{"symbol":"APH1B","synonyms":["TAAV688","PRO1328","APH-1B","PSFL"],"name":"APH1B gamma secretase subunit","description":"This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":83464,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/83464","proteins":[{"symbol":"APH1B_HUMAN","href":"/api/1.0/protein/APH1B_HUMAN"}],"hgncRootFamilies":[]}