{"symbol":"AKR7L","synonyms":["AFAR3","AFB1-AR3","AKR7A4","AFB1-AR 3"],"name":"aldo-keto reductase family 7-like (gene/pseudogene)","description":"This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]","ncbiEntrezGeneId":246181,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/246181","proteins":[{"symbol":"ARK74_HUMAN","href":"/api/1.0/protein/ARK74_HUMAN"}],"hgncRootFamilies":[]}