{"symbol":"ARF1","synonyms":[],"name":"ADP-ribosylation factor 1","description":"ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":375,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/375","proteins":[{"symbol":"ARF1_HUMAN","href":"/api/1.0/protein/ARF1_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"},{"name":"Ras small GTPases superfamily","href":"/api/1.0/gene_family/Ras+small+GTPases+superfamily"}]}