{"symbol":"ANAPC7","synonyms":["APC7"],"name":"anaphase promoting complex subunit 7","description":"This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]","ncbiEntrezGeneId":51434,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51434","proteins":[{"symbol":"APC7_HUMAN","href":"/api/1.0/protein/APC7_HUMAN"}],"hgncRootFamilies":[{"name":"Tetratricopeptide repeat domain containing (TTC)","href":"/api/1.0/gene_family/Tetratricopeptide+repeat+domain+containing+%28TTC%29"},{"name":"Anaphase promoting complex subunits (ANAPC)","href":"/api/1.0/gene_family/Anaphase+promoting+complex+subunits+%28ANAPC%29"}]}