{"symbol":"AGAP3","synonyms":["CNT-G3","CRAG","MRIP-1","AGAP-3","CENTG3"],"name":"ArfGAP with GTPase domain, ankyrin repeat and PH domain 3","description":"This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]","ncbiEntrezGeneId":116988,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/116988","proteins":[{"symbol":"AGAP3_HUMAN","href":"/api/1.0/protein/AGAP3_HUMAN"}],"hgncRootFamilies":[{"name":"ArfGAPs","href":"/api/1.0/gene_family/ArfGAPs"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"},{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}