{"symbol":"AGR3","synonyms":["HAG3","HAG-3","PDIA18","AG-3","BCMP11"],"name":"anterior gradient 3","description":"This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]","ncbiEntrezGeneId":155465,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/155465","proteins":[{"symbol":"AGR3_HUMAN","href":"/api/1.0/protein/AGR3_HUMAN"}],"hgncRootFamilies":[{"name":"Protein disulfide isomerases (PDI)","href":"/api/1.0/gene_family/Protein+disulfide+isomerases+%28PDI%29"}]}