{"symbol":"ARAP3","synonyms":["DRAG1","CENTD3"],"name":"ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3","description":"This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]","ncbiEntrezGeneId":64411,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64411","proteins":[{"symbol":"ARAP3_HUMAN","href":"/api/1.0/protein/ARAP3_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"},{"name":"ArfGAPs","href":"/api/1.0/gene_family/ArfGAPs"},{"name":"Sterile alpha motif (SAM) domain containing (SAMD)","href":"/api/1.0/gene_family/Sterile+alpha+motif+%28SAM%29+domain+containing+%28SAMD%29"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}