{"symbol":"ABL2","synonyms":["ARG","ABLL"],"name":"ABL proto-oncogene 2, non-receptor tyrosine kinase","description":"This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]","ncbiEntrezGeneId":27,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27","proteins":[{"symbol":"ABL2_HUMAN","href":"/api/1.0/protein/ABL2_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}