{"symbol":"APOC1","synonyms":["apo-CIB","APO-CI","APOC-I","apoC-IB"],"name":"apolipoprotein C-I","description":"This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]","ncbiEntrezGeneId":341,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/341","proteins":[{"symbol":"APOC1_HUMAN","href":"/api/1.0/protein/APOC1_HUMAN"}],"hgncRootFamilies":[{"name":"Apolipoproteins (APO)","href":"/api/1.0/gene_family/Apolipoproteins+%28APO%29"}]}