{"symbol":"ABCE1","synonyms":["OABP","RLI","RLI1","RNASELI","RNS4I","ABC38","RNASEL1"],"name":"ATP-binding cassette, sub-family E (OABP), member 1","description":"The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":6059,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6059","proteins":[{"symbol":"ABCE1_HUMAN","href":"/api/1.0/protein/ABCE1_HUMAN"}],"hgncRootFamilies":[{"name":"ATP binding cassette transporters (ABC)","href":"/api/1.0/gene_family/ATP+binding+cassette+transporters+%28ABC%29"}]}