{"symbol":"ANKH","synonyms":["CPPDD","CCAL2","MANK","CMDJ","HANK","SLC62A1"],"name":"ANKH inorganic pyrophosphate transport regulator","description":"This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":56172,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56172","proteins":[{"symbol":"ANKH_HUMAN","href":"/api/1.0/protein/ANKH_HUMAN"}],"hgncRootFamilies":[]}