{"symbol":"AMBRA1","synonyms":["WDR94","DCAF3"],"name":"autophagy/beclin-1 regulator 1","description":"Enables enzyme binding activity; protein phosphatase activator activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including macroautophagy; positive regulation of free ubiquitin chain polymerization; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytosol. Part of Cul4-RING E3 ubiquitin ligase complex. Is active in cytoskeleton; mitochondrion; and nucleus. Biomarker of multiple system atrophy. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":55626,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55626","proteins":[{"symbol":"AMRA1_HUMAN","href":"/api/1.0/protein/AMRA1_HUMAN"}],"hgncRootFamilies":[{"name":"DDB1 and CUL4 associated factors (DCAF)","href":"/api/1.0/gene_family/DDB1+and+CUL4+associated+factors+%28DCAF%29"},{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}