{"symbol":"ACLY","synonyms":["ACL","CLATP","ATPCL"],"name":"ATP citrate lyase","description":"ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]","ncbiEntrezGeneId":47,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/47","proteins":[{"symbol":"ACLY_HUMAN","href":"/api/1.0/protein/ACLY_HUMAN"}],"hgncRootFamilies":[]}