{"symbol":"ABCG2","synonyms":["UAQTL1","ABCP","EST157481","MXR-1","MXR1","CD338","CDW338","GOUT1","BCRP","ABC15","BMDP","MXR"],"name":"ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)","description":"The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":9429,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9429","proteins":[{"symbol":"ABCG2_HUMAN","href":"/api/1.0/protein/ABCG2_HUMAN"}],"hgncRootFamilies":[{"name":"ATP binding cassette transporters (ABC)","href":"/api/1.0/gene_family/ATP+binding+cassette+transporters+%28ABC%29"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}