{"symbol":"ABCB4","synonyms":["PFIC-3","PGY3","GBD1","ABC21","ICP3","MDR3","MDR2","MDR2/3"],"name":"ATP-binding cassette, sub-family B (MDR/TAP), member 4","description":"The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.  ABC proteins transport various molecules across extra- and intra-cellular membranes.  ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).  This protein is a member of the MDR/TAP subfamily.  Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.  This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate.  The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile.  Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5244,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5244","proteins":[{"symbol":"MDR3_HUMAN","href":"/api/1.0/protein/MDR3_HUMAN"}],"hgncRootFamilies":[{"name":"ATP binding cassette transporters (ABC)","href":"/api/1.0/gene_family/ATP+binding+cassette+transporters+%28ABC%29"}]}