{"symbol":"ADAMTS3","synonyms":["HKLLS3","ADAMTS-4"],"name":"ADAM metallopeptidase with thrombospondin type 1 motif, 3","description":"This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":9508,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9508","proteins":[{"symbol":"ATS3_HUMAN","href":"/api/1.0/protein/ATS3_HUMAN"}],"hgncRootFamilies":[{"name":"Metzincin metallopeptidases","href":"/api/1.0/gene_family/Metzincin+metallopeptidases"}]}