{"symbol":"APLP1","synonyms":["APLP"],"name":"amyloid beta (A4) precursor-like protein 1","description":"This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":333,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/333","proteins":[{"symbol":"APLP1_HUMAN","href":"/api/1.0/protein/APLP1_HUMAN"}],"hgncRootFamilies":[]}