{"symbol":"ACTL6B","synonyms":["BAF53B","arpNalpha"],"name":"actin-like 6B","description":"The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":51412,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51412","proteins":[{"symbol":"ACL6B_HUMAN","href":"/api/1.0/protein/ACL6B_HUMAN"}],"hgncRootFamilies":[]}