{"symbol":"AKR1C2","synonyms":["BABP","MCDR2","AKR1C-PSEUDO","DDH2","DD-2","HAKRD","DD2","TDD","DD/BABP","SRXY8"],"name":"aldo-keto reductase family 1, member C2","description":"This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":1646,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1646","proteins":[{"symbol":"AK1C2_HUMAN","href":"/api/1.0/protein/AK1C2_HUMAN"}],"hgncRootFamilies":[{"name":"Aldo-keto reductases (AKR)","href":"/api/1.0/gene_family/Aldo-keto+reductases+%28AKR%29"}]}