{"symbol":"ADAMTS7","synonyms":["ADAMTS-7","ADAM-TS 7","ADAM-TS7"],"name":"ADAM metallopeptidase with thrombospondin type 1 motif, 7","description":"The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":11173,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11173","proteins":[{"symbol":"ATS7_HUMAN","href":"/api/1.0/protein/ATS7_HUMAN"}],"hgncRootFamilies":[{"name":"Metzincin metallopeptidases","href":"/api/1.0/gene_family/Metzincin+metallopeptidases"}]}