{"symbol":"ALDH3A1","synonyms":["ALDH3","ALDHIII"],"name":"aldehyde dehydrogenase 3 family, member A1","description":"Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]","ncbiEntrezGeneId":218,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/218","proteins":[{"symbol":"AL3A1_HUMAN","href":"/api/1.0/protein/AL3A1_HUMAN"}],"hgncRootFamilies":[{"name":"Aldehyde dehydrogenases (ALDH)","href":"/api/1.0/gene_family/Aldehyde+dehydrogenases+%28ALDH%29"}]}