{"symbol":"API5","synonyms":["AAC-11","AAC11"],"name":"apoptosis inhibitor 5","description":"This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":8539,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8539","proteins":[{"symbol":"API5_HUMAN","href":"/api/1.0/protein/API5_HUMAN"}],"hgncRootFamilies":[]}