{"symbol":"ADRBK1","synonyms":["BETA-ARK1","BARK1","GRK2"],"name":"adrenergic, beta, receptor kinase 1","description":"This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer\u0027s disease. [provided by RefSeq, Sep 2017]","ncbiEntrezGeneId":156,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/156","proteins":[{"symbol":"ARBK1_HUMAN","href":"/api/1.0/protein/ARBK1_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}