{"symbol":"AGR2","synonyms":["XAG-2","AG2","HAG-2","HEL-S-116","PDIA17","AG-2","GOB-4"],"name":"anterior gradient 2","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]","ncbiEntrezGeneId":10551,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10551","proteins":[{"symbol":"AGR2_HUMAN","href":"/api/1.0/protein/AGR2_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}