{"symbol":"ADGRL1","synonyms":["LEC2","CIRL1","LPHN1"],"name":"adhesion G protein-coupled receptor L1","description":"This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":22859,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22859","proteins":[{"symbol":"LPHN1_HUMAN","href":"/api/1.0/protein/LPHN1_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}