{"symbol":"APLN","synonyms":["XNPEP2","APEL"],"name":"apelin","description":"This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":8862,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8862","proteins":[{"symbol":"APEL_HUMAN","href":"/api/1.0/protein/APEL_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}