{"symbol":"AGO3","synonyms":["EIF2C3"],"name":"argonaute RISC catalytic component 3","description":"This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":192669,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/192669","proteins":[{"symbol":"AGO3_HUMAN","href":"/api/1.0/protein/AGO3_HUMAN"}],"hgncRootFamilies":[{"name":"Argonaute/PIWI family (AGO, PIWIL)","href":"/api/1.0/gene_family/Argonaute%24slash%24PIWI+family+%28AGO%2C+PIWIL%29"}]}