{"symbol":"ARAP1","synonyms":["CENTD2"],"name":"ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1","description":"The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]","ncbiEntrezGeneId":116985,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/116985","proteins":[{"symbol":"ARAP1_HUMAN","href":"/api/1.0/protein/ARAP1_HUMAN"}],"hgncRootFamilies":[{"name":"ArfGAPs","href":"/api/1.0/gene_family/ArfGAPs"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}