{"symbol":"ACTR1A","synonyms":["ARP1A","CTRN1"],"name":"ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)","description":"This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10121,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10121","proteins":[{"symbol":"ACTZ_HUMAN","href":"/api/1.0/protein/ACTZ_HUMAN"}],"hgncRootFamilies":[]}