{"symbol":"AP5Z1","synonyms":["KIAA0415","SPG48"],"name":"adaptor-related protein complex 5, zeta 1 subunit","description":"This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). [provided by RefSeq, Jan 2011]","ncbiEntrezGeneId":9907,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9907","proteins":[{"symbol":"AP5Z1_HUMAN","href":"/api/1.0/protein/AP5Z1_HUMAN"}],"hgncRootFamilies":[]}