{"symbol":"ABCB11","synonyms":["PGY4","ABC16","PFIC-2","BRIC2","PFIC2","BSEP","SPGP"],"name":"ATP-binding cassette, sub-family B (MDR/TAP), member 11","description":"The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8647,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8647","proteins":[{"symbol":"ABCBB_HUMAN","href":"/api/1.0/protein/ABCBB_HUMAN"}],"hgncRootFamilies":[{"name":"ATP binding cassette transporters (ABC)","href":"/api/1.0/gene_family/ATP+binding+cassette+transporters+%28ABC%29"}]}