{"symbol":"ACTL6A","synonyms":["ARPN-BETA","BAF53A","INO80K","Arp4","ACTL6"],"name":"actin-like 6A","description":"This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":86,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/86","proteins":[{"symbol":"ACL6A_HUMAN","href":"/api/1.0/protein/ACL6A_HUMAN"}],"hgncRootFamilies":[{"name":"INO80 complex subunits (INO80)","href":"/api/1.0/gene_family/INO80+complex+subunits+%28INO80%29"}]}