{"symbol":"AKT3","synonyms":["PKBG","PRKBG","PKB-GAMMA","STK-2","RAC-PK-GAMMA","RAC-GAMMA","MPPH2"],"name":"v-akt murine thymoma viral oncogene homolog 3","description":"The protein encoded by this gene is a member of the AKT, also called PKB,  serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10000,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10000","proteins":[{"symbol":"AKT3_HUMAN","href":"/api/1.0/protein/AKT3_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}