{"symbol":"ACACA","synonyms":["ACC1","ACC","ACACAD","ACAC"],"name":"acetyl-CoA carboxylase alpha","description":"Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5\u0027 sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":31,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/31","proteins":[{"symbol":"ACACA_HUMAN","href":"/api/1.0/protein/ACACA_HUMAN"}],"hgncRootFamilies":[]}