{"symbol":"ANAPC10","synonyms":["APC10"],"name":"anaphase promoting complex subunit 10","description":"ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]","ncbiEntrezGeneId":10393,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10393","proteins":[{"symbol":"APC10_HUMAN","href":"/api/1.0/protein/APC10_HUMAN"}],"hgncRootFamilies":[{"name":"Anaphase promoting complex subunits (ANAPC)","href":"/api/1.0/gene_family/Anaphase+promoting+complex+subunits+%28ANAPC%29"}]}