{"symbol":"ARAP2","synonyms":["CENTD1","PARX"],"name":"ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2","description":"The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]","ncbiEntrezGeneId":116984,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/116984","proteins":[{"symbol":"ARAP2_HUMAN","href":"/api/1.0/protein/ARAP2_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"},{"name":"ArfGAPs","href":"/api/1.0/gene_family/ArfGAPs"}]}