{"symbol":"ADAMTS10","synonyms":["ADAM-TS10","WMS1","ADAMTS-10"],"name":"ADAM metallopeptidase with thrombospondin type 1 motif, 10","description":"This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":81794,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/81794","proteins":[{"symbol":"ATS10_HUMAN","href":"/api/1.0/protein/ATS10_HUMAN"}],"hgncRootFamilies":[{"name":"Metzincin metallopeptidases","href":"/api/1.0/gene_family/Metzincin+metallopeptidases"}]}