{"symbol":"ADH5","synonyms":["FALDH","ADHX","ADH-3","GSH-FDH","FDH","GSNOR","HEL-S-60p"],"name":"alcohol dehydrogenase 5 (class III), chi polypeptide","description":"This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":128,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/128","proteins":[{"symbol":"ADHX_HUMAN","href":"/api/1.0/protein/ADHX_HUMAN"}],"hgncRootFamilies":[{"name":"Alcohol dehydrogenases (ADH)","href":"/api/1.0/gene_family/Alcohol+dehydrogenases+%28ADH%29"}]}