{"symbol":"ADH4","synonyms":["HEL-S-4","ADH-2"],"name":"alcohol dehydrogenase 4 (class II), pi polypeptide","description":"This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":127,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/127","proteins":[{"symbol":"ADH4_HUMAN","href":"/api/1.0/protein/ADH4_HUMAN"}],"hgncRootFamilies":[{"name":"Alcohol dehydrogenases (ADH)","href":"/api/1.0/gene_family/Alcohol+dehydrogenases+%28ADH%29"}]}