{"symbol":"ACVR1B","synonyms":["ALK4","ACVRLK4","ACTRIB","SKR2"],"name":"activin A receptor, type IB","description":"This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]","ncbiEntrezGeneId":91,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/91","proteins":[{"symbol":"ACV1B_HUMAN","href":"/api/1.0/protein/ACV1B_HUMAN"}],"hgncRootFamilies":[{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"}]}