{"symbol":"ARHGAP8","synonyms":["BPGAP1","PP610"],"name":"Rho GTPase activating protein 8","description":"This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]","ncbiEntrezGeneId":23779,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23779","proteins":[{"symbol":"RHG08_HUMAN","href":"/api/1.0/protein/RHG08_HUMAN"}],"hgncRootFamilies":[{"name":"Rho GTPase activating proteins (ARHGAP)","href":"/api/1.0/gene_family/Rho+GTPase+activating+proteins+%28ARHGAP%29"}]}