{"symbol":"ACVR1C","synonyms":["ACVRLK7","ALK7"],"name":"activin A receptor, type IC","description":"ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":130399,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/130399","proteins":[{"symbol":"ACV1C_HUMAN","href":"/api/1.0/protein/ACV1C_HUMAN"}],"hgncRootFamilies":[{"name":"Receptor kinases","href":"/api/1.0/gene_family/Receptor+kinases"}]}