{"symbol":"AKT2","synonyms":["RAC-BETA","PRKBB","PKBBETA","HIHGHH","PKBB"],"name":"v-akt murine thymoma viral oncogene homolog 2","description":"This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]","ncbiEntrezGeneId":208,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/208","proteins":[{"symbol":"AKT2_HUMAN","href":"/api/1.0/protein/AKT2_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}