{"symbol":"ADRB1","synonyms":["ADRB1R","RHR","BETA1AR","B1AR"],"name":"adrenoceptor beta 1","description":"The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Sep 2019]","ncbiEntrezGeneId":153,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/153","proteins":[{"symbol":"ADRB1_HUMAN","href":"/api/1.0/protein/ADRB1_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}