{"symbol":"ADH1C","synonyms":["ADH3"],"name":"alcohol dehydrogenase 1C (class I), gamma polypeptide","description":"This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]","ncbiEntrezGeneId":126,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/126","proteins":[{"symbol":"ADH1G_HUMAN","href":"/api/1.0/protein/ADH1G_HUMAN"}],"hgncRootFamilies":[{"name":"Alcohol dehydrogenases (ADH)","href":"/api/1.0/gene_family/Alcohol+dehydrogenases+%28ADH%29"}]}