX-1_OE_GDS4262_435_human_HAECT - aortic endothelial cell line - 24 Hours GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null Sperm flagellum COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.881 KATOIII CCLE Cell Line Gene CNV Profiles -1.0 -1.34101 BRD-K75148160 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53087 ZBTB12 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 22.0434 ESET_KO_GDS4508_348_mouse_Dorsal telencephalon from E14.5 embryos GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null peripheral portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.11557 ALK_KD_GDS2724_105_human_DAOY medulloblastoma cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null GSE191105_2_v_4_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null CRCGN016_MCF10A.TP53.M_24H:E19 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0191 PMC4387713-supp_gad.255984.114_Table_S5.xlsx-S5E-Down_H3K27me3_DPY30_KD-Unnamed_12_AR Rummagene Transcription Factor Associations 2026 1.0 null CRCGN017_MCF10A.WT.HP_24H:E07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21115 SP in ventrolateral prefrontal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.14232 SETDB1 ChEA Transcription Factor Targets 1.0 null Disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.08 BRD-K95922469 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.39182 CRCGN013_HEPG2_24H:H24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.5722 membrane COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.055547 CDX2 ChEA Transcription Factor Targets 1.0 null SK-MEL-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.82944 HCC-15 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25679 BRD-K82364958 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06043 Entorhinal area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.65022 superficial stratum of AOB Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.52885 Heart Diseases CTD Gene-Disease Associations 1.0 1.0241 intracellular part GO Cellular Component Annotations 2015 1.0 null Neuro D MotifMap Predicted Transcription Factor Targets 1.0 null EED-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null TEAD3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.2035 CRCGN017_MCF10A.TP53.M_24H:P24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.84492 GSE191105_2_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null L363 DepMap CRISPR Gene Dependency 1.0 2.44485 Esophagus - Gastroesophageal Junction GTEx Tissue Gene Expression Profiles 2023 1.0 7.21237 turnover GeneRIF Biological Term Annotations 1.0 null PLCPRF5 CCLE Cell Line Gene Expression Profiles 1.0 1.47896 H3K27me3_megakaryocyte_mm9_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null Postpiriform transition area Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.28452 BRD-K98637033 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.41141 PAX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7647 PMC8423434-mmc7.xlsx-SOX2_Primed-Genes_n_3042_SOX2 Rummagene Transcription Factor Associations 2026 1.0 null Intracellular organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 female reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.052802 inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12835 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01198 ChIP_JARID2_20075857 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null inner SZ in midlateral temporal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 3.34509 BRD-K07557785 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.10789 EGR4_01_132 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 0.96947 NR3C2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 17.9344 Adrenocortical carcinoma_ACC_TCGA-OR-A5KU-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K09468701 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.89295 HCC70 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.953401 SNU-182 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.25679 RNF2-16625203-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null anterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.947697 CRCGN014_HEPG2_24H:A16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.21915 Arcuate hypothalamic nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.33676 cuneiform nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.17635 H3K4me1_olfactory bulb_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K23793049 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07905 CRCGN015_MCF10A.TP53.M_24H:C24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.0264 posterior triangular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.6015 PLAGL2_deficiency_GDS3010_139_mouse_embryonic small intestine GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null primary auditory cortex (core)_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.838544 Granular corneal dystrophy 2 DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.02 MG-63 COSMIC Cell Line Gene Mutation Profiles 1.0 null NCIH82 DepMap CRISPR Gene Dependency 1.0 2.815 OVISE COSMIC Cell Line Gene Mutation Profiles 1.0 null Laryngeal cancer cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.635 BRD-K52932858 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.77695 LBP-1 MotifMap Predicted Transcription Factor Targets 1.0 null CRCGN015_MCF10A.TP53.M_24H:C22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 3.9183 NCI-H510A Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68893 NCI-H889 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.68893 dorsolateral prefrontal cortex_40 yrs_F_12304 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.18599 ChIP_K27me3_17603471_mouseMEF ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null BRD-K50413145 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.9291 BRD-K02637547 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.67748 mantle zone of r2Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.57307 EJM Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.36883 H zone COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.537 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EK-A2RK-01A-11R-A18M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVCA420 DepMap CRISPR Gene Dependency 1.0 2.00741 BRD-K71870778 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.39024 Liver hepatocellular carcinoma_LIHC_TCGA-G3-A7M7-01A-12R-A352-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null cytoplasmic part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.042264 BRD-K81660107 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.24583 H3K4me3_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null superficial stratum of the VAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.21619 MEG01 CCLE Cell Line Gene CNV Profiles 1.0 1.61938 BRD-K43050752 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.41552 BRD-K61565464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23178 Sarcoma_SARC_TCGA-DX-A1KW-01A-22R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TestisGermCell BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 1.07196 BRD-K50884475 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.81422 SPI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K81293413 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.88142 chlorprothixene-6692 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null M14 COSMIC Cell Line Gene Mutation Profiles 1.0 null SNAI2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.35967 JUND JASPAR Predicted Human Transcription Factor Targets 2025 1.0 34.8991 intracellular COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 ONS76 CCLE Cell Line Gene CNV Profiles -1.0 -1.42383 BRD-K87269010 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22941 BRD-K43271856 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00877 orbital frontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.09782 BRD-K50053371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.86821 layer 2 of LOT Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06559 NCIH2081 CCLE Cell Line Gene Expression Profiles -1.0 -1.72269 HCC1833 CCLE Cell Line Gene Expression Profiles -1.0 -2.79962 W-13-643 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CTCF_embryonic fibroblast_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Pancreatic adenocarcinoma_PAAD_TCGA-HV-A7OP-01A-11R-A33R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NCI-H661 COSMIC Cell Line Gene Mutation Profiles 1.0 null ZBTB6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 26.4086 lateral nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.07703 tiotropium LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.01907 Radial spoke head COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.68 ubiquitin-protein transferase activity GO Molecular Function Annotations 2023 1.0 null superficial stratum of the Fc Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 3.13221 LN340 CCLE Cell Line Gene Expression Profiles 1.0 1.86789 ciclosporin-602 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null CRCGN008_HEPG2_24H:J06 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.11085 CRCGN013_HEPG2_24H:M13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.03614 BRD-K45428339 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83564 BRD-K56699877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.26316 raloxifene-376 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null inferolateral temporal cortex (area TEv, area 20)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.26905 gonad TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null membrane region COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.116657 BRD-K53104784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.89068 TGIF1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4349 BRD-K58248556 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00877 PBX3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 27.5485 G121 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828364 BRD-K02066524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.18011 CD4+_Tcells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.858546 A253 COSMIC Cell Line Gene Mutation Profiles 1.0 null Flocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.98853 BRD-K44328896 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.23016 H3K4me3_G1E_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null OCI-M1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.63054 SETDB1_KO_GSE40296_7_mouse_brain (telencephalon) GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null superficial stratum of r2BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17141 primary visual cortex (striate cortex, area V1/17)_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.10099 H3K27me3_ES-Bruce4_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null amiloride-1890 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null superficial stratum of LPrP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.19619 BRD-K28429328 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.82516 reproductive system TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 dorsolateral prefrontal cortex_13 pcw_M_12888 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01313 ICC2 DepMap CRISPR Gene Dependency 1.0 2.04801 BRCA1-BARD1 complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.74 putamen, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.865848 BRD-K15690866 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.75875 JMSU1 CCLE Cell Line Gene Expression Profiles -1.0 -1.78159 SREBF2 ChEA Transcription Factor Targets 1.0 null EWSR1_KD_GDS4962_469_human_Ewing sarcoma and prostate cancer GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null endomembrane system COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.188905 Skin Cutaneous Melanoma_SKCM_TCGA-FS-A1ZZ-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K14250524 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.11405 CRCGN008_HEPG2_24H:I13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.909 hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.011897 BRD-K25226763 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.33453 SW837 CCLE Cell Line Gene CNV Profiles -1.0 -1.49448 Sepsis_Splenocyte_GSE4479 GEO Signatures of Differentially Expressed Genes for Diseases 1.0 1.57878 H3K36me3_G1E-ER4_mm9_3 ENCODE Transcription Factor Binding Site Profiles 1.0 null Sarcoma_SARC_TCGA-MJ-A68H-01A-11R-A30C-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Kidney renal clear cell carcinoma_KIRC_TCGA-CJ-4642-01B-01R-1305-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K83898323 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07999 Nucleus of the lateral olfactory tract, pyramidal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.16422 modification-dependent protein catabolic process GO Biological Process Annotations 2025 1.0 null cellular_component COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.098109 H3K9me3_myotube_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null intermediate stratum of Ist Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.82183 SUZ12-18692474-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LXFL529 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.52929 Brain Lower Grade Glioma_LGG_TCGA-E1-A7YY-01A-11R-A34R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null FLI1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null QPCTL CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.46157 NBSUSSR COSMIC Cell Line Gene Mutation Profiles 1.0 null HDAC2_K562_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null COR-L279 GDSC Cell Line Gene Expression Profiles 1.0 1.62794 midbrain raphe nuclei, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.30714 BRD-K18435317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.70588 BRD-K72773830 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.35129 Crus I, right, lateral hemisphere Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.97561 paracentral lobule, posterior part, right, lateral bank of gyrus Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.3487 GSE236454,GSE236456_0_v_1_angiotensin ii_mouse RummaGEO Drug Perturbation Signatures 1.0 null benzocaine-4224 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null central nuclear group Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.64097 Sarcoma_SARC_TCGA-JV-A75J-01A-11R-A32Q-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null PC3 CCLE Cell Line Gene CNV Profiles 1.0 1.50171 Glucosidase II complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.853 HS578T Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -0.881153 EN COSMIC Cell Line Gene Mutation Profiles 1.0 null HDAC6_H1-hESC_hg19_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Lateral visual area, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.6382 Zic2 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 32.4772 BRD-K33597325 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04346 F36P CCLE Cell Line Gene CNV Profiles -1.0 -1.71468 496100515_HIP_dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.9603 orbital frontal cortex_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.30312 HT55 DepMap CRISPR Gene Dependency 1.0 3.22354 RUNX2-22187159-PCA-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Becker GDSC Cell Line Gene Expression Profiles -1.0 -1.56469 BRD-K96637326 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.58331 hand TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.781894 TALL-1 COSMIC Cell Line Gene Mutation Profiles 1.0 null KARPAS-620 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.30274 basolateral nucleus, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.09622 PMC10123531-NIHMS1874945-supplement-Table_S3.xlsx-DAY1_SOX17_peaks-Gene_Name_SOX17 Rummagene Transcription Factor Associations 2026 1.0 null primary visual cortex (striate cortex, area V1/17)_23 yrs_M_12300 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.16841 BDCA4+_DentriticCells BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -1.71987 TC-YIK COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-K30594227 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.59048 CRCGN016_MCF10A.TP53.M_24H:O13 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.88499 PMC9941047-41591_2022_2163_MOESM3_ESM.xlsx-ST12-Unnamed_1_KLF6 Rummagene Transcription Factor Associations 2026 1.0 null Orbital area, ventrolateral part, layer 6a Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.02156 primary visual cortex (striate cortex, area V1/17)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.904651 GSS CCLE Cell Line Gene Expression Profiles -1.0 -1.54834 Cortical amygdalar area, anterior part, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.08815 PMC10641274-mmc2.xlsx-FOXK1_Insulin-SYMBOL_FOXK1 Rummagene Transcription Factor Associations 2026 1.0 null Superior colliculus, zonal layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.37341 supragenual nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.26746 EZH2-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LC-2-AD COSMIC Cell Line Gene Mutation Profiles 1.0 null G402 DepMap CRISPR Gene Dependency 1.0 7.2995 posterior hypothalamic area, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.88925 SNU213 CCLE Cell Line Gene Expression Profiles -1.0 -1.58473 SNU878 CCLE Cell Line Gene Expression Profiles 1.0 1.76715 AR-19668381-PC3-HUMAN ChEA Transcription Factor Binding Site Profiles 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-KQ-A41P-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null DK-MG GDSC Cell Line Gene Expression Profiles 1.0 1.73375 Cul7-RING ubiquitin ligase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.682 Internal male genital organ TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null HMEL CCLE Cell Line Gene Expression Profiles 1.0 2.65491 RARA_01_51 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 2.63971 bounding membrane of organelle COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.052771 CRCGN017_MCF10A.TP53.M_24H:K07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.59237 tetraethylenepentamine-406 CMAP Signatures of Differentially Expressed Genes for Small Molecules -1.0 null BRD-K14359942 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.54853 ETV5::FIGLA JASPAR Predicted Human Transcription Factor Targets 2025 1.0 40.5014 vestibular nuclei, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.06921 CREB3L4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 25.4518 PcPV part of the periaqueductal gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22366 DG-75 COSMIC Cell Line Gene Mutation Profiles 1.0 null central portion of GPi Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.37127 SW-1417 cell TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.859 endoplasmic reticulum membrane GO Cellular Component Annotations 2023 1.0 null S0-EE-XMXE_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 0.221158 BRD-A95239561 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17181 Sarcoma_SARC_TCGA-WK-A8XT-01A-11R-A37L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Brain Lower Grade Glioma_LGG_TCGA-HT-8015-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K85271599 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.77504 BRD-K46269666 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.11407 CA2 field, left Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.25837 r4 liminal central gray Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54438 CANX Pathway Commons Protein-Protein Interactions 1.0 null ethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03695 Primary visual area, layer 1 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24808 BRD-K45037973 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.45765 BRD-K97707303 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.32825 Ventral pallidus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.07951 Nucleus of the posterior commissure Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.03451 18537972-TableS4 GeneSigDB Published Gene Signatures 1.0 null RCOR3-21632747-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null spermatogonium TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.178164 cortico-medial group, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.888166 NCCSTCK140 CCLE Cell Line Gene Expression Profiles -1.0 -1.82477 dorsolateral prefrontal cortex_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.83983 lateral tuberal nuclei Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.19257 AML193 CCLE Cell Line Gene Expression Profiles -1.0 -1.4999 PMC12826982-mmc5.xlsx-Table_S4-Supplementary_Table_S4_Differentially_Bound_Down-regulated_Peak-Related_Genes_in_Flag-SOX3-HSV-1_vs_Flag-SOX3-Mock_SOX3 Rummagene Transcription Factor Associations 2026 1.0 null inferolateral temporal cortex (area TEv, area 20)_8 pcw_M_13058 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.71826 r3 part of cochlear sensory column Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32286 SARS-CoV MA15_Day4-PFU-10^2_None_GSE33266 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 1.99929 SMAD2/3-21741376-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null CRCGN016_MCF10A.TP53.M_24H:H10 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.35295 PMC8545815-Table8.XLSX-Sheet1-ZNF623_1_ZNF623 Rummagene Transcription Factor Associations 2026 1.0 null HLF CCLE Cell Line Gene Expression Profiles -1.0 -1.50995 plexiform layer of TuPal Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.03638 Bladder Urothelial Carcinoma_BLCA_TCGA-E7-A97Q-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null NR2C1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.2604 ht55 TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 0.902 Nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 H3K36me3_H1 BMP4 Derived Trophoblast Cultured Cells Roadmap Epigenomics Histone Modification Site Profiles 1.0 null MEIS1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null limb TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.404039 ETV2-25802403-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null NCIH1650 CCLE Cell Line Gene CNV Profiles -1.0 -2.20497 UBE2N Pathway Commons Protein-Protein Interactions 1.0 null BRD-K26472648 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.43652 Pheochromocytoma and Paraganglioma_PCPG_TCGA-QR-A6H3-01A-11R-A35K-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ubiquitin-like protein ligase activity GO Molecular Function Annotations 2023 1.0 null BRD-K73442516 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44749 Fatty Liver CTD Gene-Disease Associations 1.0 1.07768 prostate disease DISEASES Text-mining Gene-Disease Association Evidence Scores 1.0 1.0732 Nodulus (X), molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.36467 OCIMY7 CCLE Cell Line Gene CNV Profiles 1.0 1.32969 CTCF_thymus_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null PMC9574515-mmc1.xls-THP1_60_min_GM-CSF-Target_Gene_Symbol_GLI2 Rummagene Transcription Factor Associations 2026 1.0 null Posterior limiting nucleus of the thalamus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.10342 mantle zone of Hb Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07707 Kidney renal papillary cell carcinoma_KIRP_TCGA-BQ-5885-01A-11R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K93126086 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12018 roof plate of p2 (epithalamic roofplate) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.53769 A-VN-1203-2004(H5N1)_Day1-10^2pfu_22074594_GSE33263 GEO Signatures of Differentially Expressed Genes for Viral Infections 1.0 2.39188 H3K27me3_spleen_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null HT-115 COSMIC Cell Line Gene Mutation Profiles 1.0 null Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-C5-A8YR-01A-12R-A37O-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null mediodorsal nucleus of thalamus_30 yrs_F_12290 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.19098 homatropine-5477 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null MOLM-16 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 2.14218 PRDM14-21183938-MESC-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null Zinc finger, RING-type InterPro Predicted Protein Domain Annotations 1.0 null TASK1 DepMap CRISPR Gene Dependency 1.0 5.27288 BRD-K36393312 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.3002 BRD-K79324911 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.00227 496100645_HIP_no dementia_no TBI_90-94_F Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.94986 BRD-K04757670 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.21633 BRD-K28140275 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.03671 GAREM2 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7601 NCI-H1581 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.07601 Paraflocculus, granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.29923 Brain Lower Grade Glioma_LGG_TCGA-S9-A6UB-01A-21R-A33Z-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Acute Myeloid Leukemia_LAML_TCGA-AB-2824-03A-01T-0736-13 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TAL1 ChEA Transcription Factor Targets 1.0 null ELK1 ChEA Transcription Factor Targets 1.0 null H2BK12ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null HUH-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.57888 Orbital area, medial part, layer 2/3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.0676 CLPP_KO_GSE40207_392_mouse_Testis GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null PMC9733061-13059_2022_2800_MOESM5_ESM.xlsx-Table_S4-Table_S4_Genes_assigned_to_JUNB_binding_sites_Each_peak_was_assigned_to_the_nearest_TSS_JUNB Rummagene Transcription Factor Associations 2026 1.0 null SNU216 CCLE Cell Line Gene Expression Profiles 1.0 1.37469 SK-MEL-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null H3K4me1_erythroblast_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null ZNF395_02_69 KnockTF Gene Expression Profiles with Transcription Factor Perturbations 1.0 3.70695 496100387_TCx_no dementia_no TBI_78_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 3.96584 BRD-K72738889 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31847 HDAC2 ENCODE Transcription Factor Targets 1.0 null layer 1 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.61546 Brain Lower Grade Glioma_LGG_TCGA-TM-A84O-01A-11R-A36H-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null male reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.562441 CD33+_Myeloid BioGPS Human Cell Type and Tissue Gene Expression Profiles -1.0 -0.941778 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO Biological Process Annotations 2025 1.0 null superficial stratum of r3Co Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.63037 PMC8709578-elife-69843-supp2.xlsx-MIX_E2_1h-Nearest_Ensembl_MIXL1 Rummagene Transcription Factor Associations 2026 1.0 null periventricular stratum of JcPL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.52913 HUPT4 DepMap CRISPR Gene Dependency 1.0 4.07412 CREB1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.6072 RERF-GC-1B COSMIC Cell Line Gene Mutation Profiles 1.0 null Kidney renal papillary cell carcinoma_KIRP_TCGA-DW-5560-01A-01R-1592-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ZNF16 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 47.1705 CRCGN016_MCF10A.WT.HP_24H:A22 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.14224 PMC7291745-12967_2020_2407_MOESM2_ESM.xlsx-Table_S1D_CCF_pairs-locus_PITX1 Rummagene Transcription Factor Associations 2026 1.0 null BRD-K91952416 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.39218 NEUROD1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3694 cytoplasm GO Cellular Component Annotations 2015 1.0 null BRD-K96280720 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.50012 JARID2-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null proteasome-mediated ubiquitin-dependent protein catabolic process GO Biological Process Annotations 2025 1.0 null PNGase complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.664 Lung adenocarcinoma_LUAD_TCGA-69-A59K-01A-11R-A262-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null intrinsic component of membrane GO Cellular Component Annotations 2015 1.0 null Nucleus of the lateral lemniscus, dorsal part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4957 alvespimycin-993 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null RARA_KD_GDS4065_42_human_MCF-7 GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null BRD-K21997380 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -5.18612 KIF1A CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.91674 testis TISSUES Curated Tissue Protein Expression Evidence Scores 1.0 null H3K27me3_small intestine_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null SP in temporal polar cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.47239 CB-16-SY72_1uM NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles 1.0 1.38454 BRD-K63800697 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.13288 BRD-K44521151 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05089 GSE142684_2_v_1_prdm16_mouse RummaGEO Gene Perturbation Signatures 1.0 null ChIP_EED_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null PKNOX2 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 24.3242 HCC2998 BioGPS Cell Line Gene Expression Profiles -1.0 -1.06615 LMO2-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null nuclear outer membrane-endoplasmic reticulum membrane network COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.463997 BRD-K39692099 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.76446 thymus BioGPS Mouse Cell Type and Tissue Gene Expression Profiles 1.0 0.894474 internal male genital organ TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.399492 TAL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Targets 2022 1.0 null cerebellar cortex_10 mos_M_12977 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.49908 K029AX DepMap CRISPR Gene Dependency 1.0 4.96016 BRD-K50479239 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.6025 BRD-K83752863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.15763 gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054251 inner CP in lateral temporal-occipital cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.866495 CTCF-20526341-ESCS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null HCC2814 CCLE Cell Line Gene Expression Profiles 1.0 1.68136 OC-314 GDSC Cell Line Gene Expression Profiles -1.0 -1.52457 BRD-K40612106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.06032 Disease of anatomical entity DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.042 Bladder Urothelial Carcinoma_BLCA_TCGA-MV-A51V-01A-11R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r6 part of magnocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.05165 PMC4219345-1471-2121-14-52-S4.xlsx-BORIS_6dN-Gene_Symbol_CTCFL Rummagene Transcription Factor Associations 2026 1.0 null DHX57 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.67382 GSE152050,GSE152052_1_v_0_arid1a_mouse RummaGEO Gene Perturbation Signatures 1.0 null striatum_21 pcw_F_12365 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.834388 BRD-K52335877 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.18092 BRD-K27610371 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.05574 NCIH1573 CCLE Cell Line Gene Expression Profiles 1.0 1.43007 H3K14ac_H9 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null COR-L279 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 0.828364 BRD-K11942486 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.20126 BRD-K07802542 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.60655 ventrolateral prefrontal cortex_21 yrs_F_13057 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.53692 CLPP_KO_GDS4791_537_mouse_testis GEO Signatures of Differentially Expressed Genes for Gene Perturbations 1.0 null regulation of cell cycle GO Biological Process Annotations 2023 1.0 null KMS-11 COSMIC Cell Line Gene Mutation Profiles 1.0 null CHAGO-K-1 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -2.26336 RNF2-18974828-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CA1 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.48046 anterior (rostral) cingulate (medial prefrontal) cortex_12 pcw_F_12960 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 2.28429 GSE191105_0_v_3_nat1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Radial spoke COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.963 Sarcoma_SARC_TCGA-K1-A42X-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Nodulus (X) Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.35115 MV-4-11 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.06456 BRD-K31851055 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.28574 H3K27me3_brain_mm9_1 ENCODE Transcription Factor Binding Site Profiles 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-D3-A2JF-06A-11R-A18S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K82521348 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16161 KMH-2 COSMIC Cell Line Gene Mutation Profiles 1.0 null layer 6a of PrS Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.19239 secondary spermatocyte TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.192092 ZNF692 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 37.0165 BRD-K98890753 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.06438 superficial stratum of r5BI Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14193 r2 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.17141 BRD-K21789048 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.12278 BRD-K65494150 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.75905 SET2 CCLE Cell Line Gene CNV Profiles -1.0 -2.10961 testis TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.241132 BRD-K24004917 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07205 hippocampus (hippocampal formation)_36 yrs_M_12302 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.02442 RCOR1_K562_hg19_2 ENCODE Transcription Factor Binding Site Profiles 1.0 null HNF1A_OE_GDS1499_252_human_HEK293 embryonic kidney cells GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null ALK_DN.V1 MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations 1.0 null ctnnb1_19652203_myeloma_lof_human_gpl570_gds3578 GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations -1.0 -0.326773 BRD-K27881453 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.12235 Zic3 JASPAR Predicted Mouse Transcription Factor Targets 2025 1.0 28.8664 r10 part of external cuneate nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 2.17321 Derlin-1 retrotranslocation complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 1.766 BHT-101 GDSC Cell Line Gene Expression Profiles -1.0 -1.50004 orbital frontal cortex_1 yrs_F_12830 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.949584 HT-29 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.12048 Brain Lower Grade Glioma_LGG_TCGA-FG-8189-01B-11R-A28M-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null r1 part of lateral pontine nuclei Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.32153 dorsolateral prefrontal cortex_26 pcw_F_12949 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.2176 mRNA_KLF4_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null IZ in caudal perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.42261 T3M4 DepMap CRISPR Gene Dependency 1.0 2.22886 LIVF001-019 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.83017 superior periolivary nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.06656 BRD-K69337311 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.14664 FLI1-26923725-CHIP-SEQ-MACROPHAGESS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K32370845 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.43268 nucleus accumbens, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.42396 BRD-K87290989 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.17516 BRD-K42976515 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.29945 cellular_component LOCATE Curated Protein Localization Annotations 1.0 null H3K9me3_GM12878_hg19_1 ENCODE Histone Modification Site Profiles 1.0 null OCI-LY-3 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.0939 EP300-20729851-FORBRAIN-MIDBRAIN-LIMB-HEART-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K81751970 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.00371 BRD-K12340493 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 4.79275 CRCGN017_MCF10A.TP53.M_24H:K08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.26829 KLM1 CCLE Cell Line Gene CNV Profiles -1.0 -1.4953 SUZ12-20075857-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null LB771-HNC COSMIC Cell Line Gene Mutation Profiles 1.0 null CREB3 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 15.6481 CA3 field, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.83398 H3K4me1_ES-E14_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null AKT1_knockout_213_GSE39699 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations 1.0 1.44742 NB6 DepMap CRISPR Gene Dependency 1.0 7.74896 reproductive system TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.301398 spinal trigeminal nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.857741 H3K9me3_G1E-ER4_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null EGFR_druginhibition_82_GSE27638 GEO Signatures of Differentially Expressed Genes for Kinase Perturbations -1.0 -1.86311 amodiaquine-1570 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null cytoplasm COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 Bed nuclei of the stria terminalis, anterior division, fusiform nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.12645 layer 2 of ERCx Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.75291 posterior (caudal) superior temporal cortex (area 22c)_12 pcw_F_13060 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.28832 SG in rostral perirhinal cortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.857454 H3K4me1_embryonic fibroblast_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null H3K9ac_ES-E14_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null BRD-K41141507 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.52026 BRD-K97805186 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.4962 NatB complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.568 superficial stratum of r9BL Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.11906 Cochlear nucleus, subpedunclular granular region Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.54409 RL952 CCLE Cell Line Gene Expression Profiles 1.0 1.48784 PAX6-23342162-BETA-FORBRAIN-LENS-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null BRD-K07826724 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.5265 membrane part GO Cellular Component Annotations 2015 1.0 null Lung adenocarcinoma_LUAD_TCGA-69-7979-01A-11R-2187-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null occipital pole, left, inferior aspect Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -1.90613 ChIP_MTF2_20144788 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null TP63-22573176-HFKS-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K17420784 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.26791 496100518_HIP_no dementia_TBI_90-94_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.77418 pedunculo(pontine) tegmental nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.979919 superficial stratum of LAP Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.14356 EZH2 ChEA Transcription Factor Targets 1.0 null tissues, cell types and enzyme sources TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.053747 endoplasmic reticulum part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.381584 RING1B-27294783-CHIP-SEQ-ESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null primary auditory cortex (core)_16 pcw_M_12287 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.24981 striatum_8 yrs_M_12841 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -1.14379 GSE63048_11_v_6_morc1_mouse RummaGEO Gene Perturbation Signatures -1.0 null Blau syndrome DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.243 mRNA_MSC_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null BRD-K51511759 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.47946 H3K4me1_iPS DF 19.11 Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K05409106 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.83919 head and face region of M1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.879087 NKX2-8 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 16.7132 ZKSCAN8 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60027 CRCGN015_MCF10A.TP53.M_24H:K09 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 5.10125 A-CA-04-2009(H1N1)_3Hour_None_GSE37571 GEO Signatures of Differentially Expressed Genes for Viral Infections -1.0 -1.37027 stratum radiatum of caudal CA1 Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 1.1918 ChIP_RNF2_16625203 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null Nuclear proteasome complex COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 1.0 0.533 cell COMPARTMENTS Curated Protein Localization Evidence Scores 1.0 0.03318 CRCGN015_MCF10A.TP53.M_24H:K11 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1299 Whole body TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 tremorine-1579 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null BRD-K84517695 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.04082 CCNO CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 3.0188 intracellular membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null HOXB7-26014856-BT474-HUMAN ChEA Transcription Factor Targets 2022 1.0 null BRD-K87658102 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.0079 SREBP2-21459322-LIVER-MOUSE ChEA Transcription Factor Targets 2022 1.0 null principal sensory nucleus of trigeminal nerve Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.25579 OLIG2-26023283-AINV15-MOUSE ChEA Transcription Factor Targets 2022 1.0 null BRD-K07164317 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.22576 subethmoid nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.04104 SET-2 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.99888 Head and Neck squamous cell carcinoma_HNSC_TCGA-CX-7086-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null BRD-K94506829 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.42081 substantia nigra, pars reticulata, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.891294 dorsal juxtacommissural pretectal nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.65436 ChIP_RCOR3_21632747 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null H3K9me3_G1E_mm9_3 ENCODE Histone Modification Site Profiles 1.0 null r7 part of trigeminal transition zone Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.07989 Lung adenocarcinoma_LUAD_TCGA-55-1596-01A-01R-0946-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null COGAR359 DepMap CRISPR Gene Dependency 1.0 4.59821 cell part COMPARTMENTS Text-mining Protein Localization Evidence Scores 1.0 0.041452 mRNA_CDX2_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null gonad TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.221989 BRD-K77139764 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 6.84764 Male reproductive gland TISSUES Curated Tissue Protein Expression Evidence Scores 2025 1.0 4.0 HCC38 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles -1.0 -1.65394 ES8 DepMap CRISPR Gene Dependency 1.0 2.86853 UBE2D4 Pathway Commons Protein-Protein Interactions 1.0 null Machado-Joseph disease DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 1.0 1.135 inferolateral temporal cortex (area TEv, area 20)_4 yrs_M_12298 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -2.1386 Cervical squamous cell carcinoma and endocervical adenocarcinoma_CESC_TCGA-EA-A4BA-01A-21R-A26T-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null UBE2G2 Pathway Commons Protein-Protein Interactions 1.0 null BRD-K78668110 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.07935 BCL6 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 32.203 HCT15 BioGPS Cell Line Gene Expression Profiles -1.0 -0.902932 BRD-K44027058 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.17238 superior olivary complex, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.93635 CRO-AP2 COSMIC Cell Line Gene Mutation Profiles 1.0 null BRD-A50701104 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.07002 lateral part of r7B Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.22655 BRD-K71486446 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20765 496100602_TCx_dementia_TBI_81_M Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles 1.0 2.96581 nixinznrf4 GeneRIF Biological Term Annotations 1.0 null whole body TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.054145 naloxone-4645 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null SP in dorsomedial parietal cortex (area 7m) Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.872063 LUDLU1 DepMap CRISPR Gene Dependency 1.0 2.13011 BRD-A89354030 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.02257 Head and Neck squamous cell carcinoma_HNSC_TCGA-DQ-7591-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null OVMANA DepMap CRISPR Gene Dependency 1.0 2.39498 r5 part of parvocellular medial vestibular nucleus Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.00251 EED-16625203-MESC-mouse ChEA Transcription Factor Binding Site Profiles 1.0 null primary motor cortex (area M1, area 4)_16 pcw_M_12837 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 0.899753 BRD-A26343863 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.35154 NCI-H2009 COSMIC Cell Line Gene Mutation Profiles 1.0 null posterior cortical nucleus Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.952459 HCC2279 CCLE Cell Line Gene CNV Profiles 1.0 1.44216 EFM-192B Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.995061 GSE164494_0_v_2_rab22a_mouse RummaGEO Gene Perturbation Signatures -1.0 null orbital frontal cortex_16 pcw_M_12879 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.21078 HCC1937 COSMIC Cell Line Gene Mutation Profiles 1.0 null CLPP_KO_GDS4791_107_mouse_heart GEO Signatures of Differentially Expressed Genes for Gene Perturbations -1.0 null BRD-K96265882 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.3593 mRNA_SUZ12_19796622 ESCAPE Omics Signatures of Genes and Proteins for Stem Cells -1.0 null internal male genital organ TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 VI, right, paravermis Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.934378 TAL1-20887958-HPC-7-MOUSE ChEA Transcription Factor Binding Site Profiles 1.0 null H3K9me3_G1E_mm9_2 ENCODE Histone Modification Site Profiles 1.0 null SUZ12-18692474-MEFS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null CRCGN010_HEPG2_24H:H08 Carcinogenome Chemical Perturbation Carcinogenicity Signatures -1.0 -2.27385 STAT1 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 19.8187 Brain Lower Grade Glioma_LGG_TCGA-DU-5851-01A-13R-1896-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null endocrine gland TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 0.055752 KU812 COSMIC Cell Line Gene Mutation Profiles 1.0 null Flocculus, molecular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -2.98853 BRD-K56776985 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09589 bendroflumethiazide-2555 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null H3K27me3_Brain Anterior Caudate Roadmap Epigenomics Histone Modification Site Profiles 1.0 null BRD-K76755163 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.03886 H3K9me3_CH12.LX_mm9_1 ENCODE Histone Modification Site Profiles 1.0 null zinc ion binding GO Molecular Function Annotations 2015 1.0 null CRCGN015_MCF10A.TP53.M_24H:J24 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.1788 Adrenocortical carcinoma_ACC_TCGA-OR-A5JG-01A-11R-A29S-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null dorsal lateral geniculate nucleus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 0.91029 BRD-K98301999 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.49475 Alveolar macrophage cell line TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 1.0 1.192 gonad TISSUES Experimental Tissue Protein Expression Evidence Scores 1.0 1.0758 cell part GO Cellular Component Annotations 2015 1.0 null KMS-27 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles 1.0 1.03221 Testis BioGPS Human Cell Type and Tissue Gene Expression Profiles 1.0 2.08496 SUZ12 ChEA Transcription Factor Targets 1.0 null Skin Cutaneous Melanoma_SKCM_TCGA-EE-A180-06A-11R-A21D-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null regulation of cell cycle GO Biological Process Annotations 2025 1.0 null BRD-K63813316 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.6198 BRD-K82637883 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.44328 Retrosplenial area, ventral part, layer 5 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.24955 BRD-K92433833 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.52552 CRCGN016_MCF10A.TP53.M_24H:P16 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.48483 BRD-K09960817 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.74208 Head and Neck squamous cell carcinoma_HNSC_TCGA-CV-7424-01A-11R-2081-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null membrane-bounded organelle LOCATE Predicted Protein Localization Annotations 1.0 null ChIP_H3K9me3_19884255_mouseESC ESCAPE Omics Signatures of Genes and Proteins for Stem Cells 1.0 null ZNF574 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 33.3018 tetracycline-1397 CMAP Signatures of Differentially Expressed Genes for Small Molecules 1.0 null Cognition Disorders CTD Gene-Disease Associations 1.0 1.06552 Lung adenocarcinoma_LUAD_TCGA-97-A4M0-01A-11R-A24X-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Bladder Urothelial Carcinoma_BLCA_TCGA-UY-A78O-01A-12R-A33J-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null ubiquitin-like protein ligase activity GO Molecular Function Annotations 2025 1.0 null periventricular stratum of SeDg Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.21507 BRD-K86966177 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.29097 MCF7 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 0.588441 NCI-H920 Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -0.875779 Pyramus (VIII), granular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.54846 BRD-K86893953 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.53059 Taenia tecta, dorsal part, layer 3 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.4957 TCF4 JASPAR Predicted Human Transcription Factor Targets 2025 1.0 29.074 ZNF528 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.60452 CDX2-19796622-MESCS-MOUSE ChEA Transcription Factor Targets 2022 1.0 null SRF JASPAR Predicted Transcription Factor Targets 1.0 null BRD-K07697589 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -4.28975 BRD-A35871558 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.16749 molecular layer of caudal subiculum Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles 1.0 0.843612 paraventricular nucleus of the hypothalamus, right Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles 1.0 1.19163 BRD-K39206254 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.80725 CRCGN009_HEPG2_24H:C07 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 2.04205 dorsal part of alar p2 Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.07749 BRD-K69387464 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.09081 SMAD4 ChEA Transcription Factor Targets 1.0 null Ventromedial hypothalamic nucleus, anterior part Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles 1.0 1.14865 lateral group of nuclei, left, dorsal division Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles -1.0 -0.98353 astrocytes BioGPS Cell Line Gene Expression Profiles 1.0 0.845596 BRD-K27915221 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.20698 BRD-K56405136 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.01484 ASH-3 COSMIC Cell Line Gene Mutation Profiles 1.0 null rostral migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -0.892906 BRD-K59402582 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.70844 PA1 DepMap CRISPR Gene Dependency 1.0 2.74714 VZ in midcingulate neocortex Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.42466 SNU886 CCLE Cell Line Gene Expression Profiles -1.0 -2.38486 Bladder Urothelial Carcinoma_BLCA_TCGA-ZF-AA4X-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null YAPC Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles -1.0 -1.19348 seminal plasma TISSUES Text-mining Tissue Protein Expression Evidence Scores 1.0 1.15362 Brain Lower Grade Glioma_LGG_TCGA-HT-A614-01A-11R-A29R-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null CRLS1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 2.7971 BRD-K90136643 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.32188 BRD-K03243737 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures -1.0 -3.09655 rostral (anterior) extramural migratory stream Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles -1.0 -1.1235 MDAMB453 Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles 1.0 1.81582 Accessory olfactory bulb, glomerular layer Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles -1.0 -1.18692 primary auditory cortex (core)_13 yrs_F_12831 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray 1.0 1.01645 BRD-K99116119 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.31686 Bladder Urothelial Carcinoma_BLCA_TCGA-2F-A9KW-01A-11R-A38B-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Intracellular membrane-bounded organelle COMPARTMENTS Curated Protein Localization Evidence Scores 2025 1.0 5.0 CRCGN016_MCF10A.WT.HP_24H:D05 Carcinogenome Chemical Perturbation Carcinogenicity Signatures 1.0 4.91205 inferolateral temporal cortex (area TEv, area 20)_13 pcw_M_12820 Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray -1.0 -0.945067 BRD-K50718861 LINCS L1000 CMAP Chemical Perturbation Consensus Signatures 1.0 3.37939 GCT DepMap CRISPR Gene Dependency 1.0 2.22271 Prostate adenocarcinoma_PRAD_TCGA-EJ-7788-01A-11R-2118-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null Pheochromocytoma and Paraganglioma_PCPG_TCGA-WB-A81A-01A-11R-A35L-07 TCGA Signatures of Differentially Expressed Genes for Tumors 1.0 null TJAP1 CM4AI KOLF21J CRISPRi Gene Perturbation Atlas 1.0 4.14099