{"symbol":"ADRA1A","synonyms":["ADRA1L1","ALPHA1AAR","ADRA1C"],"name":"adrenoceptor alpha 1A","description":"Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":148,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/148","proteins":[{"symbol":"ADA1A_HUMAN","href":"/api/1.0/protein/ADA1A_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}